1. Isolated primary CNS lymphoma after liver transplantation for autoimmune hepatitis: a case report
- Author
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Alaa Zayed, Qusay Abdoh, Asmaa Sarama, and Abdalhakim Shubietah
- Subjects
Neurology ,Lymphoma ,Posttransplant lymphoproliferative disorder ,PTLD ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Post-transplantation primary central nervous system lymphoma (PT-PCNSL) is a rare neoplasm that occurs in immunocompromised patients. It can manifest months or years after transplantation, presenting with various neurological symptoms. A 64-year-old woman, who had received a liver transplant due to autoimmune hepatitis, presented with generalized weakness, headache, and confusion. Further investigation revealed multiple ring-enhancing lesions in the right frontal and temporoparietal regions on brain MRI. A brain biopsy confirmed the diagnosis of PT-PCNSL. This case underscores the importance of considering PT-PCNSL in the differential diagnosis of contrast-enhancing brain lesions in post-transplant patients. Timely recognition of PT-PCNSL is crucial for appropriate management and improved outcomes. To the best of our knowledge, this report describes the first instance of isolated CNS lymphoma in a liver transplant recipient, due to autoimmune hepatitis, successfully brought to complete remission with a rituximab-methotrexate regimen.
- Published
- 2024
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