Search

Your search keyword '"Alaoui-Tahiri K"' showing total 103 results
Start Over Author "Alaoui-Tahiri K"
103 results on '"Alaoui-Tahiri K"'

1. A genome-wide association study of pulmonary tuberculosis in Morocco

Author

Grant, A. V., Sabri, A., Abid, A., Abderrahmani Rhorfi, I., Benkirane, M., Souhi, H., Naji Amrani, H., Alaoui-Tahiri, K., Gharbaoui, Y., Lazrak, F., Sentissi, I., Manessouri, M., Belkheiri, S., Zaid, S., Bouraqadi, A., El Amraoui, N., Hakam, M., Belkadi, A., Orlova, M., Boland, A., Deswarte, C., Amar, L., Bustamante, J., Boisson-Dupuis, S., Casanova, J. L., Schurr, E., El Baghdadi, J., and Abel, L.

Published
2016
Full Text
View/download PDF

5. LA DYSPNEE : MECANISMES ET EVALUATION

Author

BELAGUID, A., NEJJARI, C., and ALAOUI TAHIRI, K.

Subjects
dyspnée, récepteurs pulmonaires, chémorécepteurs, psychophysiologie
Abstract

Le but de ce travail est double, il décrit les mécanismes physiopathologiques de la dyspnée, puis aborde l'évaluation de l'intensité des sensations dyspnéiques. Les études des mécanismes de la dyspnée montrent que celle-ci peut résulter, d'une dysfonction des muscles respiratoires, d'une stimulation excessive et/ou d'une altération de la sensibilté des récepteurs pulmonaires et extrapulmonaires et d'une stimulation directe et excessive des centres respiratoires. L'évaluation de la dyspnée peut s'effectuer généralement par des méthodes indirectes utilisant des questionnaires et directes utilisant des techniques de psychophysiologie. La compréhension des mécanismes physiopathologiques et l'étude de l'évaluation de l'intensité des sensations dyspnéiques constituent les clés de base dans la stratégie d'une thérapeutique efficace et bien orientée., Maroc Médical, Vol. 24, No 4 (2002)

Published
2013
Full Text
View/download PDF

34. Cancer bronchique métastatique

Author

Ebongue, S.A., primary, Aharmime, M., additional, El Merini, A., additional, Gharbaoui, Y., additional, Rhorfi, I.A., additional, Abid, A., additional, and Alaoui-Tahiri, K., additional

Published
2012
Full Text
View/download PDF

41. Chondrome pulmonaire multiple

Author

Arsalane, A., primary, Zidane, A., additional, Atoini, F., additional, Ghorfi, I., additional, Alaoui-Tahiri, K., additional, and Kabiri, E.H., additional

Published
2006
Full Text
View/download PDF

43. 272 La rhinite tuberculeuse

Author

Herrag, M., primary, Talhaoui, M., additional, Nia, F., additional, Ouarssani, A., additional, Abid, A., additional, and Alaoui Tahiri, K., additional

Published
2004
Full Text
View/download PDF

47. Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco.

Author

Sabri A, Grant AV, Cosker K, El Azbaoui S, Abid A, Abderrahmani Rhorfi I, Souhi H, Janah H, Alaoui-Tahiri K, Gharbaoui Y, Benkirane M, Orlova M, Boland A, Deswarte C, Migaud M, Bustamante J, Schurr E, Boisson-Dupuis S, Casanova JL, Abel L, and El Baghdadi J

Subjects
Adolescent, Adult, Aged, Alleles, Case-Control Studies, Child, Child, Preschool, Female, Genotype, Humans, Infant, Interferon-gamma immunology, Interleukin-12 immunology, Male, Middle Aged, Morocco, Mycobacterium tuberculosis genetics, Mycobacterium tuberculosis immunology, Polymorphism, Single Nucleotide, Risk, STAT4 Transcription Factor immunology, Tuberculosis, Pulmonary immunology, Young Adult, Genetic Predisposition to Disease genetics, Interferon-gamma genetics, Interleukin-12 genetics, STAT4 Transcription Factor genetics, Tuberculosis, Pulmonary genetics
Abstract

Background: Only a minority of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis. Genetic epidemiological evidence suggests that pulmonary tuberculosis has a strong human genetic component. Previous genetic findings in Mendelian predisposition to more severe mycobacterial infections, including by M. tuberculosis, underlined the importance of the interleukin 12 (IL-12)/interferon γ (IFN-γ) circuit in antimycobacterial immunity., Methods: We conducted an association study in Morocco between pulmonary tuberculosis and a panel of single-nucleotide polymorphisms (SNPs) covering 14 core IL-12/IFN-γ circuit genes. The analyses were performed in a discovery family-based sample followed by replication in a case-control population., Results: Out of 228 SNPs tested in the family-based sample, 6 STAT4 SNPs were associated with pulmonary tuberculosis (P = .0013-.01). We replicated the same direction of association for 1 cluster of 3 SNPs encompassing the promoter region of STAT4. In the combined sample, the association was stronger among younger subjects (pulmonary tuberculosis onset <25 years) with an odds ratio of developing pulmonary tuberculosis at rs897200 for GG vs AG/AA subjects of 1.47 (1.06-2.04). Previous functional experiments showed that the G allele of rs897200 was associated with lower STAT4 expression., Conclusions: Our present findings in a Moroccan population support an association of pulmonary tuberculosis with STAT4 promoter-region polymorphisms that may impact STAT4 expression., (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.)

Published
2014
Full Text
View/download PDF

48. Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.

Author

Grant AV, El Baghdadi J, Sabri A, El Azbaoui S, Alaoui-Tahiri K, Abderrahmani Rhorfi I, Gharbaoui Y, Abid A, Benkirane M, Raharimanga V, Richard V, Orlova M, Boland A, Migaud M, Okada S, Nolan DK, Bustamante J, Barreiro LB, Schurr E, Boisson-Dupuis S, Rasolofo V, Casanova JL, and Abel L

Subjects
Adult, Age Factors, Alleles, Case-Control Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genotype, Humans, Linkage Disequilibrium, Madagascar, Male, Morocco, Mycobacterium tuberculosis isolation & purification, Polymorphism, Single Nucleotide, Tuberculosis, Pulmonary microbiology, White People, Chromosomes, Human, Pair 8, Genetic Linkage, High Mobility Group Proteins genetics, Tuberculosis, Pulmonary genetics
Abstract

Only a small fraction of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB) in their lifetime. Genetic epidemiological evidence suggests a genetic determinism of pulmonary TB (PTB), but the molecular basis of genetic predisposition to PTB remains largely unknown. We used a positional-cloning approach to carry out ultrafine linkage-disequilibrium mapping of a previously identified susceptibility locus in chromosomal region 8q12-13 by genotyping 3,216 SNPs in a family-based Moroccan sample including 286 offspring with PTB. We observed 44 PTB-associated SNPs (p < 0.01), which were genotyped in an independent set of 317 cases and 650 controls from Morocco. A single signal, consisting of two correlated SNPs close to TOX, rs1568952 and rs2726600 (combined p = 1.1 × 10(-5) and 9.2 × 10(-5), respectively), was replicated. Stronger evidence of association was found in individuals who developed PTB before the age of 25 years (combined p for rs1568952 = 4.4 × 10(-8); odds ratio of PTB for AA versus AG/GG = 3.09 [1.99-4.78]). The association with rs2726600 (p = 0.04) was subsequently replicated in PTB-affected subjects under 25 years in a study of 243 nuclear families from Madagascar. Stronger evidence of replication in Madagascar was obtained for additional SNPs in strong linkage disequilibrium with the two initial SNPs (p = 0.003 for rs2726597), further confirming the signal. We thus identified around rs1568952 and rs2726600 a cluster of SNPs strongly associated with early-onset PTB in Morocco and Madagascar. SNP rs2726600 is located in a transcription-factor binding site in the 3' region of TOX, and further functional explorations will focus on CD4 T lymphocytes., (Copyright © 2013 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.)

Published
2013
Full Text
View/download PDF

49. [Adverse effects of BCG revaccination: 12 cases].

Author

El Ouazzani H, Lamsyah H, Alioua Z, Rhorfi I, Rguibi M, Ghfir M, Abid A, Sedrati O, and Alaoui-Tahiri K

Subjects
Adult, BCG Vaccine administration & dosage, Female, Humans, Male, Retrospective Studies, BCG Vaccine adverse effects, Tuberculosis prevention & control
Abstract

Introduction: Calmette-Guérin bacillus (BCG) is a live attenuated strain used in tuberculosis vaccination. Local and systemic side-effects, although rare, are associated with BCG vaccine. They are common in cases of overdose and with poor vaccination techniques. These complications also occur in some cases of revaccination., Patients and Methods: This was a retrospective study over a period of 5 years between January 2000 and March 2005. 12 patients presenting complications following revaccination with BCG were observed. Patients were revaccinated with BCG following a negative intradermal reaction test. The following parameters were recorded: age, gender, history, vaccination method, type of complication, treatment and outcome., Results: There were 10 men and 2 and women of mean age 21 years (19 to 23 years). Mean time to consultation was 4 weeks. Complications comprised subcutaneous abscess in 8 cases, deep chronic ulcers in 4 cases complicated by humeral osteitis in one case. The dose administered was 0.1 ml in 9 patients and 1 ml in 3 others (i.e. 10 times the recommended dose). Six patients had extensive and progressive ulceration, with one positive culture, the presence of a granuloma with caseum necrosis and one case of humeral osteitis, and specific treatment was given., Discussion: Revaccination is no longer recommended by the WHO since efficacy is considered to be low or even nil. Intradermal injection is the reference method for BCG vaccination. Technical errors such as injection of an excessively high dose of the vaccine or subcutaneous administration of the vaccine solution increase the incidence of adverse effects. In our study, three patients erroneously received 1 ml of vaccine and the injection was too deep in 9 cases. There are few reports in the literature concerning the underlying mechanisms of these post-revaccination accidents; two major physiopathological mechanisms, infectious and immunological, are discussed. There is no consensus regarding treatment of these complications. Six of the 12 patients received specific therapy for 6 months.

Published
2007
Full Text
View/download PDF

50. [Multiple pulmonary chondromas].

Author

Arsalane A, Zidane A, Atoini F, Ghorfi I, Alaoui-Tahiri K, and Kabiri EH

Subjects
Chondromatosis surgery, Diagnosis, Differential, Humans, Lung Neoplasms surgery, Male, Middle Aged, Treatment Outcome, Chondromatosis diagnosis, Lung Neoplasms diagnosis
Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results