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Background Exercise improves health outcomes and quality of life in persons with chronic kidney disease (CKD). The numbers of persons with advanced CKD meeting physical activity guidelines however is low. We undertook a qualitative study of men and women aged 36–74 from various race/ethnic populations with advanced CKD not requiring dialysis to describe their experiences and opinions around prior physical activity, motivating factors for and barriers to exercise, and perceptions of exercise-promoting technology and group-based programming designed to improve physical activity levels. Methods Nineteen persons with advanced CKD not requiring dialysis were interviewed at two high volume nephrology clinics enriched with racial/ethnic minority patients (Emory University and Santa Clara Valley Medical Center). We used thematic analysis to identify dominant themes (n = 4) and subthemes (n = 19) around exercise experience, barriers, motivators, views, and preferences. Results Four dominant themes and 19 subthemes were identified. The most common motivators to exercise included physical and mental health benefits, appearance, improvement in energy levels, and potential social interaction in group-based programs. Common barriers included health concerns, particularly complications related to other co-morbidities, as well as time and transportation constraints. Participants were skeptical of exercise programs solely reliant on technology. Conclusions The use of group-based exercise programs may motivate persons with CKD to increase exercise levels, while programs entirely based on technology may be less effective.

PURPOSE: One third of the U.S. adult population is estimated to have prediabetes. Hispanics have a 50% higher type 2 diabetes (T2DM) death rate compared to non-Hispanic whites, yet low participation in lifestyle change programs, making this subgroup an important target for prevention efforts. The purpose of this study was to determine the effects of an exercise intervention implementing the Center for Disease Control and Prevention (CDC) National Diabetes Prevention Program (NDPP) plus recreational soccer (RS) in Hispanic men. METHODS: Overweight and obese Hispanic men, aged 30–57 years with prediabetes at screening were recruited from the community. Trained soccer coaches led 30-min facilitated discussion of the NDPP modules after each RS session, with two wkly sessions delivered over 12 wks, then once a wk until 24 wks. The 1-h RS sessions followed the Football Fitness curriculum structure. Standardized study assessments included objectively measured physical activity via fitness tracker, physical fitness via validated field tests, GPS soccer specific metrics and behavior change questionnaires. Mixed models assessed the outcomes as a function of time and cohort and incorporated an unstructured covariance structure to examine the difference between baseline, 12 and 24 wks. All analyses were conducted as intent-to-treat and generated using SAS v 9.4. RESULTS: Hispanic males (n=41; mean age 41.9 [6.2 SD] years) were obese at baseline (mean BMI 32.7, standard error [0.7]). After 24 wks of the NDPP+RS intervention, there were significant beneficial changes in vertical jump (2.8 [1.3] cm; p=0.048), agility and lower extremity muscular power (figure 8-run) at 12 wks (−4.7% change; p=0.001) and 24 wks (−7.2% change; p

Purpose: Social influences on health are inadequately understood, hindering progress in eliminating disparities in cancer. One such influence, social isolation, is well established as an independent risk factor for mortality and comparable in magnitude to other risks such as obesity. Social isolation is associated with smoking, which is increasingly concentrated in socioeconomically disadvantaged (SED) populations. However, the association between social isolation and smoking is understudied. This study examined the extent to which psychosocial, life-contextual, and health care factors account for the social isolation-smoking relationship among SED adults. Methods: The study used data from a cross-sectional survey of SED adults (N=3064) recruited from an information and referral program that helps individuals with meeting basic needs (e.g., food). Measures included current smoking status, social isolation, psychosocial factors (stress, loneliness), life-contextual factors (unmet basic needs), health care factors (time since last routine checkup, health self-efficacy), and demographics. A social isolation score was derived using a modified version of the Social Network Index. Bivariate analyses and multivariable logistic regression examined the association between social isolation and smoking. Path analyses estimated indirect associations between social isolation and smoking via psychosocial, life-contextual, and health care factors while controlling for demographics. Path analyses used full information maximum likelihood with robust estimation and the theta parameterization. Model fit was assessed using the comparative fit index (CFI ≥0.95) and root mean square error of approximation (RMSEA Results: The sample was predominantly female (81%), non-Hispanic Black (79%), and highly SED, with 44% having a high school education or less and 52% having an annual household income less than $10,000. Overall, 29% of participants were current smokers, and 62% were highly socially isolated. Social isolation was associated with smoking, with only 10% of the least isolated individuals smoking currently compared to 39% of the most socially isolated individuals (p Conclusions: Findings elucidate possible mechanisms driving the social isolation-smoking relationship in SED populations, suggesting several potential intervention approaches for reducing cancer disparities. Evidence-based interventions that consider psychosocial and life-contextual issues may be especially salubrious for SED populations. This abstract is also being presented as Poster A090. Citation Format: Kassandra I. Alcaraz, Rhyan N. Vereen, Antonika Souder, Alan Bienvenida. Contextualizing the association between social isolation and smoking among socioeconomically disadvantaged adults: Psychosocial, life-contextual, and health care factors [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr PR02.