Search

Abstract Small‐scale horizontal axis wind‐turbines (SHAWTs) are acquiring relevance within the regulatory policies of the wind sector aiming at net‐zero emissions, while reducing visual and environmental impact by means of distributed grids. SHAWTs operate transitionally, at Reynolds numbers that fall between 1×105

Physical exercise (EX) is well established for its positive impact on brain health. However, conventional EX may not be feasible for certain individuals. In this regard, this study explores electromyostimulation (EMS) as a potential alternative for enhancing cognitive function. Conducted on both human participants and rats, the study involved two sessions of EMS applied to the quadriceps with a duration of 30 min at one-week intervals. The human subjects experienced assessments of cognition and mood, while the rats underwent histological and biochemical analyses on the prefrontal cortex, hippocampus, and quadriceps. Our findings indicated that EMS enhanced executive functions and reduced anxiety in humans. In parallel, our results from the animal studies revealed an elevation in brain-derived neurotrophic factor (BDNF), specifically in the hippocampus. Intriguingly, this increase was not associated with heightened neuronal activity or cerebral hemodynamics; instead, our data point towards a humoral interaction from muscle to brain. While no evidence of increased muscle and circulating BDNF or FNDC5/irisin pathways could be found, our data highlight lactate as a bridging signaling molecule of the muscle–brain crosstalk following EMS. In conclusion, our results suggest that EMS could be an effective alternative to conventional EX for enhancing both brain health and cognitive function.

Abstract While resultant maximal voluntary contraction (MVC) is commonly used to assess muscular performance, the simultaneous activation of antagonist muscles may dramatically underestimate the strength of the agonist muscles. Although quantification of antagonist torque has been performed in isometric conditions, it has yet to be determined in anisometric conditions. The aim of the study was to compare the mechanical impact of antagonist torque between eccentric, isometric and concentric contractions in PF and DF MVCs. The MVCs in dorsiflexion (DF) and plantar-flexion (PF) were measured in isometric, concentric and eccentric conditions (10° s-1) in nine healthy men (26.1 ± 2.7 years; 1.78 ± 0.05 m; 73.4 ± 6.5 kg) through two sessions. Electromyographic (EMG) activities from the soleus, gastrocnemius medialis and lateralis, and tibialis anterior muscles were simultaneously recorded. The EMG biofeedback method was used to quantify antagonist torque. Resultant torque significantly underestimated agonist torque in DF MVC (30–65%) and to a lesser extent in PF MVC (3%). Triceps surae antagonist torque was significantly modified with muscle contraction type, showing higher antagonist torque in isometric (29 Nm) than in eccentric (23 Nm, p

Summary: In humans, moving efficiently along the gravity axis requires shifts in muscular contraction modes. Raising the arm up involves shortening contractions of arm flexors, whereas the reverse movement can rely on lengthening contractions with the help of gravity. Although this control mode is universal, the neuromuscular mechanisms that drive gravity-oriented movements remain unknown. Here, we designed neurophysiological experiments that aimed to track the modulations of cortical, spinal, and muscular outputs of arm flexors during vertical movements with specific kinematics (i.e., optimal motor commands). We report a specific drop of corticospinal excitability during lengthening versus shortening contractions, with an increase of intracortical inhibition and no change in spinal motoneuron responsiveness. We discuss these contraction-dependent modulations of the supraspinal motor output in the light of feedforward mechanisms that may support gravity-tuned motor control. Generally, these results shed a new perspective on the neural policy that optimizes movement control along the gravity axis.

The prolonged application (>20 min) of local vibration (LV) on muscles or tendons is known to reduce maximal isometric strength. However, the effect of short vibration durations (≤6 min) is still unknown. In fourteen participants, the changes in maximal voluntary isometric contraction (MVIC) were measured after 1, 3, and 6 min of rest (CONT) or local vibration (LV) over the quadricipital tendon (frequency: 100 Hz; amplitude: 0.5 mm). Before and after each condition, the amplitude of the twitch induced by a 100 Hz potentiated electrical doublet (PDPOT); the relative electromyographic activity of the vastus medialis and rectus femoris muscle during the MVIC (RMSMVIC.M−1); the torque developed 50 ms after the onset of contraction (T50); and the voluntary activation level (VAL) were evaluated. None of the three LV durations significantly changed the MVIC compared with the control condition (p = 0.379). The indices of central (i.e., VAL, T50, RMSMVIC.M−1) and peripheral (e.g., PDPOT) fatigue were unaffected (p > 0.147). In conclusion, a short-duration LV (≤6 min) on a voluminous muscle group does not impair maximal force production or induce any central or peripherical fatigue.

Neuromuscular fatigability is a failure to produce or maintain a required torque, and commonly quantified with the decrease of maximal torque production during a few seconds-long maximal voluntary contraction (MVC). The literature shows that the MVC reduction after exercises with different torque-time integral (TTI), is often similar. However, it was shown that after a fatiguing exercise, the decline in the capacity to sustain the maximal voluntary contraction for 1 min (MVC1-MIN) differs from the decrease in the capacity to perform a brief-MVC, suggesting that this latter can only partially assess neuromuscular fatigability. This study aims to highlight the relevance of using a sustained MVC to further explore the neuromuscular alterations induced by fatiguing exercises with different TTI. We used two contraction intensities (i.e., 20% and 40% MVC) to modulate the TTI, and two exercise modalities [i.e., voluntary (VOL) and electrical induced (NMES)], since the letter are known to be more fatiguing for a given TTI. Thirteen subjects performed a plantar-flexors MVC1-MIN before and after the fatiguing exercises. A similar MVC loss was obtained for the two exercise intensities despite a greater TTI at 40% MVC, regardless of the contraction modality. On the other hand, the torque loss during MVC1-MIN was significantly greater after the 40% compared to 20% MVC exercise. These findings are crucial because they demonstrate that maximal torque production and sustainability are two complementary features of neuromuscular fatigability. Hence, MVC1-MIN assessing simultaneously both capacities is essential to provide a more detailed description of neuromuscular fatigability.

How corticospinal excitability changes during eccentric locomotor exercise is unknown. In the present study, 13 volunteers performed 30-min strenuous concentric and eccentric cycling bouts at the same power output (60% concentric peak power output). Transcranial magnetic and electrical femoral nerve stimulations were applied at exercise onset (3rd min) and end (25th min). Motor-evoked potentials (MEPs) amplitude was measured for the rectus femoris (RF) and vastus lateralis (VL) muscles with surface electromyography (EMG) and expressed as a percentage of maximal M-wave amplitude (MMAX). EMG amplitude 100 ms prior to MEPs and the silent period duration were calculated. There was no change in any neural parameter during the exercises (all P > 0.24). VL and RF MMAX were unaffected by exercise modality (all P > 0.38). VL MEP amplitude was greater (26 ± 11.4 vs. 15.2 ± 7.7% MMAX; P = 0.008) during concentric than eccentric cycling whereas RF MEP amplitude was not different (24.4 ± 10.8 vs. 17.2 ± 9.8% MMAX; P = 0.051). While VL EMG was higher during concentric than eccentric cycling (P = 0.03), RF EMG showed no significant difference (P = 0.07). Similar silent period durations were found (RF: 120 ± 30 ms; VL: 114 ± 27 ms; all P > 0.61), but the silent period/MEP ratio was higher during eccentric than concentric cycling for both muscles (all P < 0.02). In conclusion, corticospinal excitability to the knee extensors is lower and relative silent period longer during eccentric than concentric cycling, yet both remained unaltered with time.

Elevation of cerebral blood flow (CBF) may contribute to the cerebral benefits of the regular practice of physical exercise. Surprisingly, while electrically induced contraction of a large muscular mass is a potential substitute for physical exercise to improve cognition, its effect on CBF remains to be investigated. Therefore, the present study investigated CBF in the cortical area representing the hindlimb, the hippocampus and the prefrontal cortex in the same anesthetized rats subjected to either acute (30 min) or chronic (30 min for 7 days) electrically induced bilateral hindlimb contraction. While CBF in the cortical area representing the hindlimb was assessed from both laser doppler flowmetry (LDFCBF) and changes in p-eNOSSer1177 levels (p-eNOSCBF), CBF was evaluated only from changes in p-eNOSSer1177 levels in the hippocampus and the prefrontal cortex. The contribution of increased cardiac output and increased neuronal activity to CBF changes were examined. Stimulation was associated with tachycardia and no change in arterial blood pressure. It increased LDFCBF with a time- and intensity-dependent manner as well as p-eNOSCBF in the area representing the hindlimb. By contrast, p-eNOSCBF was unchanged in the two other regions. The augmentation of LDFCBF was partially reduced by atenolol (a ß1 receptor antagonist) and not reproduced by the administration of dobutamine (a ß1 receptor agonist). Levels of c-fos as a marker of neuronal activation selectively increased in the area representing the hindlimb. In conclusion, electrically induced bilateral hindlimb contraction selectively increased CBF in the cortical area representing the stimulated muscles as a result of neuronal hyperactivity and increased cardiac output. The absence of CBF changes in cognition-related brain regions does not support flow-dependent neuroplasticity in the pro-cognitive effect of electrically induced contraction of a large muscular mass.

This study examined the influence of knee extensors’ hip and knee angle on force production capacity and their neuromuscular and architectural consequences. Sixteen healthy men performed sub-maximal and maximal voluntary isometric contractions (MVIC) of knee extensors with four different combinations of the knee and hip angles. Muscle architecture, excitation-contraction coupling process, muscular activity, and corticospinal excitability were evaluated on the vastus lateralis (VL) and rectus femoris (RF) muscles. MVIC and evoked peak twitch (Pt) torques of knee extensors increased significantly (p

ObjectivesIt is commonly accepted that motor imagery (MI), i.e. the mental simulation of a movement, leads to an increased size of cortical motor evoked potentials (MEPs), although the magnitude of this effect differs between studies. Its impact on the spinal level is even more variable in the literature. Such discrepancies may be explained by many different experimental approaches. Therefore, the question of the optimal stimulation parameters to assess both spinal and corticospinal excitabilities remains open.MethodsH-reflexes and MEPs of the triceps surae were evoked in 11 healthy subjects during MI, weak voluntary contraction (CON) and rest (REST). In each condition, the full recruitment curve from the response threshold to maximal potential was investigated.ResultsAt stimulation intensities close to the maximal response, MEP amplitude was increased by CON compared to REST on the triceps surae. No effect of the different conditions was found on the H-reflex recruitment curve, except a small variation beyond maximal H-reflex in the soleus muscle.ConclusionBased on our results, we recommend to assess corticospinal excitability between 70% and 100% of maximal MEP intensity instead of the classical use of a percentage of the motor threshold and to elicit H-reflexes on the ascending part of the recruitment curve.

Short-interval intracortical inhibition (SICI) represents an inhibitory phenomenon acting at the cortical level. However, SICI estimation is based on the amplitude of a motor-evoked potential (MEP), which depends on the discharge of spinal motoneurones and the generation of compound muscle action potential (M-wave). In this study, we underpin the importance of taking into account the proportion of spinal motoneurones that are activated or not when investigating the SICI of the right flexor carpi radialis (normalization with maximal M-wave (Mmax) and MEPtest, respectively), in 15 healthy subjects. We probed SICI changes according to various MEPtest amplitudes that were modulated actively (four levels of muscle contraction: rest, 10%, 20% and 30% of maximal voluntary contraction (MVC)) and passively (two intensities of test transcranial magnetic stimulation (TMS): 120 and 130% of motor thresholds). When normalized to MEPtest, SICI remained unchanged by stimulation intensity and only decreased at 30% of MVC when compared with rest. However, when normalized to Mmax, we provided the first evidence of a strong individual relationship between SICI and MEPtest, which was ultimately independent from experimental conditions (muscle states and TMS intensities). Under similar experimental conditions, it is thus possible to predict SICI individually from a specific level of corticospinal excitability in healthy subjects.