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2. 313. Gestational Food Restriction and Insulin Sensitivity in Rats: A Transcriptomic Analysis in the Nucleus Accumbens Across Developmental Stages

Author

Alberry, Bonnie, primary, Barth, Barbara, additional, Batra, Aashita, additional, Alves, Marcio Bonesso, additional, O'Toole, Nicholas, additional, Zhang, Tie Yuan, additional, Wen, Xianglan, additional, Arcego, Danusa Mar, additional, Dalle Molle, Roberta, additional, Laureano, Daniela Pereira, additional, Lupinsky, Derek, additional, Miguel, Patricia, additional, Meaney, Michael, additional, and Silveira, Patricia Pelufo, additional

Published
2024
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3. Coordinated Tcf7l2 regulation in a mouse model implicates Wnt signaling in fetal alcohol spectrum disorders

Author

Chater-Diehl, Eric, Sokolowski, Dustin, Alberry, Bonnie, and Singh, Shiva M.

Subjects
Analysis, Epigenetic inheritance -- Analysis, Neurophysiology -- Analysis, Methylation -- Analysis, Genes -- Analysis, Transcription (Genetics) -- Analysis, Pregnant women -- Analysis, DNA binding proteins -- Analysis, Fetal alcohol syndrome -- Analysis, Histones -- Analysis, Antisense RNA -- Analysis, Fetus -- Effect of alcohol on, Genetic transcription -- Analysis
Abstract

Introduction Understanding the fetal origin for many disorders and diseases remains a major challenge. Such disorders often involve prenatal encounters, including exposure to various lifestyles, drugs, and chemicals. One example [...], Mouse models of fetal alcohol spectrum disorders (FASD) have repeatedly identified genes with long-term changes in expression, DNA methylation, noncoding RNA, and histone modifications in response to neurodevelopmental alcohol exposure. Articulation of FASD is achieved via alcohol&apos;s effect on gene expression, likely involving epigenetic regulation. The list of genes affected is large and heterogeneous, depending on experimental protocol. We present reanalysis and synthesis of results highlighting the Wnt transcription factor 7 like 2 (Tcf7l2) gene as uniquely compatible with hippocampal DNA methylation, histone modifications, and gene expression changes in a coordinated response to neurodevelopmental alcohol exposure. We data-mined the literature for Tcf7l2 alterations in response to prenatal alcohol exposure. Four studies identified changes in brain Tcf7l2 expression in different FASD models. Further, we performed an in silico TCF7L2 binding site analysis for FASD mouse model data sets. Seven of these published gene lists were significantly enriched for TCF7L2 binding, indicating potential functional relationships. Finally, TCF7L2 is involved in regulation of hundreds of genes, with a role in brain development, myelination, and neuronal function. Tcf7l2 may be involved in neurological defects associated with alcohol exposure via dysregulation of many genes through Wnt signaling. Further functional work is warranted to validate this model for FASD. Key words: epigenetics, alcohol, FASD, Wnt, methylation. Les modeles de troubles du spectre de l&apos;alcoolisation foetale (TSAF) chez la souris ont mis en evidence de facon recurrente des genes dont l&apos;expression a long terme est modifiee, une methylation de 1&apos;ADN et des modifications d&apos;ARN non codants et d&apos;histones en reponse a une exposition neuro-developpementale a l&apos;alcool. L&apos;articulation des TSAF s&apos;accomplit par l&apos;effet de l&apos;alcool sur l&apos;expression genique, impliquant probablement une regulation epigenetique. La liste des genes affectes est longue et heterogene, dependamment du protocole experimental. Les auteurs presentent une reanalyse et une synthese des resultats qui mettent l&apos;accent sur le gene codant le facteur de transcription Tcf7l2 (<< transcription factor 7 like 2 >>) de la voie de Wnt comme compatible avec la methylation de l&apos;ADN, les modifications d&apos;histones et les changements d&apos;expression genique dans l&apos;hippocampe, dans une reponse coordonnee a l&apos;exposition neuro-developpementale a l&apos;alcool. Ils ont realise une exploration de donnees de la litterature portant sur les modifications de Tcf7l2 en reponse a une exposition prenatale a l&apos;alcool. Quatre etudes ont etabli des changements de l&apos;expression de Tcf7l2 dans le cerveau dans differents modeles de TSAF. Par ailleurs, ils ont realise une analyse in silico des sites de liaison de TCF7L2 dans des ensembles de donnees de modeles de TSAF chez la souris. Sept de ces listes publiees de genes ont ete significativement enrichies quant a la liaison de TCF7L2, pointant vers l&apos;existence de relations fonctionnelles potentielles. Finalement, TCF7L2 est implique dans la regulation de centaines de genes jouant un role dans le developpement du cerveau, la myelinisation et la fonction neuronale. Tcf7l2 peut etre implique dans les deficits neurologiques associes a l&apos;exposition a l&apos;alcool issus de la deregulation de plusieurs genes par la signalisation de Wnt. Des travaux supplementaires sur le plan fonctionnel se justifient pour valider ce modele dans les TSAF. [Traduit par la Redaction] Mots-cles: epigenetique, alcool, TSAF, Wnt, methylation.

Published
2019
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7. List of Contributors

Author

Abadie-Guedes, Ricardo, primary, Abate, Paula, additional, Abbott, Charles W., additional, Acquas, Elio, additional, Acuff, Samuel F., additional, Alberry, Bonnie, additional, Albrecht, Paula A., additional, Ameno, Kiyoshi, additional, Andrade, Jackie, additional, Angulo-Alcalde, Asier, additional, Anker, Justin J., additional, Asatryan, Liana, additional, Babić, Dragan, additional, Baker, Jessica A., additional, Bekker, Alex, additional, Bell, Richard L., additional, Bergeson, Susan E., additional, Bezerra, Ranilson de Souza, additional, Bianco, Claudia D., additional, Billieux, Joël, additional, Blanton, Henry L., additional, Boyadjieva, Nadka Ivanova, additional, Brancato, Anna, additional, Brocardo, Patricia S., additional, Campanella, Salvatore, additional, Cancela, Liliana M., additional, Cannizzaro, Carla, additional, Cardenas, Valerie, additional, Casañas-Sánchez, Verónica, additional, Cesconetto, Patricia A., additional, Chartier, Magali, additional, Chevillard, Lucie, additional, Chiò, Adriano, additional, Choi, Doo-Sup, additional, Chotro, M. Gabriela, additional, Coates, Jason M., additional, Concas, Alessandra, additional, Connor, Jason P., additional, Correa, Mercè, additional, Cortés-Tomás, María-Teresa, additional, Costa, Victor Diego Cupertino, additional, Davies, Daryl L., additional, de Almeida, Antônio-Carlos Guimarães, additional, de Andrade, Arthur Guerra, additional, de Castro-Neto, Antonio Gomes, additional, de Medeiros, Pollyanna Fausta Pimentel, additional, De Troyer, Rani, additional, De Vos, Aurelie, additional, Dennhardt, Ashley A., additional, Deza-Ponzio, Romina, additional, Di Nicola, Marco, additional, Díaz, Mario, additional, Didden, Robert, additional, Dilley, Julian, additional, dos Santos, Manuel Alves, additional, Dougherty, Donald M., additional, D’Hondt, Fabien, additional, D’Ovidio, Fabrizio, additional, Farré, Magí, additional, Feeney, Gerald F.X., additional, Fein, George, additional, Ferri, Vittoria Rachele, additional, Froehlich, Janice, additional, Gaztañaga, Mirari, additional, Germov, John, additional, Gierski, Fabien, additional, Gil-Mohapel, Joana, additional, Giménez-Costa, José-Antonio, additional, Gonzales, Rueben, additional, Gonzalez-Arnay, Emilio, additional, González-Reimers, Emilio, additional, Gopalsamy, Keshamalini, additional, Grisel, Judith E., additional, Guedes, Rubem Carlos Araújo, additional, Guindon, Josée, additional, Gullo, Matthew J., additional, Hamre, Kristin M., additional, Harro, Jaanus, additional, Hepworth, Julie, additional, Hernández-Fonseca, Karla, additional, Hill-Kapturczak, Nathalie, additional, Huffman, Kelly J., additional, Huynh, Nhat, additional, Ibrahim, Baharudin, additional, Imbert, Bruce, additional, Ito, Asuka, additional, Jakowec, Michael W., additional, Jamal, Mostofa, additional, Janiri, Luigi, additional, Javors, Martin A., additional, Jeanblanc, Jérôme, additional, Jesse, Sarah, additional, Juárez, Jorge, additional, Kamarajan, Chella, additional, Kang, Seungwoo, additional, Karlović, Dalibor, additional, Karns-Wright, Tara E., additional, Karpyak, Victor, additional, Kavanagh, David J., additional, Khoja, Sheraz, additional, Kinoshita, Hiroshi, additional, Koike, Haruki, additional, Kolla, Nathan J., additional, Kruisselbrink, L. Darren, additional, Kushner, Matt G., additional, Lannoy, Séverine, additional, Laramée, Philippe, additional, Leontini, Rose, additional, Lindell, Annukka K., additional, Lindsay, Jo, additional, López-Cruz, Laura, additional, Lopez-Cruzan, Marisa, additional, Lu, Lu, additional, Ludolph, Albert, additional, Macedo, Danielle, additional, Manera, Umberto, additional, Martinac, Marko, additional, Martín-González, Candelaria, additional, Mattalloni, Mara S., additional, Maurage, Pierre, additional, May, Jon, additional, McNally, Gavan P., additional, Mégarbane, Bruno, additional, Méndez, Milagros, additional, Moccia, Lorenzo, additional, Molina-Martínez, Luz M., additional, Morgan, Daniel J., additional, Morrow, A. Leslie, additional, Muga, Robert, additional, Müller-Oehring, Eva M., additional, Murphy, James G., additional, Naassila, Mickael, additional, Nentwig, Todd B., additional, Neupane, Sudan P., additional, Nicholson, Emily, additional, Panaccione, Isabella, additional, Panduro, Arturo, additional, Papaseit, Esther, additional, Pautassi, Ricardo Marcos, additional, Peana, Alessandra T., additional, Pérez, José A., additional, Pierrefiche, O., additional, Porcu, Patrizia, additional, Porru, Simona, additional, Prasad, Asheeta A., additional, Preedy, Victor R., additional, Quintero-Platt, Geraldine, additional, Quinto-Alemany, David, additional, Rahman, Shafiqur, additional, Rajendram, Rajkumar, additional, Rameh-de-Albuquerque, Rossana Carla, additional, Ramos-Lopez, Omar, additional, Richter, Linda, additional, Rivera-Iñiguez, Ingrid, additional, Rivera-Meza, Mario, additional, Roache, John D., additional, Rodrigues, Antônio Márcio, additional, Rohac, David J., additional, Rolland, Benjamin, additional, Roman, Sonia, additional, Romero-Acevedo, Lucía, additional, Salamone, John D., additional, Santolaria-Fernández, Francisco, additional, Santos, Luiz Eduardo Canton, additional, Sanvisens, Arantza, additional, Sari, Youssef, additional, Scheggi, Simona, additional, Schofield, Toni, additional, Schröder, Elisa, additional, Schulte, Tilman, additional, Scorza, Carla Alessandra, additional, Scorza, Fúlvio Alexandre, additional, Shiwalkar, Nimisha, additional, Singh, Shiva M., additional, Soares de Sousa, Caren Nádia, additional, Stove, Christophe, additional, Sundaram, Saranya, additional, Supski, Sian, additional, Takakura, Ayaka, additional, Tanaka, Naoko, additional, Tanner, Claire, additional, Uchôa, Roberta, additional, Vaht, Mariliis, additional, Valcheva-Traykova, Maria Lozanova, additional, van Duijvenbode, Neomi, additional, VanDerNagel, Joanne E.L., additional, Varadinova, Miroslava Georgieva, additional, Vasconcelos, Germana Silva, additional, Vasconcelos, Silvânia Maria Mendes, additional, Vaswani, Meera, additional, Vena, Ashley A., additional, Virgolini, Miriam B., additional, Wang, Christine C., additional, Wininger, Katheryn, additional, Yamashita, Ayako, additional, Ye, Jiang-Hong, additional, Yoshioka, Shin-ichi, additional, Young, Ross McD., additional, Yurasek, Ali M., additional, Zamoner, Ariane, additional, Zuluaga, Paola, additional, and Zuo, Wanhong, additional

Published
2019
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11. Behavioural And Molecular Consequences Of Postnatal Stress In A Mouse Model Of Fetal Alcohol Spectrum Disorder

Author

Alberry, Bonnie

Subjects
Molecular Genetics, Disorders of Environmental Origin, WGCNA, Gene Expression, Molecular and Cellular Neuroscience, Epigenetics, Behaviour, Disease Modeling, Animal Model, RNA-Seq, MeDIP-Seq
Abstract

Fetal alcohol spectrum disorders (FASD) are caused by prenatal alcohol exposure (PAE) and affect 1‑5% of the North American population. Children born with FASD often face maternal separation throughout childhood. How this early life stress (ELS) affects the severity of FASD-related deficits is poorly understood. Using a mouse model, this dissertation establishes that behavioural deficits accumulate following prenatal alcohol exposure and early life stress, assessed using tests for activity, anxiety-like behaviour as well as learning and memory. Hippocampal gene expression was evaluated using RNA-seq followed by clustering of expression profiles through weighted gene co-expression network analysis (WGCNA). A set of transcripts are associated with anxiety-like behaviour (r = 0.79, p = 0.002) and treatment (r = 0.68, p = 0.015). Genes in this module are overrepresented by transcriptional regulation and neurodevelopment genes. One member of this module, Polr2a, is downregulated by the combination of treatments. Hippocampal promoter DNA methylation was assessed using methylated DNA immunoprecipitation sequencing (MeDIP-Seq). Methylation at different genes is affected by each treatment independently, and a unique set of genes are affected by the combination of treatments. PAE leads to altered promoter DNA methylation at genes important for transcriptional regulation and ELS leads to changes at genes important for histone methylation and immune response. The combination of treatments results in DNA methylation changes at genes important for neuronal migration and immune response. The results from the same samples show that genes with altered expression and promoter methylation are critical in brain development and function. Also, there is minimal complementarity between changes in promoter DNA methylation and gene expression. Mechanisms beyond promoter DNA methylation are likely involved in lasting gene expression changes leading to behavioural deficits seen in FASD. Although further research is required to elucidate the mechanism, the results included may be valuable towards early and reliable diagnosis, together with the development of novel strategies for the amelioration of FASD-related deficits.

Published
2020

16. 30. Prenatal Adversity Promotes Sex-Specific Alterations in the Medial Prefrontal Cortex Transcriptomics, Executive Function, and Feeding Risk-Taking Behavior.

Author

Miguel, Patricia Maidana, Alberry, Bonnie, Barth, Barbara, Alves, Marcio Bonesso, Dalle Molle, Roberta, Gómez-Ilescas, Ameyalli, Batra, Aashita, Arcego, Danusa Mar, Zhang, Tie Yuan, Wen, Xianglan, Parent, Carine, O'Toole, Nicholas, Floresco, Stan, Meaney, Michael, and Silveira, Patricia Pelufo

Subjects
*RISK-taking behavior, *PREFRONTAL cortex, *EXECUTIVE function, *TRANSCRIPTOMES
Published
2024
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17. Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16–20 October 2015

Author

Zai, Gwyneth, primary, Alberry, Bonnie, additional, Arloth, Janine, additional, Bánlaki, Zsófia, additional, Bares, Cristina, additional, Boot, Erik, additional, Camilo, Caroline, additional, Chadha, Kartikay, additional, Chen, Qi, additional, Cole, Christopher B., additional, Cost, Katherine T., additional, Crow, Megan, additional, Ekpor, Ibene, additional, Fischer, Sascha B., additional, Flatau, Laura, additional, Gagliano, Sarah, additional, Kirli, Umut, additional, Kukshal, Prachi, additional, Labrie, Viviane, additional, Lang, Maren, additional, Lett, Tristram A., additional, Maffioletti, Elisabetta, additional, Maier, Robert, additional, Mihaljevic, Marina, additional, Mittal, Kirti, additional, Monson, Eric T., additional, O’Brien, Niamh L., additional, Østergaard, Søren D., additional, Ovenden, Ellen, additional, Patel, Sejal, additional, Peterson, Roseann E., additional, Pouget, Jennie G., additional, Rovaris, Diego L., additional, Seaman, Lauren, additional, Shankarappa, Bhagya, additional, Tsetsos, Fotis, additional, Vereczkei, Andrea, additional, Wang, Chenyao, additional, Xulu, Khethelo, additional, Yuen, Ryan K.C., additional, Zhao, Jingjing, additional, Zai, Clement C., additional, and Kennedy, James L., additional

Published
2016
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