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11 results on '"Alcorta Lorenzo, N."'

1. AB0761 MULTICENTRIC SPANISH ANALYSIS OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS PATIENTS TREATED WITH MEPOLIZUMAB

Author

Rubiño, F., primary, Garcia-Vicuna, R., additional, Vicente-Rabaneda, E. F., additional, Rodríguez Almaraz, E., additional, Lozano Rivas, N., additional, Freire González, M., additional, Olive, A., additional, Nack, A., additional, Narváez, J., additional, Moya, P., additional, Uriarte Isacelaya, E., additional, Alcorta Lorenzo, N., additional, Marenco, J. L., additional, Ramos Giráldez, C., additional, Pinillos, V., additional, Blanco, R., additional, Benavides-Villanueva, F., additional, Martínez-Vidal, M. P., additional, and Rua-Figueroa, I., additional

Published
2023
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2. AB0330 EXPERIENCE IN THE CURRENT PRACTICE WITH BARICITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS AND INTERSTICIAL LUNG DISEASE OF THE DONOSTIA UNIVERSITY HOSPITAL

Author

Valero Jaimes, J. A., primary, De Diego Sola, A., additional, Alcorta Lorenzo, N., additional, Egües Dubuc, C. A., additional, Belzunegui Otano, J. M., additional, Uriarte Isacelaya, E., additional, Cancio Fanlo, J. J., additional, Lopez Dominguez, L. M., additional, and Maiz-Alonso, O., additional

Published
2022
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3. AB0230 OPTIMIZED TREATMENT OF BIOLOGICAL DISEASE MODIFYING DRUGS IN ROUTINE CLINICAL PRACTICE: SURVIVAL STUDY ANDANALYSIS OF PATIENT CHARACTERISTICS

Author

De Diego Sola, A., primary, Alcorta Lorenzo, N., additional, Egües, C. A., additional, Lopez Dominguez, L. M., additional, Maiz-Alonso, O., additional, Cancio Fanlo, J. J., additional, Uriarte Isacelaya, E., additional, Irastorza Larburu, M. B., additional, Aranguren Redondo, M. A., additional, and Belzunegui Otano, J. M., additional

Published
2021
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4. FRI0201 OPHTHALMOLOGICAL FEATURES AT DIAGNOSIS AND IN RECURRENCES IN PATIENTS WITH GIANT CELL ARTERITIS CONFIRMED BY BIOPSY IN A TERTIARY HOSPITAL

Author

De Diego Sola, A., primary, Alcorta Lorenzo, N., additional, Valero Jaimes, J. A., additional, Egüés Dubuc, C. A., additional, Maiz-Alonso, O., additional, Blanco Esteban, A. C., additional, Cancio Fanlo, J. J., additional, Uriarte Isacelaya, E., additional, and Belzunegui Otano, J. M., additional

Published
2020
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5. AB1205 PARADOXICAL BIOLOGICS-INDUCED AUTOIMMUNE DISEASES

Author

Alcorta Lorenzo, N., primary, De Diego Sola, A., additional, Valero Jaimes, J. A., additional, Egües, C. A., additional, Cancio Fanlo, J. J., additional, Lopez Dominguez, L. M., additional, Maiz-Alonso, O., additional, Belzunegui Otano, J. M., additional, and Uriarte Isacelaya, E., additional

Published
2020
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6. SAT0516 CLINICAL CHARACTERISTICS AND PROGNOSTIC FACTORS IN PATIENTS WITH SECONDARY HEMOPHAGOCYTIC SYNDROME

Author

Egües Dubuc, C. A., primary, De Diego, A., additional, Cabrera Miranda, P., additional, Alcorta Lorenzo, N., additional, Valero Jaimes, J. A., additional, Furundarena Salsamendi, J. R., additional, Maiz-Alonso, O., additional, Lopez Dominguez, L. M., additional, Uriarte Isacelaya, E., additional, Cancio Fanlo, J. J., additional, Calvo, J., additional, and Belzunegui Otano, J. M., additional

Published
2020
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7. THU0521 EVALUATION OF LIVER FIBROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS UNDER METHOTREXATE TREATMENT. UTILITY OF FIBROSCAN AND BIOMARKERS IN ROUTINE CLINICAL PRACTICE.

Author

De Diego Sola, A., primary, Vaamonde Lorenzo, M., additional, Castiella Eguzkiza, A., additional, Sánchez Iturri, M. J., additional, Alcorta Lorenzo, N., additional, Samaniego Leoz, L., additional, Valero Jaimes, J. A., additional, Egüés Dubuc, C. A., additional, Lopez Dominguez, L. M., additional, Maiz-Alonso, O., additional, Uriarte Isacelaya, E., additional, Cancio Fanlo, J. J., additional, Zapata Morcillo, E. M., additional, and Belzunegui Otano, J. M., additional

Published
2020
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8. FRI0481 HEMOPHAGOCYTIC SECONDARY SYNDROME. DIFFERENCES BETWEEN AUTOIMMUNE AND HEMATO-ONCOLOGICAL ETIOLOGIES

Author

Egües Dubuc, C. A., primary, De Diego, A., additional, Cabrera Miranda, P., additional, Alcorta Lorenzo, N., additional, Valero Jaimes, J. A., additional, Furundarena Salsamendi, J. R., additional, Lopez Dominguez, L. M., additional, Cancio Fanlo, J. J., additional, Maiz-Alonso, O., additional, Uriarte Isacelaya, E., additional, Calvo, J., additional, and Belzunegui Otano, J. M., additional

Published
2020
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9. MULTICENTRIC SPANISH ANALYSIS OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS PATIENTS TREATED WITH MEPOLIZUMAB.

Author

Rubiño, F., Garcia-Vicuna, R., Vicente-Rabaneda, E. F., Rodríguez Almaraz, E., Lozano Rivas, N., Freire González, M., Olive, A., Nack, A., Narváez, J., Moya, P., Uriarte Isacelaya, E., Alcorta Lorenzo, N., Marenco, J. L., Ramos Giráldez, C., Pinillos, V., Blanco, R., Benavides-Villanueva, F., Martínez-Vidal, M. P., and Rua-Figueroa, I.

Published
2023
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10. Mepolizumab efficacy and safety in patients with eosinophilic granulomatosis with polyangiitis in real practice: Data from a Spanish retrospective multicentric register from Rheumatology departments.

Author

Rubiño Juárez F, García de Vicuña R, Vicente E, Rodríguez Almaraz E, Lozano Rivas N, Freire González M, Olivé Marqués A, Nack A, Narváez García J, Moya Alvarado P, Uriarte Itzazelaia E, Alcorta Lorenzo N, Marenco de la Fuente JL, Ramos C, Pinillos Aransay V, Blanco Alonso R, Benavides Villanueva F, Martínez Vidal MP, González Martín JM, and Rúa-Figueroa Í

Subjects
Humans, Retrospective Studies, Female, Male, Middle Aged, Spain, Aged, Treatment Outcome, Adult, Registries, Granulomatosis with Polyangiitis drug therapy, Rheumatology, Immunosuppressive Agents therapeutic use, Immunosuppressive Agents adverse effects, Churg-Strauss Syndrome drug therapy, Antibodies, Monoclonal, Humanized therapeutic use, Antibodies, Monoclonal, Humanized adverse effects
Abstract

Objectives: Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of ANCA-associated vasculitis mostly mediated by eosinophils. Mepolizumab (MPZ) reduces the absolute number of eosinophils in the peripheral blood and tissues and has proven efficacy in the maintenance of EGPA, as shown in a randomized controlled trial. The aim of this study is to describe the use of MPZ in EGPA in real clinical practice., Methods: This is a descriptive, retrospective and comparative analysis of the clinical features, course, response rates, outcomes and adverse effects of patients receiving MPZ for EGPA in thirteen Spanish Rheumatology departments., Results: A total of 30 EGPA patients treated with MPZ were included in the analysis. Up to 19 patients needed at least one concomitant immunosuppressant. The mean follow-up was 16 months. The use of MPZ reduced the median Birmingham Vasculitis Activity Score (BVAS), as well as the mean C-reactive protein and the levels of eosinophils. In addition, the median dose of glucocorticoids (GC) required was reduced in 79.3% of the patients and was completely suspended in 57.1%. Interestingly, the median Vasculitis Damage Index (VDI) was also calculated in 27 patients (90%), and remained stable (3 [0-12] pre-MPZ and 3 [0-12] post-MPZ). None of the patients suffered severe adverse effect, local reactions or serious infections during the treatment., Conclusions: Our data on the real practice use of MPZ in EGPA suggests that this drug has good efficacy, is safe and reduces the dependence on glucocorticoids or even their complete withdrawal. Furthermore, it appears to prevent the organic damage progression associated with this disease., (Copyright © 2024 Sociedad Española de Reumatología (SER), Colegio Mexicano de Reumatología (CMR) and Elsevier España, S.L.U. All rights reserved.)

Published
2025
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