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Your search keyword '"Alberdi, Lucrecia"' showing total 9 results
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9 results on '"Alberdi, Lucrecia"'

2. Regulation of kinesin-1 activity by the Salmonella enterica effectors PipB2 and SifA

Author

Alberdi, Lucrecia, primary, Vergnes, Alexandra, additional, Manneville, Jean-Baptiste, additional, Tembo, Dumizulu L., additional, Fang, Ziyan, additional, Zhao, Yaya, additional, Schroeder, Nina, additional, Dumont, Audrey, additional, Lagier, Margaux, additional, Bassereau, Patricia, additional, Redondo-Morata, Lorena, additional, Gorvel, Jean-Pierre, additional, and Méresse, Stéphane, additional

Published
2020
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9. Galectin-3 is upregulated in activated glia during Junin virus-induced murine encephalitis.

Author

Jaquenod De Giusti C, Alberdi L, Frik J, Ferrer MF, Scharrig E, Schattner M, and Gomez RM

Subjects
Animals, Animals, Newborn, Arenaviridae Infections pathology, Astrocytes metabolism, Astrocytes pathology, Astrocytes virology, Disease Models, Animal, Encephalitis, Viral pathology, Hemorrhagic Fever, American metabolism, Hemorrhagic Fever, American pathology, Hemorrhagic Fever, American virology, Mice, Mice, Inbred C57BL, Microglia metabolism, Microglia pathology, Microglia virology, Neuroglia pathology, Arenaviridae Infections metabolism, Encephalitis, Viral metabolism, Galectin 3 biosynthesis, Junin virus pathogenicity, Neuroglia metabolism, Neuroglia virology, Up-Regulation physiology
Abstract

Argentine haemorrhagic fever (AHF) is a systemic febrile syndrome characterized by several haematological and neurological alterations caused by Junín virus (JUNV), a member of the Arenaviridae family. Newborn mice are highly susceptible to JUNV and the course of infection has been associated with the viral strain used. Galectin-3 (Gal-3) is an animal lectin that has been proposed to play an important role in some central nervous system (CNS) diseases. In this study, we analysed Gal-3 expression at the transcriptional and translational expression levels during JUNV-induced CNS disease. We found that Candid 1 strain induced, with relatively low mortality, a subacute/chronic CNS disease with significant glia activation and upregulation of Gal-3 in microglia cells as well as in reactive astrocytes that correlated with viral levels. Our results suggest an important role for Gal-3 in viral-induced CNS disease., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2011
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