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Your search keyword '"Alaa A. Sobieh"' showing total 3 results
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3 results on '"Alaa A. Sobieh"'

1. Ficolin‐1 gene ( FCN1 ) −144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under‐five Egyptian children: A multicenter study

Author

Mohamed A. Elkoumi, Sawsan H. Abdellatif, Dalia S. Fahmy, Sherif F Osman, A.A. Soliman, Naglaa F Boraey, Mohamed I. Alanwar, Nevin M. Waked, Rabab M. Saleh, Ahmed Salah, Alaa A. Sobieh, Mohamed A M Ibrahim, Sahbaa F. M. Hafez, Mohammed Soliman, Ahmed A. Elhewala, Mohamed Sayed Fahim, Naglaa A. Elshehawy, Adel M. Abdou, Nagwa E. Akeel, Ahmed A. Emam, Marwa M. Abdel-Aziz, Faisal Y. Mohamed, Ahmed Sherif, Mohamed H. Mashali, NourEldin M. Abdelaal, Amira A Abd El-Rahman Mosbah, Nancy M S Zeidan, Manal A. A. Youssef, Shaimaa S. A. Elashkar, Mervat T. Zakaria, Mustafa I.A. Hashem, Yasser Sedky, Ahmed A. Elshehawy, Mohamed M Shehab, Anas M. Elshreif, Mai M. Malek, and Abdelrahman A. A. Ahmed

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Genotype, Polymorphism, Single Nucleotide, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Lectins, 030225 pediatrics, Internal medicine, Odds Ratio, medicine, Humans, Genetic Predisposition to Disease, Prospective Studies, Allele, Promoter Regions, Genetic, Under-five, business.industry, Infant, Pneumonia, Odds ratio, Confidence interval, Child mortality, 030228 respiratory system, Child, Preschool, Pediatrics, Perinatology and Child Health, Egypt, Female, Gene polymorphism, business, Ficolin
Abstract

BACKGROUND Pneumonia is the foremost cause of child death worldwide. M-ficolin is encoded by the FCN1 gene and represents a novel link between innate and adaptive immunity. OBJECTIVES To investigate the FCN1 -144 C/A (rs10117466) polymorphism as a potential marker for pneumonia severity and adverse outcome namely complications or mortality in the under-five Egyptian children. METHODS This was a prospective multicenter study that included 620 children hospitalized with World Health Organization-defined severe pneumonia and 620 matched healthy control children. Polymorphism rs10117466 of the FCN1 gene promoter was analyzed by PCR-SSP, while serum M-ficolin levels were assessed by ELISA. RESULTS The FCN1 A/A genotype and A allele at the -144 position were more frequently observed in patients compared to the control children (43.4% vs 27.6%; odds ratio [OR]: 1.62; [95% confidence interval {CI}: 1.18-2.2]; for the A/A genotype) and (60.8% vs 52.5%; OR: 1.4; [95% CI: 1.19-1.65]; for the A allele); P

Published
2020
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2. Association of IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms with risk of mitral valve disease in children with rheumatic heart disease

Author

Yasser Sedky, Alaa A. Sobieh, and Sherif M. Yousry

Subjects
Male, medicine.medical_specialty, Adolescent, Heart disease, Population, Disease, 030204 cardiovascular system & hematology, Gastroenterology, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Internal medicine, Mitral valve, medicine, Humans, Genetic Predisposition to Disease, 030212 general & internal medicine, Allele, Child, education, Allele frequency, Alleles, education.field_of_study, Polymorphism, Genetic, business.industry, Rheumatic Heart Disease, Case-control study, Mitral Valve Insufficiency, General Medicine, medicine.disease, Interleukin-10, medicine.anatomical_structure, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Cardiology, Egypt, Female, Interleukin-4, Cardiology and Cardiovascular Medicine, business
Abstract

AimRheumatic heart disease is an inflammatory disease of cardiac tissue. The underlying pathogenic mechanisms highlight a complex interplay of immunological, genetic, and environmental factors. The aim of the present study was to investigate whether IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms could be associated with susceptibility and/or severity of rheumatic heart disease among patients from the Egyptian population.Materials and methodsA cohort of 140 Egyptian children with rheumatic heart disease and 100 healthy controls were enrolled in this case–control study. Genotyping for IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms was carried out for all patients using a polymerase chain reaction-based analysis.ResultsNo significant difference in the distribution of genotypes and allelic frequencies between rheumatic heart disease cases and controls for IL-4 (intron 3) (p=0.17; OR 1.07, 95% CI 0.82–3.74) and IL-10 (-1082) (p=0.49; OR 1.03, 95% CI 0.65–2.71) gene polymorphisms was observed. Further categorisation of patients into mitral valve disease and combined valve disease subgroups showed that cases with mitral valve disease have significantly higher frequency of the RP2 allele of IL-4 (intron 3) (p=0.03; OR 2.98, 95% CI 1.93–6.15) and the G allele of IL-10 (-1082) (p=0.04; OR 2.14, 95% CI 1.62–4.95) when compared with controls.DiscussionOur study shows that IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms are not significantly associated with susceptibility to rheumatic heart disease, but they might play a role in the pathogenesis of patients with mitral valve disease.

Published
2015
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3. Association of IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms with risk of mitral valve disease in children with rheumatic heart disease.

Author

Yousry SM, Sedky Y, and Sobieh A

Subjects
Adolescent, Alleles, Case-Control Studies, Child, Child, Preschool, Egypt, Female, Gene Frequency, Humans, Male, Genetic Predisposition to Disease, Interleukin-10 genetics, Interleukin-4 genetics, Mitral Valve Insufficiency genetics, Polymorphism, Genetic, Rheumatic Heart Disease complications
Abstract

Unlabelled: Aim Rheumatic heart disease is an inflammatory disease of cardiac tissue. The underlying pathogenic mechanisms highlight a complex interplay of immunological, genetic, and environmental factors. The aim of the present study was to investigate whether IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms could be associated with susceptibility and/or severity of rheumatic heart disease among patients from the Egyptian population. Materials and methods A cohort of 140 Egyptian children with rheumatic heart disease and 100 healthy controls were enrolled in this case-control study. Genotyping for IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms was carried out for all patients using a polymerase chain reaction-based analysis., Results: No significant difference in the distribution of genotypes and allelic frequencies between rheumatic heart disease cases and controls for IL-4 (intron 3) (p=0.17; OR 1.07, 95% CI 0.82-3.74) and IL-10 (-1082) (p=0.49; OR 1.03, 95% CI 0.65-2.71) gene polymorphisms was observed. Further categorisation of patients into mitral valve disease and combined valve disease subgroups showed that cases with mitral valve disease have significantly higher frequency of the RP2 allele of IL-4 (intron 3) (p=0.03; OR 2.98, 95% CI 1.93-6.15) and the G allele of IL-10 (-1082) (p=0.04; OR 2.14, 95% CI 1.62-4.95) when compared with controls. Discussion Our study shows that IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms are not significantly associated with susceptibility to rheumatic heart disease, but they might play a role in the pathogenesis of patients with mitral valve disease.

Published
2016
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