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Humans use socially relevant stimuli to guide perceptual processing of the surrounding environment, with emotional stimuli receiving preferential attention due to their social importance. Predictive coding theory asserts this cognitive process occurs efficiently by combining predictions about what is to be perceived with incoming sensory information, generating prediction errors that are then used to update future predictions. Recent evidence has identified differing neural activity that demonstrates how spatial and feature-based attention may interact with prediction, yet how emotion-guided attention may influence this relationship remains unknown. In the present study, participants viewed a display of two faces in which attention, prediction, and emotion were manipulated, and responded to a face expressing a specific emotion (anger or happiness). The N170 was found to be enhanced by unpredictable as opposed to predictable stimuli, indicating that it indexes general prediction error signalling processes. The N300 amplitudes were also enhanced by unpredictable stimuli, but they were also affected by the attentional status of angry but not happy faces, suggesting that there are differences in prediction error processes indexed by the N170 and N300. Overall, the findings suggest that the N170 and N300 both index violations of expectation for spatial manipulations of stimuli in accordance with prediction error responding processes.

Previous research on emotional face processing has shown that emotional faces such as fearful faces may be processed without visual awareness. However, evidence for nonconscious attention capture by fearful faces is limited. In fact, studies using sensory manipulation of awareness (e.g., backward masking paradigms) have shown that fearful faces do not attract attention during subliminal viewings nor when they were task-irrelevant. Here, we used a three-phase inattentional blindness paradigm and electroencephalography to examine whether faces (fearful and neutral) capture attention under different conditions of awareness and task-relevancy. We found that the electrophysiological marker for attention capture, the N2-posterior-contralateral (N2pc), was elicited by face stimuli only when participants were aware of the faces and when they were task-relevant (phase 3). When participants were unaware of the presence of faces (phase 1) or when the faces were irrelevant to the task (phase 2), no N2pc was observed. Together with our previous work, we concluded that fearful faces, or faces in general, do not attract attention unless we want them to.

Recognition of social hierarchy is a key feature that helps us navigate through our complex social environment. Neuroimaging studies have identified brain structures involved in the processing of hierarchical stimuli, but the precise temporal dynamics of brain activity associated with such processing remains largely unknown. In this investigation, we used event-related potentials (ERPs) to examine the effect of social hierarchy on the neural responses elicited by dominant and nondominant faces. Participants played a game where they were led to believe that they were middle-rank players, responding alongside other alleged players, whom they perceived as higher or lower-ranking. ERPs were examined in response to dominant and nondominant faces, and low-resolution electromagnetic tomography (LORETA) was used to identify the implicated brain areas. The results revealed that the amplitude of the N170 component was enhanced for faces of dominant individuals, showing that hierarchy influences the early stages of face processing. A later component, the late positive potential (LPP) appearing between 350–700 ms, also was enhanced for faces of higher-ranking players. Source localisation suggested that the early modulation was due to an enhanced response in limbic regions. These findings provide electrophysiological evidence for enhanced early visual processing of socially dominant faces.

Mixed findings have been reported for the nonconscious processing of fearful faces. Here, we used multivariate pattern analysis on electroencephalography data from three backward masking experiments to decode the conscious and nonconscious processing of fearful faces. Three groups of participants were shown pairs of faces that were presented either subliminally (16 ms) or supraliminally (266 ms) and were required to complete tasks where the face stimuli were either task-relevant (Experiment 1) or task-irrelevant (Experiments 2 and 3). We decoded the neural activity to examine the temporal dynamics of visual awareness, and to investigate whether the presence and location of a fearful face were processed when levels of awareness varied. The results reveal that the spatial location of fearful faces can be decoded from neural patterns only when they are consciously seen and relevant to participants’ task. Nevertheless, the processing of the mere presence of fearful faces can occur in the absence of visual awareness, and the related neural patterns can be generalised to the conscious, non-spatial processing of fearful faces. Additionally, the flexibility of spatial attention seems to modulate the processing of fearful faces.

It has been repeatedly claimed that emotional faces capture attention readily, and that they are processed without awareness. Yet some observations cast doubt on these assertions. Part of the problem may lie in the experimental paradigms employed. Here, we used a free viewing visual search task and simultaneously recorded electroencephalography and eye-movements. Fixation-related potentials were computed for fearful and neutral facial expressions, and the electrical response compared when participants were aware or unaware of the fixated stimulus. We showed that the P300 increased across repeated fixations on the unseen targets, culminating in a conscious report, likely reflecting evidence accumulation. Awareness of the stimulus was associated with electrical changes emerging at around 130 ms, with emotions of the stimulus being dissociated only after awareness had arisen. These results suggest that the earliest electrical correlate of awareness emerges at around 130 ms in visual search and that emotion processing requires visual awareness.

This study aimed at assessing visual word recognition in normal skilled (NRs) and disabled adult Arabic readers (DRs) using masked subliminal and supraliminal word presentations in a lexical decision task (LDT). The main assumption of this investigation was that, as a consequence of their reading disability, DRs would exhibit slower reaction times (RTs) and lower performance than NR in the supraliminal condition. By contrast, since words identified subliminally are thought to occur thanks to advanced orthographic (not phonological skills), it was assumed that this presentation mode would diminish the differences between DRs and NRs. RTs and d’ detection measures were analyzed in 59 NRs and 21 DRs who had to decide whether visually presented letter strings corresponded to real Arabic words or to pseudowords. The statistical analyses conducted on RTs and d’ showed that, although both groups showed a lexicality effect (faster RTs for words than for pseudowords), the DRs compared to NRs showed longer RTs and lower detection measures in the supraliminal mode. Importantly, in the subliminal mode, no group effect was found in terms of RTs and the size of the difference between groups in terms of detection decreased. Also, in this latter presentation condition, we observed that the lexicality effect was significant in the DRs but not in the NRs. These findings are discussed in relation to other studies indicating that DRs might have benefited from good orthographic skills, on which they rely to compensate for their phonological deficits.

We present here a unifying framework for affective phenomena: the Human Affectome. By synthesizing a large body of literature, we have converged on definitions that disambiguate the commonly used terms—affect, feeling, emotion, and mood. Based on this definitional foundation, and under the premise that affective states reflect allostatic concerns, we take a goal-directed, enactive perspective. The human affectome is comprised of allostatic features (valence, motivation, and arousal) and allostatic concerns, which differ in the amount of action required to alleviate allostatic load. Allostatic concerns often fall into three ranges: physiological (the most immediate), operational (intermediate to distal), and global. Global concerns involve summations of overall trajectory, general wellbeing, and self-identity. Within this organizational scheme, the human affectome allows vastly different scientific interests to reside within the same theoretical framework and relate to each other. We hope this framework serves as a common focal point for affective research.

Voxel-wise meta-analyses of task-evoked regional activity were conducted for healthy individuals during the unconscious processing of emotional and neutral faces with an aim to examine whether and how different experimental paradigms influenced brain activation patterns. Studies were categorized into sensory and attentional unawareness paradigms. Thirty-four fMRI studies including 883 healthy participants were identified. Across experimental paradigms, unaware emotional faces elicited stronger activation of the limbic system, striatum, inferior frontal gyrus, insula and the temporal lobe, compared to unaware neutral faces. Crucially, in attentional unawareness paradigms, unattended emotional faces elicited a right-lateralized increased activation (i.e., right amygdala, right temporal pole), suggesting a right hemisphere dominance for processing emotional faces during inattention. By contrast, in sensory unawareness paradigms, unseen emotional faces elicited increased activation of the left striatum, the left amygdala and the right middle temporal gyrus. Additionally, across paradigms, unconsciously processed positive emotions were found associated with more activation in temporal and parietal cortices whereas unconsciously processed negative emotions elicited stronger activation in subcortical regions, compared to neutral faces.

Recent evidence suggests that looming emotional faces are processed rapidly by the neural system, and that this apparent approach further interacts with emotion, causing an enhanced neural response for angry expressions. However, previous research has not demonstrated unequivocally if these effects are due to low-level visual features, or if they are indeed due to the emotional content of the stimuli. To address this question, the current study presented upright and inverted angry and neutral faces, which either expanded or contracted in size on a constant depth-cued background, such that they appeared to approach or retreat from the viewer. EEG/ERP measures were used to identify the time course of brain activity for these stimuli. The results showed that when faces were upright, both the P1 and N170 were enhanced for angry expressions, with the P1 being further increased with looming angry faces. The inversion of the faces caused an increase in both the P1 and N170 amplitudes, but no modulation was found for emotions. These findings show an early modulation of brain activity for upright looming angry faces and rule out the influence of low-level visual features as a contributing factor.

Due to their ability to capture attention, emotional stimuli tend to benefit from enhanced perceptual processing, which can be helpful when such stimuli are task-relevant but hindering when they are task-irrelevant. Altered emotion-attention interactions have been associated with symptoms of affective disturbances, and emerging research focuses on improving emotion-attention interactions to prevent or treat affective disorders. In line with the Human Affectome Project's emphasis on linguistic components, we also analyzed the language used to describe attention-related aspects of emotion, and highlighted terms related to domains such as conscious awareness, motivational effects of attention, social attention, and emotion regulation. These terms were discussed within a broader review of available evidence regarding the neural correlates of (1) Emotion-Attention Interactions in Perception, (2) Emotion-Attention Interactions in Learning and Memory, (3) Individual Differences in Emotion-Attention Interactions, and (4) Training and Interventions to Optimize Emotion-Attention Interactions. This comprehensive approach enabled an integrative overview of the current knowledge regarding the mechanisms of emotion-attention interactions at multiple levels of analysis, and identification of emerging directions for future investigations. ispartof: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS vol:108 pages:559-601 ispartof: location:United States status: published

The neural fate of task-irrelevant emotional faces under different awareness conditions is poorly understood. Here, we examined the electrophysiological activity during an experiment where the location of target information (contrast-induced line) was manipulated orthogonally to the location of task-irrelevant fearful faces, under subliminal or supraliminal viewing conditions. We found that only target lines elicited an N2-posterior-contralateral (N2pc), indexing spatial attention shifting, in the supraliminal condition. No N2pc was found for the targets in the subliminal condition or for task-irrelevant fearful faces in either conditions. However, the mere presence of a fearful face enhanced early neural activity between 200 and 300 ms only in the subliminal condition. Additionally, the presence of a target line, but not a fearful face, enhanced the P3. Our results suggest that the N2pc is dependent on visual awareness and task-relevancy of the information and that laterally-presented task-irrelevant fearful expressions can be processed without awareness during early visual processing.

Although the brain is known to process threatening emotional stimuli and looming motion rapidly, little is known about how the emotion and motion interact. To address this question, two experiments were carried out which presented angry and neutral emotional faces on a depth-cued background that induced the perception of distance, or a non-cued background. Furthermore, faces either expanded or contracted in size such that they appeared to approach or recede from the viewer. EEG/ERP measures were used to identify the time course of brain activity for these looming and receding, angry and neutral emotional faces. The results of both experiments revealed that the P1 was enhanced by looming angry faces on the depth-cued background, compared to neutral approaching faces, as well as all receding faces, indicating an early interaction of emotion and motion within 100 ms of presentation. Angry expressions were also found to enhance the N170 regardless of movement. These findings suggest that processing of threat and looming motion interact at the very early stages of visual processing. Furthermore, as the modulating effect of looming motion on angry expressions only arose on the depth-cued background, the findings highlight the importance of approaching movements rather than sole increases in the retinal size of the stimuli.

During visual perception, the brain must combine its predictions about what is to be perceived with incoming relevant information. The present study investigated how this process interacts with attention by using event-related potentials that index these cognitive mechanisms. Specifically, this study focused on examining how the amplitudes of the N170, N2pc, and N300 would be modulated by violations of expectations for spatial and featural attributes of visual stimuli. Participants viewed a series of shape stimuli in which a salient shape moved across a set of circular locations so that the trajectory of the shape implied the final position and shape of the stimulus. The final salient stimuli occurred in one of four possible outcomes: predictable position and shape, predictable position but unpredictable shape, unpredictable position but predictable shape, and unpredictable position and shape. The N170 was enhanced by unpredictable positions and shapes, whereas the N300 was enlarged only by unpredictable positions. The N2pc was not modulated by violations of expectations for shapes or positions. Additionally, it was observed post-hoc that the P1pc amplitude was increased by unpredictable shapes. These findings revealed that incorrect prediction increases neural activity. Furthermore, they suggest that prediction and attention interact differently in different stages of visual perception, depending on the type of attention being engaged: The N170 indexes initial prediction error signalling irrespective of the type of information (spatial or featural) in which error occurs, followed by the N300 as a marker of prediction updating involving reorientation of spatial attention.

Transcranial Direct Current Stimulation (tDCS) has shown that stimulation of Dorsolateral Prefrontal Cortex (DLPFC) facilitates task performance in working-memory tasks. However, little is known about its potential effects on effort. This study examined whether tDCS affects effort during a working-memory task. Participants received anodal, cathodal and sham stimulation over DLPFC across three sessions before carrying out a 2-back task. During the task, effort-related cardiovascular measures were recorded—especially the Initial Systolic Time Interval (ISTI). Results showed that anodal stimulation produced a shorter ISTI, indicating a greater effort compared to cathodal and sham conditions, where effort was lower. These findings demonstrate that anodal stimulation helps participants to maintain engagement in a highly demanding task (by increasing task mastery), without which they would otherwise disengage. This study is the first to show that tDCS impacts the extent of effort engaged by individuals during a difficult task.

Cognitive models of social anxiety propose that socially anxious individuals engage in excessive self-focusing attention when entering a social situation. In the present study, speech anxiety was induced to socially anxious and control participants. Event-related potentials were recorded while participants performed a perceptual judgement task using distinct or ambiguous stimuli, before and after social feedback. Disputed feedback led to more revisions and decreased levels of confidence, especially among socially anxious individuals. Prior feedback, greater occipital P1 amplitudes in both groups for ambiguous probes indicated heightened sensory facilitation to ambiguous information, and greater anterior N1 amplitudes for ambiguous stimuli in highly anxious participants suggested anticipation of negative feedback in this group. Post-feedback, P1, N1 and LPP amplitudes were reduced overall among socially anxious individuals indicating a reduction in sensory facilitation of visual information. These results suggest excessive self-focusing among socially anxious individuals, possibly linked to anticipation of an anxiety-provoking social situation.

Emotional expressions and attentional processes interact such that emotion increases perceptual sensitivity in modality-specific brain areas leading to more efficient processing of the stimulus. In the current study, we asked the question of whether the emotional expressions can be processed subliminally when faces are attended but the emotional expression is irrelevant. We presented angry and neutral male and female faces supraliminally and subliminally to participants in an attention-shifting paradigm. Emotional expression was irrelevant to the task, but the gender of the face was predictive of the location of a subsequent target. Analysis of reaction times revealed that, in the supraliminal condition, targets appearing at validly cued locations produced quicker responses than targets at invalidly cued locations. Target-locked event-related potentials (ERPs) confirmed this result and showed that attention selection elicited higher responses at attended locations, as reflected by the N1 component. However, voluntary attention shifting was not triggered when the cue was not consciously perceived. No effects of emotion were observed following target presentation, suggesting that the high attentional load required by the experiment may have prevented the processing of emotion for undetectable faces, as demonstrated by the fact that, following cue onset, the N170 was modulated by emotion in supraliminal trials only. We therefore show that emotional expressions cannot be processed without awareness when faces are attended, but the emotional expression is irrelevant.

In bilinguals, language proficiency has been advanced to influence the involvement of domain-general control networks in language selection. We assessed, in university student translators with moderate- to high-second language (L2) proficiency depending on their translation educational level, the functional activity in the key language and control areas (the caudate nucleus, anterior cingulate, and prefrontal cortex), during task- and language-selection in an oral production context. We found that L2 proficiency influenced the relative involvement of our regions of interest during language selection vs domain-general cognitive control processes. While the left middle frontal and left caudate areas were more involved during linguistic than alphanumeric task selection in the low L2 proficiency group, these regions were similarly involved in both tasks in the high-L2 proficiency group. These findings suggest that language selection relies primarily on a network within domain-general cognitive control system with an increase in resource needs when L2 proficiency is low.

It remains unclear to date whether spatial attention towards emotional faces is contingent on, or independent of visual awareness. To investigate this question, a bilateral attentional blink paradigm was used in which lateralised fearful faces were presented at various levels of detectability. Twenty-six healthy participants were presented with two rapid serial streams of human faces, while they attempted to detect a pair of target faces (T2) displayed in close or distant succession of a first target pair (T1). Spatial attention shifting to the T2 fearful faces, indexed by the N2-posterior-contralateral component, was dependent on visual awareness and its magnitude covaried with the visual awareness negativity, a neural marker of awareness at the perceptual level. Additionally, information consolidation in working memory, indexed by the sustained posterior contralateral negativity, positively correlated with the level of visual awareness and spatial attention shifting. These findings demonstrate that spatial attention shifting to fearful faces depends on visual awareness, and these early processes are closely linked to information maintenance in working memory.

Face Inversion Effects (FIEs) – differences in response to upside down faces compared to upright faces – occur for both behavioural and electrophysiological responses when people view face stimuli. In EEG, the inversion of a face is often reported to evoke an enhanced amplitude and delayed latency of the N170 event-related potential. This response has historically been attributed to the indexing of specialised face processing mechanisms within the brain. However, inspection of the literature revealed that while the N170 is consistently delayed to photographed, schematic, Mooney and line drawn face stimuli, only naturally photographed faces enhance the amplitude upon inversion. This raises the possibility that the increased N170 amplitudes to inverted faces may have other origins than the inversion of the face’s structural components. In line with previous research establishing the N170 as a prediction error signal, we hypothesise that the unique N170 amplitude response to inverted photographed faces stems from multiple expectation violations, over and above structural inversion. For instance, rotating an image of a face upside down not only violates the expectation that faces appear upright, but also lifelong priors that illumination comes from above and gravity pulls from below. To test this hypothesis, we recorded EEG whilst participants viewed face stimuli (upright versus inverted), where the faces were illuminated from above versus below, and where the models were photographed upright versus hanging upside down. The N170 amplitudes were found to be modulated by a complex interaction between orientation, lighting and gravity factors, with the amplitudes largest when faces consistently violated all three expectations and smallest when all these factors concurred with expectations. These results confirm our hypothesis that FIEs on N170 amplitudes are driven by a violation of the viewer’s expectations across several parameters that characterise faces, rather than a disruption in the configurational disposition of its features.

Interindividual variations in the ability to perform visuospatial mental transformations have been investigated extensively, in particular through mental rotation tasks. However, the impact of early visual processes on performance has been largely ignored. To clarify this issue, we explored the time-course of early visual processing (from 0 to 450 ms poststimulus) using event-related potentials topographic analyses. The main findings demonstrated a significant link between early attentional processes and accuracy scores occurring more than five seconds later, as well as a strong association between spatial covariance and microstate topographies exhibiting substantial gender differences. More specifically, the results indicated that, in a classical mental rotation task, the male brain expends more time processing visual-spatial information resulting in a longer bilateral positive potential at posterior-occipital sites. In comparison, the female brain initiates earlier processing of non-spatial information resulting in a faster transition from a bilateral positive potential of posterior-occipital sites to a negative potential at central-frontal sites. These findings illustrate how a more complete utilization of the spatiotemporal information contained in EEG recordings can provide important insights about the impact of early visual processes on interindividual differences, particularly across gender, and thus shed new light on alternate cognitive strategies.

Sexual desire can be triggered by external (visual, tactile, auditory, olfactory) or internal (memories, fantasies) stimuli. However, few studies have investigated these different components of sexual desire. In our investigation, we focused on visual stimuli with the aim of establishing whether or not there exists a specific pattern of visual exploration linked to sexual desire among male and female subjects. In another words, we wanted to investigated what parts of the body visually explored are the more relevant to feel sexual desire. To assess this question, we conducted an eye-tracking study in which participants made a judgment of sexual desire, during the visualization of explicit visual stimuli. The main results for male viewers revealed that they explored the body longer than the face (P = .05). Within the body area, the chest region was scanned more extensively than the abdomen (P = .014) and the genital area (P = .003). There were no difference between the abdomen and the genital area. For female viewers, the pattern of exploration showed they explored the body longer than the face (P = .05). Inside the body area, the abdomen was scanned more extensively than the chest/pectoral region (P

We examined whether semantic processing occurs without awareness using continuous flash suppression (CFS). In two priming tasks, participants were required to judge whether a target was a word or a non-word, and to report whether the masked prime was visible. Experiment 1 manipulated the lexical congruency between the prime-target pairs and Experiment 2 manipulated their semantic relatedness. Despite the absence of behavioral priming effects (Experiment 1), the ERP results revealed that an N4 component was sensitive to the prime-target lexical congruency (Experiment 1) and semantic relatedness (Experiment 2) when the prime was rendered invisible under CFS. However, these results were reversed with respect to those that emerged when the stimuli were perceived consciously. Our findings suggest that some form of lexical and semantic processing can occur during CFS-induced unawareness, but are associated with different electrophysiological outcomes.

The dynamics of brain activation reflecting attractiveness in humans are unclear. Among the different features affecting attractiveness of the female body, the waist-to-hip ratio (WHR) is considered to be crucial. To date, however, no event-related potential (ERP) study has addressed the question of its associated pattern of brain activation. We carried out two different experiments: (a) a behavioural study, to judge the level of attractiveness of female realistic models depicting 4 different WHRs (0.6, 0.7, 0.8, 0.9) with and without clothes; (b) an EEG paradigm, to record brain activity while participants (heterosexual men and women) viewed these same models. Behavioural results showed that WHRs of 0.7 were considered more attractive than the others. ERP analyses revealed a different pattern of activation for male and female viewers. The 0.7 ratio elicited greater positivity at the P1 level in male viewers but not females. Naked bodies increased the N190 in both groups and peaked earlier for the 0.7 ratio in the male viewers. Finally, the late positive component (LPC) was found to be greater in male than in female viewers and was globally more marked for naked bodies as well as WHRs of 0.7 in both groups of viewers. These results provide the first electrophysiological evidence of specific time periods linked to the processing of a body feature denoting attractiveness and therefore playing a role in mate choice.

In recent years, neuroscience has begun to investigate brain responses to social stimuli. To date, however, the effects of social feedback on attentional and perceptual processes remain unclear. In this study, participants were asked to judge the hues of distinct, or ambiguously coloured stimuli, and to indicate their confidence ratings. Alleged social feedback was then provided, either endorsing or disputing the participants' responses. Participants were then presented the stimulus a second time and given the option to reconsider their decision. Behavioural findings showed that confidence levels decreased both with task difficulty and with conflicting social feedback. Event-related potential data showed greater P2 and N2 amplitudes for ambiguous squares compared to distinct squares upon initial stimulus presentations, compatible with heightened attention. Moreover, a decreased P300 was found for ambiguous stimuli, consistent with an increase in metacognitive activity. After social feedback, an early-late positive potential between 270 and 370 ms continued to distinguish ambiguous from distinct stimuli. More importantly, after 400 ms, the late positive potential distinguished endorsed from disputed stimuli. These results reveal that social feedback, while decreasing effects linked to uncertainty, gives rise to later processes associated with enhanced motivational significance of the stimulus following divergence from social approval.

Evidence shows that human faces can rapidly produce impressions of trust or distrust on the basis of their facial features. However, trust is also built through repeated interactions in which an opposite party acts positively towards the subject in a consistent way. The dynamics of cortical activation of this form of interactively-experienced trust is unclear. The current study therefore investigated the electrophysiological response to trust/distrust, arising through interactions in an investment game. Using an ERP paradigm, participants took part in a money game in which they chose to entrust different amounts to fictitious players. Some of these players were associated with the higher probability of a positive outcome (trustworthy behaviour), others were associated with a higher negative outcome (untrustworthy behaviour), and yet others were neutral. Over the course of the game, a strong central positivity emerged between 450 and 650 ms for trustworthy faces, compared to both neutral and untrustworthy players. This time period thus reflects the window during which the trustworthiness of a face is processed, when based on prior interaction. In addition, by evidencing ERP modifications for trustworthy faces alone, these findings suggest that the “default mode” of processing is initially biased towards distrust.

OBJECTIVE: The prediction of verbal memory decline after temporal lobe epilepsy (TLE) surgery remains difficult at an individual level. We evaluated the prognostic value of postictal memory testing in predicting the postoperative verbal memory function. METHODS: Sixty-three consecutive patients were included in the analysis who underwent TLE surgery at our center with preoperative interictal/postictal and postoperative memory testing. Verbal memory was evaluated using the Rey Auditory Verbal Learning Test (RAVLT). We used reliable change indices with 90% confidence interval (90% RCIs) to evaluate a significant postoperative memory decline. The sensitivity (Sn), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), area under the curve (AUC), and accuracy (ACC) were calculated. The analysis was performed for all TLE patients and for the subgroup with hippocampal sclerosis (HS). RESULTS: Left-TLE patients (n = 31) had lower verbal memory scores on RAVLT than right-TLE at 3 months (57% vs 78%) and 12 months (53% vs 78%) after surgery. The 90% RCI was estimated to be a loss of 4 out of 15 items. The predictive value was Sn = 42%, Sp = 84%, PPV = 39%, NPV = 86%, AUC = 0.630, and ACC = 76% to predict a verbal memory decline in the whole group (n = 63). In HS patients (n = 41), the postictal verbal memory test had Sn = 50%, Sp = 88%, PPV = 50%, NPV = 88%, AUC = 0.689, and ACC = 81% to predict a significant postoperative decline. SIGNIFICANCE: Postictal memory is a noninvasive bedside memory test that can help predict the postoperative verbal memory decline in patients with HS with an overall accuracy of 81%.

The human brain can process facial expressions of emotions rapidly and without awareness. Several studies in patients with damage to their primary visual cortices have shown that they may be able to guess the emotional expression on a face despite their cortical blindness. This non-conscious processing, called affective blindsight, may arise through an intact subcortical visual route that leads from the superior colliculus to the pulvinar, and thence to the amygdala. This pathway is thought to process the crude visual information conveyed by the low spatial frequencies of the stimuli.In order to investigate whether this is the case, we studied a patient (TN) with bilateral cortical blindness and affective blindsight. An fMRI paradigm was performed in which fearful and neutral expressions were presented using faces that were either unfiltered, or filtered to remove high or low spatial frequencies. Unfiltered fearful faces produced right amygdala activation although the patient was unaware of the presence of the stimuli. More importantly, the low spatial frequency components of fearful faces continued to produce right amygdala activity while the high spatial frequency components did not. Our findings thus confirm that the visual information present in the low spatial frequencies is sufficient to produce affective blindsight, further suggesting that its existence could rely on the subcortical colliculo-pulvino-amygdalar pathway.

Background/Aims: Recent studies of cases with mild cognitive impairment (MCI) suggested that besides Alzheimer disease (AD)-related biomarkers, some personality dimensions are associated with progression to AD. To date, there are no studies addressing the psychological determinants of subtle cognitive decline in healthy elderly controls. Methods: 488 community-dwelling healthy controls were assessed with a detailed neuropsychological battery at baseline and an 18-month follow-up. Personality factors and facets were investigated at baseline using the NEO-Personality Inventory-Revised (NEO-PI-R). Upon follow-up, there were 264 stable controls (sCON) and 224 deteriorating controls (dCON). Their personality data were compared to those of the 102 MCI cases using one-way analysis of variance and logistic regression models. Results: Significantly higher scores of Openness factor (as well as Aesthetics, Ideas and Values facets) were found in sCON than in both dCON and MCI cases. The three groups did not differ in the other NEO-PI-R factor and facet scores. Openess factor (and the same facets) was associated with cognitive preservation in healthy controls (OR: 0.72, 95% CI: 0.59, 0.87). Lower scores in the same factor and facets conferred higher risk to have MCI (OR: 0.61, 95% CI: 0.46, 0.79). Conclusion: Higher openness to new experiences and thoughts may be a protective factor against early cognitive decline in brain aging.