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679 results on '"Alanio, Alexandre"'

1. Evolutionary origin and population diversity of a cryptic hybrid pathogen

Author

Steenwyk, Jacob L., Knowles, Sonja, Bastos, Rafael W., Balamurugan, Charu, Rinker, David, Mead, Matthew E., Roberts, Christopher D., Raja, Huzefa A., Li, Yuanning, Colabardini, Ana Cristina, de Castro, Patrícia Alves, dos Reis, Thaila Fernanda, Gumilang, Adiyantara, Almagro-Molto, María, Alanio, Alexandre, Garcia-Hermoso, Dea, Delbaje, Endrews, Pontes, Laís, Pinzan, Camila Figueiredo, Schreiber, Angélica Zaninelli, Canóvas, David, Sanchez Luperini, Rafael, Lagrou, Katrien, Torrado, Egídio, Rodrigues, Fernando, Oberlies, Nicholas H., Zhou, Xiaofan, Goldman, Gustavo H., and Rokas, Antonis

Published
2024
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2. Laboratory practices for the diagnosis and management of mucormycosis in France, 2024

Author

Millon, Laurence, Botterel, Françoise, Bonhomme, Julie, Valot, Stéphane, Poirier, Philippe, Durieux, Marie-Fleur, Bigot, Jeanne, Desoubeaux, Guillaume, Chesnais, Adélaïde, Morio, Florent, Pihet, Marc, Brunet, Kévin, Bellanger, Anne-Pauline, Imbert, Sébastien, Nevez, Gilles, Gal, Solène Le, Bourgeois, Nathalie, Debourgogne, Anne, Cornu, Marjorie, Persat, Florence, Hasseine, Lilia, Bougnoux, Marie-Elisabeth, Brun, Sophie, Cornet, Muriel, Favennec, Loïc, Gargala, Gilles, Bonnal, Christine, Gangneux, Jean-Pierre, Alanio, Alexandre, Iriart, Xavier, Mahinc, Caroline, Chouaki, Taieb, Paugam, André, Letscher-Bru, Valérie, and Dannaoui, Eric

Published
2024
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3. Reappraising Cladophialophora bantiana phaeohyphomycosis in France: retrospective nation-based study

Author

Lortholary, Olivier, Garcia-Hermoso, Dea, Sturny-Leclère, Aude, Sitbon, Karine, Nourrisson, Céline, Letscher-Bru, Valérie, Desbois-Nogard, Nicole, Bani-Sadr, Ferouze, Bastides, Frédéric, Bienvenu, Boris, Cordier, Camille, Coste, Anne, Danion, François, Dégot, Tristan, Delarbre, David, Fekkar, Arnaud, Garcie, Christophe, Garrouste, Cyril, Gits-Muselli, Maud, Guemas, Emilie, Huguenin, Antoine, Janvier, Frédéric, Kamar, Nassim, Kervinio, Cyril, Le Gal, Solène, Lesens, Olivier, Machouart, Marie, Persat, Florence, Picot, Sandrine, Rouze, Anahita, Ranque, Stéphane, Ruch, Yvon, Saada, Matthieu, Stabler, Sarah, Alanio, Alexandre, Lanternier, Fanny, and Desoubeaux, Guillaume

Published
2024
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4. WHO global research priorities for antimicrobial resistance in human health

Author

Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Rudan, Igor, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, and Weezenbeek, Kitty Van

Published
2024
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5. Epidemiology and prognostic factors of mucormycosis in France (2012–2022): a cross-sectional study nested in a prospective surveillance programme

Author

Gouzien, Laura, Che, Didier, Cassaing, Sophie, Lortholary, Olivier, Letscher-Bru, Valérie, Paccoud, Olivier, Obadia, Thomas, Morio, Florent, Moniot, Maxime, Cateau, Estelle, Bougnoux, Marie Elisabeth, Chouaki, Taieb, Hasseine, Lilia, Desoubeaux, Guillaume, Gautier, Cecile, Mahinc-Martin, Caroline, Huguenin, Antoine, Bonhomme, Julie, Sitbon, Karine, Durand, Julien, Alanio, Alexandre, Millon, Laurence, Garcia-Hermoso, Dea, and Lanternier, Fanny

Published
2024
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9. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM

Author

Chang, Christina C, Harrison, Thomas S, Bicanic, Tihana A, Chayakulkeeree, Methee, Sorrell, Tania C, Warris, Adilia, Hagen, Ferry, Spec, Andrej, Oladele, Rita, Govender, Nelesh P, Chen, Sharon C, Mody, Christopher H, Groll, Andreas H, Chen, Yee-Chun, Lionakis, Michail S, Alanio, Alexandre, Castañeda, Elizabeth, Lizarazo, Jairo, Vidal, José E, Takazono, Takahiro, Hoenigl, Martin, Alffenaar, Jan-Willem, Gangneux, Jean-Pierre, Soman, Rajeev, Zhu, Li-Ping, Bonifaz, Alexandro, Jarvis, Joseph N, Day, Jeremy N, Klimko, Nikolai, Salmanton-García, Jon, Jouvion, Grégory, Meya, David B, Lawrence, David, Rahn, Sebastian, Bongomin, Felix, McMullan, Brendan J, Sprute, Rosanne, Nyazika, Tinashe K, Beardsley, Justin, Carlesse, Fabianne, Heath, Christopher H, Ayanlowo, Olusola O, Mashedi, Olga M, Queiroz-Telles Filho, Flavio, Hosseinipour, Mina C, Patel, Atul K, Temfack, Elvis, Singh, Nina, Cornely, Oliver A, Boulware, David R, Lortholary, Olivier, Pappas, Peter G, and Perfect, John R

Published
2024
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10. Features of cryptococcosis among 652 HIV-seronegative individuals in France: a cross-sectional observational study (2005-2020)

Author

Brieu, N., Durand, C., Bertei, D., Bouchara, J.P., Pihet, M., Bland, S., Bru, J.P., Pulik, M., Le Turdu, F., Lefrand C, H., Ferrand, M., Larrouy, M., Millon, L., Delhaes, L., Imbert, S., Accoceberry, I., Bachelier, M.N., Nevez, G., Quinio, D., Le Coustumier, A., Carmagnol, F., Rivière, B., Boex, P., Podac, B., Moniot, M., Nourrisson, C., Augereau, O., Emond, J.P., Belkacem-Belkaki, G., Bacri, J.L., Berthelot, G., Dalle, F., Vallee, E., Bizet, J., Noussair, L., Herrmann, J.L., Maubon, D., Brocard, C., Guiffault, P., Layet, A., Morel, A., Angoulvant, A., Penn, P., Gigandon, A., Sendid, B., Cornu, M., Darde, M.L., Jaccard, A., Bouteille, B., Azjenberg, D., Prades, N., Bienvenu, A.L., Benoit-Cattin, T., Fiacre, A., Levy, S., Pitsch, A., Kiefer, M.H., Debourgogne, A., Moquet, O., Colot, J., Courtellemont, L., Poisson, D., Laurens, V., Kauffmann-Lacroix, C., Martres, P., Gargala, G., Godineau, N., Picot, S., Chassagne, C., Djibo, N., Devallière, R., Sabou, M., Camin-Ravenne, A.M., Bissuel, F., Janvier, F., Aubert, X., Chadapaud, S., Delbeck, X., Lafeuillade, A., Raoult, X., Baclet, V., Coignard, C., Mouton, Y., Ravaux, I., Eloy, C., Fur, A., Rezzouk, L., Mazards, E., Eloy, O., Chachaty, E., Mihaila, L., Dellion, S., Patey, O., Thouvenot, A., Limousin, L., Paugam, A., Desplaces, N., Raguin, G., Sitterlé, E., Blaize, M., Gits-Muselli, M., Hennequin, C., Poirot, J.L., Bretagne, S., Lacroix, Claire, Hamane, Samia, Paccoud, Olivier, Desnos-Ollivier, Marie, Persat, Florence, Demar, Magalie, Boukris-Sitbon, Karine, Bellanger, Anne-Pauline, Bonhomme, Julie, Bonnal, Christine, Botterel, Françoise, Bougnoux, Marie-Elisabeth, Brun, Sophie, Cassaing, Sophie, Cateau, Estelle, Chouaki, Taieb, Cornet, Muriel, Dannaoui, Eric, Desbois-Nogard, Nicole, Durieux, Marie-Fleur, Favennec, Loïc, Fekkar, Arnaud, Gabriel, Frederic, Gangneux, Jean-Pierre, Guitard, Juliette, Hasseine, Lilia, Huguenin, Antoine, Le Gal, Solène, Letscher-Bru, Valérie, Mahinc, Caroline, Morio, Florent, Nicolas, Muriel, Poirier, Philippe, Ranque, Stéphane, Roosen, Gabrielle, Rouges, Célia, Roux, Anne-Laure, Sasso, Milène, Alanio, Alexandre, Lortholary, Olivier, and Lanternier, Fanny

Published
2024
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11. Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study

Author

Goodall, J, Mawoko, N, Milburn, J, Mmipi, R, Muthoga, C, Ponatshego, P, Rulaganyang, I, Seatla, K, Tlhako, N, Tsholo, K, April, S, Bekiswa, A, Boloko, L, Bookholane, H, Crede, T, Davids, L, Goliath, R, Hlungulu, S, Hoffman, R, Kyepa, H, Masina, N, Maughan, D, Mnguni, T, Moosa, S, Morar, T, Mpalali, M, Naude, J, Oliphant, I, Sayed, S, Sebesho, L, Shey, M, Swanepoel, L, Chasweka, M, Chimang’anga, W, Chimphambano, T, Dziwani, E, Gondwe, E, Kadzilimbile, A, Kateta, S, Kossam, E, Kukacha, C, Lipenga, B, Ndaferankhande, J, Ndalama, M, Shah, R, Singini, A, Stott, K, Zambasa, A, Banda, T, Chikaonda, T, Chitulo, G, Chiwoko, L, Chome, N, Gwin, M, Kachitosi, T, Kamanga, B, Kazembe, M, Kumwenda, E, Kumwenda, M, Maya, C, Mhango, W, Mphande, C, Msumba, L, Munthali, T, Ngoma, D, Nicholas, S, Simwinga, L, Stambuli, A, Tegha, G, Zambezi, J, Ahimbisibwe, C, Akampurira, A, Alice, A, Cresswell, F, Gakuru, J, Kiiza, D, Kisembo, J, Kwizera, R, Kugonza, F, Laker, E, Luggya, T, Lule, A, Musubire, A, Muyise, R, Namujju, O, Ndyetukira, J, Nsangi, L, Okirwoth, M, Sadiq, A, Tadeo, K, Tukundane, A, Williams, D, Atwine, L, Buzaare, P, Collins, M, Emily, N, Inyakuwa, C, Kariisa, S, Mwesigye, J, Niwamanya, S, Rodgers, A, Rukundo, J, Rwomushana, I, Ssemusu, M, Stead, G, Boyd, K, Gondo, S, Kufa, P, Makaha, E, Moyo, C, Mtisi, T, Mudzingwa, S, Mwarumba, T, Zinyandu, T, Dromer, F, Johnstone, P, Hafeez, S, Mbangiwa, Tshepiso, Sturny-Leclère, Aude, Lechiile, Kwana, Kajanga, Cheusisime, Boyer-Chammard, Timothée, Hoving, Jennifer C, Leeme, Tshepo, Moyo, Melanie, Youssouf, Nabila, Lawrence, David S, Mwandumba, Henry, Mosepele, Mosepele, Harrison, Thomas S, Jarvis, Joseph N, Lortholary, Olivier, and Alanio, Alexandre

Published
2024
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12. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium

Author

Cornely, Oliver A, Alastruey-Izquierdo, Ana, Arenz, Dorothee, Chen, Sharon CA, Dannaoui, Eric, Hochhegger, Bruno, Hoenigl, Martin, Jensen, Henrik E, Lagrou, Katrien, Lewis, Russell E, Mellinghoff, Sibylle C, Mer, Mervyn, Pana, Zoi D, Seidel, Danila, Sheppard, Donald C, Wahba, Roger, Akova, Murat, Alanio, Alexandre, Al-Hatmi, Abdullah MS, Arikan-Akdagli, Sevtap, Badali, Hamid, Ben-Ami, Ronen, Bonifaz, Alexandro, Bretagne, Stéphane, Castagnola, Elio, Chayakulkeeree, Methee, Colombo, Arnaldo L, Corzo-León, Dora E, Drgona, Lubos, Groll, Andreas H, Guinea, Jesus, Heussel, Claus-Peter, Ibrahim, Ashraf S, Kanj, Souha S, Klimko, Nikolay, Lackner, Michaela, Lamoth, Frederic, Lanternier, Fanny, Lass-Floerl, Cornelia, Lee, Dong-Gun, Lehrnbecher, Thomas, Lmimouni, Badre E, Mares, Mihai, Maschmeyer, Georg, Meis, Jacques F, Meletiadis, Joseph, Morrissey, C Orla, Nucci, Marcio, Oladele, Rita, Pagano, Livio, Pasqualotto, Alessandro, Patel, Atul, Racil, Zdenek, Richardson, Malcolm, Roilides, Emmanuel, Ruhnke, Markus, Seyedmousavi, Seyedmojtaba, Sidharthan, Neeraj, Singh, Nina, Sinko, János, Skiada, Anna, Slavin, Monica, Soman, Rajeev, Spellberg, Brad, Steinbach, William, Tan, Ban Hock, Ullmann, Andrew J, Vehreschild, Jörg J, Vehreschild, Maria JGT, Walsh, Thomas J, White, P Lewis, Wiederhold, Nathan P, Zaoutis, Theoklis, Chakrabarti, Arunaloke, and Group, Mucormycosis ECMM MSG Global Guideline Writing

Subjects
Clinical Research, Good Health and Well Being, Disease Management, Humans, Mucormycosis, Mucormycosis ECMM MSG Global Guideline Writing Group, Clinical Sciences, Medical Microbiology, Public Health and Health Services, Microbiology
Abstract

Mucormycosis is a difficult to diagnose rare disease with high morbidity and mortality. Diagnosis is often delayed, and disease tends to progress rapidly. Urgent surgical and medical intervention is lifesaving. Guidance on the complex multidisciplinary management has potential to improve prognosis, but approaches differ between health-care settings. From January, 2018, authors from 33 countries in all United Nations regions analysed the published evidence on mucormycosis management and provided consensus recommendations addressing differences between the regions of the world as part of the "One World One Guideline" initiative of the European Confederation of Medical Mycology (ECMM). Diagnostic management does not differ greatly between world regions. Upon suspicion of mucormycosis appropriate imaging is strongly recommended to document extent of disease and is followed by strongly recommended surgical intervention. First-line treatment with high-dose liposomal amphotericin B is strongly recommended, while intravenous isavuconazole and intravenous or delayed release tablet posaconazole are recommended with moderate strength. Both triazoles are strongly recommended salvage treatments. Amphotericin B deoxycholate is recommended against, because of substantial toxicity, but may be the only option in resource limited settings. Management of mucormycosis depends on recognising disease patterns and on early diagnosis. Limited availability of contemporary treatments burdens patients in low and middle income settings. Areas of uncertainty were identified and future research directions specified.

Published
2019

13. Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial

Author

Goodall, Jack, Lechiile, Kwana, Mawoko, Norah, Mbangiwa, Tshepiso, Milburn, James, Mmipi, Refilwe, Ponatshego, Ponego, Rulaganyang, Ikanyang, Seatla, Kaelo, Siamisang, Keatlaretse, Tlhako, Nametso, Tsholo, Katlego, April, Samantha, Bekiswa, Abulele, Boloko, Linda, Bookholane, Hloni, Crede, Thomas, Davids, Lee-Ann, Goliath, Rene, Hlungulu, Siphokazi, Hoffman, Regina, Kyepa, Henriette, Masina, Noma, Maughan, Deborah, Mnguni, Trevor, Moosa, Sumaiyya, Morar, Tania, Mpalali, Mkanyiseli, Naude, Jonathan, Oliphant, Ida, Singh, Achita, Sayed, Sumaya, Sebesho, Leago, Shey, Muki, Swanepoel, Loraine, Chasweka, Madalitso, Chimang'anga, Wezi, Chimphambano, Tipatseni, Gondwe, Ebbie, Mzinganjira, Henry, Kadzilimbile, Aubrey, Kateta, Steven, Kossam, Evelyn, Kukacha, Christopher, Lipenga, Bright, Ndaferankhande, John, Ndalama, Maureen, Shah, Reya, Singini, Andreas, Stott, Katherine, Zambasa, Agness, Banda, Towera, Chikaonda, Tarsizio, Chitulo, Gladys, Chiwoko, Lorren, Chome, Nelecy, Gwin, Mary, Kachitosi, Timothy, Kamanga, Beauty, Kazembe, Mussah, Kumwenda, Emily, Kumwenda, Masida, Maya, Chimwemwe, Mhango, Wilberforce, Mphande, Chimwemwe, Msumba, Lusungu, Munthali, Tapiwa, Ngoma, Doris, Nicholas, Simon, Simwinga, Lusayo, Stambuli, Anthony, Tegha, Gerald, Zambezi, Janet, Ahimbisibwe, Cynthia, Akampurira, Andrew, Alice, Anamudde, Cresswell, Fiona, Gakuru, Jane, Kagimu, Enock, Kasibante, John, Kiiza, Daniel, Kisembo, John, Kwizera, Richard, Kugonza, Florence, Laker, Eva, Luggya, Tonny, Lule, Andrew, Musubire, Abdu, Muyise, Rhona, Namujju, Carol Olivie, Ndyetukira, Jane Francis, Nsangi, Laura, Okirworth, Michael, Rhein, Joshua, Rutakingirwa, Morris K, Sadiq, Alisat, Ssebambulidde, Kenneth, Tadeo, Kiiza, Tukundane, Asmus, Atwine, Leo, Buzaare, Peter, Collins, Muganzi, Emily, Ninsima, Inyakuwa, Christine, Kariisa, Samson, Mwesigye, James, Nuwamanya, Simpson, Rodgers, Ankunda, Rukundo, Joan, Rwomushana, Irene, Ssemusu, Mike, Stead, Gavin, Boyd, Kathyrn, Gondo, Secrecy, Kufa, Prosper, Makaha, Edward, Moyo, Colombus, Mtisi, Takudzwa, Mudzinga, Shepherd, Mutata, Constantine, Mwarumba, Taddy, Zinyandu, Tawanda, Alanio, Alexandre, Dromer, Francoise, Lortholary, Olivier, Sturny-Leclere, Aude, Griffin, Philippa, Hafeez, Sophia, Loyse, Angela, van Widenfelt, Erik, Lawrence, David S, Muthoga, Charles, Meya, David B, Tugume, Lillian, Williams, Darlisha, Rajasingham, Radha, Boulware, David R, Mwandumba, Henry C, Moyo, Melanie, Dziwani, Eltas N, Maheswaran, Hendramoorthy, Kanyama, Cecilia, Hosseinipour, Mina C, Chawinga, Chimwemwe, Meintjes, Graeme, Schutz, Charlotte, Comins, Kyla, Bango, Funeka, Muzoora, Conrad, Jjunju, Samuel, Nuwagira, Edwin, Mosepele, Mosepele, Leeme, Tshepo, Ndhlovu, Chiratidzo E, Hlupeni, Admire, Shamu, Shepherd, Boyer-Chammard, Timothée, Molloy, Síle F, Youssouf, Nabila, Chen, Tao, Shiri, Tinevimbo, Jaffar, Shabbar, Harrison, Thomas S, Jarvis, Joseph N, and Niessen, Louis W

Published
2022
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15. Auranofin is active against Histoplasma capsulatum and reduces the expression of virulence-related genes.

Author

de Abreu Almeida, Marcos, Baeza, Lilian Cristiane, Silva, Leandro B. R., Bernardes-Engemann, Andréa Reis, Almeida-Silva, Fernando, Coelho, Rowena Alves, de Andrade, Iara Bastos, Corrêa-Junior, Dario, Frases, Susana, Zancopé-Oliveira, Rosely Maria, Alanio, Alexandre, Taborda, Carlos Pelleschi, and Almeida-Paes, Rodrigo

Subjects
TENEBRIO molitor, DRUG efficacy, YEAST fungi, AURANOFIN, MYCOSES, HISTOPLASMOSIS
Abstract

Background: Auranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi. The auranofin activity against Histoplasma capsulatum, the dimorphic fungus that causes histoplasmosis, has not been properly addressed. Since there are few therapeutic options for this life-threatening systemic mycosis, this study evaluated the effects of auranofin on H. capsulatum growth and expression of virulence factors. Methodology/principal findings: Minimal inhibitory and fungicidal concentrations (MIC and MFC, respectively) of auranofin against 15 H. capsulatum strains with distinct genetic backgrounds were determined using the yeast form of the fungus and a microdilution protocol. Auranofin activity was also assessed on a macrophage model of infection and on a Tenebrio molitor invertebrate animal model. Expression of virulence-related genes was compared between auranofin treated and untreated H. capsulatum yeast cells using a quantitative PCR assay. Auranofin affected the growth of different strains of H. capsulatum, with MIC and MFC values ranging from 1.25 to 5.0 μM and from 2.5 to >10 μM, respectively. Auranofin was able to kill intracellular H. capsulatum yeast cells and conferred protection against the fungus in the experimental animal model of infection. Moreover, the expression of catalase A, HSP70, superoxide dismutase, thioredoxin reductase, serine proteinase, cytochrome C peroxidase, histone 2B, formamidase, metallopeptidase, Y20 and YPS3 proteins were reduced after six hours of auranofin treatment. CONCLUSIONS/SIGNIFICANCE: Auranofin is fungicidal against H. capsulatum and reduces the expression of several virulence-related genes, which makes this anti-rheumatic drug a good candidate for new medicines against histoplasmosis. Author summary: Histoplasmosis is a serious disease caused by the fungus Histoplasma capsulatum, which can be life-threatening and has limited treatment options. In this study, we investigated the potential of auranofin, a drug originally approved for treating rheumatoid arthritis, to combat H. capsulatum. We tested auranofin against different strains of the fungus and found that it effectively inhibited fungal growth. This drug was also effective in killing the fungus within cells from the immune system and provided protection in an experimental animal model. Furthermore, auranofin reduced the expression of several genes associated with the fungus's ability to cause disease. These genes are involved in critical functions such as detoxifying harmful substances and maintaining cellular structures. By suppressing these genes, auranofin hampers the fungus's ability to survive and cause infection. These findings suggest that auranofin could be repurposed as a treatment for histoplasmosis, offering a new avenue for therapy against this challenging infection. This research is significant because it highlights the potential of existing drugs to treat other diseases, broadening our arsenal of available treatments and contributing to better healthcare solutions. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Strengths and limitations of molecular diagnostics for Pneumocystis jirovecii pneumonia.

Author

Brown, Lottie, Alanio, Alexandre, Cruciani, Mario, Barnes, Rosemary, Donnelly, J. Peter, Loeffler, Juergen, Rautemaa-Richardson, Riina, and White, P. Lewis

Abstract

Introduction: While Pneumocystis pneumonia (PcP) remains a major AIDS-defining disease, the majority of cases of PcP now present in the HIV-negative cohort, causing significant mortality. PcP PCR diagnosis is not novel, and the optimal route of diagnosis remains unclear, with an imperfect reference method and complexity in result interpretation for alternative tests. Areas covered: This extensive review utilizing a literature search underpinning a recent systematic review/meta-analysis discusses the technical and clinical performance of PcP PCR, the added benefits of PCR testing, future aspects/considerations, and how PCR may be best used in clinical algorithms to provide a probability of PcP. Expert opinion: Given the current imperfect reference test for PcP, an alternative would be beneficial. Concerns over PcP PCR generating false positive results are valid but can be resolved by using positivity thresholds that drive specificity. Unfortunately, the extensive range of PCR assays complicates the provision of a PCR reference method. Combination testing incorporating PCR and B-D-Glucan, along with clinical and host risk factors, is key to understanding the individual probability of PcP. It is critical that access to PcP PCR testing is improved through technical and logistical development. Conversely, syndromic approaches including PcP need to be fully evaluated. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Emergence of Difficult-to-Treat Tinea Corporis Caused by Trichophyton mentagrophytes Complex Isolates, Paris, France

Author

Delliere, Sarah, Joannard, Brune, Benderdouche, Mazouz, Mingui, Anselme, Gits-Muselli, Maud, Hamane, Samia, Alanio, Alexandre, Petit, Antoine, Gabison, Germaine, Bagot, Martine, and Bretagne, Stephane

Subjects
Drug resistance in microorganisms -- Causes of -- Genetic aspects, Ringworm -- Drug therapy -- Causes of, Dermatophytes -- Identification and classification -- Genetic aspects, Health
Abstract

Dermatophytes are filamentous keratinophilic fungi responsible for superficial fungal diseases involving the skin, hair, or nails. On the basis of the site of the lesions, conditions are called tinea corporis, [...]

Published
2022
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18. Yeast Infections

Author

Alanio, Alexandre, Chen, Sharon C. -A., Dreyling, Martin, Series Editor, Cornely, Oliver A., editor, and Hoenigl, Martin, editor

Published
2021
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20. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study

Author

Gangneux, Jean-Pierre, Dannaoui, Eric, Fekkar, Arnaud, Luyt, Charles-Edouard, Botterel, Françoise, De Prost, Nicolas, Tadié, Jean-Marc, Reizine, Florian, Houzé, Sandrine, Timsit, Jean-François, Iriart, Xavier, Riu-Poulenc, Béatrice, Sendid, Boualem, Nseir, Saad, Persat, Florence, Wallet, Florent, Le Pape, Patrice, Canet, Emmanuel, Novara, Ana, Manai, Melek, Cateau, Estelle, Thille, Arnaud W, Brun, Sophie, Cohen, Yves, Alanio, Alexandre, Mégarbane, Bruno, Cornet, Muriel, Terzi, Nicolas, Lamhaut, Lionel, Sabourin, Estelle, Desoubeaux, Guillaume, Ehrmann, Stephan, Hennequin, Christophe, Voiriot, Guillaume, Nevez, Gilles, Aubron, Cécile, Letscher-Bru, Valérie, Meziani, Ferhat, Blaize, Marion, Mayaux, Julien, Monsel, Antoine, Boquel, Frédérique, Robert-Gangneux, Florence, Le Tulzo, Yves, Seguin, Philippe, Guegan, Hélène, Autier, Brice, Lesouhaitier, Matthieu, Pelletier, Romain, Belaz, Sorya, Bonnal, Christine, Berry, Antoine, Leroy, Jordan, François, Nadine, Richard, Jean-Christophe, Paulus, Sylvie, Argaud, Laurent, Dupont, Damien, Menotti, Jean, Morio, Florent, Soulié, Marie, Schwebel, Carole, Garnaud, Cécile, Guitard, Juliette, Le Gal, Solène, Quinio, Dorothée, Morcet, Jeff, Laviolle, Bruno, Zahar, Jean-Ralph, and Bougnoux, Marie-Elisabeth

Published
2022
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21. Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing

Author

Garcia-Hermoso, Dea, Criscuolo, Alexis, Lee, Soo Chan, Legrand, Matthieu, Chaouat, Marc, Denis, Blandine, Lafaurie, Matthieu, Rouveau, Martine, Soler, Charles, Schaal, Jean-Vivien, Mimoun, Maurice, Mebazaa, Alexandre, Heitman, Joseph, Dromer, Françoise, Brisse, Sylvain, Bretagne, Stéphane, Alanio, Alexandre, Lockhart, Shawn, and Voigt, Kerstin

Subjects
Infectious Diseases, Emerging Infectious Diseases, Biotechnology, Aetiology, 2.2 Factors relating to the physical environment, Infection, Burn Units, Burns, Cluster Analysis, Cross Infection, Disease Outbreaks, France, Genetic Variation, Genotype, Humans, Molecular Epidemiology, Molecular Typing, Mucor, Mucormycosis, Phylogeny, Whole Genome Sequencing, Wound Infection, Wounds and Injuries, Mucor circinelloides, Mucorales, burn, clade, genome, genotype, mixed infection, mucormycosis, outbreak, strains, whole-genome sequencing, wound, Microbiology
Abstract

Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole-genome sequencing (WGS) analysis. We analyzed M. circinelloides isolates from patients in our burn unit (BU1, Hôpital Saint-Louis, Paris, France) together with nonoutbreak isolates from Burn Unit 2 (BU2, Paris area) and from France over a 2-year period (2013 to 2015). A total of 21 isolates, including 14 isolates from six BU1 patients, were analyzed by whole-genome sequencing (WGS). Phylogenetic classification based on de novo assembly and assembly free approaches showed that the clinical isolates clustered in four highly divergent clades. Clade 1 contained at least one of the strains from the six epidemiologically linked BU1 patients. The clinical isolates were specific to each patient. Two patients were infected with more than two strains from different clades, suggesting that an environmental reservoir of clonally unrelated isolates was the source of contamination. Only two patients from BU1 shared one strain, which could correspond to direct transmission or contamination with the same environmental source. In conclusion, WGS of several isolates per patients coupled with precise epidemiological data revealed a complex situation combining potential cross-transmission between patients and multiple contaminations with a heterogeneous pool of strains from a cryptic environmental reservoir.IMPORTANCE Invasive wound mucormycosis (IWM) is a severe infection due to environmental molds belonging to the order Mucorales. Severely burned patients are particularly at risk for IWM. Here, we used whole-genome sequencing (WGS) analysis to resolve an outbreak of IWM due to Mucor circinelloides that occurred in our hospital (BU1). We sequenced 21 clinical isolates, including 14 from BU1 and 7 unrelated isolates, and compared them to the reference genome (1006PhL). This analysis revealed that the outbreak was mainly due to multiple strains that seemed patient specific, suggesting that the patients were more likely infected from a pool of diverse strains from the environment rather than from direct transmission among them. This study revealed the complexity of a Mucorales outbreak in the settings of IWM in burn patients, which has been highlighted based on WGS combined with careful sampling.

Published
2018

22. Polymerase Chain Reaction on Respiratory Tract Specimens of Immunocompromised Patients to Diagnose Pneumocystis Pneumonia: A Systematic Review and Meta-analysis

Author

Brown, Lottie, primary, Rautemaa-Richardson, Riina, additional, Mengoli, Carlo, additional, Alanio, Alexandre, additional, Barnes, Rosemary A, additional, Bretagne, Stéphane, additional, Chen, Sharon C A, additional, Cordonnier, Catherine, additional, Donnelly, J Peter, additional, Heinz, Werner J, additional, Jones, Brian, additional, Klingspor, Lena, additional, Loeffler, Juergen, additional, Rogers, Thomas R, additional, Rowbotham, Eleanor, additional, White, P Lewis, additional, and Cruciani, Mario, additional

Published
2024
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24. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM

Author

MMB, MMB Medische Staf, Chang, Christina C., Harrison, Thomas S., Bicanic, Tihana A., Chayakulkeeree, Methee, Sorrell, Tania C., Warris, Adilia, Hagen, Ferry, Spec, Andrej, Oladele, Rita, Govender, Nelesh P., Chen, Sharon C., Mody, Christopher H., Groll, Andreas H., Chen, Yee Chun, Lionakis, Michail S., Alanio, Alexandre, Castañeda, Elizabeth, Lizarazo, Jairo, Vidal, José E., Takazono, Takahiro, Hoenigl, Martin, Alffenaar, Jan Willem, Gangneux, Jean Pierre, Soman, Rajeev, Zhu, Li Ping, Bonifaz, Alexandro, Jarvis, Joseph N., Day, Jeremy N., Klimko, Nikolai, Salmanton-García, Jon, Jouvion, Grégory, Meya, David B., Lawrence, David, Rahn, Sebastian, Bongomin, Felix, McMullan, Brendan J., Sprute, Rosanne, Nyazika, Tinashe K., Beardsley, Justin, Carlesse, Fabianne, Heath, Christopher H., Ayanlowo, Olusola O., Mashedi, Olga M., Queiroz-Telles Filho, Flavio, Hosseinipour, Mina C., Patel, Atul K., Temfack, Elvis, Singh, Nina, Cornely, Oliver A., Boulware, David R., Lortholary, Olivier, Pappas, Peter G., Perfect, John R., MMB, MMB Medische Staf, Chang, Christina C., Harrison, Thomas S., Bicanic, Tihana A., Chayakulkeeree, Methee, Sorrell, Tania C., Warris, Adilia, Hagen, Ferry, Spec, Andrej, Oladele, Rita, Govender, Nelesh P., Chen, Sharon C., Mody, Christopher H., Groll, Andreas H., Chen, Yee Chun, Lionakis, Michail S., Alanio, Alexandre, Castañeda, Elizabeth, Lizarazo, Jairo, Vidal, José E., Takazono, Takahiro, Hoenigl, Martin, Alffenaar, Jan Willem, Gangneux, Jean Pierre, Soman, Rajeev, Zhu, Li Ping, Bonifaz, Alexandro, Jarvis, Joseph N., Day, Jeremy N., Klimko, Nikolai, Salmanton-García, Jon, Jouvion, Grégory, Meya, David B., Lawrence, David, Rahn, Sebastian, Bongomin, Felix, McMullan, Brendan J., Sprute, Rosanne, Nyazika, Tinashe K., Beardsley, Justin, Carlesse, Fabianne, Heath, Christopher H., Ayanlowo, Olusola O., Mashedi, Olga M., Queiroz-Telles Filho, Flavio, Hosseinipour, Mina C., Patel, Atul K., Temfack, Elvis, Singh, Nina, Cornely, Oliver A., Boulware, David R., Lortholary, Olivier, Pappas, Peter G., and Perfect, John R.

Published
2024

25. WHO global research priorities for antimicrobial resistance in human health

Author

Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, and Zignol, Matteo

Abstract

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

Published
2024

26. Risk Factors and Outcome Associated With Fungal Infections in Patients With Severe Burn Injury: 10-year Retrospective IFI-BURN Study.

Author

Dudoignon, Emmanuel, Chevret, Sylvie, Tsague, Sorel, Hamane, Samia, Chaouat, Marc, Plaud, Benoit, Vicault, Eric, Mebazaa, Alexandre, Legrand, Matthieu, Alanio, Alexandre, Denis, Blandine, Dépret, Francois, and Dellière, Sarah

Subjects
MYCOSES, RISK assessment, BIOPSY, BURNS & scalds, RESEARCH funding, POLYMERASE chain reaction, SEVERITY of illness index, RETROSPECTIVE studies, INVASIVE candidiasis, DESCRIPTIVE statistics, LONGITUDINAL method, BRONCHOALVEOLAR lavage, CONFIDENCE intervals, DISEASE risk factors
Abstract

Background In burn patients, skin barrier disruption and immune dysfunctions increase susceptibility to invasive fungal diseases (IFDs) like invasive candidiasis (IC) and invasive mold infections (IMI). We provide an in-depth analysis of IFD-related factors and outcomes in a 10-year cohort of severe burn patients. Methods This retrospective cohort study includes adult patients admitted to the burn intensive care unit (BICU) between April 2014 and May 2023 with total burn surface area (TBSA) ≥15%. Patients were classified as proven IFD according to EORTC/MSGERC criteria applicable for IC. Putative IMIs were defined with: ≥2 positive cultures from a skin biopsy/bronchoalveolar lavage or ≥2 positive blood specific-quantitative polymerase chain reactions (qPCRs) or a combination of both. Results Among 1381 patients admitted, 276 consecutive patients with TBSA ≥15% were included. Eighty-seven (31.5%; IC n = 30; IMI n = 43; both n = 14) patients fulfilled the criteria for probable/putative IFD. At Day 30 after the burn injury, the estimated cumulative incidence proven/putative (pr/pu) IFD was 26.4% (95% confidence interval [CI], 21.4%–31.8%). Factors independently associated with IFDs were TBSA, severity scores and indoor burn injury (ie, from confined space fire). Overall mortality was 15.3% and 36.8% in the no IFD, pr/pu IFD groups respectively (P <.0001). IFD was independently associated with a risk of death (hazard ratio [HR]: 1.94 for pr/pu IFD; 95% CI, 1.12–3.36; P =.019). Conclusions This study describes twenty-first-century characteristics of IFDs in severe burn patients confirming known risk factors with thresholds and identifying the indoor injury as an independent factor associated to IFDs. This suggests a link to contamination caused by fire damage, which is highly susceptible to aerosolizing spores. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Epidemiology, Clinical Manifestations, Treatment, and Outcome of Mucormycosis: A Review of 77 Cases From a Single Center in France.

Author

Denis, Blandine, Resche-Rigon, Matthieu, Raffoux, Emmanuel, Ronchetti, Anne-Marie, Dudoignon, Emmanuel, Verillaud, Benjamin, Valade, Sandrine, Lorillon, Gwenaël, Rabian, Florence, Xhaard, Aliénor, Touratier, Sophie, Hamane, Samia, Alanio, Alexandre, and Castro, Nathalie De

Subjects
BLOOD diseases, SYMPTOMS, AMPHOTERICIN B, MIXED infections, POLYMERASE chain reaction, MUCORMYCOSIS
Abstract

Background The aim of this study was to assess the epidemiology, clinical manifestations, and outcome of mucormycosis over 15 years in a single center in France. Methods We conducted a retrospective analysis of all mucormycosis cases in our institution from 1 January 2006 to 31 December 2020 and analyzed patients' medical records, laboratory results, and treatment to describe the epidemiology, clinical manifestations, diagnosis, treatment, and outcome. Mucorales quantitative polymerase chain reaction (qPCR) for the diagnosis was implemented in 2015. Results Seventy-seven mucormycosis cases were analyzed in 77 patients, with a median age of 54 years (60% male). Identified risk factors were hematological diseases (46 cases [60%]), solid malignancies (2 cases), solid organ transplants (3), burns (18), diabetes only (7), and trauma (1). Sites of infection were lungs (42%), sinus (36%), skin (31%), central nervous system (9%), liver (8%), others (6%), and disseminated (12%). Diagnosis remained difficult and qPCR contributed to mucormycosis diagnosis in 30% of cases. Among hematology patients, serum qPCR was the only positive test in 15% of cases. A mixed mold infection was diagnosed in 24 of 77 (31%) patients. Surgical treatment was undertaken in 43 (56%) cases. Most patients received liposomal amphotericin B (89%), with a combination therapy in 18 of 77 cases (23%). Three-month survival rate was 40% (95% confidence interval [CI],.30–.53]). As for treatment, adjunction of surgery (hazard ratio, 0.47 [95%CI,.25–.91); P = 0.02) was associated with lower mortality. Conclusions Mucormycosis remained associated with high mortality, especially in the hematological and burn populations. Surgery in combination with antifungal treatment was associated with improved survival. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Population heterogeneity in Cryptococcus neoformans: Impact on pathogenesis.

Author

Agrawal, Ruchi, de Castro, Raffael J. Araújo, Sturny-Leclère, Aude, and Alanio, Alexandre

Subjects
CRYPTOCOCCUS neoformans, MOLECULAR biology, FUNGAL membranes, HETEROGENEITY, TRANSCRIPTION factors
Abstract

This article discusses the population heterogeneity in Cryptococcus neoformans and its impact on pathogenesis. Cryptococcus neoformans is a prevalent global threat, especially for people living with HIV. The article explores the different ways in which the human-Cryptococcus interaction can progress, including latent/dormant cryptococcosis, pulmonary cryptococcosis, disseminated cryptococcosis, and cryptococcal relapse. The article also examines population heterogeneity in C. neoformans, which provides benefits to the pathogen in coping with changing conditions and contributes to its survival. The specific manifestations of population heterogeneity discussed in the article include heteroresistance, viable but nonculturable state, antifungal persistence, and biofilm formation. The article highlights the influence of population heterogeneity on the survival and pathogenesis of C. neoformans. [Extracted from the article]

Published
2024
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29. Dual quantitative PCR assays for the rapid detection of Trichophyton indotineae from clinical samples.

Author

Baron, Audrey, Hamane, Samia, Gits-Muselli, Maud, Legendre, Lina, Benderdouche, Mazouz, Mingui, Anselme, Ghelfenstein-Ferreira, Théo, Alanio, Alexandre, and Dellière, Sarah

Abstract

Trichophyton indotineae is an emerging species of the Trichophyton mentagrophytes complex (TMC), responsible for an epidemic of widespread hairless skin infections that is frequently (50–70%) resistant to terbinafine. In order to initiate appropriate treatment as quickly as possible without waiting for culture positivity (10–15 days) and molecular identification from the strain, we developed a dual quantitative PCR (qPCR) for the direct detection of T. indotineae in clinical samples. We first designed a T. indotineae -specific qPCR assay (TI -qPCR) targeting a single specific polymorphism in the internal transcribed spacer region. Although none of the 94 non-dermatophyte and 7 dermatophyte species were amplified, this TI -qPCR allowed amplification of other TMC species at a lower yield. With equal amounts (0.1 ng) of DNA per reaction, the mean quantitative cycle (Cq) values for T. indotineae and non- indotineae TMC were 27.9 (±0.1) and 38.9 (±0.3), respectively. Therefore, we normalized this assay against a previously validated pan-dermatophyte qPCR assay (PD-qPCR) and relied on the ΔCq [(TI -qPCR) − (PD-qPCR)] to identify T. indotineae versus other TMC species. Dual assay was validated using 86 clinical samples of culture-confirmed T. indotinea and 19 non- indotineae TMC cases. The mean ΔCq for non- indotineae TMC was 9.6 ± 2.7, whereas the ΔCq for T. indotinea was −1.46 ± 2.1 (P  < .001). Setting the ΔCq at 4.5 as a cutoff value resulted in 100% specificity for the detection of T. indotineae. This dual qPCR assay quickly detects T. indotineae from skin scrapings, aiding in early diagnosis and treatment for patients with suspected infection. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Features of cryptococcosis among 652 HIV-seronegative individuals in France: a cross-sectional observational study (2005-2020)

Author

Paccoud, Olivier, primary, Desnos-Ollivier, Marie, additional, Persat, Florence, additional, Demar, Magalie, additional, Boukris-Sitbon, Karine, additional, Bellanger, Anne-Pauline, additional, Bonhomme, Julie, additional, Bonnal, Christine, additional, Botterel, Françoise, additional, Bougnoux, Marie-Elisabeth, additional, Brun, Sophie, additional, Cassaing, Sophie, additional, Cateau, Estelle, additional, Chouaki, Taieb, additional, Cornet, Muriel, additional, Dannaoui, Eric, additional, Desbois-Nogard, Nicole, additional, Durieux, Marie-Fleur, additional, Favennec, Loïc, additional, Fekkar, Arnaud, additional, Gabriel, Frederic, additional, Gangneux, Jean-Pierre, additional, Guitard, Juliette, additional, Hasseine, Lilia, additional, Huguenin, Antoine, additional, Le Gal, Solène, additional, Letscher-Bru, Valérie, additional, Mahinc, Caroline, additional, Morio, Florent, additional, Nicolas, Muriel, additional, Poirier, Philippe, additional, Ranque, Stéphane, additional, Roosen, Gabrielle, additional, Rouges, Célia, additional, Roux, Anne-Laure, additional, Sasso, Milène, additional, Alanio, Alexandre, additional, Lortholary, Olivier, additional, Lanternier, Fanny, additional, Brieu, N., additional, Durand, C., additional, Bertei, D., additional, Bouchara, J.P., additional, Pihet, M., additional, Bland, S., additional, Bru (Annecy), J.P., additional, Pulik, M., additional, Le Turdu, F., additional, Lefrand, C, H., additional, Ferrand, M., additional, Larrouy, M., additional, Millon, L., additional, Delhaes, L., additional, Imbert, S., additional, Accoceberry, I., additional, Bachelier, M.N., additional, Nevez, G., additional, Quinio, D., additional, Le Coustumier, A., additional, Carmagnol, F., additional, Rivière, B., additional, Boex, P., additional, Podac, B., additional, Moniot, M., additional, Nourrisson, C., additional, Augereau, O., additional, Emond, J.P., additional, Belkacem-Belkaki, G., additional, Bacri, J.L., additional, Berthelot, G., additional, Dalle, F., additional, Vallee, E., additional, Bizet, J., additional, Noussair, L., additional, Herrmann, J.L., additional, Maubon, D., additional, Brocard, C., additional, Guiffault, P., additional, Layet, A., additional, Morel, A., additional, Angoulvant, A., additional, Penn, P., additional, Gigandon, A., additional, Sendid, B., additional, Cornu, M., additional, Darde, M.L., additional, Jaccard, A., additional, Bouteille, B., additional, Azjenberg, D., additional, Prades, N., additional, Bienvenu, A.L., additional, Benoit-Cattin, T., additional, Fiacre, A., additional, Levy, S., additional, Pitsch, A., additional, Kiefer, M.H., additional, Debourgogne, A., additional, Moquet, O., additional, Colot, J., additional, Courtellemont, L., additional, Poisson, D., additional, Laurens, V., additional, Kauffmann-Lacroix, C., additional, Martres, P., additional, Gargala, G., additional, Godineau, N., additional, Picot, S., additional, Chassagne, C., additional, Djibo, N., additional, Devallière, R., additional, Sabou, M., additional, Camin-Ravenne, A.M., additional, Bissuel, F., additional, Janvier, F., additional, Aubert, X., additional, Chadapaud, S., additional, Delbeck, X., additional, Lafeuillade, A., additional, Raoult, X., additional, Baclet, V., additional, Coignard, C., additional, Mouton, Y., additional, Ravaux, I., additional, Eloy, C., additional, Fur, A., additional, Rezzouk, L., additional, Mazards, E., additional, Eloy, O., additional, Chachaty, E., additional, Mihaila, L., additional, Dellion, S., additional, Patey, O., additional, Thouvenot, A., additional, Limousin, L., additional, Paugam, A., additional, Desplaces, N., additional, Raguin, G., additional, Sitterlé, E., additional, Blaize, M., additional, Gits-Muselli, M., additional, Hennequin, C., additional, Poirot, J.L., additional, Bretagne, S., additional, Lacroix, Claire, additional, and Hamane, Samia, additional

Published
2024
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33. Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study

Author

Mbangiwa, Tshepiso, primary, Sturny-Leclère, Aude, additional, Lechiile, Kwana, additional, Kajanga, Cheusisime, additional, Boyer-Chammard, Timothée, additional, Hoving, Jennifer C, additional, Leeme, Tshepo, additional, Moyo, Melanie, additional, Youssouf, Nabila, additional, Lawrence, David S, additional, Mwandumba, Henry, additional, Mosepele, Mosepele, additional, Harrison, Thomas S, additional, Jarvis, Joseph N, additional, Lortholary, Olivier, additional, Alanio, Alexandre, additional, Goodall, J, additional, Mawoko, N, additional, Milburn, J, additional, Mmipi, R, additional, Muthoga, C, additional, Ponatshego, P, additional, Rulaganyang, I, additional, Seatla, K, additional, Tlhako, N, additional, Tsholo, K, additional, April, S, additional, Bekiswa, A, additional, Boloko, L, additional, Bookholane, H, additional, Crede, T, additional, Davids, L, additional, Goliath, R, additional, Hlungulu, S, additional, Hoffman, R, additional, Kyepa, H, additional, Masina, N, additional, Maughan, D, additional, Mnguni, T, additional, Moosa, S, additional, Morar, T, additional, Mpalali, M, additional, Naude, J, additional, Oliphant, I, additional, Sayed, S, additional, Sebesho, L, additional, Shey, M, additional, Swanepoel, L, additional, Chasweka, M, additional, Chimang’anga, W, additional, Chimphambano, T, additional, Dziwani, E, additional, Gondwe, E, additional, Kadzilimbile, A, additional, Kateta, S, additional, Kossam, E, additional, Kukacha, C, additional, Lipenga, B, additional, Ndaferankhande, J, additional, Ndalama, M, additional, Shah, R, additional, Singini, A, additional, Stott, K, additional, Zambasa, A, additional, Banda, T, additional, Chikaonda, T, additional, Chitulo, G, additional, Chiwoko, L, additional, Chome, N, additional, Gwin, M, additional, Kachitosi, T, additional, Kamanga, B, additional, Kazembe, M, additional, Kumwenda, E, additional, Kumwenda, M, additional, Maya, C, additional, Mhango, W, additional, Mphande, C, additional, Msumba, L, additional, Munthali, T, additional, Ngoma, D, additional, Nicholas, S, additional, Simwinga, L, additional, Stambuli, A, additional, Tegha, G, additional, Zambezi, J, additional, Ahimbisibwe, C, additional, Akampurira, A, additional, Alice, A, additional, Cresswell, F, additional, Gakuru, J, additional, Kiiza, D, additional, Kisembo, J, additional, Kwizera, R, additional, Kugonza, F, additional, Laker, E, additional, Luggya, T, additional, Lule, A, additional, Musubire, A, additional, Muyise, R, additional, Namujju, O, additional, Ndyetukira, J, additional, Nsangi, L, additional, Okirwoth, M, additional, Sadiq, A, additional, Tadeo, K, additional, Tukundane, A, additional, Williams, D, additional, Atwine, L, additional, Buzaare, P, additional, Collins, M, additional, Emily, N, additional, Inyakuwa, C, additional, Kariisa, S, additional, Mwesigye, J, additional, Niwamanya, S, additional, Rodgers, A, additional, Rukundo, J, additional, Rwomushana, I, additional, Ssemusu, M, additional, Stead, G, additional, Boyd, K, additional, Gondo, S, additional, Kufa, P, additional, Makaha, E, additional, Moyo, C, additional, Mtisi, T, additional, Mudzingwa, S, additional, Mwarumba, T, additional, Zinyandu, T, additional, Dromer, F, additional, Johnstone, P, additional, and Hafeez, S, additional

Published
2024
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34. Cladophialophora Bantiana &nbsp;Phaeohyphomycosis in France:&nbsp;A Reappraisal of Epidemiology, Therapeutic Strategy, and Outcome

Author

Lortholary, Olivier, primary, Garcia-Hermoso, Dea, additional, Sturny Leclère, Aude, additional, Boukris-Sitbon, Karine, additional, Nourrisson, Celine, additional, Letscher-Bru, Valérie, additional, Desbois-Nogard, Nicole, additional, Bani-Sadr, Firouzé, additional, Bienvenu, Boris, additional, Cordier, Camille, additional, Coste, Anne, additional, Danion, François, additional, Degot, Tristan, additional, Delarbre, David, additional, Fekkar, Arnaud, additional, Garcie, Christophe, additional, Garrouste, Cyril, additional, Desoubeaux, Guillaume, additional, Gits-Muselli, Maud, additional, Guemas, Emilie, additional, Hugenin, Antoine, additional, Janvier, Frédéric, additional, Kamar, NAssim, additional, Kervinio, Cyril., additional, Le Gal, Solène, additional, Lesens, Olivier, additional, Machouart, Marie, additional, Persat, Florence, additional, Picot, Sandrine, additional, Rouze, Anahita, additional, Ranque, Stéphane, additional, Ruch, Yvon, additional, Saada, Matthieu, additional, Stabler, Sarah, additional, Alanio, Alexandre, additional, Lanternier, Fanny, additional, and Bastides, Frederic, additional

Published
2024
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35. Gradient concentration strip–specific epidemiological cut-off values of antifungal drugs in various yeast species and five prevalent Aspergillus species complexes

Author

Mercier, Victor, Letscher-Bru, Valérie, Bougnoux, Marie-Elisabeth, Delhaes, Laurence, Botterel, Francoise, Maubon, Danièle, Dalle, Frédéric, Alanio, Alexandre, Houzé, Sandrine, Dannaoui, Eric, Cassagne, Carole, Cassaing, Sophie, Durieux, Marie-Fleur, Fekkar, Arnaud, Bouchara, Jean-Philippe, Gangneux, Jean-Pierre, Bonhomme, Julie, Dupont, Damien, Costa, Damien, Sendid, Boualem, Chouaki, Taieb, Bourgeois, Nathalie, Huguenin, Antoine, Brun, Sophie, Mahinc, Caroline, Hasseine, Lilia, Le Gal, Solène, Bellanger, Anne-Pauline, Bailly, Eric, Morio, Florent, Nourrisson, Céline, Desbois-Nogard, Nicole, Perraud-Cateau, Estelle, Debourgogne, Anne, Yéra, Hélène, Lachaud, Laurence, and Sasso, Milène

Published
2023
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36. Dormancy in Cryptococcus neoformans: 60 years of accumulating evidence

Author

Alanio, Alexandre

Subjects
Mycoses, Antifungal agents, Infection, Epidemiology, Health care industry
Abstract

Cryptococcus neoformans is an opportunistic yeast that is present worldwide and interacts with various organisms. In humans, it is responsible for cryptococcosis, a deadly invasive fungal infection that represents around 220,000 cases per year worldwide. Starting from the natural history of the disease in humans, there is accumulating evidence on the capacity of this organism to enter dormancy. In response to the harsh host environment, the yeast is able to adapt dramatically and escape the vigilance of the host's immune cells to survive. Indeed, the yeast exposed to the host takes on pleiotropic phenotypes, enabling the generation of populations in heterogeneous states, including dormancy, to eventually survive at low metabolic cost and revive in favorable conditions. The concept of dormancy has been validated in C. neoformans from both epidemiological and genotyping data, and more recently from the biological point of view with the characterization of dormancy through the description of viable but nonculturable cells., Cryptococcus neoformans is a basidiomycetous opportunistic yeast that is widely present in the environment. It causes human cryptococcosis, which mainly affects immunocompromised patients and presents as a meningoencephalitis (1) that [...]

Published
2020
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41. Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis

Author

de Castro, Raffael Júnio Araújo, primary, Marina, Clara Luna, additional, Sturny-Leclère, Aude, additional, Hoffmann, Christian, additional, Bürgel, Pedro Henrique, additional, Wong, Sarah Sze Wah, additional, Aimanianda, Vishukumar, additional, Varet, Hugo, additional, Agrawal, Ruchi, additional, Bocca, Anamélia Lorenzetti, additional, and Alanio, Alexandre, additional

Published
2023
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45. Invasive fungal diseases in patients with autoimmune diseases: a case series from the French RESSIF network

Author

Galmiche, Simon, primary, Thoreau, Benjamin, additional, Bretagne, Stéphane, additional, Alanio, Alexandre, additional, Paugam, André, additional, Letscher-Bru, Valérie, additional, Cassaing, Sophie, additional, Gangneux, Jean-Pierre, additional, Guegan, Hélène, additional, Favennec, Loïc, additional, Minoza, Alida, additional, Morio, Florent, additional, Bonhomme, Julie, additional, Desoubeaux, Guillaume, additional, Eloy, Odile, additional, Hasseine, Lilia, additional, Sasso, Milène, additional, Millon, Laurence, additional, Bellanger, Anne-Pauline, additional, Poirier, Philippe, additional, Moniot, Maxime, additional, Chouaki, Taieb, additional, Huguenin, Antoine, additional, Dalle, Frédéric, additional, Bouteille, Bernard, additional, Nicolas, Muriel, additional, Desbois-Nogard, Nicole, additional, Bougnoux, Marie-Elisabeth, additional, Danion, François, additional, Poindron, Vincent, additional, Néel, Antoine, additional, Boukris-Sitbon, Karine, additional, Lanternier, Fanny, additional, and Terrier, Benjamin, additional

Published
2023
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46. Development and validation of a new quantitative reverse transcription PCR assay for the diagnosis of human sporotrichosis

Author

Marques de Macedo, Priscila, primary, Sturny-Leclère, Aude, additional, Freitas, Dayvison Francis Saraiva, additional, Ghelfenstein-Ferreira, Theo, additional, Gutierrez-Galhardo, Maria Clara, additional, Almeida, Marcos de Abreu, additional, Rodrigues, Anderson Messias, additional, Pautet, Thierry, additional, Hamane, Samia, additional, Almeida-Paes, Rodrigo, additional, Zancopé-Oliveira, Rosely Maria, additional, and Alanio, Alexandre, additional

Published
2023
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47. Cryptococcus neoformans Infections Differ Among Human Immunodeficiency Virus (HIV)–Seropositive and HIV-Seronegative Individuals: Results From a Nationwide Surveillance Program in France.

Author

Paccoud, Olivier, Desnos-Ollivier, Marie, Cassaing, Sophie, Boukris-Sitbon, Karine, Alanio, Alexandre, Bellanger, Anne-Pauline, Bonnal, Christine, Bonhomme, Julie, Botterel, Françoise, Bougnoux, Marie-Elisabeth, Brun, Sophie, Chouaki, Taieb, Cornet, Muriel, Dannaoui, Eric, Demar, Magalie, Desbois-Nogard, Nicole, Durieux, Marie-Fleur, Favennec, Loïc, Fekkar, Arnaud, and Gabriel, Frederic

Subjects
HIV, CRYPTOCOCCUS neoformans, SYMPTOMS, CRYPTOCOCCOSIS, HIV status
Abstract

Among 1107 cryptococcosis cases from the French surveillance network (2005–2020), the proportion of HIV-seronegative individuals has recently surpassed that of HIV-seropositive individuals. We observed marked differences in patient characteristics, disease presentations, cryptococcal antigen results, infecting species, and mortality according to HIV serostatus. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformans

Author

Rizzo, Juliana, primary, Trottier, Adèle, additional, Moyrand, Frédérique, additional, Coppée, Jean-Yves, additional, Maufrais, Corinne, additional, Zimbres, Ana Claudia G., additional, Dang, Thi Tuong Vi, additional, Alanio, Alexandre, additional, Desnos-Ollivier, Marie, additional, Mouyna, Isabelle, additional, Péhau-Arnaude, Gérard, additional, Commere, Pierre-Henri, additional, Novault, Sophie, additional, Ene, Iuliana V., additional, Nimrichter, Leonardo, additional, Rodrigues, Marcio L., additional, and Janbon, Guilhem, additional

Published
2023
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