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We numerically investigate the effect of feedback from the ionizing radiation heating from massive stars on the evolution of giant molecular clouds (GMCs) and their star formation efficiency (SFE). We find that the star-forming regions within the GMCs are invariably formed by gravitational contraction. After an initial period of contraction, the collapsing clouds begin forming stars, whose feedback evaporates part of the clouds' mass, opposing the continuing accretion from the infalling gas. The competition of accretion against dense gas consumption by star formation (SF) and evaporation by the feedback, regulates the clouds' mass and energy balance, as well as their SFE. We find that, in the presence of feedback, the clouds attain levels of the SFE that are consistent at all times with observational determinations for regions of comparable SF rates (SFRs). However, we observe that the dense gas mass is larger in general in the presence of feedback, while the total (dense gas + stars) is nearly insensitive to the presence of feedback, suggesting that the total mass is determined by the accretion, while the feedback inhibits mainly the conversion of dense gas to stars. The factor by which the SFE is reduced upon the inclusion of feedback is a decreasing function of the cloud's mass, for clouds of size ~ 10 pc. This naturally explains the larger observed SFEs of massive-star forming regions. We also find that the clouds may attain a pseudo-virialized state, with a value of the virial mass very similar to the actual cloud mass. However, this state differs from true virialization in that the clouds are the center of a large-scale collapse, continuously accreting mass, rather than being equilibrium entities., Comment: Submitted to ApJ (abstract abridged)