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186 results on '"Alberts, M J"'

14. P3840Use of oral anticoagulation is less among hospitalized patients with paroxysmal compared to persistent or permanent atrial fibrillation

Author

Pokorney, S D, primary, Thomas, K L, additional, James, B, additional, Alberts, M J, additional, Berger, P B, additional, Dorsch, M, additional, Fermann, G J, additional, House, J, additional, Mann, M, additional, Naccarelli, G V, additional, Vijapurkar, U, additional, Granger, C B, additional, and Hylek, E M, additional

Published
2018
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15. Genetic Linkage Studies in Late-Onset Alzheimer’s Disease Families

Author

Pericak-Vance, M. A., Yamaoka, L. H., Haynes, C. S., Haines, J. L., Gaskell, P. C., Hung, W.-Y., Clark, C. M., Heyman, A. L., Trofatter, J. A., Eisenmenger, J. P., Gilbert, J. R., Lee, J. E., Alberts, M. J., Speer, M. C., Dawson, D. V., Bartlett, R. J., Earl, N. L., Siddique, T., Roses, A. D., Christen, Yves, editor, Sinet, Pierre Marie, editor, and Lamour, Yvon, editor

Published
1988
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16. High cardiovascular event rates in patients with asymptomatic carotid stenosis: the REACH Registry

Author

Aichner, F T, Topakian, R, Alberts, M J, Bhatt, D L, Haring, H-P, Hill, M D, Montalescot, G, Goto, S, Touzé, E, Mas, J-L, Steg, P G, Röther, J, Iversen, Helle Klingenberg, Aichner, F T, Topakian, R, Alberts, M J, Bhatt, D L, Haring, H-P, Hill, M D, Montalescot, G, Goto, S, Touzé, E, Mas, J-L, Steg, P G, Röther, J, and Iversen, Helle Klingenberg

Abstract

BACKGROUND AND PURPOSE: Data on current cardiovascular event rates in patients with asymptomatic carotid artery stenosis (ACAS) are sparse. We compared the 1-year outcomes of patients with ACAS > or =70% versus patients without ACAS in an international, prospective cohort of outpatients with or at risk of atherothrombosis. METHODS: The Reduction of Atherothrombosis for Continued Health Registry enrolled patients with either > or =3 atherothrombotic risk factors or established atherothrombotic disease. We investigated the 1-year follow-up data of patients for whom physicians reported presence/absence of ACAS at the time of inclusion. RESULTS: Compared with patients without ACAS (n = 30 329), patients with ACAS (n = 3164) had higher age- and sex-adjusted 1-year rates of transient ischaemic attack (3.51% vs. 1.61%, P <0.0001), non-fatal stroke (2.65% vs. 1.75%, P = 0.0009), fatal stroke (0.49% vs. 0.26%, P = 0.04), cardiovascular death (2.29% vs. 1.52%, P = 0.002), the composite end-point cardiovascular death/myocardial infarction/stroke (6.03% vs. 4.29%, P <0.0001) and bleeding events (1.41% vs. 0.81%, P = 0.002). In patients with ACAS, Cox regression analyses identified history of cerebrovascular ischaemic events as most important predictor of future stroke (HR 3.21, 95% CI 1.82-5.65, P <0.0001). CONCLUSION: Asymptomatic carotid artery stenosis was associated with high 1-year rates of cardiovascular and cerebrovascular ischaemic events. Stroke was powerfully predicted by prior cerebrovascular ischaemic events.

Published
2009

18. Association of apolipoprotein E allele 4 with late-onset familial and sporadic Alzheimer's disease

Author

Saunders, A. M., primary, Strittmatter, W. J., additional, Schmechel, D., additional, St. George-Hyslop, P. H., additional, Pericak-Vance, M. A., additional, Joo, S. H., additional, Rosi, B. L., additional, Gusella, J. F., additional, Crapper-MacLachlan, D. R., additional, Alberts, M. J., additional, Hulette, C., additional, Crain, B., additional, Goldgaber, D., additional, and Roses, A. D., additional

Published
2011
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32. Apolipoprotein E 4

Author

Roses, A. D., primary, Saunders, A. M., additional, Alberts, M. J., additional, Strittmatter, W. J., additional, and Schmechel, D. E., additional

Published
1994
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36. Association of apolipoprotein E allele 4 with late-onset familial and sporadic Alzheimer's disease

Author

Saunders, A. M., primary, Strittmatter, W. J., additional, Schmechel, D., additional, St. George-Hyslop, P. H., additional, Pericak-Vance, M. A., additional, Joo, S. H., additional, Rosi, B. L., additional, Gusella, J. F., additional, Crapper-MacLachlan, D. R., additional, Alberts, M. J., additional, Hulette, C., additional, Crain, B., additional, Goldgaber, D., additional, and Roses, A. D., additional

Published
1993
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45. Diagnosis and treatment of ischemic stroke.

Author

Alberts, Mark J. and Alberts, M J

Subjects
*CEREBROVASCULAR disease, *ISCHEMIA, *CEREBROVASCULAR disease diagnosis, *CEREBROVASCULAR disease prevention, *HEPARIN, *TISSUE plasminogen activator, *ANTICOAGULANTS, *CEREBRAL ischemia, *DIFFERENTIAL diagnosis, *CEREBROVASCULAR disease patient rehabilitation, *DISEASE complications, *THERAPEUTICS
Abstract

Most patients who have a stroke are evaluated initially by a primary care physician. For patients to benefit from new stroke therapies that must be initiated within a few hours of stroke onset, primary care physicians must be prepared to diagnose stroke and initiate acute treatment. This article provides information on the rapid and accurate diagnosis and management of patients with acute ischemic stroke. This information is particularly relevant due to the relatively high risk:benefit ratio associated with some acute stroke therapies, such as tissue plasminogen activator. Information is also provided about medical and surgical therapies to prevent subsequent strokes. [ABSTRACT FROM AUTHOR]

Published
1999
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50. Aspiration after stroke: lesion analysis by brain MRI.

Author

Alberts, Mark, Horner, Jennifer, Gray, Linda, Brazer, Scott, Alberts, M J, Horner, J, Gray, L, and Brazer, S R

Subjects
BRAIN, CEREBROVASCULAR disease, DEGLUTITION disorders, MAGNETIC resonance imaging, DISEASE complications
Abstract

Aspiration is a common problem following stroke, resulting in feeding difficulties and aspiration pneumonia. Despite past studies using clinical assessments and computed tomographic (CT) scans of the head, the correlation of stroke location with aspiration remains unclear. Since brain magnetic resonance imaging is more sensitive than CT for many stroke types, we have correlated MRI lesions with aspiration in patients who have sustained a stroke. We selected patients with acute stroke who underwent brain MRI and a swallowing evaluation. Aspiration was present in 21 of 38 patients (55%). Patients with just small vessel infarcts had a significantly lower occurrence of aspiration (3 of 14, 21%) compared to those with both large- and small-vessel infarcts (15 of 20, 75%, p = 0.002). Multivariate analysis of several specific brain areas failed to identify a significant association between stroke location and the occurrence of aspiration. These findings suggest that patients who have experienced stroke should be individually evaluated for swallowing dysfunction regardless of stroke location or size, since even small-vessel strokes can be associated with aspiration in greater than 20% of cases. [ABSTRACT FROM AUTHOR]

Published
1992
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