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Your search keyword '"AlSaffar, Rana M."' showing total 24 results
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24 results on '"AlSaffar, Rana M."'

17. List of contributors

Author

Aggarwal, Sadhna, Ahmad, Rais, Ahmad, Hilal, Ahmad, Sheikh Bilal, Alauddin, Ali, Aarif, Ali Farooq, Muhammad, Alsaffar, Rana M., Anitha, Kuttiappan, Ashraf, Suhail, Ayaz, Owais, Ayaz, Aadil, Bhat, Kaisar Ahmad, Bhat, Mohammad Saleem, Chenchula, Santenna, Dar, Mashooq Ahmad, Faheem, Saleha, Firdous, Aimen, Firdous, Sameen, Ganie, Showkat Ahmad, Ghumman, Shazia Akram, Hameed, Huma, Hussain, Mir Sarvar, Imran, Abdullah, Iqbal, Gowhar, Jabeen, Farhat, Jain, Preeti, Jeelani, Asma, Jeelani, Gh, John, Arjumand, Khan, Mahtab Ahmad, Khursheed, Nuzhat, Mahmood, Asif, Manzoor, Zainab, Mohammed, Irtefa, Mujtaba, Haamid, Muntaha, Sidra Tul, Nazir, Aanisa, Nisar, Bisma, Prakash, Satya, Rasool, Seerat, Rehman, Muneeb U., Samantaray, Saumya Subhra, Sarfraz, Rai Muhammad, Sarwar, Hafiz Shoaib, Shah, Ishteyaq Majeed, Phulen Sharma, Jogender, Singh, N., Tariq, Fatima, Wani, Amir Bashir, Wojda, Urszula, Zahid, Usman, Zahoor, Mudasir, and Zaman, Muhammad

Published
2024
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18. List of contributors

Author

Ahmad, Sheikh Bilal, Ajai Krishnan, M.J., Ali, Aarif, Ali, Nurshad, Alsaffar, Rana M., Alsuwayni, Bashayr M., Amir, S., Anjali, K., Bansal, Parveen, Bansal, Renu, Bera, Arijit, Bernardino de la Serna, Jorge, Biswas, Antara, Bradu, Pragya, Chavan, Ananya, Chen, Yangyumeng, Chiome, Tafadzwa Justin, Choudhary, Harsha, Chowdary, Pavani, Gandhi, Sonu, Ganie, Showkat Ahmad, Garg, Shubham, Ghosh, Satyajit, Ghosh, Surajit, Girisa, Sosmitha, Gopalakrishnan, Abilash Valsala, Grace Raji, R., Gupta, Vikas, Harsha, Choudhary, Hegde, Mangala, Jacob, Sharon, John, Renu, Joseph, X., Kalsi, Harjinderpal Singh, Kannampuzha, Sandra, Katsouli, Jenny, Kaur, Gaganjyot, Kaur, Gunpreet, Kaushik, Medha, Kaushik, Pooja, Kensel Rajeev, A., Khan, Hiba, Khan, Sara Akhtar, Kumar, Sanjiv, Kumar, V.B. Sameer, Kumaran, Kriya, Liu, Xiangxu, M.V.S.S.T., Subba Rao, Megha, K.B., Mishra, Mamata, Mohanan, P.V., Mohandas, Sundhar, Mukherjee, Anirban Goutam, Murali, Reshma, Mushtaq, Saima, Nechikat, Greeshma, Nisar, Bisma, Parameswara Panicker, Sreejith, Paramio, Patricia, Parvez, Suhel, Patil, Megha, Pogu, Sunil Venkanna, Poojary, Brinda, Prakashan, Drishya, Ramkumar, Kunka Mohanram, Rehman, Muneeb U., Rengan, Aravind Kumar, Renu, Kaviyarasi, Reshma, S., Roy, Rajsekhar, Saha, Abhijit, Sathish, N., Shah, Maitri, Sharma, Priyankal, Sharma, Ravinder, Singh, Suman, Srinivasan, Asha, Tasleem, Ammar, Thankachan Mangalathettu, Binumon, V.S., Pramitha, Vellingiri, Balachandar, Vijay, Aswathy, Vishwakarma, Neelam, Wani, Amir Bashir, Wanjari, Uddesh Ramesh, Wilkinson, John Malcolm, Yadav, Dokkari Nagalaxmi, Yan, Chunyu, and Świst-Szulik, Katarzyna Maria

Published
2024
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19. D-limonene (5 (one-methyl-four-[1-methylethenyl]) cyclohexane) diminishes CCl4-induced cardiac toxicity by alleviating oxidative stress, inflammatory and cardiac markers.

Author

AlSaffar, Rana M., Rashid, Summya, Ahmad, Sheikh Bilal, Rehman, Muneeb U., Hussain, Ishraq, Parvaiz Ahmad, Sheikh, and Ganaie, Majid Ahmad

Subjects
*CARDIOTOXICITY, *MONOTERPENES, *CORTICOTROPIN releasing hormone, *INFLAMMATORY mediators, *TROPONIN I, *OXIDATIVE stress, *COPEPTINS
Abstract

Background: The cardiovascular crisis is advancing rapidly throughout the world. A large number of studies have shown that plant polyphenols affect major mechanisms involved in cardiovascular events through their action on the antioxidant system, signaling, and transcription pathways. D-limonene, a monocyclic monoterpene obtained from citrus fruits, is reported to possess many pharmacological activities. Methods: The experiment was designed to determine the protective effect of D-limonene against cardiac injury induced by CCl4 in Wistar rats. Rats were treated with two doses of D-limonene against cardiac injury induced by CCl4. Serum toxicity markers, cardiac toxicity biomarker enzymes, inflammatory mediators, anti-oxidant armory, lipid peroxidation, lipid profile, and histology were done. Results: CCl4 intoxication resulted in a substantial rise in FFA, TC, TG, PL, LDL, VLDL, and a reduction in HDL, restoring these changes with the administration of D-limonene at a dosage of 200 mg/kg. CCl4 administration also resulted in lipid oxidation and decreased antioxidant activity. At the same time, D-limonene at a dosage of 200 mg/kg body weight inhibited LPO and restored in vivo antioxidant components to normal. CCl4 intoxication also resulted in a significant increase in inflammatory markers like IL-6, TNF-α, high sensitivity Corticotropin Releasing Factor (Hs-CRF), and biomarkers of cardiac toxicity like alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase MB (CKMB), and Troponin I & troponin-t activities. D-limonene reversed all these changes to normal. Histology further confirmed our obtained results. Conclusion: These findings indicate that D-limonene can ameliorate cardiac injury at a 200 mg/kg body weight dosage. Henceforth, D-Limonene intervenes in mediating CCl4 induced toxicity by various signaling pathways. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Zingerone Targets Status Epilepticus by Blocking Hippocampal Neurodegeneration via Regulation of Redox Imbalance, Inflammation and Apoptosis

Author

Rashid, Summya, primary, Wali, Adil Farooq, additional, Rashid, Shahzada Mudasir, additional, Alsaffar, Rana M., additional, Ahmad, Ajaz, additional, Jan, Basit L., additional, Paray, Bilal Ahmad, additional, Alqahtani, Saeed M. A., additional, Arafah, Azher, additional, and Rehman, Muneeb U., additional

Published
2021
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22. Nanogel-based Transdermal Drug Delivery System: A Therapeutic Strategy with Under Discussed Potential

Author

Tariq, Lubna, Arafah, Azher, Ali, Shafat, Beigh, Saba, Dar, Mashooq Ahmad, Dar, Tanvir ul Hassan, Dar, Aqib Iqbal, Alsaffar, Rana M., Masoodi, Mubashir Hussain, and Rehman, Muneeb U.

Abstract

The application of nanoparticles in medication delivery has revolutionized the field of therapeutic biology. To improve medical efficacy, currently, drug nanocarriers are employed to control the release and stability, expand its circulation time, or protect it from cell clearance or premature breakdown. A crosslinked polymeric framework is used to crosslink the hydrogel nanoparticle dispersions for safer and stable delivery on target sites. Nanogels have developed in the last two decades as potential biomaterials with a wide variety of applications. Later attributes of nanogels are mainly due to large surface areas, retention of molecules, size flexibility, and water-based formulations that have made them popular as drug delivery vehicles, as seen by several in vivo uses. The gel matrix containing the nanoparticle drug demonstrated a considerable increase in drug penetration in transdermal drug and topical delivery methods. This review aims to understand why and how nanogels are considered so innovative as a drug delivery method. It also examines their preparation methods and applications in the pharmaceutical and biomedical fields and discusses the benefits of nanogels, including swelling capacity and stimulus stimuli sensitivity. Nanogels, on the other hand, have recently been investigated for applications outside the field of biomedicine. Since there are many possible uses for nanogels, we have comprehensively reviewed the current state of the art for all feasible nanogel applications and manufacturing methods.

Published
2023
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