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A resolved Eulerian-Lagrangian numerical approach is used to study the heat transfer of 1204 heated spheres fluidized in a slit bed. This approach uses a direct numerical simulation combined with the immersed boundary method (DNS-IB). Pan et al. (2002, "Fluidization of 1204 Spheres: Simulation and Experimentl . Fluid Mech., 451, pp. 169-192) studied the fluidization of 1204 spheres by a uniform flow without heat transfer using a fictitious domain-based DNS. The focus of this study is placed on the heat transfer between the heated spheres and fluid and also the fluidization by a jet flow. In the DNSIB method, fluid velocity and temperature fields are obtained by solving the modified momentum and heat transfer equations, which result from the presence of heated spheres in the fluid. Particles are tracked individually and their velocities and positions are solved based on the equations of linear and angular motions; particle temperature is assumed to be a constant. The momentum and heat exchange between a particle and the surrounding fluid at its surface are resolved using the IB method with the direct forcing scheme. By exploring the rich data generated from the DNS-IB simulations, we are able to obtain statistically averaged fluid and particle velocity as well as particle heat transfer rate in a fluidized bed. Our results on the pressure drop and bed height are compared to the results of Pan et al. (2002, "Fluidization of 1204 Spheres: Simulation and Experiment," J. Fluid Mech., 451, pp. 169-192), which show good agreements. The case of the fluidization of 1204 spheres by a jet flow has also been studied and compared against the case of the fluidization by a uniform flow. The flow structures, drag, and heat transfer rate of two spheres placed along flow directions have been studied to understand the influence of a neighboring sphere. Results show that the trailing sphere has an insignificant effect on the leading sphere when it comes to the drag and heat transfer rate. On the contrary, the leading sphere can reduce the drag and heat transfer rate of the trailing sphere by more than 20% even when the two spheres are separated by six diameters. This demonstrates the need of a fully resolved DNS in accurately modeling dense particulate flows where a particle could be surrounded by multiple neighboring particles. [ABSTRACT FROM AUTHOR]

Thymus linearis from the Himalayan woodlands of Gilgit Baltistan, Pakistan, is a phytomedicine that has not been well-studied. Traditionally, it is recognized for its potential in treating conditions such as dermatitis, psoriasis, weight loss, and discomfort. The study investigates the wound-healing properties of methanolic extracts from the plant's stems, leaves, and roots. GC-MS disclosed cadaverine, dihydroxy-3,3-dimethyl-3-hydroxy-N-isopropylbutyramide, phthalic acid-di(2-propylpentyl)ester, and benzo[h]quinolone-2,4-dimethyl in stem along with betamethasone velerate, 17-pentatriacontene, 1,1-cyclobutanedicarboxmide, heptadecane-9-hexyl, cyclohexanol-2-methylene-3(1-methylethenyl) and pentacyclo[12.3.0.0(1,13).0(2,10).0(5,9)]hepatodecane-6-ol-15-one in leaf extracts and 2-myristynonyl pantetheine, 7,8-epoxylanostan-11-ol-3-acetoxy, heneicosane (1-(1-ethyl propyl)), 2-piperidinone-N-[4-bromobutyl] and 1-monolinoleoylglycerol trimethyl silyl ether in the root extract. The antioxidant activity was assessed using several assays including DPPH, bound iron %, ABTS, total flavonoid content, and total phenolic content. The methanolic stem extract (MSE) showed the highest antioxidant capacity compared to the leaf and root extracts.  The stem extract demonstrated the highest wound-healing potential, followed by leaves and roots in albino mice. The findings were supported by computational analysis, which revealed that the binding interactions of phytochemicals from stem have more affinity than leaf and root with specific receptor sites. The in-silico analysis ascertains that dihydroxy-3,3-dimethyl-3-hydroxy-N-isopropylbutyramide from MSE is the most effective wound-healing agent. Moreover, ADME predictions demonstrated the drug-like properties of the hit compounds., (© 2024 Wiley‐VCH GmbH.)