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A biosensitive analysis method development and validation was performed for accurate and rapid quantification of cefdinir (CDR) in human plasma by a liquid chromatography–tandem mass spectrometry technique coupled with electrospray ionization. Analysis was carried out using a C18 column with a flow rate of 1.0 mL/min and operating temperature of 30.0 ± 1°C. The drug was eluted by optimizing the m/z ratios of 396.20 → 227.20 and 428.17 → 241.10, for cefdinir and IS (internal standard), respectively. The intraday precision (%CV) for Cefdinir ranged from 2.8% and 6.7% as lower limit of quantification of quality control (LLOQ QC) and higher level of quantification of quality control (HQC QC), respectively, whereas these value were found to be as 3.0% and 5.6% for LLOQ and HQC, respectively after interday precision. Moreover, accuracy ranged from 107.70% (HQC QC) to 95.5% (LLOQ QC). The extraction mean recovery was found to be 83.91 ± 6.0% for cefdinir and 76.7 ± 6.23% for IS. The drug was stable throughout the analysis period. It was possible to analyze several plasma samples every day since each sample took <2.5 min to run. The method demonstrated successful quantification of CDR in human plasma, followed by pharmacokinetic profiles that were simple, accurate, sensitive and cost-effective. [ABSTRACT FROM AUTHOR]

Tectona grandis L.f is a timber plant that is commonly referred to as teak. Its wide use as a medicine in the various indigenous systems makes it a plant of importance. A wide gamut of phytoconstituents like alkaloids, phenolic glycosides, steroids, etc. has been reported. A renewed interest in this plant has resulted in scientific investigations by various researchers towards the isolation and identification of active constituents along with scientific proof of its biological activities. The different parts of the plant have been scientifically evaluated for their antioxidant, antipyretic, analgesic, hypoglycemic, wound healing, cytotoxic, and many more biological activities. Documentation of this scientific knowledge is of importance to have consolidated precise information encompassing the various aspects of this plant, which could provide a base for future studies. This review is a compilation of the salient reports on these investigations concerning phytochemistry, the methods used to identify and quantify the constituents, the evaluation methods of the biological activity, toxicological studies, allergies and the patent/patent applications. This will further help researchers to find an area of the gap for future studies. [ABSTRACT FROM AUTHOR]

Pyridazine derivatives represent one of the most active classes of compounds possessing a wide spectrum of biological activity. They are widely used in pharmaceuticals and agrochemicals. In view of these facts and in continuation of our interest in the chemistry of pyridazines, pyridazinones are six membered cyclic 1,2-diazine having carbonyl group at 3-position of ring system. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This short review compiles examples of the most promising antibacterial activity. An overview on the antifungal activity is also described. [ABSTRACT FROM AUTHOR]

Hydrazones possess an azomethine -NHN=CH group and are considered as derivatives of aldehydes and ketones in which the oxygen atom has been replaced by the NNH2 functional group. These are widely studied molecules owing to their ease of preparation and diverse pharmacological potential. This has led researchers to synthesize different heterocyclic compounds bearing hydrazones. Medicinal chemists across the world have done immense work on hydrazones and developed agents with better activity and low toxicity profiles. Following different synthetic protocols and through proper SAR studies differently substituted hydrazones have been developed and found to be active against different pharmcological targets. They are known to possess different biological activities viz. antimicrobial, antiinflammatory, anticancer, antimalarial etc. These observations can be used as guidance for the development of new hydrazones that possess various biological activities. The review aims to highlight the diverse biological activities of hydrazones. [ABSTRACT FROM AUTHOR]

Pyrazoline is an important five membered nitrogen heterocycle, which has been extensively researched upon. The ring is quite stable and has inspired chemists to carry out various structural variations in the ring. This has propelled the development of distinct pyrazolines with an array of pharmacological activities viz. anti-inflammatory, analgesic, antimicrobial, anticancer, antidepressant etc. The review aims at highlighting this pharmacological diversity of pyrazolines. The review is a gist of latest work done describing the pharmacological aspects and potential of pyrazoline ring.