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26 results on '"Alaidaroos, Bothaina A."'

1. Effects of dietary commercial phytobiotic “Sanacore® GM” on Pacific white shrimp (Litopenaeus vannamei) growth, immune response, redux status, intestinal health, and disease resistance against Fusarium solani

Author

Eissa, El-Sayed Hemdan, Elbahnaswy, Samia, El-Baz, Amira Hussein, El-Haroun, Ehab, Ashour, Mohamed, Mansour, Abdallah Tageldein, Saadony, Saadea, El-Saeed, Adel F., Kabary, Hoda, Jastaniah, Samyah D., Alaidaroos, Bothaina A., Shafi, Manal E., Abd El-Hack, Mohamed E., Eissa, Moaheda E. H., and Eldessouki, Elsayed A.

Published
2024
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3. Protective effects of Chlorella vulgaris as a feed additive on growth performance, immunity, histopathology, and disease resistance against Vibrio parahaemolyticus in the Pacific white shrimp

Author

Eissa, El-Sayed Hemdan, Aljarari, Rabab Mohamed, Elfeky, Amal, Abd El-Aziz, Yasmin M., Munir, Mohammad Bodrul, Jastaniah, Samyah D., Alaidaroos, Bothaina Ali, Shafi, Manal E., Abd El-Hamed, Nadia Nazmy B., AL-Farga, Ammar, Dighiesh, Hagar Sedeek, Okon, Ekemini Moses, Abd El-Hack, Mohamed E., Ezzo, Omaima H., Eissa, Moaheda E. H., and ElBanna, Noha I.

Published
2024
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7. Effects of dietary commercial phytobiotic “Sanacore® GM” on Pacific white shrimp (Litopenaeus vannamei) growth, immune response, redux status, intestinal health, and disease resistance against Fusarium solani

Author

Eissa, El-Sayed Hemdan, primary, Elbahnaswy, Samia, additional, El-Baz, Amira Hussein, additional, El-Haroun, Ehab, additional, Ashour, Mohamed, additional, Mansour, Abdallah Tageldein, additional, Saadony, Saadea, additional, El-Saeed, Adel F., additional, Kabary, Hoda, additional, Jastaniah, Samyah D., additional, Alaidaroos, Bothaina A., additional, Shafi, Manal E., additional, Abd El-Hack, Mohamed E., additional, Eissa, Moaheda E. H., additional, and Eldessouki, Elsayed A., additional

Published
2023
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8. Dietary Pediococcus acidilactici improved the growth performance, feed utilization, gut microbiota, and disease resistance against Fusarium solani in Pacific white shrimp, Litopenaeus vannamei

Author

Jastaniah, Samyah D., primary, Alaidaroos, Bothaina A., additional, Shafi, Manal E., additional, Aljarari, Rabab M., additional, Abd El-Aziz, Yasmin M., additional, Munir, Mohammad Bodrul, additional, Eissa, Moaheda E. H., additional, AL-Farga, Ammar, additional, Eissa, El-Sayed Hemdan, additional, and Said, Radwa M., additional

Published
2023
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9. Impacts of Dietary Selenium Nanoparticles from Spirulina platensis on Growth Performance, Physio-Biochemical Components and Alleviating Effect against Cadmium Toxicity in Pacific White Shrimp Litopenaeus vannamei

Author

Said, Radwa M., primary, Nassar, Safaa E., additional, Alaidaroos, Bothaina A., additional, Jastaniah, Samyah D., additional, Dighiesh, Hagar Sedeek, additional, Eissa, El-Sayed Hemdan, additional, AL-Farga, Ammar, additional, Kari, Zulhisyam Abdul, additional, Téllez-Isaías, Guillermo, additional, and Attia, Mai S., additional

Published
2023
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10. Dietary Effects of Nano Curcumin on Growth Performances, Body Composition, Blood Parameters and Histopathological Alternation in Red Tilapia (Oreochromis sp.) Challenged with Aspergillus flavus

Author

Eissa, El-Sayed Hemdan, primary, Alaidaroos, Bothaina A., additional, Jastaniah, Samyah D., additional, Munir, Mohammad Bodrul, additional, Shafi, Manal E., additional, El-Aziz, Yasmin M. Abd, additional, Bazina, Walaa K., additional, Ibrahim, Saadiah binti, additional, Eissa, Moaheda E. H., additional, Paolucci, Marina, additional, Alaryani, Fatima S., additional, El-Hamed, Nadia N. B. Abd, additional, El-Hack, Mohamed E. Abd, additional, and Saadony, Saadea, additional

Published
2023
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11. Advancing Eco-Sustainable Bioremediation for Hydrocarbon Contaminants: Challenges and Solutions.

Author

Alaidaroos, Bothaina A.

Subjects
POLYCYCLIC aromatic hydrocarbons, POLLUTANTS, PETROLEUM waste, BIOREMEDIATION, HYDROCARBONS
Abstract

In an era of rising population density and industrialization, the environment confronts growing challenges. Soil, agricultural land, and water bodies are becoming increasingly polluted by petroleum waste and hydrocarbons. While hydrocarbons are naturally present in crude oil, refining processes compound the complexity and toxicity of hydrocarbons. This is particularly evident in polycyclic aromatic hydrocarbons (PAHs) found in the air and soil, known for their carcinogenic, mutagenic, and teratogenic properties. In response, biodegradation emerges as an eco-friendly, cost-effective solution, especially in petroleum-contaminated settings. Biodiverse microbial communities play a pivotal role in managing hydrocarbon contamination, contingent on location, toxicity, and microbial activity. To optimize biodegradation, understanding its mechanisms is essential. This review delves into varied bioremediation techniques, degradation pathways, and the contributions of microbial activities to efficiently removing hydrocarbon pollutants. Recent research spotlights specific microorganisms like bacteria, microalgae, and fungi adept at hydrocarbon degradation, offering a contemporary perspective on petroleum hydrocarbon pollutant bioremediation. These microorganisms efficiently break down petroleum hydrocarbons, with enzymatic catalysis markedly accelerating pollutant breakdown compared to conventional methods. Given the intricate nature of hydrocarbon contamination, cooperative bacterial consortia are instrumental in effective cleanup, driven by specific genes guiding bacterial metabolism. For cost-effective and efficient removal from compromised environments, it is advisable to adopt an integrated approach that combines biostimulation and bioaugmentation. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Antimicrobial impacts of zinc oxide nanoparticles on shiga toxin-producing Escherichia coli (serotype O26)

Author

Sherif, Rasha M., primary, Talat, Dalia, additional, Alaidaroos, Bothaina A., additional, Farsi, Reem M., additional, Hassoubah, Shahira A., additional, Jaber, Fatima A., additional, Azer, Treza M., additional, El-Masry, Reham M., additional, Abd El-Hack, Mohamed E., additional, Ibrahim, Madiha S., additional, and Elbestawy, Ahmed, additional

Published
2022
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14. Antimicrobial impacts of zinc oxide nanoparticles on Shiga toxin-producing Escherichia coli (serotype O26).

Author

Sherif, Rasha M., Talat, Dalia, Alaidaroos, Bothaina A., Farsi, Reem M., Hassoubah, Shahira A., Jaber, Fatima A., Azer, Treza M., El-Masry, Reham M., Abd El-Hack, Mohamed E., Ibrahim, Madiha S., and Elbestawy, Ahmed

Subjects
ESCHERICHIA coli, HEMOLYTIC-uremic syndrome, SEROTYPES, ZINC oxide, MULTIDRUG resistance, PROTEIN expression, ESCHERICHIA coli O157:H7
Abstract

The antibacterial activity of zinc oxide nanoparticles (ZnO NPs) has received significant attention worldwide due to the emergence of multidrug-resistant microorganisms. Shiga toxin-producing Escherichia coli is a major foodborne pathogen that causes gastroenteritis that may be complicated by hemorrhagic colitis or hemolytic uremic syndrome. Therefore, this study aimed to evaluate the antimicrobial effect of ZnO NPs against E. coli O26 and its Shiga toxin type 2 (Stx2). Multidrug resistance phenotype was observed in E. coli O26, with co-resistance to several unrelated families of antimicrobial agents. Different concentrations of ZnO NPs nanoparticles (20 nm) were tested against different cell densities of E. coli O26 (108, 106 and 105 CFU/ml). The minimum inhibitory concentration (MIC) value was 1 mg/ml. Minimum bactericidal concentration (MBC) was 1.5 mg/ml, 2.5 mg/ml and 3 mg/ml, respectively, depending on ZnO NPs concentrations and bacterial cell density. Results showed a significant (P≤0.05) decrease in Stx2 level in a response to ZnO NPs treatment. As detected by quantitative real-time PCR, ZnO NPs down-regulated the expression of the Stx2 gene (P≤0.05). Moreover, various concentrations of ZnO NPs considerably reduced the total protein content in E. coli O26. There was a significant reduction in protein expression with increased ZnO NPs concentration compared to the non-treated control. Scanning electron micrographs (SEM) of the treated bacteria showed severe disruptive effects on E. coli O26 with increasing ZnO NPs concentration. The results revealed a strong correlation between the antibacterial effect and ZnO NPs concentrations. ZnO NPs exert their antibacterial activities through various mechanisms and could be used as a potent antibacterial agent against E. coli O26. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Comparative Effect of Commercially Available Nanoparticles on Soil Bacterial Community and “Botrytis fabae” Caused Brown Spot: In vitro and in vivo Experiment

Author

Sabra, Mayada A., primary, Alaidaroos, Bothaina A., additional, Jastaniah, Samyah D., additional, Heflish, Ahmed I., additional, Ghareeb, Rehab Y., additional, Mackled, Marwa I., additional, El-Saadony, Mohamed T., additional, Abdelsalam, Nader R., additional, and Conte-Junior, Carlos Adam, additional

Published
2022
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19. Antimicrobial impacts of zinc oxide nanoparticles on Shiga toxin-producing Escherichia coli(serotype O26)

Author

Sherif, Rasha M., Talat, Dalia, Alaidaroos, Bothaina A., Farsi, Reem M., Hassoubah, Shahira A., Jaber, Fatima A., Azer, Treza M., El-Masry, Reham M., Abd El-Hack, Mohamed E., Ibrahim, Madiha S., and Elbestawy, Ahmed

Abstract

The antibacterial activity of zinc oxide nanoparticles (ZnO NPs) has received significant attention worldwide due to the emergence of multidrug-resistant microorganisms. Shiga toxin-producing Escherichia coliis a major foodborne pathogen that causes gastroenteritis that may be complicated by hemorrhagic colitis or hemolytic uremic syndrome. Therefore, this study aimed to evaluate the antimicrobial effect of ZnO NPs against E. coliO26 and its Shiga toxin type 2 (Stx2). Multidrug resistance phenotype was observed in E. coliO26, with co-resistance to several unrelated families of antimicrobial agents. Different concentrations of ZnO NPs nanoparticles (20 nm) were tested against different cell densities of E. coliO26 (108, 106and 105CFU/ml). The minimum inhibitory concentration (MIC) value was 1 mg/ml. Minimum bactericidal concentration (MBC) was 1.5 mg/ml, 2.5 mg/ml and 3 mg/ml, respectively, depending on ZnO NPs concentrations and bacterial cell density. Results showed a significant (P≤0.05) decrease in Stx2level in a response to ZnO NPs treatment. As detected by quantitative real-time PCR, ZnO NPs down-regulated the expression of the Stx2gene (P≤0.05). Moreover, various concentrations of ZnO NPs considerably reduced the total protein content in E. coliO26. There was a significant reduction in protein expression with increased ZnO NPs concentration compared to the non-treated control. Scanning electron micrographs (SEM) of the treated bacteria showed severe disruptive effects on E. coliO26 with increasing ZnO NPs concentration. The results revealed a strong correlation between the antibacterial effect and ZnO NPs concentrations. ZnO NPs exert their antibacterial activities through various mechanisms and could be used as a potent antibacterial agent against E. coliO26.

Published
2023
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21. Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor

Author

Maamoun, Hanaa Salah Salah, Rabie, Gamal H., Shaker, Ibrahim, Alaidaroos, Bothaina A., and El-Sayed, Ashraf S. A.

Subjects
Aspergillus terreus, kojic acid, undecanoic acid, Penicillium copticola, tyrosinase
Abstract

Tyrosinase is a copper-containing monooxygenase catalyzing the O-hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine then to dopaquinone that is profoundly involved in melanin synthesis in eukaryotes. Overactivation of tyrosinase is correlated with hyperpigmentation that is metabolically correlated with severe pathological disorders, so, inhibition of this enzyme is the most effective approach in controlling the overproduction of melanin and its hazardous effects. Thus, searching for a powerful, selective inhibitor of human tyrosinase to limit the hyper-synthesis of melanin is a challenge. Unlike the difficulty of overexpression of human tyrosinase, using fungal tyrosinase as a model enzyme to the human one to evaluate the mechanistics of enzyme inhibition in response to various compounds is the most feasible strategy. Thus, the purification of highly catalytic-efficient fungal tyrosinase, exploring a novel inhibitor, and evaluating the mechanistics of enzyme inhibition are the main objectives of this work. Aspergillus terreus and Penicillium copticola were reported as the most potential tyrosinase producers. The biochemical properties suggest that this enzyme displays a higher structural and catalytic proximity to human tyrosinase. Upon nutritional bioprocessing by Plackett–Burman design, the yield of tyrosinase was increased by about 7.5-folds, compared to the control. The purified tyrosinase was strongly inhibited by kojic acid and A. flavus DCM extracts with IC50 values of 15.1 and 12.6 µg/mL, respectively. From the spectroscopic analysis, the main anti-tyrosinase compounds of A. flavus extract was resolved, and verified as undecanoic acid. Further studies are ongoing to unravel the in vivo effect and cytotoxicity of this compound in fungi and human, that could be a novel drug to various diseases associated with hyperpigmentation by melanin.

Published
2021
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22. Impacts of Supplementing Broiler Diets with Biological Curcumin, Zinc Nanoparticles and Bacillus licheniformis on Growth, Carcass Traits, Blood Indices, Meat Quality and Cecal Microbial Load

Author

Abd El-Hack, Mohamed E., primary, Alaidaroos, Bothaina A., additional, Farsi, Reem M., additional, Abou-Kassem, Diaa E., additional, El-Saadony, Mohamed T., additional, Saad, Ahmed M., additional, Shafi, Manal E., additional, Albaqami, Najah M., additional, Taha, Ayman E., additional, and Ashour, Elwy A., additional

Published
2021
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24. Impacts of dietary supplementation of pyocyanin powder on growth performance, carcase traits, blood chemistry, meat quality and gut microbial activity of broilers

Author

Ashour, Elwy A., primary, Farsi, Reem M., additional, Alaidaroos, Bothaina A., additional, Abdel-Moneim, Abdel-Moneim E., additional, El-Saadony, Mohamed T., additional, Osman, Ali O., additional, Abou Sayed-Ahmed, Eman T., additional, Albaqami, Najah M., additional, Shafi, Manal E., additional, Taha, Ayman E., additional, and Abd El-Hack, Mohamed E., additional

Published
2021
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25. Purification and Characterization of Ornithine Decarboxylase from Aspergillus terreus

Author

El-Sayed, Ashraf, George, Nelly, Yassin, Marwa, Alaidaroos, Bothaina, Bolbol, Ahmed, Mohamed, Marwa, Rady, Amgad, Aziz, Safa, Zayed, Rawia, and Sitohy, Mahmoud

Subjects
Aspergillus terreus, genetic structures, kinetics, fungi, ornithine decarboxylase, curcumin, inhibition
Abstract

l-Ornithine decarboxylase (ODC) is the rate-limiting enzyme of de novo polyamine synthesis in humans and fungi. Elevated levels of polyamine by over-induction of ODC activity in response to tumor-promoting factors has been frequently reported. Since ODC from fungi and human have the same molecular properties and regulatory mechanisms, thus, fungal ODC has been used as model enzyme in the preliminary studies. Thus, the aim of this work was to purify ODC from fungi, and assess its kinetics of inhibition towards various compounds. Forty fungal isolates were screened for ODC production, twenty fungal isolates have the higher potency to grow on L-ornithine as sole nitrogen source. Aspergillus terreus was the most potent ODC producer (2.1 µmol/mg/min), followed by Penicillium crustosum and Fusarium fujikuori. These isolates were molecularly identified based on their ITS sequences, which have been deposited in the NCBI database under accession numbers MH156195, MH155304 and MH152411, respectively. ODC was purified and characterized from A. terreus using SDS-PAGE, showing a whole molecule mass of ~110 kDa and a 50 kDa subunit structure revealing its homodimeric identity. The enzyme had a maximum activity at 37 °C, pH 7.4–7.8 and thermal stability for 20 h at 37 °C, and 90 days storage stability at 4 °C. A. terreus ODC had a maximum affinity (Km) for l-ornithine, l-lysine and l-arginine (0.95, 1.34 and 1.4 mM) and catalytic efficiency (kcat/Km) (4.6, 2.83, 2.46 × 10−5 mM−1·s−1). The enzyme activity was strongly inhibited by DFMO (0.02 µg/mL), curcumin (IC50 0.04 µg/mL), propargylglycine (20.9 µg/mL) and hydroxylamine (32.9 µg/mL). These results emphasize the strong inhibitory effect of curcumin on ODC activity and subsequent polyamine synthesis. Further molecular dynamic studies to elucidate the mechanistics of ODC inhibition by curcumin are ongoing.

Published
2019
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26. Biodegradation of picric acid (2,4,6-trinitrophenol, TNP) by free and immobilized marine Enterococcus thailandicusisolated from the red sea, Saudi Arabia

Author

Farsi, Reem M., Alharbi, Najwa M., Basingab, Fatemah S., Nass, Nada M., Qattan, Shaza Y., Hassoubah, Shahira A., Alrahimi, Jehan S., and Alaidaroos, Bothaina A.

Abstract

Nitroaromatic effluents are common wastes generated from different industrial activities. These wastes can cause various environmental problems due to their toxicity on living organisms and difficulties to decompose either chemically or biologically. However, picric acid (2,4,6-trinitrophenol, TNP) could be used as a sole carbon, nitrogen, and energy source by a few bacterial cells. In this study, a bacterial strain isolated from the Red Sea, Jeddah, Saudi Arabia, has been shown to utilize picric acid as a sole carbon and nitrogen source at a relatively high concentration. The growth medium altered from yellow into the orange-red color (hydride-Meisenheimer complex) after 48 h of incubation as detected using High-Performance Liquid Chromatography (HPLC). The stoichiometric release of 0.285 mol of nitrite showed strongevidence that the picric acid was completely mineralized. Molecular identification using 16S rRNA analysis indicated that the isolated strain is Enterococcus thailandicusRF1 (Genbank Accession No. MN960654). This strain is capable of utilizing TNP aerobically at pH 7.0 and 30 °C with nitrite release. Furthermore, Enterococcus thailandicusRF1 cells were immobilized by adsorption on polyurethane foam and TNP degradation was enhanced and increased to 1.12-folds of free cells. The immobilized cells were found to be used efficiently for bioremediation of TNP from wastewaters.

Published
2021
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