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The association between PM2.5 and cardiovascular and respiratory mortality from a gender perspective is scarce in the literature, despite the fifth sustainable development goal (SDG 5) related to gender equality. This study aims to assess whether gender analysis in the association of PM2.5 on respiratory and cardiovascular mortality shows a different impact on women than men around diverse regions of the world. We conducted a scoping review of the Web of Science database citations for epidemiological studies published between June 2020 and October 2021. The articles that met our inclusion criteria were grouped into three categories based on gender-induced effects to compare the registered risks between men and women. Of 956 articles identified, 36 published were eligible. The regions with the most gender analysis studies were Asia (n = 15), North America (n = 15), and Europe (n = 6). Irrespective of the gender-induced effect category, 7 articles reported a higher risk for women than men, and 14 declared the contrary. The magnitude of the impact of PM2.5 on cardiovascular and respiratory mortality in women is unclear. Differences in covariates, methods of analysis, and regional characteristics of each country could influence the results. All studies lacked indoor PM2.5 measurements, which may bias mortality estimates for the female population. The use of indoor PM2.5 measurements would more accurately reflect the air quality that women and girls typically breathe. [ABSTRACT FROM AUTHOR]

Objective: The prostate-specific antigen (PSA) is the primary biomarker to diagnose prostate cancer. Hepcidin has been reported as an alternative for this diagnosis; however, it is unclear how PSA and hepcidin function at high altitude (HA). This study aims to assess the association between hepcidin with PSA in HA residents chronically exposed to hypobaric hypoxia. Methods: We retrospectively examined data of 70 healthy males (aged 18–65-yearsold) from four different altitudes cities in Peru: Lima (<150 m), Huancayo (2380 m), Puno (3800 m), and Cerro de Pasco (4320 m). Serum hepcidin, testosterone, and PSA were analyzed by chemiluminescence immunoassay. HA parameters (hemoglobin [Hb], pulse oxygen saturation [SpO2 ], and chronic mountain sickness [CMS] score) were also included in the study. Bivariate analyses and a multivariate linear mixed model were used to evaluate the association between hepcidin and PSA, adjusted by HA parameters, age, and body mass index (BMI). Results: Cases of excessive erythrocytosis (EE) (Hb >21 g/dL) were observed in the three highest cities. Hepcidin was positively correlated with Hb, CMS score, and BMI (P ≤ 0.05). Hepcidin was higher in Huancayo with respect to Puno, while PSA was lower in Cerro de Pasco in regard to Puno and Lima (P ≤ 0.05). Neither hepcidin nor PSA was increased by altitude in each city (P > 0.05). We did not find an association between hepcidin and PSA, even adjusted by age, BMI, Hb, and SpO2 (P ≤ 0.05). Conclusion: These findings showed no association between hepcidin and PSA levels in healthy residents at HA. [ABSTRACT FROM AUTHOR]

This article attempts to capture the bioethical-environmental panorama of the health in the residents who live on the Peruvian highlands, highlighting the inequity in access to health services that exist in this region and reflecting on the possible historical and current contextual causes that have originated differences between Inca-Andean settler and modern-Andean settler. The change in the view of the world about the environment and natural resources, the decline of justice approach, loss of solidarity, welfare, and respect to human being and nature. Besides, we describe health from a historical scenario of this region, where Public health has and will have as a challenge the application of programs that respond to the specific needs of this population, with a focus on the environment. [ABSTRACT FROM AUTHOR]

Objective: The prostate-specific antigen (PSA) is the primary biomarker to diagnose prostate cancer. Hepcidin has been reported as an alternative for this diagnosis; however, it is unclear how PSA and hepcidin function at high altitude (HA). This study aims to assess the association between hepcidin with PSA in HA residents chronically exposed to hypobaric hypoxia., Methods: We retrospectively examined data of 70 healthy males (aged 18-65-years-old) from four different altitudes cities in Peru: Lima (<150 m), Huancayo (2380 m), Puno (3800 m), and Cerro de Pasco (4320 m). Serum hepcidin, testosterone, and PSA were analyzed by chemiluminescence immunoassay. HA parameters (hemoglobin [Hb], pulse oxygen saturation [SpO 2 ], and chronic mountain sickness [CMS] score) were also included in the study. Bivariate analyses and a multivariate linear mixed model were used to evaluate the association between hepcidin and PSA, adjusted by HA parameters, age, and body mass index (BMI)., Results: Cases of excessive erythrocytosis (EE) (Hb >21 g/dL) were observed in the three highest cities. Hepcidin was positively correlated with Hb, CMS score, and BMI ( P ≤ 0.05). Hepcidin was higher in Huancayo with respect to Puno, while PSA was lower in Cerro de Pasco in regard to Puno and Lima ( P ≤ 0.05). Neither hepcidin nor PSA was increased by altitude in each city ( P > 0.05). We did not find an association between hepcidin and PSA, even adjusted by age, BMI, Hb, and SpO 2 ( P ≤ 0.05)., Conclusion: These findings showed no association between hepcidin and PSA levels in healthy residents at HA., (Copyright: © International Journal of Health Sciences.)

Background: We have previously documented an inverse relationship between PM 2.5 in Lima, Peru, and reproductive outcomes. Here, we investigate the effect of temperature on birth weight, birth weight-Z-score adjusted for gestational age, low birth weight, and preterm birth. We also explore interactions between PM 2.5 and temperature., Methods: We studied 123,034 singleton births in three public hospitals of Lima with temperature and PM 2.5 during gestation between 2012 and 2016. We used linear, logistic, and Cox regression to estimate associations between temperature during gestation and birth outcomes and explored possible modification of the temperature effect by PM 2.5 ., Results: Exposure to maximum temperature in the last trimester was inversely associated with both birth weight [β: -23.7; 95% confidence interval [CI]: -28.0, -19.5] and z-score weight-for-gestational-age (β: -0.024; 95% CI: -0.029, -0.020) with an interquartile range of 5.32 °C. There was also an increased risk of preterm birth with higher temperature (interquartile range) in the first trimester (hazard ratio: 1.04; 95% CI: 1.001, 1.070). The effect of temperature on birthweight was primarily seen at higher PM 2.5 levels. There were no statistically significant associations between temperature exposure with low birth weight., Conclusions: Exposition to maximum temperature was associated with lower birth weight and z-score weight-for-gestational-age and higher risk of preterm birth, in accordance with much of the literature. The effects on birth weight were seen only in the third trimester., (Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.)