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121 results on '"Alarcon, I"'

8. POS1244 THE EFFECT OF SECUKINUMAB ON THE HUMORAL RESPONSE FOLLOWING TWO AND THREE DOSES OF THE BNT162b2 mRNA VACCINE IN PATIENTS WITH SPONDYLOARTHRITIS

Author

Elkayam, O., primary, Eviatar, T., additional, Peleg, H., additional, Paran, D., additional, Levartovsky, D., additional, Kaufman, I., additional, Broyde, A., additional, Elalouf, O., additional, Polachek, A., additional, Feld, J., additional, Haddad, A., additional, Gazitt, T., additional, Elias, M., additional, Hijaze, N., additional, Aassi, M., additional, Quebe-Fehling, E., additional, Alarcon, I., additional, Pel, S., additional, Zisman, D., additional, and Furer, V., additional

Published
2022
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9. List of Contributors

Author

Aguirre, J., primary, Alarcon, I., additional, Alavi, A., additional, Apalla, Z., additional, Argenziano, G., additional, Avci, P., additional, Beylergil, V., additional, Bonmarin, M., additional, Bourgeois, A.C., additional, Bradley, Y.C., additional, Burkes, S.A., additional, Camp, C.H., additional, Campos, S., additional, Casazza, G.C., additional, Castagnetti, F., additional, Charles-Edwards, G., additional, Chen, K., additional, Cicchi, R., additional, Doronin, A., additional, Eaton, K.P., additional, Erovic, B.M., additional, Evans, C.L., additional, Fardin, S., additional, Farkas, D.L., additional, Feng, X., additional, Gardini, S., additional, Gholami, S., additional, Göbel, K.E., additional, Goh, V., additional, González, S., additional, Griffin, N., additional, Guan, G., additional, Gupta, G.K., additional, Hamblin, M.R., additional, Hegyi, J., additional, Hegyi, V., additional, Higgins, H.W., additional, Ho, D., additional, Huang, Z., additional, Ioannides, D., additional, Jacques, S.L., additional, Jagdeo, J., additional, Jain, N., additional, Jemec, G.B.E., additional, Kadletz, L., additional, Kapsokalyvas, D., additional, Khopkar, U., additional, Kraeva, E., additional, Lallas, A., additional, Lazaridou, E., additional, Lee, T.K., additional, Le Gal, F.A., additional, Lencastre, A., additional, Levenson, R.M., additional, Li, C., additional, Liu, Q., additional, Longo, C., additional, Lui, H., additional, MacKinnon, N., additional, Mamalis, A., additional, Markhvida, I., additional, McLean, D.I., additional, Meglinski, I., additional, Monroe, M.M., additional, Moy, A.J., additional, Neel, V.A., additional, Nemec, S.F., additional, Ntziachristos, V., additional, Omar, M., additional, Ong, Y.H., additional, Osborne, J.R., additional, Papoiu, Alexandru D.P., additional, Pasciak, A.S., additional, Pavone, F.S., additional, Pellacani, G., additional, Perez, J.A., additional, Peters, B., additional, Petersen, B.W., additional, Piana, S., additional, Ragazzi, M., additional, Randall Wickett, R., additional, Rook, A.H., additional, Rowlands, C., additional, Schwarz, M., additional, Sidoroff, A., additional, So, P.T.C., additional, Tchvialeva, L., additional, Themstrup, L., additional, Tunnell, J.W., additional, Vanhoenacker, F.M., additional, Vasefi, F., additional, Visscher, M.O., additional, Wang, H., additional, Wang, L.V., additional, Wang, R., additional, Werner, T.J., additional, Westerland, O., additional, Wortsman, X., additional, Yaroslavsky, A.N., additional, Yew, E., additional, Yuen, C., additional, Zeng, H., additional, Zhao, J., additional, and Zhou, Y., additional

Published
2016
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26. Expert consensus on the persistence of biological treatments in moderate-to-severe psoriasis

Author

Dobao, P, Notario, J, Ferrandiz, C, Estebaranz, J, Alarcon, I, Sulleiro, S, Borras, J, Dauden, E, Carrascosa, J, Carazo, J, Boquet, E, and Puig, L

Abstract

Background Treatment persistence is becoming a useful measure to evaluate long-term effectiveness and safety of biological therapies in real-world settings. Objective The main objective of this study was to explore the scientific opinion of a panel of dermatologists and hospital pharmacists to reach a consensus about the impact, causes, and best strategies and interventions that might be associated with improved drug persistence in patients with psoriasis in Spain. Methods This research was conducted using a modified Delphi method organized in two rounds and involving a panel of 90 dermatologists and 34 hospital pharmacists. A questionnaire of 70 items was developed. The items proposed to reach a consensus included topics such as definitions and measures in the treatment of psoriasis, analysis of treatment persistence, factors that may influence treatment persistence, impact of treatment persistence and economic cost of treatment. Results Dermatologists reached a consensus on 77.1% of the items proposed, and hospital pharmacists reached a consensus on 71.4%. Both groups agreed that it is important to use standardized measures in the evaluation of treatment maintenance over time. Dermatologists agreed that treatment survival, persistence and retention are synonymous, but hospital pharmacists considered only treatment persistence as a valid term. In addition, panelists agreed that drug persistence is an indicator of success in the treatment of psoriasis that may be influenced by a drug's effectiveness and safety profile, as well as by patient satisfaction. They agreed that the different causes of treatment discontinuation should be considered in Kaplan-Meier analysis of treatment persistence. Moreover, treatment persistence was agreed to decrease the cost of therapy. Conclusion This Delphi consensus highlights the different perspectives of dermatologists and hospital pharmacists regarding the interpretation of treatment persistence, and the challenge of harmonizing the results obtained.

Published
2019

30. Spanish Version of Actinic Keratosis Quality of Life Questionnaire (AKQoL)

Author

Alarcon, I., Vinding, G. R., Christensen, K. B., Esmann, S., Malvehy, J., Puig, S., Jemec, G. B. E., Alarcon, I., Vinding, G. R., Christensen, K. B., Esmann, S., Malvehy, J., Puig, S., and Jemec, G. B. E.

Abstract

BACKGROUND: Patient Reported Outcome Measures are very important outcomes. For specific diseases Health Related Quality of Life-instruments (HRQoL) are increasingly used to provide data on patients' overall perceptions of the course of a given disease. Actinic keratoses (AKs) are common keratotic lesions that occur on chronically sunlight-exposed skin. Only few studies regarding HRQoL in AKs have been made.OBJECTIVE: In order to be able to compare HRQoL among different countries and cultures we aimed to translate and validate the Actinic Keratosis Quality of Life (AKQoL) questionnaire into Spanish and quantify the impairment caused by AKs in Spanish patients.METHODS: The AKQoL was translated. Then 15 patients with AKs were interviewed to ensure cultural adaption before it was tested in one hundred patients with AK lesions at the Melanoma Unit of Hospital Clinic in Barcelona.RESULTS: Validation showed high inter-item correlations, as well as a high correlation of each item and the total score. Internal consistency (Cronbachs coefficient alpha) was also high at 0.91 and an alpha value of 0.90 at retest. The test-retest correlation was 0.96 and the intra class coefficient was 0.98.CONCLUSION: The presented data support the AKQoL Spanish version as a valid and reliable HRQoL questionnaire for the description of AK-related QoL, and may provide a method for comparison of AK specific QoL between different cultures and countries. This article is protected by copyright. All rights reserved.

Published
2017

42. Tumor regrowth and development of keratinocytic neoplasms in patients under smoothened inhibition: in vivo assessment with reflectance confocal microscopy.

Author

Alarcon, I., Pasquali, P., Malvehy, J., and Puig, S.

Subjects
*CONFOCAL microscopy, *BASAL cell carcinoma, *ACTINIC keratosis, *SKIN tumors, *SKIN cancer
Abstract

Background The regrowth of a tumor after complete clinical response and the development of keratinocytic neoplasms while patients are still undergoing continuous vismodegib have stressed the importance of the accurate monitoring to detect recurrences earlier and ensure the best possible outcome. Objective The objective of this study was to determine the role of reflectance confocal microscopy ( RCM) in monitoring the response of locally advanced basal cell carcinoma (la BCC) to vismodegib and to discard secondary resistance. Methods Seven patients presenting with nine la BCC, were prospectively included and their response to this drug was assessed by means of clinical examination, dermoscopy, and RCM. The study was conducted at the Melanoma Unit in Hospital Clinic of Barcelona, between June 2012 and March 2013. Results Histologically confirmed lesion 10 mm or larger in diameter for which surgery was contraindicated and radiation therapy was inappropriate. The median patient age was 73 years and the most common histological type was infiltrating BCC. RCM allowed the identification of residual tumor in two lesions and to confirm complete response in the other four cases. Two patients developed new lesions within the tumor bed, they were assessed by RCM showing features of actinic keratosis which were confirmed by histopathology. Conclusion The use of in vivo RCM allowed the characterization of the dynamic morphologic changes in tumor response helping to better define partial response and to differentiate it from secondary resistance. Another interesting observation was the recognition of a phenomenon characterized by the development of keratinocytic neoplasms within the tumor bed. [ABSTRACT FROM AUTHOR]

Published
2017
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