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Your search keyword '"Albert K. Amegadzie"' showing total 2 results
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2 results on '"Albert K. Amegadzie"'

1. Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

Author

Brian A. Lanman, Jennifer R. Allen, John G. Allen, Albert K. Amegadzie, Kate S. Ashton, Shon K. Booker, Jian Jeffrey Chen, Ning Chen, Michael J. Frohn, Guy Goodman, David J. Kopecky, Longbin Liu, Patricia Lopez, Jonathan D. Low, Vu Ma, Ana E. Minatti, Thomas T. Nguyen, Nobuko Nishimura, Alexander J. Pickrell, Anthony B. Reed, Youngsook Shin, Aaron C. Siegmund, Nuria A. Tamayo, Christopher M. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C. Yang, Pragathi Achanta, Michael D. Bartberger, Jude Canon, L. Steven Hollis, John D. McCarter, Christopher Mohr, Karen Rex, Anne Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, Douglas A. Whittington, Stephan G. Zech, J. Russell Lipford, and Victor J. Cee

Subjects
Drug Discovery, Molecular Medicine
Published
2019
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2. Unusual polyketides from the wood-decay fungus Sistotrema raduloides

Author

William A. Ayer, Lynne. Sigler, and Albert K. Amegadzie

Subjects
Wood-decay fungus, biology, Stereochemistry, Sistotrema raduloides, Chemistry, Organic Chemistry, General Chemistry, Fungus, biology.organism_classification, Catalysis
Abstract

The metabolites of the wood rot decay fungus Sistotremaraduloides (P. Karst) Donk have been investigated and a new type of norpentaketide has been discovered. The compounds sistodiolynne (1), sistolynone (5), and sistopyrone (6) represent new carbon skeletons among natural products. The compounds are very unstable and readily polymerize in the presence of air to give black insoluble material. It has been shown by 13C NMR labelling experiments that they arise from five acetate units, and that a methyl carbon of one of the acetate units is lost during the biosynthesis. The structures were determined by spectroscopy methods, mainly NMR, and the absolute configuration of sistodiolynne was established by circular dichroism methods. Keywords: fungal metabolites, Sistotremaraduloides, norpentaketides, biosynthetic studies, polyacetylenes.

Published
1995
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