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22 results on '"Alam, Ali M."'

1. Utilising accessible and reproducible neurological assessments in clinical studies: Insights from use of the Neurological Impairment Scale in the multi-centre COVID-CNS study

Author

Alam, Ali M., Webb, Glynn W., Collie, Ceryce, Mariathasan, Sashini, Huang, Yun, Hilton, Orla, Shil, Rajish, Dodd, Katherine C., Lilleker, James B., Smith, Craig J., Easton, Ava, Tamborska, Arina, Thomas, Rhys H., Davies, Nicholas W.S., Jenkins, Thomas M., Zandi, Michael, Benjamin, Laura, Ellul, Mark A., Solomon, Tom, Pollak, Thomas A., Nicholson, Tim, Breen, Gerome, van Wamelen, Daniel J., Wood, Nicholas W., and Michael, Benedict D.

Published
2024
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3. Addressing ethnic disparities in neurological research in the United Kingdom: An example from the prospective multicentre COVID-19 Clinical Neuroscience Study

Author

van Wamelen, Daniel J., Rota, Silvia, Hartmann, Monika, Martin, Naomi H., Alam, Ali M., Thomas, Rhys H., Dodd, Katherine C., Jenkins, Thomas, Smith, Craig J., Zandi, Michael S., Easton, Ava, Carr, Georgina, Benjamin, Laura A., Lilleker, James B., Saucer, David, Coles, Alasdair J., Wood, Nicholas, Ray Chaudhuri, K., Breen, Gerome, and Michael, Benedict Daniel

Published
2024
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12. Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts

Author

Wood, Greta K, primary, Babar, Roshan, additional, Ellul, Mark A, additional, Thomas, Rhys Huw, additional, Van Den Tooren, Harriet, additional, Easton, Ava, additional, Tharmaratnam, Kukatharmini, additional, Burnside, Girvan, additional, Alam, Ali M, additional, Castell, Hannah, additional, Boardman, Sarah, additional, Collie, Ceryce, additional, Facer, Bethany, additional, Dunai, Cordelia, additional, Defres, Sylviane, additional, Granerod, Julia, additional, Brown, David W G, additional, Vincent, Angela, additional, Marson, Anthony Guy, additional, Irani, Sarosh R, additional, Solomon, Tom, additional, and Michael, Benedict D, additional

Published
2022
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15. How does research activity align with research need in chronic subdural haematoma: a gap analysis of systematic reviews with end-user selected knowledge gaps.

Author

Gillespie, Conor S., Fung, Kwan Wai, Alam, Ali M., Yanez Touzet, Alvaro, Dhesi, Jugdeep, Edlmann, Ellie, Coles, Jonathan, Menon, David K., Hutchinson, Peter J., Stubbs, Daniel J., and Davies, Benjamin M.

Subjects
SUBDURAL hematoma, RESEARCH questions, ELDER care, DATABASE searching, INDIVIDUAL needs, OPERATING room nursing
Abstract

Background: Chronic subdural haematoma (CSDH) is increasingly common. Although treatment is triaged and provided by neurosurgery, the role of non-operative care, alongside observed peri-operative morbidity and patient complexity, suggests that optimum care requires a multi-disciplinary approach. A UK consortium (Improving Care in Elderly Neurosurgery Initiative [ICENI]) has been formed to develop the first comprehensive clinical practice guideline. This starts by identifying critical questions to ask of the literature. The aim of this review was to consider whether existing systematic reviews had suitably addressed these questions. Methods: Critical research questions to inform CSDH care were identified using multi-stakeholder workshops, including patient and public representation. A CSDH umbrella review of full-text systematic reviews and meta-analysis was conducted in accordance with the PRISMA statement (CRD42022328562). Four databases were searched from inception up to 30 April 2022. Review quality was assessed using AMSTAR-2 criteria, mapped to critical research questions. Results: Forty-four critical research questions were identified, across 12 themes. Seventy-three articles were included in the umbrella review, comprising 206,369 patients. Most reviews (86.3%, n=63) assessed complications and recurrence after surgery. ICENI themes were not addressed in current literature, and duplication of reviews was common (54.8%, n=40). AMSTAR-2 confidence rating was high in 7 (9.6%) reviews, moderate in 8 (11.0%), low in 10 (13.7%) and critically low in 48 (65.8%). Conclusions: The ICENI themes have yet to be examined in existing secondary CSDH literature, and a series of new reviews is now required to address these questions for a clinical practice guideline. There is a need to broaden and redirect research efforts to meet the organisation of services and clinical needs of individual patients. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Sequelae of neurological infection: management in primary care.

Author

Alam, Ali M, Easton, Ava, Bavikatte, Ganesh, Mahendran, Shagufay, and Michael, Benedict D

Subjects
*PRIMARY care, *INFECTION, *BRAIN injuries, *MEDICAL emergencies, *DEATH rate
Abstract

Neurological infections are a medical emergency, and although death rates have improved most survivors have acquired brain injury, which often presents in primary care in the months after infection and needs early referral. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality

Author

Ali M. Alam, Conor S. Gillespie, Jack Goodall, Tina Damodar, Lance Turtle, Ravi Vasanthapuram, Tom Solomon, Benedict D. Michael, Alam, Ali M [0000-0001-6014-3263], and Apollo - University of Cambridge Repository

Subjects
Medicine and health sciences, Research and analysis methods, Physical sciences, Infectious Diseases, Biology and life sciences, Scrub Typhus, Public Health, Environmental and Occupational Health, FOS: Physical sciences, Humans, Child, Research Article
Abstract

Background Scrub typhus has become a leading cause of central nervous system (CNS) infection in endemic regions. As a treatable condition, prompt recognition is vital. However, few studies have focused on describing the symptomology and outcomes of neurological scrub typhus infection. We conducted a systematic review and meta-analysis to report the clinical features and case fatality ratio (CFR) in patients with CNS scrub typhus infection. Methods A search and analysis plan was published in PROSPERO [ID 328732]. A systematic search of PubMed and Scopus was performed and studies describing patients with CNS manifestations of proven scrub typhus infection were included. The outcomes studied were weighted pooled prevalence (WPP) of clinical features during illness and weighted CFR. Results Nineteen studies with 1,221 (656 adults and 565 paediatric) patients were included. The most common clinical features in CNS scrub typhus were those consistent with non-specific acute encephalitis syndromes (AES), such as fever (WPP 100.0% [99.5%-100.0%, I2 = 47.8%]), altered sensorium (67.4% [54.9–78.8%, I2 = 93.3%]), headache (65.0% [51.5–77.6%, I2 = 95.1%]) and neck stiffness 56.6% (29.4–80.4%, I2 = 96.3%). Classical features of scrub typhus were infrequently identified; an eschar was found in only 20.8% (9.8%-34.3%, I2 = 95.4%) and lymphadenopathy in 24.1% (95% CI 11.8% - 38.9%, I2 = 87.8%). The pooled CFR (95% CI) was 3.6% (1.5%– 6.4%, I2 = 67.3%). Paediatric cohorts had a CFR of 6.1% (1.9–12.1%, I2 = 77%) whilst adult cohorts reported 2.6% (0.7–5.3%, I2 = 43%). Conclusion Our meta-analyses illustrate that 3.6% of patients with CNS manifestations of scrub typhus die. Clinicians should have a high index of suspicion for scrub typhus in patients presenting with AES in endemic regions and consider starting empiric treatment whilst awaiting results of investigations, even in the absence of classical signs such as an eschar or lymphadenopathy.

Published
2022

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