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Jawza H Alfarraj,1 AbdulAziz A Alsaeed2 1Pediatric Dentistry, King Fahad Medical City, Riyadh, Saudi Arabia; 2Endodontics, King Abdul-Aziz Medical City, Riyadh, Saudi ArabiaCorrespondence: Jawza H Alfarraj, Tel +966 509948859, Email Jawza500@gmail.comAbstract: The term molar incisor hypomineralization (MIH) describes the clinical manifestation of enamel hypomineralization of systemic origin affecting one or more permanent first molars and incisors. The purpose of this case report is to discuss the management of two mandibular molars with hypomineralization and to emphasize endodontic treatment for pediatric patients. An 8-year-old girl was referred to the pediatric dental clinic for restorations of multiple carious teeth. Upon clinical examination, based on the pattern of enamel hypomineralization and posteruptive breakdown presented, the diagnosis of MIH was established. As a part of the comprehensive treatment, one molar was restored with resin-based composite restorations. The other was endodontically involved and was treated with apexification and then covered with a stainless-steel crown. A two-year recall appointment revealed both molars to be free from signs and symptoms of inflammation. Management of MIH-affected molars should follow a conservative approach and endodontic treatment should be considered.Keywords: case report, molar incisor hypomineralization, MIH, apexification, mineral trioxide aggregate, pediatric dentistry

Purpose: To assess a quantitative and reproducible association between the position of the knee joint line and recognizable anatomical landmarks around it in order to help in restoring joint line in arthroplasty cases., Methods: Magnetic resonance imaging (MRI) of 130 normal knees were investigated. Anatomical measurements of the knee joint distances on the obtained planes were performed manually by distance measurements using a ruler tool, followed by 6 anatomical bony landmarks determination about the knee to identify the joint line which included the joint line, medial epicondyle, lateral epicondyle, medial flare, lateral flare, and proximal tibiofibular joint. The entire process was examined twice by two independent fellowship trained musculoskeletal radiologists, with a 2-week interval between the first and second sets of readings., Results: The lateral epicondyle to the joint line of the knee (LEJL) could be a reliable landmark for accurate distance measurements for the knee joint line level, with an absolute distance of 24.4 ± 2.8 mm. The analysis showed that the femorotibial ratio between the LEJL and proximal tibiofibular joint (PTFJ) was 1.0 (LEJL/PTFJJL = 1.0 ± 0.1), confirming the location of the knee joint at the midpoint between the lateral epicondyle and PTFJ, revealing two identifiable landmarks., Conclusions: LEJL is the most precise landmark for determination of an accurate knee joint line because the knee is located at the midline between the lateral epicondyle and PTFJ. These reproducible quantitative relationships can be widely employed in various imaging modalities to help restore the knee JL in arthroplasty surgeries., (© 2023. The Author(s).)

Background: The demand for organ donation has increased because of the sharp rise in the number of transplant candidates worldwide. The main influences on the organ donation rate in Saudi Arabia were religious considerations and a lack of knowledge. The aim of this study was to explore community knowledge of and attitude toward organ donation in Saudi Arabia., Methods: An online cross-sectional survey study was conducted to assess community knowledge of and attitude toward organ donation in Saudi Arabia in January 2022. The study population consisted of everyone who is currently residing in Saudi Arabia and is aged ≥18 years. The participants were questioned regarding the types of organs that might be donated, the potential health risks associated with organ donation, and the Saudi Arabian system for organ donation. Logistic regression was used to identify predictors of better knowledge of and attitude toward organ donation., Results: The study involved 1208 participants, of which 63% reported that they would be willing to donate their organs for a family member. The most reported organs for which the participants reported they are willing to donate were the kidneys (48%), liver (25%), and heart (21%). Most reported that they would donate their organs to save someone's life (93%). The study participants showed mild to moderate level of knowledge about organ donation with a mean score of 5.4 (standard deviation [SD] 1.6), which is equal to 68% of the maximum obtainable score (which is 8). The study participants showed a mild positive attitude toward organ donation with a mean score of 3.3 (SD 1.3), which is equal to 47% of the maximum obtainable score (which is 7). Younger participants (aged 19-30 years) and those who work in the health care sector were more likely than others to be knowledgeable about organ donation (P ≤ .01). At the same time, participants aged 31 to 40 years were more likely than others to have positive attitudes toward organ donation (P ≤ .01)., Conclusions: The present study participants showed mild to moderate level of knowledge of and mild positive attitude toward organs donation. Awareness campaigns should be directed toward the elderly population to enhance their awareness and attitude toward this important lifesaving practice., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Airports could serve as hotspots for the spread of the COVID-19 infection. We aimed to assess the awareness, attitude, and behaviors of non-Saudi travelers about COVID-19 and their satisfaction with preventive measures at Saudi airports. A cross-sectional study was conducted among non-Saudi travelers arriving in Saudi Arabia at two international airports. Data were collected using a questionnaire in Arabic, Hindi, and Urdu languages. Awareness, attitude, behavior scores, and satisfaction levels were calculated. Linear regression analyses were done to assess the predictors of awareness, attitude, and behaviors. A total of 633 participants were included in the study. The mean awareness, attitude, and behavior scores were 16.3/22, 18.3/24, and 3.2/5, respectively. Nationality, education, and income were significant predictors of awareness. Nationality was the only significant predictor of attitude, while gender and nationality were predictors of behaviors. Overall satisfaction with preventive measures was: transportation (94%), lounges and corridors (96%), counters (98%), and airport staff (97%). There was overall good awareness and attitude among travelers. Behavior scores were relatively low, which needs to change as air travel poses a threat to the spread of infectious diseases. Airport authorities need to manage passengers properly to ensure adequate distancing to prevent the potential transmission of infections.

Introduction:  Diabetes mellitus (DM), a chronic metabolic noncommunicable disease (NCD), has assumed epidemic proportions worldwide. Type 2 diabetes (T2D) is defined as chronic high blood glucose levels due to the deficiency of insulin or resistance to it. Dyslipidemia is one of the major causes of cardiovascular diseases in patients with T2D. It is characterized by elevated plasma triglyceride (TG), low high-density lipoprotein (HDL) cholesterol, and high low-density lipoprotein (LDL) cholesterol, which is mostly present in patients with DM., Methods:  We conducted a retrospective cross-sectional study at the King Faisal University (KFU) Health Center in the eastern region of Saudi Arabia. The data of patients from October 2014 to February 2021 were collected. We collected the patients' data from the KFU Health Center after obtaining approval from the KFU polyclinic administration. Prior ethical approval was taken from the Institutional Review Board of Ethics and Research Committee in the College of Medicine, KFU (approval number, 2020-10-62). We collected patients' data, including their gender, age, nationality, and blood analysis (lipids profile - TGs, HDL, LDL, and hemoglobin A1c [HbA1c] levels)., Result:  This study included 191 patients with T2D, 137 (71.7%) were from Saudi Arabia, and 54 (28.3%) were from other countries. Patients' age ranged from 21 to 100 years, with a mean age of 56.2 ± 11.8 years. There were 107 (56%) females. Cholesterol levels ranged from 102 to 300 mg/dl with a mean value of 187.3 mg/dl., Conclusion: In the current study, we assessed the association between HbA1c levels and lipid profiles in patients with T2D at the KFU Health Center in the eastern region of the Kingdom of Saudi Arabia. Our results on the adjusted relationship of HbA1c with lipid profile through regression model have demonstrated that HDL alone had significant adjusted relation with HbA1c if other factors are kept constant. We suggest focusing on TC and HDL levels in T2D health management in future studies., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021, Al Ghadeer et al.)

Acceptance of COVID-19 vaccines needs a health promotion approach to address various social, environmental and personal factors leading to vaccine hesitancy. We assessed the vaccine hesitancy rate and applied social cognitive theory (SCT) to understand COVID-19 vaccine rejection in Qassim, Saudi Arabia. A cross-sectional study was conducted among visitors of 10 randomly selected primary health care centers in Buraidah, Saudi Arabia. Data was collected by a self-administrated questionnaire. The variables were grouped into six constructs of SCT. Logistic regression was used to assess the predictors of vaccine rejection. Out of 486 participants included in the study, 30.5% rejected the vaccine. The most common reason for vaccine rejection was uncertainty about the vaccine's effectiveness (78%). Among various constructs of SCT, reciprocal determinism (nationality, income and suffering from COVID-19 infection), behavioral capability (knowledge about vaccine safety), self-efficacy (registered for vaccine), and observational learning (getting the vaccine after friends and family members) were significant predictors. Expectation and reinforcement constructs did not show significant association. There was high vaccine rejection in Qassim, KSA. This calls for further improving the mass education strategies. Social cognitive theory can be used to predict vaccine rejection and to develop strategies to increase the utilization of COVID-19 vaccines in Saudi Arabia.

Nowadays, surgical intervention is an accepted treatment for congenital pseudoarthrosis of the clavicle (CPC). The purpose of this literature review is to evaluate the current body of evidence for methods and outcomes of surgical intervention for CPC. CPC is a rare deformity of the middle third of the clavicle not often identified until three to five years of age, at which time surgery is often recommended. The most common indication for surgery is cosmetic appearance, but other indications include pain, shoulder dysfunction, and prevention of complications later in life. Surgical intervention involves the resection and excision of the pseudoarthrosis, bone grafting (most commonly autologous tissue from the iliac crest), and internal fixation using plates or Kirschner wires (K-wires). Plate fixation tends to have fewer complications and better long-term outcomes. Following surgery, outcomes include satisfaction with cosmetic appearance, decreased pain, and improved shoulder function., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021, Alsaeed et al.)

Objective: This study investigates the reasons for bypassing local primary healthcare centres (PHCs) by patients with minor illnesses in Qassim Region, KSA., Methods: A cross-sectional study was performed on 266 patients that visited emergency departments in public hospitals in Qassim Region. The patients were randomly selected and categorised as level five patients (LFPs) using the Canadian Triage and Acuity Scale (CTAS) for patient characterisation., Results: Of the 266 patients, 85.7% had previous experience of visiting PHC facilities. The majority of these patients were not satisfied with their treatment in PHCs. Approximately 52.9% of the patients reported that the working hours at PHCs were not sufficient, 38.1% mentioned a lack of experienced staff, and 31.7% believed that PHCs were insufficient for diagnostic tests. Another 13.8% of the patients reported the unavailability of prescribed medicines. Interestingly, 17.7% of the patients reported that they never bypassed PHCs. In general, the data demonstrate that patients' gender, employment, and marital status have no significant role in their decision to skip PHCs in favor of emergency departments of public hospitals ( p  > 0.05)., Conclusions: Patients bypassing PHCs without a referral form is a serious concern that have a deleterious effect on the healthcare system, particularly emergency departments. If bypassing continues, it will increase the burden on emergency departments, particularly on healthcare services for the general population., (© 2021 The Authors.)

Objective: To study the prevalence of various errors of refraction among the medical students studying at the college of medicine, Qassim University, Saudi Arabia., Methods: This is a cross-sectional descriptive study conducted at Qassim University clinics over a period of two months. The study population comprised 162 male and female students from different academic years. The students were selected randomly so that around 35-40 students were taken from each academic class. The selected study population was explained the objectives of the study and a written consent form that stated the purpose, methods, risks, benefits, and the assurance of the confidentiality of the data was obtained from each student. After giving the consent, each subject was examined by auto refractometer. The examination was carried out by an optometrist without using cycloplegia. Both right and left eyes were thoroughly examined by auto refractometer and on the average three readings of the refraction measurements were taken. The readings were recorded on a data sheet of every individual, and the Statistical analysis was performed using Statistical Package for Social Sciences (SPSS)., Results: One hundred and sixty-two (162) students with a mean age of 22.44 years, Std 1.661 and a range of 8 (19-27) were included in the study. Of the total number, 111 (68.51%) were males and remaining 51 (31.48%) were females. Of the total sample, only 1 (0.617%) student had diabetes mellitus, and 6 (3.70%) students gave a history of previous ocular surgery. Myopia was found to be the commonest error of refraction 53.7% with hyperopia next to it., Conclusion: Myopia is found to be a common error of refraction in young adults. A regular checkup is essential to timely correct the error and to prevent deterioration of the vision.

Background: The present study aimed at evaluation of the usefulness of point shear wave elastography (pSWE) in characterization of FLL(s) by quantifying their stiffness., Methods: In total, 197 patients (mean age was 56.57 years) with FLL(s) on conventional ultrasound were included. Final diagnoses, confirmed by imaging and/or biopsy whenever possible, included hepatocellular carcinoma (HCC) (n = 143), metastasis (n = 36), hemangioma (n = 16), and focal nodular hyperplasia (n = 2). Stiffness evaluation was performed by pSWE. Stiffness ratio (lesion to background liver) was calculated. ROC analysis was performed to evaluate the diagnostic accuracy of the stiffness value and stiffness ratio and to extract the optimal cutoff values for characterisation of FLL(s)., Results: HCC was significantly softer than its surrounding liver parenchyma [5.43 (3.03) vs. 17.05 (8.53) kPa, p <0.001]. However, the stiffness values for the other examined FLLs were comparable to their surrounding liver parenchyma. No significant difference was detected across different types of metastases or between metastases and surrounding liver (p>0.05). Stiffness ratio was superior to stiffness value in discrimination of HCC from metastasis (AUROC, 0.91 vs. 0.51 respectively)., Conclusion: pSWE could provide a complementary information about FLLs especially in differentiation between HCCs from metastases.

Many risk factors may contribute to renal disease in patients with hemophilia A., Aim: We aimed to evaluate functional and structural renal abnormalities among a group of Egyptian children with severe and moderate hemophilia A using technetium-99m diethylene triamine pentaacetic acid ( 99m Tc-DTPA) and technetium-99 m dimercaptusuccinic acid ( 99m Tc-DMSA) scan. We also aimed to determine the relation between these abnormalities and different risk factors and disease severity., Patients and Methods: Forty male patients, 16 with severe and 24 with moderate hemophilia A, were enrolled in this study. Their mean age was 10.2 ± 4.3 years (range, 5-17 years). Full history taking, clinical examination, laboratory, and radionuclide investigations including serum creatinine, blood urea nitrogen (BUN), urine analysis, creatinine clearance, 24-hour urinary protein, 99m Tc-DTPA scan, and 99m Tc-DMSA scan were performed to all enrolled patients., Results: Serum creatinine and BUN were normal in all patients, and corrected creatinine clearance was diminished in 2 patients. However, 99m Tc-DTPA results yielded 19 (47.5%) patients with diminished glomerular filtration rate (GFR). Moreover, it showed that 14 (35%) had obstructive uropathy, 15 (37.5%) had obstructive nephropathy, while 11 (27.5%) patients showed normal scan. One patient had atrophy of 1 kidney on 99m Tc-DMSA scan. Among our cohort, 5 (12.5%) patients were hypertensive. Microscopic hematuria was detected in 14 (35%) patients while 72.5% had proteinuria. We found an association between hematuria and hypertension with diminished GFR., Conclusion: Despite normal kidney functions (serum creatinine and BUN), we found a high rate of diminished GFR and obstructive uropathy and nephropathy as detected by 99m Tc-DTPA scan among children with hemophilia A.

Objectives: Febrile neutropenia (FN) is a common adverse effect of chemotherapy. Current management of FN is expensive and may induce side effects. Honey, as a natural honeybee product, has antioxidant, antimicrobial, immunomodulator and anticancer effects. Additionally, honey is not expensive. The aim of this study is to test the effects of a 12-week honey consumption on children with acute lymphoblastic leukemia (ALL) particularly with regard to FN., Design: A randomized crossover clinical trial. Forty patients of both sexes, aged 2.5-10 years, were randomized into two equal groups [intervention to control (I/C) and control to intervention (C/I)]., Setting: Children Hospital of Ain Shams University-Cairo-Egypt. The dietary intervention consisted of honey in a dose of 2.5 g//kg body weight per dose twice weekly for 12 weeks., Main Outcome Measure: Febrile neutropenia in terms of frequency and duration of hospital admission., Results: The intervention resulted in a significant decrease of FN episodes, the number of patients admitted with FN and the duration of hospital stay. Also, honey consumption improved the levels of hemoglobin and did not produce any serious side effect. As a possible effect of honey withdrawal in the I/C group, the Hb%, the absolute neutrophil count and the platelet count decreased., Conclusion: Honey intervention in a group of children with ALL resulted in positive effects on FN and hematologic parameters. Further studies that include a larger number of patients are recommended to confirm that honey, has beneficial effects, as a complementary agent, in children with ALL., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

All previous studies on nasal anthropometry of Middle Eastern populations were done on Persian, Turkish, and North African populations; with no studies arising from the Arabic Gulf Region. This study aimed to define nasal anthropometric measurements in Saudi Arabia (the largest Arabic Gulf country) and compare them with different races. A total of 104 Saudi men and 105 Saudi women with a mean age of 22 years (range, 18-27 years) were included in the study. A total of 25 nasal anthropometric variables were measured. Comparison with other races was done using the t-test (P < 0.05 is considered significant). The intercanthal distance of Saudi men is significantly smaller than that in women (the reverse is true for other races). Hence, Saudi women (and not men) have significantly wider intercanthal distance than do whites. The nasal widths of Saudi men and women lie between the whites and the Chinese. A unique feature of the Saudi nose is the significantly larger nasofrontal angle of Saudi men and women compared with all other races. Within the Saudi race, the nasofacial angle of men is so much larger than that of women (41.4 vs 33.3 degrees). In other races, the difference between men and women is usually slight (0- to 1-mm difference only). In Saudi men, the nasofacial angle is significantly larger than that in whites, but the value for Saudi women is significantly smaller than that for whites. Finally, in both Saudi sexes, the nasal tip angle/nasal tip protrusion is significantly smaller than all other races. It was concluded that the Saudi nose has several unique features when compared with other races including other Middle Eastern populations.