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37 results on '"Alam, Md. Jahir"'

7. In Vitro Antioxidant and In Vivo Hepatoprotective Properties of Wissadula periplocifolia Extract

Author

Hossain, Kazi Nadim, primary, Islam, Md. Shafiqul, additional, Rahman, Sheikh Hasibur, additional, Sarker, Subroto, additional, Mondal, Milon, additional, Rahman, Mohammad Asikur, additional, Alhag, Sadeq K., additional, Al-Shuraym, Laila A., additional, Alghamdi, Othman A., additional, Islam, Muhammad Torequl, additional, AL-Farga, Ammar, additional, El-Shazly, Mohamed, additional, Alam, Md. Jahir, additional, and El-Nashar, Heba A. S., additional

Published
2023
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14. Therapeutic Potentials of Colocasia affinis Leaf Extract for the Alleviation of Streptozotocin-Induced Diabetes and Diabetic Complications: In vivo and in silico-Based Studies

Author

Shill,Manik Chandra, Bepari,Asim Kumar, Khan,Mahi, Tasneem,Zarin, Ahmed,Tania, Hasan,Md Asif, Alam,Md Jahir, Hossain,Murad, Rahman,Md Ashrafur, Sharker,Shazid Md, Shahriar,Masum, Rahman,Ghazi Muhammad Sayedur, Reza,Hasan Mahmud, Shill,Manik Chandra, Bepari,Asim Kumar, Khan,Mahi, Tasneem,Zarin, Ahmed,Tania, Hasan,Md Asif, Alam,Md Jahir, Hossain,Murad, Rahman,Md Ashrafur, Sharker,Shazid Md, Shahriar,Masum, Rahman,Ghazi Muhammad Sayedur, and Reza,Hasan Mahmud

Abstract

Manik Chandra Shill,1 Asim Kumar Bepari,1 Mahi Khan,1 Zarin Tasneem,1 Tania Ahmed,1 Md Asif Hasan,1 Md Jahir Alam,1 Murad Hossain,1 Md Ashrafur Rahman,1 Shazid Md Sharker,1 Masum Shahriar,2 Ghazi Muhammad Sayedur Rahman,1 Hasan Mahmud Reza1 1Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka, 1229, Bangladesh; 2Department of Pharmacy, Jahangirnagar University, Savar, BangladeshCorrespondence: Manik Chandra Shill; Hasan Mahmud RezaDepartment of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka, 1229, BangladeshEmail manik.shill@northsouth.edu; hasan.reza@northsouth.eduIntroduction: Hypoglycemia in diabetes mellitus (DM) correlates with hepatic impairment, nephropathy, lipid abnormalities, and oxidative stress and subsequently complicates the disease pathogenesis. Medicinal plants have been used for the management of diabetes since ancient times. In this study, we explored the potentials of Colocasia affinis (CA), a plant known to possess anti-allergic and anti-inflammatory activities, as a remedy for diabetes and related complications.Methods: We induced diabetes in rats using a single intraperitoneal dose (65 mg/kg) of streptozotocin (STZ). We next treated the rats with an ethanolic extract of leaves of CA to reveal its antidiabetic and organ-protective potentials. Biomarkers of diabetes, inflammation, and oxidative stress were measured using biochemical and histopathological analysis. We also performed molecular docking for three major phytochemicals (kaempferol, myricetin, and rosmarinic acid) of CA.Results: Oral administration of the CA leaves extract at 250 mg/kg and 500 mg/kg doses decreased blood glucose level significantly (p< 0.05) in STZ-induced diabetic rats. The extract also considerably attenuated plasma HbA1c levels and normalized blood lipids, glycogen, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Additionally, treatment with the extract improved kidney complications by de

Published
2021

16. Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Author

Mondal, Milon, primary, Quispe, Cristina, additional, Sarkar, Chandan, additional, Bepari, Tapash Chandra, additional, Alam, Md. Jahir, additional, Saha, Sushmita, additional, Ray, Pranta, additional, Rahim, Mohammod Abdur, additional, Islam, Muhammad Torequl, additional, Setzer, William N., additional, Salehi, Bahare, additional, Ahmadi, Mehdi, additional, Abdalla, Mohnad, additional, Sharifi-Rad, Javad, additional, and Kundu, Sukalyan Kumar, additional

Published
2021
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17. Therapeutic Potentials of Colocasia affinis Leaf Extract for the Alleviation of Streptozotocin-Induced Diabetes and Diabetic Complications: In vivo and in silico-Based Studies

Author

Shill, Manik Chandra, primary, Bepari, Asim Kumar, additional, Khan, Mahi, additional, Tasneem, Zarin, additional, Ahmed, Tania, additional, Hasan, Md Asif, additional, Alam, Md Jahir, additional, Hossain, Murad, additional, Rahman, Md Ashrafur, additional, Sharker, Shazid Md, additional, Shahriar, Masum, additional, Rahman, Ghazi Muhammad Sayedur, additional, and Reza, Hasan Mahmud, additional

Published
2021
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20. Anti-diarrheal activities of phytol along with its possible mechanism of action through in-vivo and in-silico models

Author

Islam, Muhammad Torequl, primary, Rahman, Mohammad Asikur, additional, Saeed, Maria, additional, Ul-Haq, Zaheer, additional, Alam, Md. Jahir, additional, Mondal, Milon, additional, Hossain, Rajib, additional, Mubarak, Mohammad S., additional, Salehi, Bahare, additional, Setzer, William N., additional, Abdull Razis, Ahmad Faizal, additional, and Sharifi-Rad, Javad, additional

Published
2020
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37. Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensisLeaf: In Vivo and in Silico Studies

Author

Mondal, Milon, Quispe, Cristina, Sarkar, Chandan, Bepari, Tapash Chandra, Alam, Md. Jahir, Saha, Sushmita, Ray, Pranta, Rahim, Mohammod Abdur, Islam, Muhammad Torequl, Setzer, William N., Salehi, Bahare, Ahmadi, Mehdi, Abdalla, Mohnad, Sharifi-Rad, Javad, and Kundu, Sukalyan Kumar

Abstract

The objective of our present study is to scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensisleaf using different in vivo assay models at doses of 100, 200, and 400 mg/kg body weight. Twenty chemical compounds, which were isolated from the leaves essential oil of E. camaldulensis, were docked using AutodockVina against cyclooxygenase 2, tumor necrosis factor-α, and interleukin-1β convertase to elucidate the analgesic and anti-inflammatory activity. The essential oil of E. camaldulensisexhibited noteworthy analgesic activities in the writhing test. In the tail immersion and hot-plate test, the essential oil significantly extended the latency period. The number of licks in the formalin-induced paw licking test was markedly reduced following essential oil administration. In addition, E. camaldulensisessential oil revealed notable anti-inflammatory responses in carrageenan-induced paw edema, xylene induced ear edema and cotton pellet induced granuloma methods. Among 20 compounds, 5 (cis-sabinol, globulol, α-eudesmol, β-eudesmol, and γ-eudesmol) showed better binding for cyclooxygenase-2 while β-eudesmol exhibited higher affinity for TNFα than that of TNF-alpha-IN-1 and standard drug. In the case of interleukin 1β convertase, maximum affinity was shown by α-eudesmol than the synthetic drug belnacasan. Chemical components of the essential oil interacted with diverse amino acid residues which were similar to the natural substrate and standard drugs. In conclusion, E. camaldulensisessential oil can be an effective source of analgesic and anti-inflammatory treatment and additional modification and docking studies will be required to justify the efficiency of globulol, α-eudesmol, β-eudesmol, and γ-eudesmol.

Published
2021
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