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Your search keyword '"Alberghina, Cristiana"' showing total 7 results
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7 results on '"Alberghina, Cristiana"'

2. Microglia and glioblastoma heterocellular interplay sustains tumour growth and proliferation as an off‐target effect of radiotherapy.

Author

Alberghina, Cristiana, Torrisi, Filippo, D'Aprile, Simona, Longhitano, Lucia, Giallongo, Sebastiano, Scandura, Grazia, Mannino, Giuliana, Mele, Stefania, Sabini, Maria Gabriella, Cammarata, Francesco P., Russo, Giorgio, Abdelhameed, Ali S., Zappalà, Agata, Lo Furno, Debora, Giuffrida, Rosario, Li Volti, Giovanni, Tibullo, Daniele, Vicario, Nunzio, and Parenti, Rosalba

Subjects
*MICROGLIA, *BRAIN tumors, *GLIOBLASTOMA multiforme, *TUMOR microenvironment, *OXIDATIVE phosphorylation
Abstract

Glioblastoma (GBM), a WHO grade IV glioma, is a malignant primary brain tumour for which combination of surgery, chemotherapy and radiotherapy is the first‐line approach despite adverse effects. Tumour microenvironment (TME) is characterized by an interplay of cells and soluble factors holding a critical role in neoplastic development. Significant pathophysiological changes have been found in GBM TME, such as glia activation and oxidative stress. Microglia play a crucial role in favouring GBM growth, representing target cells of immune escape mechanisms. Our study aims at analysing radiation‐induced effects in modulating intercellular communication and identifying the basis of protective mechanisms in radiation‐naïve GBM cells. Tumour cells were treated with conditioned media (CM) derived from 0, 2 or 15 Gy irradiated GBM cells or 0, 2 or 15 Gy irradiated human microglia. We demonstrated that irradiated microglia promote an increase of GBM cell lines proliferation through paracrine signalling. On the contrary, irradiated GBM‐derived CM affect viability, triggering cell death mechanisms. In addition, we investigated whether these processes involve mitochondrial mass, fitness and oxidative phosphorylation and how GBM cells respond at these induced alterations. Our study suggests that off‐target radiotherapy modulates microglia to support GBM proliferation and induce metabolic modifications. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Epigenetics and Metabolism Reprogramming Interplay into Glioblastoma: Novel Insights on Immunosuppressive Mechanisms

Author

Torrisi, Filippo, primary, D’Aprile, Simona, additional, Denaro, Simona, additional, Pavone, Anna Maria, additional, Alberghina, Cristiana, additional, Zappalà, Agata, additional, Giuffrida, Rosario, additional, Salvatorelli, Lucia, additional, Broggi, Giuseppe, additional, Magro, Gaetano Giuseppe, additional, Calabrese, Vittorio, additional, Vicario, Nunzio, additional, and Parenti, Rosalba, additional

Published
2023
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4. Neurotrophic and immunomodulatory effects of olfactory ensheathing cells as a strategy for neuroprotection and regeneration

Author

Denaro, Simona, primary, D’Aprile, Simona, additional, Alberghina, Cristiana, additional, Pavone, Anna Maria, additional, Torrisi, Filippo, additional, Giallongo, Sebastiano, additional, Longhitano, Lucia, additional, Mannino, Giuliana, additional, Lo Furno, Debora, additional, Zappalà, Agata, additional, Giuffrida, Rosario, additional, Tibullo, Daniele, additional, Li Volti, Giovanni, additional, Vicario, Nunzio, additional, and Parenti, Rosalba, additional

Published
2022
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5. The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression

Author

Torrisi, Filippo, primary, Alberghina, Cristiana, additional, D’Aprile, Simona, additional, Pavone, Anna M., additional, Longhitano, Lucia, additional, Giallongo, Sebastiano, additional, Tibullo, Daniele, additional, Di Rosa, Michelino, additional, Zappalà, Agata, additional, Cammarata, Francesco P., additional, Russo, Giorgio, additional, Ippolito, Massimo, additional, Cuttone, Giacomo, additional, Li Volti, Giovanni, additional, Vicario, Nunzio, additional, and Parenti, Rosalba, additional

Published
2022
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7. Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing

Author

Vicario, Nunzio, primary, Spitale, Federica M., additional, Tibullo, Daniele, additional, Giallongo, Cesarina, additional, Amorini, Angela M., additional, Scandura, Grazia, additional, Spoto, Graziana, additional, Saab, Miriam W., additional, D’Aprile, Simona, additional, Alberghina, Cristiana, additional, Mangione, Renata, additional, Bernstock, Joshua D., additional, Botta, Cirino, additional, Gulisano, Massimo, additional, Buratti, Emanuele, additional, Leanza, Giampiero, additional, Zorec, Robert, additional, Vecchio, Michele, additional, Di Rosa, Michelino, additional, Li Volti, Giovanni, additional, Lazzarino, Giuseppe, additional, Parenti, Rosalba, additional, and Gulino, Rosario, additional

Published
2021
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