1. Inhibition of the NLRP3 inflammasome prevents ovarian aging.
- Author
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Navarro-Pando, José M., Alcocer-GÃmez, ElÃsabet, CastejÃn-Vega, Beatriz, Navarro-Villarán, Elena, Condés-Hervás, MÃnica, Mundi-Roldan, MarÃa, Muntané, Jordi, Pérez-Pulido, Antonio J., Bullon, Pedro, Chun Wang, Hoffman, Hal M., Sanz, Alberto, Mbalaviele, Gabriel, Ryffel, Bernhard, and Cordero, Mario D.
- Subjects
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OVARIAN reserve , *OVARIAN follicle , *HUMAN in vitro fertilization , *OVARIAN atresia - Abstract
The article presents research report on inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome prevents ovarian aging. Topics include ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries; and age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility.
- Published
- 2021
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