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Resumen La factibilidad de producir bloques y placas mediante la aglomeración de residuos de desmote del algodón (cascarilla) con ligantes cálcicos se ha comprobado en trabajos previos. Estos residuos representan un serio inconveniente para las plantas desmotadoras, que anualmente generan gran cantidad de desechos sin destino final identificado en Argentina. La variabilidad de la producción anual de algodón, la dispersión geográfica de las desmotadoras y los costos de transporte, dificultan proponer alternativas de reutilización de alta complejidad. Se propone emplearlo como materia prima para elaborar aglomerados de cascarilla con cemento portland utilizando tecnologías sencillas, fácilmente apropiables y transferibles. Este trabajo analiza las características de los aglomerados obtenidos y la influencia que ejercen diversos parámetros de producción sobre ellas y sobre la productividad del proceso. Los resultados alcanzados muestran la mejora de la productividad del proceso mediante el empleo de aditivos de calidad industrial, así como un mejor comportamiento higrotérmico de envolventes de viviendas por la incorporación de estos aglomerados, reemplazando materiales de elevado costo y tecnologías constructivas complejas.

Hilda’s Diary of a Cape Housekeeper (1902), by Hildagonda Duckitt, is an example of culinary literature and essentially a diary of life in the Cape at the time (one that includes recipes, notes on gardening, etc.). This text is investigated in this article with the aim of examining the responsibilities of women with respect to food, food preparation and the kitchen, the depiction of men with respect to food, its preparation and the eating thereof, and the influence of class and the ethnicity of the author’s intended audience. The article notes how these responsibilities have changed over time, particularly with regard to their content and appearance, as well as discusses the relationship between cookbooks and men. Cookbooks have become a mainstream subject of academic study, of popular culture and the media, not least of all for the insights that they provide about gender (especially in terms of the division of labour), ethnicity and culture, and while they have traditionally been aimed at white women, this is no longer always the case. Such gender issues are the primary focus of this article. The context of the book, namely South Africa under British colonial rule during the late 1800s and early 1900s, is also considered in order to shed light on the questions of ethnicity and culture. Duckitt’s affinity for the British Empire is explored, as well as her views about the indigenous people of South Africa, their roles with respect to food, and their place in the colonial home. Lastly, the article takes stock of Duckitt’s voracious appetite for new knowledge and its production, despite the patriarchy of the time.

Resumen La factibilidad de producir bloques y placas mediante la aglomeración de residuos de desmote del algodón (cascarilla) con ligantes cálcicos se ha comprobado en trabajos previos. Estos residuos representan un serio inconveniente para las plantas desmotadoras, que anualmente generan gran cantidad de desechos sin destino final identificado en Argentina. La variabilidad de la producción anual de algodón, la dispersión geográfica de las desmotadoras y los costos de transporte, dificultan proponer alternativas de reutilización de alta complejidad. Se propone emplearlo como materia prima para elaborar aglomerados de cascarilla con cemento portland utilizando tecnologías sencillas, fácilmente apropiables y transferibles. Este trabajo analiza las características de los aglomerados obtenidos y la influencia que ejercen diversos parámetros de producción sobre ellas y sobre la productividad del proceso. Los resultados alcanzados muestran la mejora de la productividad del proceso mediante el empleo de aditivos de calidad industrial, así como un mejor comportamiento higrotérmico de envolventes de viviendas por la incorporación de estos aglomerados, reemplazando materiales de elevado costo y tecnologías constructivas complejas. Abstract The feasibility of producing blocks and boards through the agglomeration of cotton ginnig process waste with calcium binders was proven in previous studies. This waste represents a serious problem for ginning plants, which annually produce a high amount of waste without final destination, as is the case in Argentina. The variability of the annual cotton production, geographical dispersion of ginners and transportation costs make it difficult to propose high-complexity recycling alternatives. This study proposes that that waste is used as a raw material to manufacture composites made of cotton gin waste and portland cement, using simple, easily appropriable and transferable technologies. This paper analyses the characteristics of the composites obtained and the influence that different production parameters have on them and on the productivity of the process. The results achieved show an improvement of the process productivity by using industrial grade additives, as well as better hygrothermal behavior of housing envelopes due to the incorporation of these composites, replacing high cost materials and complex construction technologies.

Plucked anagen scalp hair is an ideal surrogate tissue to monitor drug induced transcriptional changes. High vascularisation of the hair follicle, ease of sampling and high degree of similarity of expression in hair of pathways dysregulated in cancers, make the cellular bulb of plucked human scalp hair an excellent surrogate tissue for the non-invasive monitoring of pharmacodynamic (PD) and mechanism of action (MOA) effects in clinical trials. Using our ex vivo plucked hair culture platform, plucked scalp hair bulbs from several healthy donors were exposed to BEZ235, a dual pan-class PI3K and mTOR inhibitor at different concentrations and durations. Total RNA was isolated from the cellular bulb of anagen hair post-culture and samples were assessed by microarray and RNA-seq analysis to assess dose dependent global transcriptional alterations and develop a gene expression signature indicative of BEZ235 exposure. Two different microarrays, the Affymetrix Clariom D and U133 plus 2.0 arrays, were directly compared to RNA-seq data obtained from the same ex vivo culture samples. Genetic signatures indicative of exposure of plucked scalp hair to BEZ235 were established using all three analytical techniques. The transcriptional readouts from the plucked scalp hair samples revealed strong correlations (0.97-0.99) in the genes expressed in anagen scalp hair between donors. In addition, global gene expression data indicated that assessing pooled scalp hairs was sufficient to detect significant differential expression (p Citation Format: Tim Mefo, Elliott Harrison, Alan Murdoch, Benjamin Reed. Plucked anagen scalp hair: A comparison between different analytical techniques to establish reproducible drug induced transcriptional changes and provide pharmacodynamic biomarker and target engagement information from oncology patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4947.

This paper examines the problems involved in developing collective bargaining in the traditionally non‐union environment of the strategically important UK offshore oil industry. In doing so it provides evidence on the success of the “new”, stakeholder industrial relations environment established by the present UK government. Drawing on an in‐depth insight into management and union strategies gained from action research, the paper documents the attempt to establish a collective agreement and a partnership approach to industrial relations in the drilling sector of the North Sea offshore oil industry, a sector which has had no previous history of unionisation. In doing the research provides evidence partnership policy, the literature on union recognition and the process of negotiation in international organisations.

We have observed that the red reaction product of alkaline phosphatase immuno-conjugates and certain substrate preparations produces a brilliant red fluorescence that is visible by fluorescence microscopy using both fluorescein and rhodamine filter combinations. This provides a level of sensitivity greater than that obtained with other commonly used red fluorochromes or by inspection of the reaction product under bright field illumination. Of particular value, the reaction product is unaffected by the denaturing conditions required for the detection of incorporated nuclear BrdU with FITC conjugated anti-BrdU antibody and provides a simple and robust method for the simultaneous detection of cell proliferation and cell surface markers.

Chapter summary Tissue engineering offers new strategies for developing treatments for the repair and regeneration of damaged and diseased tissues. These treatments, using living cells, will exploit new developments in understanding the principles in cell biology that control and direct cell function. Arthritic diseases that affect so many people and have a major impact on the quality of life provide an important target for tissue engineering. Initial approaches are in cartilage repair; in our own programme we are elucidating the signals required by chondrocytes to promote new matrix assembly. These principles will extend to other tissues of the musculoskeletal system, including the repair of bone, ligament and tendon.

In recent years, there has been a significant and growing interest in specific pathways the human body utilizes in response to damage and their exploitation to induce cell proliferation, differentiation and apoptosis. Epistem's Novel Therapies division has created a discovery platform to allow identification of novel soluble regulators for development of therapeutic targets in oncology, regenerative medicine, and gastrointestinal diseases. Target discovery and identification starts with a known stem cell model and the creation of a disease system in vivo to identify potential stem cell markers. A damage response model of the gastrointestinal tract for stem cell proliferation and apoptosis post-irradiation describes the different phases of the cell recovery process. Post-irradiation, the stem cells, which are located at the base of the intestinal crypt, undergo apoptosis, followed by a rapid phase of regeneration, resulting in an ‘overshoot’ in crypt cell numbers, with homeostasis finally achieved by a ‘shut off’ phase with a decrease in proliferation to basal levels. Using high resolution gene expression profiling of dissected crypts (upper and lower), from small intestine and colon, isolated at various key time points post irradiation, we have identified many candidate novel stem cell regulators involved in damage response. Recombinant proteins have been produced; purified; and characterized, then tested using our proprietary in vitro model assays, looking for efficacy in cell proliferation, apoptosis and differentiation. Proteins that demonstrated robust and reproducible activities were then further evaluated using our industry standard in vivo intestinal stem cell function assays. Pharmocodynamic gene expression profiling was then applied to establish mechanism of action (MOA) linkages between in vitro and in vivo data. Having identified novel protein therapeutics, we are currently focused on pharmacotherapeutics that can modulate the identified pathways. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):C230. Citation Format: Shaun Ainsworth, Sarah Hoyle, Aude-Marine Bonavita, Laura Kemp, Jo Read, Alan Murdoch, Lorna Woolford, Gino Miele, Cath Booth. A platform for discovery of novel stem cell modulators and subsequent development of therapeutic targets. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C230.

Immunogold labelling was used to study the distribution of newly synthesized slow muscle myosin (SM) at the ultrastructural level as it replaced fast muscle myosin (FM) in rabbit muscles undergoing stimulation-induced type transformation. Control fast muscle was labelled strongly with antibody to FM and control slow muscle with antibody to SM; label was confined to the A-band. Well-defined differences in the distribution of label within the A-band suggested that the monoclonal antibodies used corresponded to epitopes on different parts of the myosin molecule; this was confirmed by Western blots of subfragments prepared from FM and SM. After 4 weeks of continuous stimulation at 10 Hz, fibres of the tibialis anterior muscle reacted with antibodies to both isoforms; after 6 weeks, labelling was obtained only with antibody to SM. After a 7-week period of stimulation and 3 further weeks of recovery, fibres again reacted with both antibodies. In all positively-labelled sections, the distribution of gold particles was characteristic of the antibody and independent of the origin or history of the fibres. This observation supports the conclusion that newly synthesized myosin is capable of being incorporated throughout the length and cross-section of the A-band.

Ireland's director of public prosecutions has been asked to investigate whether the country's blood transfusion service board should be prosecuted for criminal negligence over the infection of women with hepatitis C virus. The call came in a letter to the director, Mr Lamonn Barnes, from Positive Action, the pressure group representing 960 Irish women who contracted hepatitis C after being treated with anti-D immunoglobulin from the blood transfusion service. In its letter the group highlights findings by an expert group set up by …

Doctors from the Republic of Ireland's major psychiatric hospitals have met health minister Michael Noonan to express concern that their patients could suffer under European Union regulations for a single insurance market. Doctors worry that opening the Irish health sector to foreign insurers will reduce levels of medical cover for psychiatric patients. In theory, the Irish market has been open since 1994 to health insurers based overseas. In practice they are waiting to see what the final regulations …

Previous studies have shown the feasibility of production of masonry blocks and panels from agglomeration of cotton gin waste and calcium binders. Cotton gin waste is a serious problem for ginning plants, because in Argentina approximately 300,000 t of lignocellulosic wastes are produced annually without any final disposal destination. The accumulation of these residues is associated with pests and fire hazards. Since these composites are produced with simple equipment and a minimum energy requirement, their cost depends mainly on the binder (Portland cement) used and the process efficiency, since with a high productivity model, labor and equipment depreciation costs are significantly reduced. This paper analyzes the influence of CaCl 2 .2H 2 O (added as an accelerator for cement paste strength) on the minimum molding time required for composites manufacturing. A central composite experimental design was developed in order to study the interrelated variables. The influence of CaCl 2 .2H 2 O content on physical-mechanical cement paste properties and their relationship with composites stability are also evaluated. The results of this work show that CaCl 2 .2H 2 O content has significant influence on the efficiency of composites manufacturing as it reduces the molding time required.