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33 results on '"AlMotairi, Abdullah"'

2. Knowledge and Attitude of Parents Regarding the Human Papillomavirus Vaccine as a New Component in the Saudi Vaccination Schedule

Author

Bin Alamir, Abdulrahman A, primary, Almotairi, Abdullah H, additional, Almutairi, Fahad H, additional, Almujel, Khaled N, additional, Almhmd, Abdalah E, additional, Alanazi, Abdulrahman F, additional, Alotaibi, Khalid F, additional, Alanazi, Mohammed H, additional, Alsaeri, Amer S, additional, Alruwaili, Meshal A, additional, and Alghamdi, Rayan S, additional

Published
2024
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4. Macrolides in critically ill patients with Middle East Respiratory Syndrome

Author

Arabi, Yaseen M., Deeb, Ahmad M., Al-Hameed, Fahad, Mandourah, Yasser, Almekhlafi, Ghaleb A., Sindi, Anees A., Al-Omari, Awad, Shalhoub, Sarah, Mady, Ahmed, Alraddadi, Basem, Almotairi, Abdullah, Al Khatib, Kasim, Abdulmomen, Ahmed, Qushmaq, Ismael, Solaiman, Othman, Al-Aithan, Abdulsalam M., Al-Raddadi, Rajaa, Ragab, Ahmad, Al Harthy, Abdulrahman, Kharaba, Ayman, Jose, Jesna, Dabbagh, Tarek, Fowler, Robert A., Balkhy, Hanan H., Merson, Laura, and Hayden, Frederick G.

Published
2019
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5. An international perspective on hospitalized patients with viral community-acquired pneumonia

Author

Aruj, Patricia Karina, Attorri, Silvia, Barimboim, Enrique, Caeiro, Juan Pablo, Garzón, María I., Cambursano, Victor Hugo, Ceccato, Adrian, Chertcoff, Julio, Cordon Díaz, Ariel, de Vedia, Lautaro, Ganaha, Maria Cristina, Lambert, Sandra, Lopardo, Gustavo, Luna, Carlos M., Malberti, Alessio Gerardo, Morcillo, Nora, Tartara, Silvina, Pensotti, Claudia, Pereyra, Betiana, Scapellato, Pablo Gustavo, Stagnaro, Juan Pablo, Shah, Sonali, Lötsch, Felix, Thalhammer, Florian, Anseeuw, Kurt, Francois, Camille A., Van Braeckel, Eva, Vincent, Jean Louis, Djimon, Marcel Zannou, Aranha Nouér, Simone, Chipev, Peter, Encheva, Milena, Miteva, Darina, Petkova, Diana, Balkissou, Adamou Dodo, Pefura Yone, Eric Walter, Mbatchou Ngahane, Bertrand Hugo, Shen, Ning, Xu, Jin-fu, Bustamante Rico, Carlos Andres, Buitrago, Ricardo, Pereira Paternina, Fernando Jose, Kayembe Ntumba, Jean-Marie, Vladic-Carevic, Vesna, Jakopovic, Marko, Matkovic, Zinka, Mitrecic, Ivan, Bouchy Jacobsson, Marie-Laure, Bro Christensen, Anette, Bødtger, Uffe, Meyer, Christian Niels, Vestergaard Jensen, Andreas, El-Said Abd El-Wahhab, Ibrahim, Elsayed Morsy, Nesreen, Shafiek, Hanaa, Sobh, Eman, Abdulsemed, Kedir Abdella, Bertrand, Fabrice, Brun-Buisson, Christian, de Montmollin, Etienne, Fartoukh, Muriel, Messika, Jonathan, Tattevin, Pierre, Khoury, Abdo, Ebruke, Bernard, Dreher, Michael, Kolditz, Martin, Meisinger, Matthias, Pletz, Mathias W., Hagel, Stefan, Rupp, Jan, Schaberg, Tom, Spielmanns, Marc, Creutz, Petra, Suttorp, Norton, Siaw-Lartey, Beatrice, Dimakou, Katerina, Papapetrou, Dimosthenis, Tsigou, Evdoxia, Ampazis, Dimitrios, Kaimakamis, Evangelos, Bhatia, Mohit, Dhar, Raja, D’Souza, George, Garg, Rajiv, Koul, Parvaiz A., Jayaraj, B.S., Narayan, Kiran Vishnu, Udnur, Hirennappa B., Krishnamurthy, Shashi Bhaskara, Kant, Surya, Swarnakar, Rajesh, Salvi, Sundeep, Limaye, Sneha, Golshani, Keihan, Keatings, Vera M., Martin-Loeches, Ignacio, Maor, Yasmin, Strahilevitz, Jacob, Battaglia, Salvatore, Carrabba, Maria, Ceriana, Piero, Confalonieri, Marco, d’Arminio Monforte, Antonella, Del Prato, Bruno, De Rosa, Marino, Fantini, Riccardo, Fiorentino, Giuseppe, Gammino, Maria Antonia, Menzella, Francesco, Milani, Giuseppe, Nava, Stefano, Palmiero, Gerardo, Petrino, Roberta, Gabrielli, Barbra, Rossi, Paolo, Sorino, Claudio, Steinhilber, Gundi, Zanforlin, Alessandro, Franzetti, Fabio, Carone, Mauro, Patella, Vincenzo, Scarlata, Simone, Comel, Andrea, Kurahashi, Kiyoyasu, Aoun Bacha, Zeina, Barajas Ugalde, Daniel, Ceballos Zuñiga, Omar, Villegas, José F., Medenica, Milic, van de Garde, E.M.W., Raj Mihsra, Deebya, Shrestha, Poojan, Ridgeon, Elliott, Ishola Awokola, Babatunde, Nwankwo, Ogonna N.O., Olufunlola, Adefuye Bolanle, Olumide, Segaolu, Ukwaja, Kingsley N., Irfan, Muhammad, Minarowski, Lukasz, Szymon, Skoczyński, Froes, Felipe, Leuschner, Pedro, Meireles, Mariana, Ferrão, Cláudia, Neves, João, Ravara, Sofia B., Brocovschii, Victoria, Ion, Chesov, Rusu, Doina, Toma, Cristina, Chirita, Daniela, Dorobat, Carmen Mihaela, Birkun, Alexei, Kaluzhenina, Anna, Almotairi, Abdullah, Bukhary, Zakeya Abdulbaqi Ali, Edathodu, Jameela, Fathy, Amal, Mushira Abdulaziz Enani, Abdullah, Eltayeb Mohamed, Nazik, Ulhadi Memon, Jawed, Bella, Abdelhaleem, Bogdanović, Nada, Milenkovic, Branislava, Pesut, Dragica, Borderìas, Luis, Bordon Garcia, Noel Manuel, Cabello Alarcón, Hugo, Cilloniz, Catia, Torres, Antoni, Diaz-Brito, Vicens, Casas, Xavier, Encabo González, Alicia, Fernández-Almira, Maria Luisa, Gallego, Miguel, Gaspar-GarcÍa, Inmaculada, González Del Castillo, Juan, Javaloyes Victoria, Patricia, Laserna Martínez, Elena, Malo de Molina, Rosa, Menéndez, Rosario, Pando-Sandoval, Ana, Prat Aymerich, Cristina, Lacoma de la Torre, Alicia, García-Olivé, Ignasi, Rello, Jordi, Moyano, Silvia, Sanz, Francisco, Sibila, Oriol, Rodrigo-Troyano, Ana, Solé-Violán, Jordi, Uranga, Ane, van Boven, Job F.M., Vendrell Torra, Ester, Pujol, Jordi Almirall, Feldman, Charles, Kee Yum, Ho, Fiogbe, Arnauld Attannon, Yangui, Ferdaous, Bilaceroglu, Semra, Dalar, Levent, Yilmaz, Ufuk, Bogomolov, Artemii, Elahi, Naheed, Dhasmana, Devesh J., Feneley, Andrew, Hancock, Carole, Hill, Adam T., Rudran, Banu, Ruiz-Buitrago, Silvia, Campbell, Marion, Whitaker, Paul, Youzguin, Alexander, Singanayagam, Anika, Allen, Karen S., Brito, Veronica, Dietz, Jessica, Dysart, Claire E., Kellie, Susan M., Franco-Sadud, Ricardo A., Meier, Garnet, Gaga, Mina, Holland, Thomas L., Bergin, Stephen P., Kheir, Fayez, Landmeier, Mark, Lois, Manuel, Nair, Girish B., Patel, Hemali, Reyes, Katherine, Rodriguez-Cintron, William, Saito, Shigeki, Soni, Nilam J., Noda, Julio, Hinojosa, Cecilia I., Levine, Stephanie M., Angel, Luis F., Anzueto, Antonio, Scott Whitlow, K., Hipskind, John, Sukhija, Kunal, Totten, Vicken, Wunderink, Richard G., Shah, Ray D., Mateyo, Kondwelani John, Carugati, Manuela, Morosi, Manuela, Monge, Elisa, Radovanovic, Dejan, Sotgiu, Giovanni, Jankovic, Mateja, Mahesh, Padukudru Anand, Marcos, Pedro Jorge, Abdalla, Mohamed I., Di Pasquale, Marta Francesca, Gramegna, Andrea, Terraneo, Silvia, Blasi, Francesco, Santus, Pierachille, Aliberti, Stefano, Reyes, Luis F., and Restrepo, Marcos I.

Published
2019
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6. Adherence to Medications of Hypertension among Hypertensive Patients of Majmaah City of Saudi Arabia.

Author

Alfhaid, Fahad Mohammad, Aljulifi, Mohammed Zaid, Almutairi, Fahad Hamdan R., Alanazi, Khalid Falah, Alanazi, Abdulaziz Mfwad, Aldhafiri, Hamad Jubair, Almutairi, Maryam Awad, Almousa, Moudi Abdulrahman, Alotaibi, Wojdan Suhail, Almotairi, Abdullah Helal, Almhmd, Abdalah Emad, and Bin Saqyan, Abdulaziz

Subjects
PATIENT compliance, HYPERTENSION, ANTIHYPERTENSIVE agents, BLOOD pressure, MARITAL status
Abstract

Objectives: To assess engagement in heart-healthy lifestyle practices and adherence to antihypertensive medications with knowledge of hypertension, for more effective blood pressure control. Methodology: It was a cross-sectional study involving adults of more than 18 years diagnosed with hypertension as study participants. Total sample size was 381. Assessment of medication adherence, and responses were calculated using Malaysian Medicine Adherence Score 8 (MALMAS 8) scale. The scoring system utilized in the MALMAS questionnaire, aligned with the MMAS-8, aids in categorizing participants based on their medication adherence levels. Data were collected using a pre-tested, self-administered questionnaire. The data were analysed using the statistical software for social sciences (SPSS26). Results: The prevalence of hypertension among the selected study participants was found to be 71%. High level of adherence was found in 33% of the participants. The medication adherence of the patient was significantly associated with gender (p<0.05). 27% of the study participants belong to the age group of 25-40 years. Around 63% of the females were having high adherence and this association was found to be statistically significant, (p value < 0.05.). There was no statistically significant association between participants' adherence to the age group they belong, marital status, educational level and their occupation. Conclusion: In conclusion, this cross-sectional study highlights the difficulty in adhering to treatment plans, with forgetfulness and trouble taking medications ranking as the biggest obstacles. Interestingly, adherence was higher in females than in males. Nevertheless, no statistically significant correlation was observed between medication adherence and other demographic variables, including age, income level, occupation, marital status, education, or occupation. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study

Author

Aruj, Patricia Karina, Attorri, Silvia, Barimboim, Enrique, Caeiro, Juan Pablo, Garzón, María I, Cambursano, Victor Hugo, Ceccato, Adrian, Chertcoff, Julio, Lascar, Florencia, Di Tulio, Fernando, Cordon Díaz, Ariel, de Vedia, Lautaro, Ganaha, Maria Cristina, Lambert, Sandra, Lopardo, Gustavo, Luna, Carlos M, Malberti, Alessio Gerardo, Morcillo, Nora, Tartara, Silvina, Pensotti, Claudia, Pereyra, Betiana, Scapellato, Pablo Gustavo, Stagnaro, Juan Pablo, Shah, Sonali, Lötsch, Felix, Thalhammer, Florian, Vincent, Jean Louis, Anseeuw, Kurt, Francois, Camille A, Van Braeckel, Eva, Djimon, Marcel Zannou, Bashi, Jules, Dodo, Roger, Aranha Nouér, Simone, Chipev, Peter, Encheva, Milena, Miteva, Darina, Petkova, Diana, Balkissou, Adamou Dodo, Pefura Yone, Eric Walter, Mbatchou Ngahane, Bertrand Hugo, Shen, Ning, Xu, Jin-fu, Bustamante Rico, Carlos Andres, Buitrago, Ricardo, Pereira Paternina, Fernando Jose, Kayembe Ntumba, Jean-Marie, Vladic Carevic, Vesna, Jakopovic, Marko, Jankovic, Mateja, Matkovic, Zinka, Mitrecic, Ivan, Bouchy Jacobsson, Marie-Laure, Bro Christensen, Anette, Heitmann Bødtger, Uffe Christian, Meyer, Christian Niels, Vestergaard Jensen, Andreas, Baunbæk-knudsen, Gertrud, Trier Petersen, Pelle, Andersen, Stine, El-Said Abd El-Wahhab, Ibrahim, Elsayed Morsy, Nesreen, Shafiek, Hanaa, Sobh, Eman, Abdulsemed, Kedir Abdella, Bertrand, Fabrice, Brun-Buisson, Christian, de Montmollin, Etienne, Fartoukh, Muriel, Messika, Jonathan, Tattevin, Pierre, Khoury, Abdo, Ebruke, Bernard, Dreher, Michael, Kolditz, Martin, Meisinger, Matthias, Pletz, Mathias W, Hagel, Stefan, Rupp, Jan, Schaberg, Tom, Spielmanns, Marc, Creutz, Petra, Suttorp, Norton, Siaw-Lartey, Beatrice, Dimakou, Katerina, Papapetrou, Dimosthenis, Tsigou, Evdoxia, Ampazis, Dimitrios, Kaimakamis, Evangelos, Bhatia, Mohit, Dhar, Raja, D'Souza, George, Garg, Rajiv, Koul, Parvaiz A, Mahesh, P A, Jayaraj, B S, Narayan, Kiran Vishnu, Udnur, Hirennappa B, Krishnamurthy, Shashi Bhaskara, Kant, Surya, Swarnakar, Rajesh, Limaye, Sneha, Salvi, Sundeep, Golshani, Keihan, Keatings, Vera M, Martin-Loeches, Ignacio, Maor, Yasmin, Strahilevitz, Jacob, Battaglia, Salvatore, Carrabba, Maria, Ceriana, Piero, Confalonieri, Marco, d'Arminio Monforte, Antonella, Del Prato, Bruno, De Rosa, Marino, Fantini, Riccardo, Fiorentino, Giuseppe, Gammino, Maria Antonia, Menzella, Francesco, Milani, Giuseppe, Nava, Stefano, Palmiero, Gerardo, Petrino, Roberta, Gabrielli, Barbra, Rossi, Paolo, Sorino, Claudio, Steinhilber, Gundi, Zanforlin, Alessandro, Franzetti, Fabio, Carugati, Manuela, Morosi, Manuela, Monge, Elisa, Carone, Mauro, Patella, Vincenzo, Scarlata, Simone, Comel, Andrea, Kurahashi, Kiyoyasu, Aoun Bacha, Zeina, Barajas Ugalde, Daniel, Ceballos Zuñiga, Omar, Villegas, José F, Medenica, Milic, van de Garde, E M W, Raj Mihsra, Deebya, Shrestha, Poojan, Ridgeon, Elliott, Ishola Awokola, Babatunde, Nwankwo, Ogonna N O, Olufunlola, Adefuye Bolanle, Olumide, Segaolu, Ukwaja, Kingsley N, Irfan, Muhammad, Minarowski, Lukasz, Szymon, Skoczynski, Froes, Felipe, Leuschner, Pedro, Meireles, Mariana, Ferrão, Cláudia, Neves, João, Ravara, Sofia B, Brocovschii, Victoria, Ion, Chesov, Rusu, Doina, Toma, Cristina, Chirita, Daniela, Dorobat, Carmen Mihaela, Birkun, Alexei, Kaluzhenina, Anna, Almotairi, Abdullah, Bukhary, Zakeya Abdulbaqi Ali, Edathodu, Jameela, Fathy, Amal, Mushira Abdulaziz Enani, Abdullah, Eltayeb Mohamed, Nazik, Ulhadi Memon, Jawed, Bella, Abdelhaleem, Bogdanovic, Nada, Milenkovic, Branislava, Pesut, Dragica, Borderìas, Luis, Bordon Garcia, Noel Manuel, Cabello Alarcón, Hugo, Cilloniz, Catia, Torres, Antoni, Diaz-Brito, Vicens, Casas, Xavier, Encabo González, Alicia, Fernández-Almira, Maria Luisa, Gallego, Miguel, Gaspar-GarcÍa, Inmaculada, González del Castillo, Juan, Javaloyes Victoria, Patricia, Laserna Martínez, Elena, Malo de Molina, Rosa, Marcos, Pedro J, Menéndez, Rosario, Pando-Sandoval, Ana, Prat Aymerich, Cristina, Lacoma de la Torre, Alicia, García-Olivé, Ignasi, Rello, Jordi, Moyano, Silvia, Sanz, Francisco, Sibila, Oriol, Rodrigo-Troyano, Ana, Solé-Violán, Jordi, Uranga, Ane, van Boven, Job FM, Vendrell Torra, Ester, Pujol, Jordi Almirall, Feldman, Charles, Kee Yum, Ho, Fiogbe, Arnauld Attannon, Yangui, Ferdaous, Bilaceroglu, Semra, Dalar, Levent, Yilmaz, Ufuk, Bogomolov, Artemii, Elahi, Naheed, Dhasmana, Devesh J, Feneley, Andrew, Ions, Rhiannon, Skeemer, Julie, Woltmann, Gerrit, Hancock, Carole, Hill, Adam T, Rudran, Banu, Ruiz-Buitrago, Silvia, Campbell, Marion, Whitaker, Paul, Youzguin, Alexander, Singanayagam, Anika, Allen, Karen S, Brito, Veronica, Dietz, Jessica, Dysart, Claire E, Kellie, Susan M, Franco-Sadud, Ricardo A, Meier, Garnet, Gaga, Mina, Holland, Thomas L, Bergin, Stephen P, Kheir, Fayez, Landmeier, Mark, Lois, Manuel, Nair, Girish B, Patel, Hemali, Reyes, Katherine, Rodriguez-Cintron, William, Saito, Shigeki, Soni, Nilam J, Noda, Julio, Hinojosa, Cecilia I, Levine, Stephanie M, Angel, Luis F, Anzueto, Antonio, Whitlow, K Scott, Hipskind, John, Sukhija, Kunal, Totten, Vicken, Wunderink, Richard G, Shah, Ray D, Mateyo, Kondwelani John, Noriega, Lorena, Alvarado, Ezequiel, Aman, Mohamed, Labra, Lucía, Aliberti, Stefano, Reyes, Luis F, Faverio, Paola, Sotgiu, Giovanni, Dore, Simone, Rodriguez, Alejandro H, and Restrepo, Marcos I

Published
2016
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9. Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome

Author

Arabi, Yaseen M., Mandourah, Yasser, Al-Hameed, Fahad, Sindi, Anees A., Almekhlafi, Ghaleb A., Hussein, Mohamed A., Jose, Jesna, Pinto, Ruxandra, Al-Omari, Awad, Kharaba, Ayman, Almotairi, Abdullah, Al Khatib, Kasim, Alraddadi, Basem, Shalhoub, Sarah, Abdulmomen, Ahmed, Qushmaq, Ismael, Mady, Ahmed, Solaiman, Othman, Al-Aithan, Abdulsalam M., Al-Raddadi, Rajaa, Ragab, Ahmed, Balkhy, Hanan H., Al Harthy, Abdulrahman, Deeb, Ahmad M., Al Mutairi, Hanan, Al-Dawood, Abdulaziz, Merson, Laura, Hayden, Frederick G., and Fowler, Robert A.

Published
2018
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11. Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study

Author

Arabi, Yaseen M., Al-Omari, Awad, Mandourah, Yasser, Al-Hameed, Fahad, Sindi, Anees A., Alraddadi, Basem, Shalhoub, Sarah, Almotairi, Abdullah, Al Khatib, Kasim, Abdulmomen, Ahmed, Qushmaq, Ismael, Mady, Ahmed, Solaiman, Othman, Al-Aithan, Abdulsalam M., Al-Raddadi, Rajaa, Ragab, Ahmed, Al Mekhlafi, Ghaleb. A., Al Harthy, Abdulrahman, Kharaba, Ayman, Ahmadi, Mashael Al, Sadat, Musharaf, Mutairi, Hanan Al, Qasim, Eman Al, Jose, Jesna, Nasim, Maliha, Al-Dawood, Abdulaziz, Merson, Laura, Fowler, Robert, Hayden, Frederick G., and Balkhy, Hanan H.

Published
2017
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12. National Approach to Standardize and Improve Mechanical Ventilation

Author

Arabi, Yaseen, Aseri, Zohair Al, Alaama, Tareef, Alqahtani, Abdulrahman, Alharthy, Abdulrhman, Almotairi, Abdullah, Qasim, Eman Al, Alzahrani, Abdullah, Qarni, Mohammed Al, Abdukahil, Sheryl Ann, Al-Hameed, Fahad, Mandourah, Yasser, Maghrabi, Khalid, Ghamdi, Adnan, Almekhalfi, Ghaleb, Mady, Ahmed, Qureshi, Ahmed, Qushmaq, Ismael, Alshahrani, Mohammed, Alkatheri, Mufareh, Saawi, Abdulmohsen, Al-Hazme, Raed, Berenholtz, Sean, Latif, Asad, Al-Moamary, Mohamed, and Mohrij, Saad

Subjects
Intensive care units -- Management, Mechanical ventilation -- Usage -- Analysis, Quality control, Evidence-based medicine, Company business management, Health
Abstract

Byline: Yaseen. Arabi, Zohair. Al Aseri, Tareef. Alaama, Abdulrahman. Alqahtani, Abdulrhman. Alharthy, Abdullah. Almotairi, Eman. Al Qasim, Abdullah. Alzahrani, Mohammed. Al Qarni, Sheryl Ann. Abdukahil, Fahad. Al-Hameed, Yasser. Mandourah, Khalid. [...]

Published
2019

13. Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients

Author

Di Pasquale, Marta Francesca, Sotgiu, Giovanni, Gramegna, Andrea, Radovanovic, Dejan, Terraneo, Silvia, Reyes, Luis F, Rupp, Jan, González del Castillo, Juan, Blasi, Francesco, Aliberti, Stefano, Restrepo, Marcos I, Aruj, Patricia Karina, Attorri, Silvia, Barimboim, Enrique, Caeiro, Juan Pablo, Garzón, María I, Cambursano, Victor Hugo, Cazaux, A, Ceccato, Adrian, Chertcoff, Julio, Lascar, Florencia, Tulio, Fernando Di, Díaz, Ariel Cordon, de Vedia, Lautaro, Ganaha, Maria Cristina, Lambert, Sandra, Lopardo, Gustavo, Luna, Carlos M, Malberti, Alessio Gerardo, Morcillo, Nora, Tartara, Silvina, Cetrangolo, Antonio A, Pensotti, Claudia, Pereyra, Betiana, Scapellato, Pablo Gustavo, Stagnaro, Juan Pablo, Shah, Sonali, Lötsch, Felix, Thalhammer, Florian, Anseeuw, Kurt, Francois, Camille A, Van Braeckel, Eva, Vincent, Jean Louis, Djimon, Marcel Zannou, Bashi, Jules, Dodo, Roger, Nouér, Simone Aranha, Chipev, Peter, Encheva, Milena, Miteva, Darina, Petkova, Diana, Balkissou, Adamou Dodo, Yone, Eric Walter Pefura, Ngahane, Bertrand Hugo Mbatchou, Shen, Ning, Xu, Jin-fu, Rico, Carlos Andres Bustamante, Buitrago, Ricardo, Paternina, Fernando Jose Pereira, Ntumba, Jean-Marie Kayembe, Carevic, Vesna Vladic, Jakopovic, Marko, Jankovic, Mateja, Matkovic, Zinka, Mitrecic, Ivan, Jacobsson, Marie-Laure Bouchy, Christensen, Anette Bro, Bødtger, Uffe Christian Heitmann, Meyer, Christian Niels, Jensen, Andreas Vestergaard, Baunbæk-Knudsen, Gertrud, Petersen, Pelle Trier, Andersen, Stine, El-Wahhab, Ibrahim El-Said Abd, Morsy, Nesreen Elsayed, Shafiek, Hanaa, Sobh, Eman, Abdulsemed, Kedir Abdella, Bertrand, Fabrice, Brun-Buisson, Christian, de Montmollin, Etienne, Fartoukh, Muriel, Messika, Jonathan, Tattevin, Pierre, Khoury, Abdo, Ebruke, Bernard, Dreher, Michael, Kolditz, Martin, Meisinger, Matthias, Niederlausitz, Klinikum, Pletz, Mathias W, Hagel, Stefan, Schaberg, Tom, Spielmanns, Marc, Creutz, Petra, Suttorp, Norton, Siaw-Lartey, Beatrice, Dimakou, Katerina, Papapetrou, Dimosthenis, Tsigou, Evdoxia, Ampazis, Dimitrios, Kaimakamis, Evangelos, Bhatia, Mohit, Dhar, Raja, D’Souza, George, Garg, Rajiv, Koul, Parvaiz A, Mahesh, P A, Jayaraj, B S, Narayan, Kiran Vishnu, Udnur, Hirennappa B, Krishnamurthy, Shashi Bhaskara, Kant, Surya, Swarnakar, Rajesh, Limaye, Sneha, Salvi, Sundeep, Golshani, Keihan, Keatings, Vera M, Martin-Loeches, Ignacio, Maor, Yasmin, Strahilevitz, Jacob, Battaglia, Salvatore, Carrabba, Maria, Ceriana, Piero, Confalonieri, Marco, Monforte, Antonella d’Arminio, Prato, Bruno Del, Rosa, Marino De, Fantini, Riccardo, Fiorentino, Giuseppe, Gammino, Maria Antonia, Menzella, Francesco, Milani, Giuseppe, Nava, Stefano, Palmiero, Gerardo, Petrino, Roberta, Gabrielli, Barbra, Rossi, Paolo, Sorino, Claudio, Steinhilber, Gundi, Zanforlin, Alessandro, Franzetti, Fabio, Carugati, Manuela, Morosi, Manuela, Monge, Elisa, Carone, Mauro, Patella, Vincenzo, Scarlata, Simone, Comel, Andrea, Kurahashi, Kiyoyasu, Bacha, Zeina Aoun, Ugalde, Daniel Barajas, Zuñiga, Omar Ceballos, Villegas, José F, Medenica, Milic, van de Garde, E M W, Mihsra, Deebya Raj, Shrestha, Poojan, Ridgeon, Elliott, Awokola, Babatunde Ishola, Nwankwo, Ogonna N O, Olufunlola, Adefuye Bolanle, Olumide, Segaolu, Ukwaja, Kingsley N, Irfan, Muhammad, Minarowski, Lukasz, Szymon, Skoczyński, Froes, Felipe, Leuschner, Pedro, Meireles, Mariana, Ferrão, Cláudia, Neves, João, Ravara, Sofia B, Brocovschii, Victoria, Ion, Chesov, Rusu, Doina, Toma, Cristina, Chirita, Daniela, Dorobat, Carmen Mihaela, Birkun, Alexei, Kaluzhenina, Anna, Almotairi, Abdullah, Bukhary, Zakeya Abdulbaqi Ali, Edathodu, Jameela, Fathy, Amal, Enani, Abdullah Mushira Abdulaziz, Mohamed, Nazik Eltayeb, Memon, Jawed Ulhadi, Bella, Abdelhaleem, Bogdanović, Nada, Milenkovic, Branislava, Pesut, Dragica, Borderìas, Luis, Garcia, Noel Manuel Bordon, Alarcón, Hugo Cabello, Cilloniz, Catia, Torres, Antoni, Diaz-Brito, Vicens, Casas, Xavier, González, Alicia Encabo, Fernández-Almira, Maria Luisa, Gallego, Miguel, Gaspar-GarcÍa, Inmaculada, del Castillo, Juan González, Victoria, Patricia Javaloyes, Martínez, Elena Laserna, de Molina, Rosa Malo, Marcos, Pedro J, Menéndez, Rosario, Pando-Sandoval, Ana, Aymerich, Cristina Prat, de la Torre, Alicia Lacoma, García-Olivé, Ignasi, Rello, Jordi, Moyano, Silvia, Sanz, Francisco, Sibila, Oriol, Rodrigo-Troyano, Ana, Solé-Violán, Jordi, Uranga, Ane, van Boven, Job F M, Torra, Ester Vendrell, Pujol, Jordi Almirall, Feldman, Charles, Yum, Ho Kee, Fiogbe, Arnauld Attannon, Yangui, Ferdaous, Bilaceroglu, Semra, Dalar, Levent, Yilmaz, Ufuk, Bogomolov, Artemii, Elahi, Naheed, Dhasmana, Devesh J, Feneley, Andrew, Ions, Rhiannon, Skeemer, Julie, Woltmann, Gerrit, Hancock, Carole, Hill, Adam T, Rudran, Banu, Ruiz-Buitrago, Silvia, Campbell, Marion, Whitaker, Paul, Youzguin, Alexander, Singanayagam, Anika, Allen, Karen S, Brito, Veronica, Dietz, Jessica, Dysart, Claire E, Kellie, Susan M, Franco-Sadud, Ricardo A, Meier, Garnet, Gaga, Mina, Holland, Thomas L, Bergin, Stephen P, Kheir, Fayez, Landmeier, Mark, Lois, Manuel, Nair, Girish B, Patel, Hemali, Reyes, Katherine, Rodriguez-Cintron, William, Saito, Shigeki, Soni, Nilam J, Noda, Julio, Hinojosa, Cecilia I, Levine, Stephanie M, Angel, Luis F, Anzueto, Antonio, Whitlow, K Scott, Hipskind, John, Sukhija, Kunal, Totten, Vicken, Wunderink, Richard G, Shah, Ray D, Mateyo, Kondwelani John, Noriega, Lorena, Alvarado, Ezequiel, Aman, Mohamed, Labra, Lucía, Value, Affordability and Sustainability (VALUE), Groningen Research Institute for Asthma and COPD (GRIAC), Di Pasquale, M. F., Sotgiu, G., Gramegna, A., Radovanovic, D., Terraneo, S., Reyes, L. F., Rupp, J., Gonzalez Del Castillo, J., Blasi, F., Aliberti, S., Restrepo, M. I., Aruj, P. K., Attorri, S., Barimboim, E., Caeiro, J. P., Garzon, M. I., Cambursano, V. H., Cazaux, A., Ceccato, A., Chertcoff, J., Lascar, F., Tulio, F. D., Diaz, A. C., de Vedia, L., Ganaha, M. C., Lambert, S., Lopardo, G., Luna, C. M., Malberti, A. G., Morcillo, N., Tartara, S., Cetrangolo, A. A., Pensotti, C., Pereyra, B., Scapellato, P. G., Stagnaro, J. P., Shah, S., Lotsch, F., Thalhammer, F., Anseeuw, K., Francois, C. A., Van Braeckel, E., Vincent, J. L., Djimon, M. Z., Bashi, J., Dodo, R., Nouer, S. A., Chipev, P., Encheva, M., Miteva, D., Petkova, D., Balkissou, A. D., Yone, E. W. P., Ngahane, B. H. M., Shen, N., Xu, J. F., Rico, C. A. B., Buitrago, R., Paternina, F. J. P., Ntumba, J. K., Carevic, V. V., Jakopovic, M., Jankovic, M., Matkovic, Z., Mitrecic, I., Jacobsson, M. B., Christensen, A. B., Bodtger, U. C. H., Meyer, C. N., Jensen, A. V., Baunbaek-Knudsen, G., Petersen, P. T., Andersen, S., El-Wahhab, I. E. A., Morsy, N. E., Shafiek, H., Sobh, E., Abdulsemed, K. A., Bertrand, F., Brun-Buisson, C., de Montmollin, E., Fartoukh, M., Messika, J., Tattevin, P., Khoury, A., Ebruke, B., Dreher, M., Kolditz, M., Meisinger, M., Niederlausitz, K., Pletz, M. W., Hagel, S., Schaberg, T., Spielmanns, M., Creutz, P., Suttorp, N., Siaw-Lartey, B., Dimakou, K., Papapetrou, D., Tsigou, E., Ampazis, D., Kaimakamis, E., Bhatia, M., Dhar, R., D'Souza, G., Garg, R., Koul, P. A., Mahesh, P. A., Jayaraj, B. S., Narayan, K. V., Udnur, H. B., Krishnamurthy, S. B., Kant, S., Swarnakar, R., Limaye, S., Salvi, S., Golshani, K., Keatings, V. M., Martin-Loeches, I., Maor, Y., Strahilevitz, J., Battaglia, S., Carrabba, M., Ceriana, P., Confalonieri, M., Monforte, A. D., Prato, B. D., Rosa, M., Fantini, R., Fiorentino, G., Gammino, M. A., Menzella, F., Milani, G., Nava, S., Palmiero, G., Petrino, R., Gabrielli, B., Rossi, P., Sorino, C., Steinhilber, G., Zanforlin, A., Franzetti, F., Carugati, M., Morosi, M., Monge, E., Carone, M., Patella, V., Scarlata, S., Comel, A., Kurahashi, K., Bacha, Z. A., Ugalde, D. B., Zuniga, O. C., Villegas, J. F., Medenica, M., van de Garde, E. M. W., Mihsra, D. R., Shrestha, P., Ridgeon, E., Awokola, B. I., Nwankwo, O. N. O., Olufunlola, A. B., Olumide, S., Ukwaja, K. N., Irfan, M., Minarowski, L., Szymon, S., Froes, F., Leuschner, P., Meireles, M., Ferrao, C., Neves, J., Ravara, S. B., Brocovschii, V., Ion, C., Rusu, D., Toma, C., Chirita, D., Dorobat, C. M., Birkun, A., Kaluzhenina, A., Almotairi, A., Bukhary, Z. A. A., Edathodu, J., Fathy, A., Enani, A. M. A., Mohamed, N. E., Memon, J. U., Bella, A., Bogdanovic, N., Milenkovic, B., Pesut, D., Borderias, L., Garcia, N. M. B., Alarcon, H. C., Cilloniz, C., Torres, A., Diaz-Brito, V., Casas, X., Gonzalez, A. E., Fernandez-Almira, Ml., Gallego, M., Gaspar-GarcIa, I., Victoria, P. J., Martinez, E. L., de Molina, R. M., Marcos, P. J., Menendez, R., Pando-Sandoval, A., Aymerich, C. P., de la Torre, A. L., Garcia-Olive, I., Rello, J., Moyano, S., Sanz, F., Sibila, O., Rodrigo-Troyano, A., Sole-Violan, J., Uranga, A., van Boven, J. F. M., Torra, E. V., Pujol, J. A., Feldman, C., Yum, H. K., Fiogbe, A. A., Yangui, F., Bilaceroglu, S., Dalar, L., Yilmaz, U., Bogomolov, A., Elahi, N., Dhasmana, D. J., Feneley, A., Ions, R., Skeemer, J., Woltmann, G., Hancock, C., Hill, A. T., Rudran, B., Ruiz-Buitrago, S., Campbell, M., Whitaker, P., Youzguin, A., Singanayagam, A., Allen, K. S., Brito, V., Dietz, J., Dysart, C. E., Kellie, S. M., Franco-Sadud, R. A., Meier, G., Gaga, M., Holland, T. L., Bergin, S. P., Kheir, F., Landmeier, M., Lois, M., Nair, G. B., Patel, H., Reyes, K., Rodriguez-Cintron, W., Saito, S., Soni, N. J., Noda, J., Hinojosa, C. I., Levine, S. M., Angel, L. F., Anzueto, A., Whitlow, K. S., Hipskind, J., Sukhija, K., Totten, V., Wunderink, R. G., Shah, R. D., Mateyo, K. J., Noriega, L., Alvarado, E., Aman, M., Labra, L., Di Pasquale M.F., Sotgiu G., Gramegna A., Radovanovic D., Terraneo S., Reyes L.F., Rupp J., Gonzalez Del Castillo J., Blasi F., Aliberti S., Restrepo M.I., Aruj P.K., Attorri S., Barimboim E., Caeiro J.P., Garzon M.I., Cambursano V.H., Cazaux A., Ceccato A., Chertcoff J., Lascar F., Tulio F.D., Diaz A.C., de Vedia L., Ganaha M.C., Lambert S., Lopardo G., Luna C.M., Malberti A.G., Morcillo N., Tartara S., Cetrangolo A.A., Pensotti C., Pereyra B., Scapellato P.G., Stagnaro J.P., Shah S., Lotsch F., Thalhammer F., Anseeuw K., Francois C.A., Van Braeckel E., Vincent J.L., Djimon M.Z., Bashi J., Dodo R., Nouer S.A., Chipev P., Encheva M., Miteva D., Petkova D., Balkissou A.D., Yone E.W.P., Ngahane B.H.M., Shen N., Xu J.F., Rico C.A.B., Buitrago R., Paternina F.J.P., Ntumba J.K., Carevic V.V., Jakopovic M., Jankovic M., Matkovic Z., Mitrecic I., Jacobsson M.B., Christensen A.B., Bodtger U.C.H., Meyer C.N., Jensen A.V., Baunbaek-Knudsen G., Petersen P.T., Andersen S., El-Wahhab I.E.A., Morsy N.E., Shafiek H., Sobh E., Abdulsemed K.A., Bertrand F., Brun-Buisson C., de Montmollin E., Fartoukh M., Messika J., Tattevin P., Khoury A., Ebruke B., Dreher M., Kolditz M., Meisinger M., Niederlausitz K., Pletz M.W., Hagel S., Schaberg T., Spielmanns M., Creutz P., Suttorp N., Siaw-Lartey B., Dimakou K., Papapetrou D., Tsigou E., Ampazis D., Kaimakamis E., Bhatia M., Dhar R., D'Souza G., Garg R., Koul P.A., Mahesh P.A., Jayaraj B.S., Narayan K.V., Udnur H.B., Krishnamurthy S.B., Kant S., Swarnakar R., Limaye S., Salvi S., Golshani K., Keatings V.M., Martin-Loeches I., Maor Y., Strahilevitz J., Battaglia S., Carrabba M., Ceriana P., Confalonieri M., Monforte A.D., Prato B.D., Rosa M., Fantini R., Fiorentino G., Gammino M.A., Menzella F., Milani G., Nava S., Palmiero G., Petrino R., Gabrielli B., Rossi P., Sorino C., Steinhilber G., Zanforlin A., Franzetti F., Carugati M., Morosi M., Monge E., Carone M., Patella V., Scarlata S., Comel A., Kurahashi K., Bacha Z.A., Ugalde D.B., Zuniga O.C., Villegas J.F., Medenica M., van de Garde E.M.W., Mihsra D.R., Shrestha P., Ridgeon E., Awokola B.I., Nwankwo O.N.O., Olufunlola A.B., Olumide S., Ukwaja K.N., Irfan M., Minarowski L., Szymon S., Froes F., Leuschner P., Meireles M., Ferrao C., Neves J., Ravara S.B., Brocovschii V., Ion C., Rusu D., Toma C., Chirita D., Dorobat C.M., Birkun A., Kaluzhenina A., Almotairi A., Bukhary Z.A.A., Edathodu J., Fathy A., Enani A.M.A., Mohamed N.E., Memon J.U., Bella A., Bogdanovic N., Milenkovic B., Pesut D., Borderias L., Garcia N.M.B., Alarcon H.C., Cilloniz C., Torres A., Diaz-Brito V., Casas X., Gonzalez A.E., Fernandez-Almira ML., Gallego M., Gaspar-GarcIa I., Victoria P.J., Martinez E.L., de Molina R.M., Marcos P.J., Menendez R., Pando-Sandoval A., Aymerich C.P., de la Torre A.L., Garcia-Olive I., Rello J., Moyano S., Sanz F., Sibila O., Rodrigo-Troyano A., Sole-Violan J., Uranga A., van Boven J.F.M., Torra E.V., Pujol J.A., Feldman C., Yum H.K., Fiogbe A.A., Yangui F., Bilaceroglu S., Dalar L., Yilmaz U., Bogomolov A., Elahi N., Dhasmana D.J., Feneley A., Ions R., Skeemer J., Woltmann G., Hancock C., Hill A.T., Rudran B., Ruiz-Buitrago S., Campbell M., Whitaker P., Youzguin A., Singanayagam A., Allen K.S., Brito V., Dietz J., Dysart C.E., Kellie S.M., Franco-Sadud R.A., Meier G., Gaga M., Holland T.L., Bergin S.P., Kheir F., Landmeier M., Lois M., Nair G.B., Patel H., Reyes K., Rodriguez-Cintron W., Saito S., Soni N.J., Noda J., Hinojosa C.I., Levine S.M., Angel L.F., Anzueto A., Whitlow K.S., Hipskind J., Sukhija K., Totten V., Wunderink R.G., Shah R.D., Mateyo K.J., Noriega L., Alvarado E., Aman M., and Labra L.

Subjects
0301 basic medicine, Male, Pediatrics, Etiology, Multidrug-resistant pathogen, MRSA, Pneumocystis pneumonia, Pneumònia adquirida a la comunitat, HOSPITALIZED-PATIENTS, 0302 clinical medicine, Community-acquired pneumonia, Risk Factors, Prevalence, Medicine, 030212 general & internal medicine, PNEUMOCYSTIS PNEUMONIA, Articles and Commentaries, Aged, 80 and over, Respiratory tract infections, Anemia, Aplastic, Middle Aged, 3. Good health, Community-Acquired Infections, Europe, Infectious Diseases, Immunocompromise, Microbiology, Multidrug-resistant pathogens, Pneumonia, Etiologia, Hematologic Neoplasms, Female, BLOOD-STREAM INFECTIONS, Lung Transplantation, Microbiology (medical), medicine.medical_specialty, Asia, Neutropenia, 030106 microbiology, RESPIRATORY-TRACT INFECTIONS, Settore MED/10 - Malattie Dell'Apparato Respiratorio, TRANSPLANT RECIPIENTS, DISEASES-SOCIETY, 03 medical and health sciences, Immunocompromised Host, Pneumonia, Bacterial, MANAGEMENT, Humans, pneumonia, BACTERIAL PNEUMONIA, Aged, Acquired Immunodeficiency Syndrome, business.industry, microbiology, Bacterial pneumonia, Australia, medicine.disease, multidrug-resistant pathogens, Mycoses, Bacteremia, Africa, RISK-FACTORS, immunocompromise, Americas, business
Abstract

Background The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics of immunocompromised patients coming from the community with pneumonia. Methods We conducted a secondary analysis of an international, multicenter study enrolling adult patients coming from the community with pneumonia and hospitalized in 222 hospitals in 54 countries worldwide. Risk factors for immunocompromise included AIDS, aplastic anemia, asplenia, hematological cancer, chemotherapy, neutropenia, biological drug use, lung transplantation, chronic steroid use, and solid tumor. Results At least 1 risk factor for immunocompromise was recorded in 18% of the 3702 patients enrolled. The prevalences of risk factors significantly differed across continents and countries, with chronic steroid use (45%), hematological cancer (25%), and chemotherapy (22%) the most common. Among immunocompromised patients, community-acquired pneumonia (CAP) pathogens were the most frequently identified, and prevalences did not differ from those in immunocompetent patients. Risk factors for immunocompromise were independently associated with neither Pseudomonas aeruginosa nor non–community-acquired bacteria. Specific risk factors were independently associated with fungal infections (odds ratio for AIDS and hematological cancer, 15.10 and 4.65, respectively; both P = .001), mycobacterial infections (AIDS; P = .006), and viral infections other than influenza (hematological cancer, 5.49; P < .001). Conclusions Our findings could be considered by clinicians in prescribing empiric antibiotic therapy for CAP in immunocompromised patients. Patients with AIDS and hematological cancer admitted with CAP may have higher prevalences of fungi, mycobacteria, and noninfluenza viruses.

Published
2019
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14. Additional file 1 of Critically ill patients with diabetes and Middle East respiratory syndrome: a multi-center observational study

Author

Jesna Jose, Al-Dorzi, Hasan M., Al-Omari, Awad, Mandourah, Yasser, Al-Hameed, Fahad, Musharaf Sadat, Qasim, Eman Al, Alraddadi, Basem, Abdulrahman Al Harthy, Ghaleb A. Al Mekhlafi, Almotairi, Abdullah, Khatib, Kasim Al, Abdulmomen, Ahmed, Qushmaq, Ismael, Anees A. Sindi, Mady, Ahmed, Solaiman, Othman, Rajaa Al-Raddadi, Maghrabi, Khalid, Ragab, Ahmed, Kharaba, Ayman, Shalhoub, Sarah, Abdulsalam M. Al-Aithan, Gajendra K. Vishwakarma, Atanu Bhattacharjee, and Arabi, Yaseen M.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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15. Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study

Author

Carugati, Manuela, Aliberti, S., Sotgiu, G., Blasi, F., Gori, A., Menendez, R., Encheva, M., Gallego, M., Leuschner, P., Ruiz-Buitrago, S., Battaglia, S., Fantini, R., Pascual-Guardia, S., Marin-Corral, J., Restrepo, M. I., Aruj, Patricia Karina, Attorri, Silvia, Barimboim, Enrique, Caeiro, Juan Pablo, Garzón, María I, Cambursano, Victor Hugo, Ceccato, Adrian, Chertcoff, Julio, Lascar, Florencia, Tulio, Fernando Di, Díaz, Ariel Cordon, de Vedia, Lautaro, Ganaha, Maria Cristina, Lambert, Sandra, Lopardo, Gustavo, Luna, Carlos M, Malberti, Alessio Gerardo, Morcillo, Nora, Tartara, Silvina, Pensotti, Claudia, Pereyra, Betiana, Scapellato, Pablo Gustavo, Stagnaro, Juan Pablo, Shah, Sonali, Lötsch, Felix, Thalhammer, Florian, Vincent, Jean Louis, Anseeuw, Kurt, Francois, Camille A, Van Braeckel, Eva, Djimon, Marcel Zannou, Bashi, Jules, Roger, Dodo, Nouér, Simone Aranha, Chipev, Peter, Encheva, Milena, Miteva, Darina, Petkova, Diana, Dodo, Balkissou Adamou, Ngahane, Mbatchou, Hugo, Bertrand, Shen, Ning, Xu, Jin-fu, Rico, Carlos Andres Bustamante, Buitrago, Ricardo, Paternina, Fernando Jose Pereira, Jean-Marie, Kayembe Ntumba, Carevic, Vesna Vladic, Jakopovic, Marko, Jankovic, Mateja, Matkovic, Zinka, Mitrecic, Ivan, Jacobsson, Marie-Laure Bouchy, Christensen, Anette Bro, HeitmannBødtger, Uff e Christian, Meyer, Christian Niels, Jensen, Andreas Vestergaard, Baunbæk-knudsen, Gertrud, Petersen, Pelle Trier, Andersen, Stine, El-Wahhab, Ibrahim El-Said Abd, Morsy, Nesreen Elsayed, Shafiek, Hanaa, Sobh, Eman, Bertrand, Fabrice, Brun-Buisson, Christian, de Montmollin, Etienne, Fartoukh, Muriel, Messika, Jonathan, Tattevin, Pierre, Dreher, Michael, Kolditz, Martin, Meisinger, Matthias, Pletz, Mathias W, Hagel, Stefan, Rupp, Jan, Schaberg, Tom, Spielmanns, Marc, Siaw-Lartey, Beatrice, Dimakou, Katerina, Papapetrou, Dimosthenis, Tsigou, Evdoxia, Ampazis, Dimitrios, Bhatia, Mohit, Dhar, Raja, D’Souza, George, Garg, Rajiv, Koul, Parvaiz A, Mahesh, P A, Jayaraj, B S, Narayan, Kiran Vishnu, Udnur, Hirennappa B, Krishnamurthy, Shashi Bhaskara, Golshani, Keihan, Keatings, Vera M, Martin-Loeches, Ignacio, Maor, Yasmin, Strahilevitz, Jacob, Battaglia, Salvatore, Carrabba, Maria, Ceriana, Piero, Confalonieri, Marco, d’Arminio Monforte, Antonella, Del Prato, Bruno, De Rosa, Marino, Fantini, Riccardo, Fiorentino, Giuseppe, Gammino, Maria Antonia, Menzella, Francesco, Milani, Giuseppe, Nava, Stefano, Palmiero, Gerardo, Petrino, Roberta, Gabrielli, Barbra, Rossi, Paolo, Sorino, Claudio, Steinhilber, Gundi, Zanforlin, Alessandro, Kurahashi, Kiyoyasu, Bacha, Zeina Aoun, Ugalde, Daniel Barajas, Zuñiga, Omar Ceballos, Villegas, José F, Medenica, Milic, van de Garde, E M W, Mihsra, Deebya Raj, Shrestha, Poojan, Ridgeon, Elliott, Awokola, Babatunde Ishola, Nwankwo, Ogonna N O, Olufunlola, Adefuye Bolanle, Olumide, Segaolu, Ukwaja, Kingsley N, Irfan, Muhammad, Minarowski, Lukasz, Szymon, Skoczyński, Froes, Felipe, Leuschner, Pedro, Meireles, Mariana, Ferrão, Cláudia, Neves, João, Ravara, Sofia B, da Beira, Cova, Brocovschii, Victoria, Ion, Chesov, Rusu, Doina, Toma, Cristina, Chirita, Daniela, Birkun, Alexei, Kaluzhenina, Anna, Almotairi, Abdullah, Abdulbaqi, Zakeya, Bukhary, Ali, Edathodu, Jameela, Fathy, Amal, Enani, Abdullah Mushira Abdulaziz, Mohamed, Nazik Eltayeb, Memon, Jawed Ulhadi, Bogdanović, Nada, Milenkovic, Branislava, Pesut, Dragica, Borderìas, Luis, Garcia, Noel Manuel Bordon, Alarcón, Hugo Cabello, Cilloniz, Catia, Torres, Antoni, Diaz-Brito, Vicens, Casas, Xavier, González, Alicia Encabo, Fernández-Almira, Maria Luisa, Gallego, Miguel, Gaspar-GarcÍa, Inmaculada, del Castillo, Juan González, Victoria, Patricia Javaloyes, Martínez, Elena Laserna, de Molina, Rosa Malo, Marcos, Pedro J, Menéndez, Rosario, PandoSandova, Ana, Aymerich, Cristina Prat, del la Torre, Alicia Lacoma, García-Olivé, Ignasi, Rello, Jordi, Moyano, Silvia, Sanz, Francisco, Sibila, Oriol, Rodrigo-Troyano, Ana, Solé-Violán, Jordi, Uranga, Ane, van Boven, Job FM, Torra, Ester Vendrell, Pujol, Jordi Almirall, Feldman, Charles, Yum, Ho Kee, Fiogbe, Arnauld Attannon, Yangui, Ferdaous, Bilaceroglu, Semra, Dalar, Levent, Yilmaz, Ufuk, Bogomolov, Artemii, Elahi, Naheed, Dhasmana, Devesh J, Ions, Rhiannon, Skeemer, Julie, Woltmann, Gerrit, Hancock, Carole, Hill, Adam T, Rudran, Banu, Ruiz-Buitrago, Silvia, Campbell, Marion, Whitaker, Paul, Allen, Karen S, Brito, Veronica, Dietz, Jessica, Dysart, Claire E, Kellie, Susan M, Franco-Sadud, Ricardo A, Meier, Garnet, Gaga, Mina, Holland, Thomas L, Bergin, Stephen P, Kheir, Fayez, Landmeier, Mark, Lois, Manuel, Nair, Girish B, Patel, Hemali, Reyes, Katherine, Rodriguez-Cintron, William, Saito, Shigeki, Soni, Nilam J, Noda, Julio, Hinojosa, Cecilia I, Levine, Stephanie M, Angel, Luis F, Anzueto, Antonio, Whitlow, K Scott, Hipskind, John, Sukhija, Kunal, Wunderink, Richard G., Shah, Ray D, Mateyo, Kondwelani John, Carugati, Manuela, Aliberti, S, Sotgiu, G, Blasi, F, Gori, A, Menendez, R, Encheva, M, Gallego, M, Leuschner, P, Ruiz-Buitrago, S, Battaglia, S, Fantini, R, Pascual-Guardia, S, Marin-Corral, J, and Restrepo, M I

Subjects
Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Community-acquired pneumonia, 030106 microbiology, Antimicrobial treatment, Prevalence, Guideline, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Guidelines, Global Health, medicine.disease_cause, Immunocompromised Host, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Internal medicine, Epidemiology, Streptococcus pneumoniae, Pneumonia, Bacterial, Humans, Medicine, 030212 general & internal medicine, Practice Patterns, Physicians', Aged, Aged, 80 and over, business.industry, Correction, General Medicine, Middle Aged, medicine.disease, Anti-Bacterial Agents, Community-Acquired Infections, Hospitalization, Pneumonia, Infectious Diseases, Practice Guidelines as Topic, Pseudomonas aeruginosa, Etiology, Original Article, Female, Guideline Adherence, business
Abstract

An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p

Published
2020

16. Critically ill patients with diabetes and Middle East respiratory syndrome: A multi-center observational study

Author

Jose, Jesna, primary, Al-Dorzi, Hasan, additional, Al-Omari, Awad, additional, Mandourah, Yasser, additional, Al-Hameed, Fahad, additional, Sadat, Musharaf, additional, Al-Qasim, Eman, additional, Alraddadi, Basem, additional, Harthy, Abdulrahman Al, additional, Mekhlafi, Ghaleb A Al, additional, Almotairi, Abdullah, additional, Khatib, Kasim Al, additional, Abdulmomen, Ahmed, additional, Qushmaq, Ismael, additional, Sindi, Anees, additional, Mady, Ahmed, additional, Solaiman, Othman, additional, Al-Raddadi, Rajaa, additional, Maghrabi, Khaled, additional, Rajab, Ahmed, additional, Kharaba, Ayman, additional, Shalhoub, Sara, additional, Al-Aithan, Abdulsalam M, additional, Vishwakarma, Gajendra K, additional, Bhattacharjee, Atanu, additional, and Arabi, Yaseen, additional

Published
2021
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17. Critically ill patients with diabetes and Middle East respiratory syndrome: A multi-center observational study

Author

Jose, Jesna, primary, Al-Dorzi, Hasan, additional, Al-Omari, Awad, additional, Mandourah, Yasser, additional, Al-Hameed, Fahad, additional, Sadat, Musharaf, additional, Al-Qasim, Eman, additional, Alraddadi, Basem, additional, Harthy, Abdulrahman Al, additional, Mekhlafi, Ghaleb A Al, additional, Almotairi, Abdullah, additional, Khatib, Kasim Al, additional, Abdulmomen, Ahmed, additional, Qushmaq, Ismael, additional, Sindi, Anees, additional, Mady, Ahmed, additional, Solaiman, Othman, additional, Al-Raddadi, Rajaa, additional, Maghrabi, Khaled, additional, Rajab, Ahmed, additional, Kharaba, Ayman, additional, Shalhoub, Sara, additional, Al-Aithan, Abdulsalam M, additional, Vishwakarma, Gajendra K, additional, Bhattacharjee, Atanu, additional, and Arabi, Yaseen, additional

Published
2020
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18. Middle East Respiratory Syndrome in Critically Ill Patients with Diabetes: A Multicenter Observational Study of Clinical Presentation, Management and Outcomes

Author

Jose, Jesna, primary, Al-Dorzi, Hasan, additional, Al-Omari, Awad, additional, Mandourah, Yasser, additional, Al-Hameed, Fahad, additional, Sadat, Musharaf, additional, Al-Qasim, Eman, additional, Alraddadi, Basem, additional, Harthy, Abdulrahman Al, additional, Mekhlafi, Ghaleb A Al, additional, Almotairi, Abdullah, additional, Khatib, Kasim Al, additional, Abdulmomen, Ahmed, additional, Qushmaq, Ismael, additional, Sindi, Anees, additional, Mady, Ahmed, additional, Solaiman, Othman, additional, Al-Raddadi, Rajaa, additional, Maghrabi, Khaled, additional, Rajab, Ahmed, additional, Kharaba, Ayman, additional, Shalhoub, Sara, additional, Al-Aithan, Abdulsalam M, additional, Vishwakarma, Gajendra K, additional, Bhattacharjee, Atanu, additional, and Arabi, Yaseen, additional

Published
2020
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19. Additional file 1: of Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

Author

Arabi, Yaseen, Alothman, Adel, Balkhy, Hanan, Abdulaziz Al-Dawood, Sameera AlJohani, Shmeylan Al Harbi, Kojan, Suleiman, Jeraisy, Majed Al, Deeb, Ahmad, Assiri, Abdullah, Al-Hameed, Fahad, AlSaedi, Asim, Mandourah, Yasser, Ghaleb Almekhlafi, Nisreen Sherbeeni, Fatehi Elzein, Memon, Javed, Yusri Taha, Almotairi, Abdullah, Maghrabi, Khalid, Qushmaq, Ismael, Bshabshe, Ali Al, Kharaba, Ayman, Shalhoub, Sarah, Jesna Jose, Fowler, Robert, Hayden, Frederick, and Hussein, Mohamed

Abstract

SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents*. (DOC 120 kb)

Published
2018
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20. Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study

Author

Arabi, Yaseen M, primary, Shalhoub, Sarah, primary, Mandourah, Yasser, primary, Al-Hameed, Fahad, primary, Al-Omari, Awad, primary, Al Qasim, Eman, primary, Jose, Jesna, primary, Alraddadi, Basem, primary, Almotairi, Abdullah, primary, Al Khatib, Kasim, primary, Abdulmomen, Ahmed, primary, Qushmaq, Ismael, primary, Sindi, Anees A, primary, Mady, Ahmed, primary, Solaiman, Othman, primary, Al-Raddadi, Rajaa, primary, Maghrabi, Khalid, primary, Ragab, Ahmed, primary, Al Mekhlafi, Ghaleb A, primary, Balkhy, Hanan H, primary, Al Harthy, Abdulrahman, primary, Kharaba, Ayman, primary, Gramish, Jawaher A, primary, Al-Aithan, Abdulsalam M, primary, Al-Dawood, Abdulaziz, primary, Merson, Laura, primary, Hayden, Frederick G, primary, and Fowler, Robert, primary

Published
2019
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21. An international perspective on hospitalized patients with viral community-acquired pneumonia

Author

Radovanovic, Dejan, primary, Sotgiu, Giovanni, additional, Jankovic, Mateja, additional, Mahesh, Padukudru Anand, additional, Marcos, Pedro Jorge, additional, Abdalla, Mohamed I., additional, Di Pasquale, Marta Francesca, additional, Gramegna, Andrea, additional, Terraneo, Silvia, additional, Blasi, Francesco, additional, Santus, Pierachille, additional, Aliberti, Stefano, additional, Reyes, Luis F., additional, Restrepo, Marcos I., additional, Aruj, Patricia Karina, additional, Attorri, Silvia, additional, Barimboim, Enrique, additional, Caeiro, Juan Pablo, additional, Garzón, María I., additional, Cambursano, Victor Hugo, additional, Ceccato, Adrian, additional, Chertcoff, Julio, additional, Cordon Díaz, Ariel, additional, de Vedia, Lautaro, additional, Ganaha, Maria Cristina, additional, Lambert, Sandra, additional, Lopardo, Gustavo, additional, Luna, Carlos M., additional, Malberti, Alessio Gerardo, additional, Morcillo, Nora, additional, Tartara, Silvina, additional, Pensotti, Claudia, additional, Pereyra, Betiana, additional, Scapellato, Pablo Gustavo, additional, Stagnaro, Juan Pablo, additional, Shah, Sonali, additional, Lötsch, Felix, additional, Thalhammer, Florian, additional, Anseeuw, Kurt, additional, Francois, Camille A., additional, Van Braeckel, Eva, additional, Vincent, Jean Louis, additional, Djimon, Marcel Zannou, additional, Aranha Nouér, Simone, additional, Chipev, Peter, additional, Encheva, Milena, additional, Miteva, Darina, additional, Petkova, Diana, additional, Balkissou, Adamou Dodo, additional, Pefura Yone, Eric Walter, additional, Mbatchou Ngahane, Bertrand Hugo, additional, Shen, Ning, additional, Xu, Jin-fu, additional, Bustamante Rico, Carlos Andres, additional, Buitrago, Ricardo, additional, Pereira Paternina, Fernando Jose, additional, Kayembe Ntumba, Jean-Marie, additional, Vladic-Carevic, Vesna, additional, Jakopovic, Marko, additional, Matkovic, Zinka, additional, Mitrecic, Ivan, additional, Bouchy Jacobsson, Marie-Laure, additional, Bro Christensen, Anette, additional, Bødtger, Uffe, additional, Meyer, Christian Niels, additional, Vestergaard Jensen, Andreas, additional, El-Said Abd El-Wahhab, Ibrahim, additional, Elsayed Morsy, Nesreen, additional, Shafiek, Hanaa, additional, Sobh, Eman, additional, Abdulsemed, Kedir Abdella, additional, Bertrand, Fabrice, additional, Brun-Buisson, Christian, additional, de Montmollin, Etienne, additional, Fartoukh, Muriel, additional, Messika, Jonathan, additional, Tattevin, Pierre, additional, Khoury, Abdo, additional, Ebruke, Bernard, additional, Dreher, Michael, additional, Kolditz, Martin, additional, Meisinger, Matthias, additional, Pletz, Mathias W., additional, Hagel, Stefan, additional, Rupp, Jan, additional, Schaberg, Tom, additional, Spielmanns, Marc, additional, Creutz, Petra, additional, Suttorp, Norton, additional, Siaw-Lartey, Beatrice, additional, Dimakou, Katerina, additional, Papapetrou, Dimosthenis, additional, Tsigou, Evdoxia, additional, Ampazis, Dimitrios, additional, Kaimakamis, Evangelos, additional, Bhatia, Mohit, additional, Dhar, Raja, additional, D’Souza, George, additional, Garg, Rajiv, additional, Koul, Parvaiz A., additional, Jayaraj, B.S., additional, Narayan, Kiran Vishnu, additional, Udnur, Hirennappa B., additional, Krishnamurthy, Shashi Bhaskara, additional, Kant, Surya, additional, Swarnakar, Rajesh, additional, Salvi, Sundeep, additional, Limaye, Sneha, additional, Golshani, Keihan, additional, Keatings, Vera M., additional, Martin-Loeches, Ignacio, additional, Maor, Yasmin, additional, Strahilevitz, Jacob, additional, Battaglia, Salvatore, additional, Carrabba, Maria, additional, Ceriana, Piero, additional, Confalonieri, Marco, additional, d’Arminio Monforte, Antonella, additional, Del Prato, Bruno, additional, De Rosa, Marino, additional, Fantini, Riccardo, additional, Fiorentino, Giuseppe, additional, Gammino, Maria Antonia, additional, Menzella, Francesco, additional, Milani, Giuseppe, additional, Nava, Stefano, additional, Palmiero, Gerardo, additional, Petrino, Roberta, additional, Gabrielli, Barbra, additional, Rossi, Paolo, additional, Sorino, Claudio, additional, Steinhilber, Gundi, additional, Zanforlin, Alessandro, additional, Franzetti, Fabio, additional, Carone, Mauro, additional, Patella, Vincenzo, additional, Scarlata, Simone, additional, Comel, Andrea, additional, Kurahashi, Kiyoyasu, additional, Aoun Bacha, Zeina, additional, Barajas Ugalde, Daniel, additional, Ceballos Zuñiga, Omar, additional, Villegas, José F., additional, Medenica, Milic, additional, van de Garde, E.M.W., additional, Raj Mihsra, Deebya, additional, Shrestha, Poojan, additional, Ridgeon, Elliott, additional, Ishola Awokola, Babatunde, additional, Nwankwo, Ogonna N.O., additional, Olufunlola, Adefuye Bolanle, additional, Olumide, Segaolu, additional, Ukwaja, Kingsley N., additional, Irfan, Muhammad, additional, Minarowski, Lukasz, additional, Szymon, Skoczyński, additional, Froes, Felipe, additional, Leuschner, Pedro, additional, Meireles, Mariana, additional, Ferrão, Cláudia, additional, Neves, João, additional, Ravara, Sofia B., additional, Brocovschii, Victoria, additional, Ion, Chesov, additional, Rusu, Doina, additional, Toma, Cristina, additional, Chirita, Daniela, additional, Dorobat, Carmen Mihaela, additional, Birkun, Alexei, additional, Kaluzhenina, Anna, additional, Almotairi, Abdullah, additional, Bukhary, Zakeya Abdulbaqi Ali, additional, Edathodu, Jameela, additional, Fathy, Amal, additional, Mushira Abdulaziz Enani, Abdullah, additional, Eltayeb Mohamed, Nazik, additional, Ulhadi Memon, Jawed, additional, Bella, Abdelhaleem, additional, Bogdanović, Nada, additional, Milenkovic, Branislava, additional, Pesut, Dragica, additional, Borderìas, Luis, additional, Bordon Garcia, Noel Manuel, additional, Cabello Alarcón, Hugo, additional, Cilloniz, Catia, additional, Torres, Antoni, additional, Diaz-Brito, Vicens, additional, Casas, Xavier, additional, Encabo González, Alicia, additional, Fernández-Almira, Maria Luisa, additional, Gallego, Miguel, additional, Gaspar-GarcÍa, Inmaculada, additional, González Del Castillo, Juan, additional, Javaloyes Victoria, Patricia, additional, Laserna Martínez, Elena, additional, Malo de Molina, Rosa, additional, Menéndez, Rosario, additional, Pando-Sandoval, Ana, additional, Prat Aymerich, Cristina, additional, Lacoma de la Torre, Alicia, additional, García-Olivé, Ignasi, additional, Rello, Jordi, additional, Moyano, Silvia, additional, Sanz, Francisco, additional, Sibila, Oriol, additional, Rodrigo-Troyano, Ana, additional, Solé-Violán, Jordi, additional, Uranga, Ane, additional, van Boven, Job F.M., additional, Vendrell Torra, Ester, additional, Pujol, Jordi Almirall, additional, Feldman, Charles, additional, Kee Yum, Ho, additional, Fiogbe, Arnauld Attannon, additional, Yangui, Ferdaous, additional, Bilaceroglu, Semra, additional, Dalar, Levent, additional, Yilmaz, Ufuk, additional, Bogomolov, Artemii, additional, Elahi, Naheed, additional, Dhasmana, Devesh J., additional, Feneley, Andrew, additional, Hancock, Carole, additional, Hill, Adam T., additional, Rudran, Banu, additional, Ruiz-Buitrago, Silvia, additional, Campbell, Marion, additional, Whitaker, Paul, additional, Youzguin, Alexander, additional, Singanayagam, Anika, additional, Allen, Karen S., additional, Brito, Veronica, additional, Dietz, Jessica, additional, Dysart, Claire E., additional, Kellie, Susan M., additional, Franco-Sadud, Ricardo A., additional, Meier, Garnet, additional, Gaga, Mina, additional, Holland, Thomas L., additional, Bergin, Stephen P., additional, Kheir, Fayez, additional, Landmeier, Mark, additional, Lois, Manuel, additional, Nair, Girish B., additional, Patel, Hemali, additional, Reyes, Katherine, additional, Rodriguez-Cintron, William, additional, Saito, Shigeki, additional, Soni, Nilam J., additional, Noda, Julio, additional, Hinojosa, Cecilia I., additional, Levine, Stephanie M., additional, Angel, Luis F., additional, Anzueto, Antonio, additional, Scott Whitlow, K., additional, Hipskind, John, additional, Sukhija, Kunal, additional, Totten, Vicken, additional, Wunderink, Richard G., additional, Shah, Ray D., additional, Mateyo, Kondwelani John, additional, Carugati, Manuela, additional, Morosi, Manuela, additional, and Monge, Elisa, additional

Published
2019
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22. Critically ill patients with diabetes and Middle East respiratory syndrome: a multi-center observational study.

Author

Jose, Jesna, Al-Dorzi, Hasan M., Al-Omari, Awad, Mandourah, Yasser, Al-Hameed, Fahad, Sadat, Musharaf, Al Qasim, Eman, Alraddadi, Basem, Al Harthy, Abdulrahman, Al Mekhlafi, Ghaleb A., Almotairi, Abdullah, Al Khatib, Kasim, Abdulmomen, Ahmed, Qushmaq, Ismael, Sindi, Anees A., Mady, Ahmed, Solaiman, Othman, Al-Raddadi, Rajaa, Maghrabi, Khalid, and Ragab, Ahmed

Subjects
MIDDLE East respiratory syndrome, PEOPLE with diabetes, CRITICALLY ill, CORONAVIRUS diseases, LOGISTIC regression analysis, SYMPTOMS
Abstract

Background: Diabetes is a risk factor for infection with coronaviruses. This study describes the demographic, clinical data, and outcomes of critically ill patients with diabetes and Middle East Respiratory Syndrome (MERS).Methods: This retrospective cohort study was conducted at 14 hospitals in Saudi Arabia (September 2012-January 2018). We compared the demographic characteristics, underlying medical conditions, presenting symptoms and signs, management and clinical course, and outcomes of critically ill patients with MERS who had diabetes compared to those with no diabetes. Multivariable logistic regression analysis was performed to determine if diabetes was an independent predictor of 90-day mortality.Results: Of the 350 critically ill patients with MERS, 171 (48.9%) had diabetes. Patients with diabetes were more likely to be older, and have comorbid conditions, compared to patients with no diabetes. They were more likely to present with respiratory failure requiring intubation, vasopressors, and corticosteroids. The median time to clearance of MERS-CoV RNA was similar (23 days (Q1, Q3: 17, 36) in patients with diabetes and 21.0 days (Q1, Q3: 10, 33) in patients with no diabetes). Mortality at 90 days was higher in patients with diabetes (78.9% versus 54.7%, p < 0.0001). Multivariable regression analysis showed that diabetes was an independent risk factor for 90-day mortality (odds ratio, 2.09; 95% confidence interval, 1.18-3.72).Conclusions: Half of the critically ill patients with MERS have diabetes; which is associated with more severe disease. Diabetes is an independent predictor of mortality among critically patients with MERS. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study.

Author

Arabi, Yaseen M, Shalhoub, Sarah, Mandourah, Yasser, Al-Hameed, Fahad, Al-Omari, Awad, Qasim, Eman Al, Jose, Jesna, Alraddadi, Basem, Almotairi, Abdullah, Khatib, Kasim Al, Abdulmomen, Ahmed, Qushmaq, Ismael, Sindi, Anees A, Mady, Ahmed, Solaiman, Othman, Al-Raddadi, Rajaa, Maghrabi, Khalid, Ragab, Ahmed, Mekhlafi, Ghaleb A Al, and Balkhy, Hanan H

Subjects
THERAPEUTIC use of interferons, CRITICAL care medicine, CRITICALLY ill, MEDICAL cooperation, SCIENTIFIC observation, PATIENTS, RESEARCH, RIBAVIRIN, MIDDLE East respiratory syndrome
Abstract

Background The objective of this study was to evaluate the effect of ribavirin and recombinant interferon (RBV/rIFN) therapy on the outcomes of critically ill patients with Middle East respiratory syndrome (MERS), accounting for time-varying confounders. Methods This is a retrospective cohort study of critically ill patients with laboratory-confirmed MERS from 14 hospitals in Saudi Arabia diagnosed between September 2012 and January 2018. We evaluated the association of RBV/rIFN with 90-day mortality and MERS coronavirus (MERS-CoV) RNA clearance using marginal structural modeling to account for baseline and time-varying confounders. Results Of 349 MERS patients, 144 (41.3%) patients received RBV/rIFN (RBV and/or rIFN-α2a, rIFN-α2b, or rIFN-β1a; none received rIFN-β1b). RBV/rIFN was initiated at a median of 2 days (Q1, Q3: 1, 3 days) from intensive care unit admission. Crude 90-day mortality was higher in patients with RBV/rIFN compared to no RBV/rIFN (106/144 [73.6%] vs 126/205 [61.5%]; P =.02]. After adjusting for baseline and time-varying confounders using a marginal structural model, RBV/rIFN was not associated with changes in 90-day mortality (adjusted odds ratio, 1.03 [95% confidence interval {CI},.73–1.44]; P =.87) or with more rapid MERS-CoV RNA clearance (adjusted hazard ratio, 0.65 [95% CI,.30–1.44]; P =.29). Conclusions In this observational study, RBV/rIFN (RBV and/or rIFN-α2a, rIFN-α2b, or rIFN-β1a) therapy was commonly used in critically ill MERS patients but was not associated with reduction in 90-day mortality or in faster MERS-CoV RNA clearance. [ABSTRACT FROM AUTHOR]

Published
2020
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24. Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study

Author

Shalhoub, Sarah, primary, Al-Hameed, Fahad, additional, Mandourah, Yasser, additional, Balkhy, Hanan H., additional, Al-Omari, Awad, additional, Al Mekhlafi, Ghaleb. A., additional, Kharaba, Ayman, additional, Alraddadi, Basem, additional, Almotairi, Abdullah, additional, Al Khatib, Kasim, additional, Abdulmomen, Ahmed, additional, Qushmaq, Ismael, additional, Mady, Ahmed, additional, Solaiman, Othman, additional, Al-Aithan, Abdulsalam M., additional, Al-Raddadi, Rajaa, additional, Ragab, Ahmed, additional, Al Harthy, Abdulrahman, additional, Al Qasim, Eman, additional, Jose, Jesna, additional, Al-Ghamdi, Ghassan, additional, Merson, Laura, additional, Fowler, Robert, additional, Hayden, Frederick G., additional, and Arabi, Yaseen M., additional

Published
2018
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25. Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia

Author

Marin-Corral, Judith, Pascual-Guardia, Sergi, Amati, Francesco, Aliberti, Stefano, Masclans, Joan R., Soni, Nilam, Rodriguez, Alejandro, Sibila, Oriol, Sanz, Francisco, Sotgiu, Giovanni, Anzueto, Antonio, Dimakou, Katerina, Petrino, Roberta, van de Garde, Ewoudt, Restrepo, Marcos I., Aruj, Patricia Karina, Attorri, Silvia, Barimboim, Enrique, Caeiro, Juan Pablo, Garzón, María I., Cambursano, Victor Hugo, Adrian Ceccato, V. H. Dr Cazaux A., Chertcoff, Julio, Lascar, Florencia, Di Tulio, Fernando, Díaz, Ariel Cordon, de Vedia, Lautaro, Ganaha, Maria Cristina, Lambert, Sandra, Lopardo, Gustavo, Luna, Carlos M., Malberti, Alessio Gerardo, Morcillo, Nora, Tartara, Silvina, Pensotti, Claudia, Pereyra, Betiana, Scapellato, Pablo Gustavo, Stagnaro, Juan Pablo, Shah, Sonali, Lötsch, Felix, Thalhammer, Florian, Anseeuw, Kurt, Francois, Camille A., Van Braeckel, Eva, Vincent, Jean Louis, Djimon, Marcel Zannou, Bashi, Jules, Dodo, Roger, Nouér, Simone Aranha, Chipev, Peter, Encheva, Milena, Miteva, Darina, Petkova, Diana, Balkissou, Adamou Dodo, Pefura Yone, Eric Walter, Mbatchou Ngahane, Bertrand Hugo, Shen, Ning, Xu, Jin-fu, Bustamante Rico, Carlos Andres, Buitrago, Ricardo, Pereira Paternina, Fernando Jose, Kayembe Ntumba, Jean-Marie, Carevic, Vesna Vladic, Jakopovic, Marko, Jankovic, Mateja, Matkovic, Zinka, Mitrecic, Ivan, Bouchy Jacobsson, Marie-Laure, Christensen, Anette Bro, Heitmann Bødtger, Uffe Christian, Meyer, Christian Niels, Jensen, Andreas Vestergaard, Baunbæk-knudsen, Gertrud, Petersen, Pelle Trier, Andersen, Stine, El-Said Abd El-Wahhab, Ibrahim, Morsy, Nesreen Elsayed, Shafiek, Hanaa, Sobh, Eman, Abdulsemed, Kedir Abdella, Bertrand, Fabrice, Brun-Buisson, Christian, de Montmollin, Etienne, Fartoukh, Muriel, Messika, Jonathan, Tattevin, Pierre, Khoury, Abdo, Ebruke, Bernard, Dreher, Michael, Kolditz, Martin, Meisinger, Matthias, Pletz, Mathias W., Hagel, Stefan, Rupp, Jan, Schaberg, Tom, Spielmanns, Marc, Creutz, Petra, Suttorp, Norton, Siaw-Lartey, Beatrice, Papapetrou, Dimosthenis, Tsigou, Evdoxia, Ampazis, Dimitrios, Kaimakamis, Evangelos, Bhatia, Mohit, Dhar, Raja, D’Souza, George, Garg, Rajiv, Koul, Parvaiz A., Mahesh, P.A., Jayaraj, B.S., Narayan, Kiran Vishnu, Udnur, Hirennappa B., Krishnamurthy, Shashi Bhaskara, Kant, Surya, Swarnakar, Rajesh, Limaye, Sneha, Salvi, Sundeep, Golshani, Keihan, Keatings, Vera M., Martin-Loeches, Ignacio, Maor, Yasmin, Strahilevitz, Jacob, Faverio, Paola, Battaglia, Salvatore, Carrabba, Maria, Ceriana, Piero, Confalonieri, Marco, Monforte, Antonella d’Arminio, Del Prato, Bruno, De Rosa, Marino, Fantini, Riccardo, Fiorentino, Giuseppe, Gammino, Maria Antonia, Menzella, Francesco, Milani, Giuseppe, Nava, Stefano, Palmiero, Gerardo, Gabrielli, Barbra, Rossi, Paolo, Sorino, Claudio, Steinhilber, Gundi, Zanforlin, Alessandro, San Luca, Ospedale, Franzetti, Fabio, Carugati, Manuela, Morosi, Manuela, Monge, Elisa, Carone, Mauro, Patella, Vincenzo, Scarlata, Simone, Comel, Andrea, Kurahashi, Kiyoyasu, Bacha, Zeina Aoun, Ugalde, Daniel Barajas, Zuñiga, Omar Ceballos, Villegas, José F., Medenica, Milic, Mihsra, Deebya Raj, Shrestha, Poojan, Ridgeon, Elliott, Awokola, Babatunde Ishola, Adefuye Bolanle Olufunlola, Ogonna N.O., Olumide, Segaolu, Ukwaja, Kingsley N., Irfan, Muhammad, Minarowski, Lukasz, Szymon, Skoczyński, Froes, Felipe, Leuschner, Pedro, Meireles, Mariana, Ferrão, Cláudia, Leuschner, Pedro, Neves, João, Salazar, Abel, Ravara, Sofia B., Brocovschii, Victoria, Rusu, Doina, Toma, Cristina, Chirita, Daniela, Dorobat, Carmen Mihaela, Birkun, Alexei, Kaluzhenina, Anna, Almotairi, Abdullah, Ali Bukhary, Zakeya Abdulbaqi, Edathodu, Jameela, Fathy, Amal, Abdulaziz Enani, Abdullah Mushira, Mohamed, Nazik Eltayeb, Memon, Jawed Ulhadi, Bella, Abdelhaleem, Bogdanović, Serbia: Nada, Milenkovic, Branislava, Pesut, Dragica, Borderìas, Luis, Bordon Garcia, Noel Manuel, Alarcón, Hugo Cabello, Cilloniz, Catia, Torres, Antoni, Diaz-Brito, Vicens, Casas, Xavier, González, Alicia Encabo, Fernández-Almira, Maria Luisa, Interna, Medicina, Gallego, Miguel, Gaspar-GarcÍa, Inmaculada, González del Castillo, Juan, Victoria, Patricia Javaloyes, Martínez, Elena Laserna, Malo de Molina, Rosa, Marcos, Pedro J., Menéndez, Rosario, Pando-Sandoval, Ana, Aymerich, Cristina Prat, Lacoma de la Torre, Alicia, García-Olivé, Ignasi, Rello, Jordi, Moyano, Silvia, Rodrigo-Troyano, Ana, Solé-Violán, Jordi, Uranga, Ane, van Boven, Job FM., Torra, Ester Vendrell, Pujol, Jordi Almirall, Feldman, Charles, Yum, Ho Kee, Arnauld Attannon Fiogbe, Inje Univ., Yangui, Ferdaous, Bilaceroglu, Semra, Levent Dalar, Izmir Dr., Yilmaz, Ufuk, Bogomolov, Artemii, Elahi, Naheed, Dhasmana, Devesh J., Feneley, Andrew, Hill, Adam T., Rudran, Banu, Ruiz-Buitrago, Silvia, Campbell, Marion, Whitaker, Paul, Youzguin, Alexander, Singanayagam, Anika, Hancock, C., Villafuerte, David, Allen, Karen S., Brito, Veronica, Dietz, Jessica, Dysart, Claire E., Kellie, Susan M., Ricardo A. Franco-Sadud, Clement J., Meier, Garnet, Gaga, Mina, Holland, Thomas L., Bergin, Stephen P., Kheir, Fayez, Landmeier, Mark, Lois, Manuel, Nair, Girish B., Patel, Hemali, Reyes, Katherine, Rodriguez-Cintron, William, Saito, Shigeki, Noda, Julio, Hinojosa, Cecilia I., Levine, Stephanie M., Reyes, Luis F., Angel, Luis F., Anzueto, Antonio, Whitlow, K. Scott, Hipskind, John, Sukhija, Kunal, Totten, Vicken, Wunderink, Richard G., Shah, Ray D., Mateyo, Kondwelani John, Noriega, Lorena, Alvarado, Ezequiel, Aman, Mohamed, and Labra, Lucía

Abstract

Aspiration community-acquired pneumonia (ACAP) and community-acquired pneumonia (CAP) in patients with aspiration risk factors (AspRFs) are infections associated with anaerobes, but limited evidence suggests their pathogenic role.

Published
2021
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26. Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome.

Author

Alraddadi, Basem M., Qushmaq, Ismael, Al‐Hameed, Fahad M., Mandourah, Yasser, Almekhlafi, Ghaleb A., Jose, Jesna, Al‐Omari, Awad, Kharaba, Ayman, Almotairi, Abdullah, Al Khatib, Kasim, Shalhoub, Sarah, Abdulmomen, Ahmed, Mady, Ahmed, Solaiman, Othman, Al‐Aithan, Abdulsalam M., Al‐Raddadi, Rajaa, Ragab, Ahmed, Balkhy, Hanan H., Al Harthy, Abdulrahman, and Sadat, Musharaf

Subjects
INTENSIVE care units, MIDDLE East respiratory syndrome, NONINVASIVE ventilation, NASAL cannula, CRITICALLY ill, ADULT respiratory distress syndrome, SAUDI Arabians
Abstract

Background: Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied. Methods: Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV). Results: Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90‐day mortality (propensity score‐adjusted odds ratio 0.61, 95% CI [0.23, 1.60] P = 0.27). Conclusions: In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study

Author

Aliberti, Stefano, primary, Reyes, Luis F, additional, Faverio, Paola, additional, Sotgiu, Giovanni, additional, Dore, Simone, additional, Rodriguez, Alejandro H, additional, Soni, Nilam J, additional, Restrepo, Marcos I, additional, Aruj, Patricia Karina, additional, Attorri, Silvia, additional, Barimboim, Enrique, additional, Caeiro, Juan Pablo, additional, Garzón, María I, additional, Cambursano, Victor Hugo, additional, Ceccato, Adrian, additional, Chertcoff, Julio, additional, Lascar, Florencia, additional, Di Tulio, Fernando, additional, Cordon Díaz, Ariel, additional, de Vedia, Lautaro, additional, Ganaha, Maria Cristina, additional, Lambert, Sandra, additional, Lopardo, Gustavo, additional, Luna, Carlos M, additional, Malberti, Alessio Gerardo, additional, Morcillo, Nora, additional, Tartara, Silvina, additional, Pensotti, Claudia, additional, Pereyra, Betiana, additional, Scapellato, Pablo Gustavo, additional, Stagnaro, Juan Pablo, additional, Shah, Sonali, additional, Lötsch, Felix, additional, Thalhammer, Florian, additional, Vincent, Jean Louis, additional, Anseeuw, Kurt, additional, Francois, Camille A, additional, Van Braeckel, Eva, additional, Djimon, Marcel Zannou, additional, Bashi, Jules, additional, Dodo, Roger, additional, Aranha Nouér, Simone, additional, Chipev, Peter, additional, Encheva, Milena, additional, Miteva, Darina, additional, Petkova, Diana, additional, Balkissou, Adamou Dodo, additional, Pefura Yone, Eric Walter, additional, Mbatchou Ngahane, Bertrand Hugo, additional, Shen, Ning, additional, Xu, Jin-fu, additional, Bustamante Rico, Carlos Andres, additional, Buitrago, Ricardo, additional, Pereira Paternina, Fernando Jose, additional, Kayembe Ntumba, Jean-Marie, additional, Vladic Carevic, Vesna, additional, Jakopovic, Marko, additional, Jankovic, Mateja, additional, Matkovic, Zinka, additional, Mitrecic, Ivan, additional, Bouchy Jacobsson, Marie-Laure, additional, Bro Christensen, Anette, additional, Heitmann Bødtger, Uffe Christian, additional, Meyer, Christian Niels, additional, Vestergaard Jensen, Andreas, additional, Baunbæk-knudsen, Gertrud, additional, Trier Petersen, Pelle, additional, Andersen, Stine, additional, El-Said Abd El-Wahhab, Ibrahim, additional, Elsayed Morsy, Nesreen, additional, Shafiek, Hanaa, additional, Sobh, Eman, additional, Abdulsemed, Kedir Abdella, additional, Bertrand, Fabrice, additional, Brun-Buisson, Christian, additional, de Montmollin, Etienne, additional, Fartoukh, Muriel, additional, Messika, Jonathan, additional, Tattevin, Pierre, additional, Khoury, Abdo, additional, Ebruke, Bernard, additional, Dreher, Michael, additional, Kolditz, Martin, additional, Meisinger, Matthias, additional, Pletz, Mathias W, additional, Hagel, Stefan, additional, Rupp, Jan, additional, Schaberg, Tom, additional, Spielmanns, Marc, additional, Creutz, Petra, additional, Suttorp, Norton, additional, Siaw-Lartey, Beatrice, additional, Dimakou, Katerina, additional, Papapetrou, Dimosthenis, additional, Tsigou, Evdoxia, additional, Ampazis, Dimitrios, additional, Kaimakamis, Evangelos, additional, Bhatia, Mohit, additional, Dhar, Raja, additional, D'Souza, George, additional, Garg, Rajiv, additional, Koul, Parvaiz A, additional, Mahesh, P A, additional, Jayaraj, B S, additional, Narayan, Kiran Vishnu, additional, Udnur, Hirennappa B, additional, Krishnamurthy, Shashi Bhaskara, additional, Kant, Surya, additional, Swarnakar, Rajesh, additional, Limaye, Sneha, additional, Salvi, Sundeep, additional, Golshani, Keihan, additional, Keatings, Vera M, additional, Martin-Loeches, Ignacio, additional, Maor, Yasmin, additional, Strahilevitz, Jacob, additional, Battaglia, Salvatore, additional, Carrabba, Maria, additional, Ceriana, Piero, additional, Confalonieri, Marco, additional, d'Arminio Monforte, Antonella, additional, Del Prato, Bruno, additional, De Rosa, Marino, additional, Fantini, Riccardo, additional, Fiorentino, Giuseppe, additional, Gammino, Maria Antonia, additional, Menzella, Francesco, additional, Milani, Giuseppe, additional, Nava, Stefano, additional, Palmiero, Gerardo, additional, Petrino, Roberta, additional, Gabrielli, Barbra, additional, Rossi, Paolo, additional, Sorino, Claudio, additional, Steinhilber, Gundi, additional, Zanforlin, Alessandro, additional, Franzetti, Fabio, additional, Carugati, Manuela, additional, Morosi, Manuela, additional, Monge, Elisa, additional, Carone, Mauro, additional, Patella, Vincenzo, additional, Scarlata, Simone, additional, Comel, Andrea, additional, Kurahashi, Kiyoyasu, additional, Aoun Bacha, Zeina, additional, Barajas Ugalde, Daniel, additional, Ceballos Zuñiga, Omar, additional, Villegas, José F, additional, Medenica, Milic, additional, van de Garde, E M W, additional, Raj Mihsra, Deebya, additional, Shrestha, Poojan, additional, Ridgeon, Elliott, additional, Ishola Awokola, Babatunde, additional, Nwankwo, Ogonna N O, additional, Olufunlola, Adefuye Bolanle, additional, Olumide, Segaolu, additional, Ukwaja, Kingsley N, additional, Irfan, Muhammad, additional, Minarowski, Lukasz, additional, Szymon, Skoczynski, additional, Froes, Felipe, additional, Leuschner, Pedro, additional, Meireles, Mariana, additional, Ferrão, Cláudia, additional, Neves, João, additional, Ravara, Sofia B, additional, Brocovschii, Victoria, additional, Ion, Chesov, additional, Rusu, Doina, additional, Toma, Cristina, additional, Chirita, Daniela, additional, Dorobat, Carmen Mihaela, additional, Birkun, Alexei, additional, Kaluzhenina, Anna, additional, Almotairi, Abdullah, additional, Bukhary, Zakeya Abdulbaqi Ali, additional, Edathodu, Jameela, additional, Fathy, Amal, additional, Mushira Abdulaziz Enani, Abdullah, additional, Eltayeb Mohamed, Nazik, additional, Ulhadi Memon, Jawed, additional, Bella, Abdelhaleem, additional, Bogdanovic, Nada, additional, Milenkovic, Branislava, additional, Pesut, Dragica, additional, Borderìas, Luis, additional, Bordon Garcia, Noel Manuel, additional, Cabello Alarcón, Hugo, additional, Cilloniz, Catia, additional, Torres, Antoni, additional, Diaz-Brito, Vicens, additional, Casas, Xavier, additional, Encabo González, Alicia, additional, Fernández-Almira, Maria Luisa, additional, Gallego, Miguel, additional, Gaspar-GarcÍa, Inmaculada, additional, González del Castillo, Juan, additional, Javaloyes Victoria, Patricia, additional, Laserna Martínez, Elena, additional, Malo de Molina, Rosa, additional, Marcos, Pedro J, additional, Menéndez, Rosario, additional, Pando-Sandoval, Ana, additional, Prat Aymerich, Cristina, additional, Lacoma de la Torre, Alicia, additional, García-Olivé, Ignasi, additional, Rello, Jordi, additional, Moyano, Silvia, additional, Sanz, Francisco, additional, Sibila, Oriol, additional, Rodrigo-Troyano, Ana, additional, Solé-Violán, Jordi, additional, Uranga, Ane, additional, van Boven, Job FM, additional, Vendrell Torra, Ester, additional, Pujol, Jordi Almirall, additional, Feldman, Charles, additional, Kee Yum, Ho, additional, Fiogbe, Arnauld Attannon, additional, Yangui, Ferdaous, additional, Bilaceroglu, Semra, additional, Dalar, Levent, additional, Yilmaz, Ufuk, additional, Bogomolov, Artemii, additional, Elahi, Naheed, additional, Dhasmana, Devesh J, additional, Feneley, Andrew, additional, Ions, Rhiannon, additional, Skeemer, Julie, additional, Woltmann, Gerrit, additional, Hancock, Carole, additional, Hill, Adam T, additional, Rudran, Banu, additional, Ruiz-Buitrago, Silvia, additional, Campbell, Marion, additional, Whitaker, Paul, additional, Youzguin, Alexander, additional, Singanayagam, Anika, additional, Allen, Karen S, additional, Brito, Veronica, additional, Dietz, Jessica, additional, Dysart, Claire E, additional, Kellie, Susan M, additional, Franco-Sadud, Ricardo A, additional, Meier, Garnet, additional, Gaga, Mina, additional, Holland, Thomas L, additional, Bergin, Stephen P, additional, Kheir, Fayez, additional, Landmeier, Mark, additional, Lois, Manuel, additional, Nair, Girish B, additional, Patel, Hemali, additional, Reyes, Katherine, additional, Rodriguez-Cintron, William, additional, Saito, Shigeki, additional, Noda, Julio, additional, Hinojosa, Cecilia I, additional, Levine, Stephanie M, additional, Angel, Luis F, additional, Anzueto, Antonio, additional, Whitlow, K Scott, additional, Hipskind, John, additional, Sukhija, Kunal, additional, Totten, Vicken, additional, Wunderink, Richard G, additional, Shah, Ray D, additional, Mateyo, Kondwelani John, additional, Noriega, Lorena, additional, Alvarado, Ezequiel, additional, Aman, Mohamed, additional, and Labra, Lucía, additional

Published
2016
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29. Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial.

Author

Arabi, Yaseen M., Alothman, Adel, Balkhy, Hanan H., Al-Dawood, Abdulaziz, AlJohani, Sameera, Al Harbi, Shmeylan, Kojan, Suleiman, Al Jeraisy, Majed, Deeb, Ahmad M., Assiri, Abdullah M., Al-Hameed, Fahad, AlSaedi, Asim, Mandourah, Yasser, Almekhlafi, Ghaleb A., Sherbeeni, Nisreen Murad, Elzein, Fatehi Elnour, Memon, Javed, Taha, Yusri, Almotairi, Abdullah, and Maghrabi, Khalid A.

Subjects
MIDDLE East respiratory syndrome, THERAPEUTIC use of interferons, INTERFERONS, TREATMENT effectiveness, LOPINAVIR-ritonavir, PHYSIOLOGY, THERAPEUTICS
Abstract

Background: It had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no specific treatment has been investigated in randomized clinical trials. Results from in vitro and animal studies suggest that a combination of lopinavir/ritonavir and interferon-β1b (IFN-β1b) may be effective against MERS-CoV. The aim of this study is to investigate the efficacy of treatment with a combination of lopinavir/ritonavir and recombinant IFN-β1b provided with standard supportive care, compared to treatment with placebo provided with standard supportive care in patients with laboratory-confirmed MERS requiring hospital admission.Methods: The protocol is prepared in accordance with the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) guidelines. Hospitalized adult patients with laboratory-confirmed MERS will be enrolled in this recursive, two-stage, group sequential, multicenter, placebo-controlled, double-blind randomized controlled trial. The trial is initially designed to include 2 two-stage components. The first two-stage component is designed to adjust sample size and determine futility stopping, but not efficacy stopping. The second two-stage component is designed to determine efficacy stopping and possibly readjustment of sample size. The primary outcome is 90-day mortality.Discussion: This will be the first randomized controlled trial of a potential treatment for MERS. The study is sponsored by King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Enrollment for this study began in November 2016, and has enrolled thirteen patients as of Jan 24-2018.Trial Registration: ClinicalTrials.gov, ID: NCT02845843 . Registered on 27 July 2016. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study.

Author

Al Ahmadi, Mashael, Al Mutairi, Hanan, Al Qasim, Eman, Biostat, Jesna Jose, Nasim, Maliha, Arabi, Yaseen M., Sadat, Musharaf, Al-Dawood, Abdulaziz, Balkhy, Hanan H., Almotairi, Abdullah, Al Khatib, Kasim, Abdulmomen, Ahmed, Al Harthy, Abdulrahman, Mady, Ahmed, Solaiman, Othman, Al-Aithan, Abdulsalam M., Al-Raddadi, Rajaa, Ragab, Ahmed, Kharaba, Ayman, and Merson, Laura

Published
2017
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31. 413

Author

Almotairi, Abdullah, primary and Shahin, Jason, additional

Published
2012
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32. Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia

Author

Judith Marin-Corral, Sergi Pascual-Guardia, Francesco Amati, Stefano Aliberti, Joan R Masclans, Nilam Soni, Alejandro Rodriguez, Oriol Sibila, Francisco Sanz, Giovanni Sotgiu, Antonio Anzueto, Katerina Dimakou, Roberta Petrino, Ewoudt van de Garde, Marcos I Restrepo, GLIMP investigators, Patricia Karina Aruj, Silvia Attorri, Enrique Barimboim, Juan Pablo Caeiro, María I Garzón, Victor Hugo Cambursano, V H Dr Cazaux A Adrian Ceccato, Julio Chertcoff, Florencia Lascar, Fernando Di Tulio, Ariel Cordon Díaz, Lautaro de Vedia, Maria Cristina Ganaha, Sandra Lambert, Gustavo Lopardo, Carlos M Luna, Alessio Gerardo Malberti, Nora Morcillo, Silvina Tartara, Claudia Pensotti, Betiana Pereyra, Pablo Gustavo Scapellato, Juan Pablo Stagnaro, Sonali Shah, Felix Lötsch, Florian Thalhammer, Kurt Anseeuw, Camille A Francois, Eva Van Braeckel, Jean Louis Vincent, Marcel Zannou Djimon, Jules Bashi, Roger Dodo, Simone Aranha Nouér, Peter Chipev, Milena Encheva, Darina Miteva, Diana Petkova, Adamou Dodo Balkissou, Eric Walter Pefura Yone, Bertrand Hugo Mbatchou Ngahane, Ning Shen, Jin-Fu Xu, Carlos Andres Bustamante Rico, Ricardo Buitrago, Fernando Jose Pereira Paternina, Jean-Marie Kayembe Ntumba, Vesna Vladic Carevic, Marko Jakopovic, Mateja Jankovic, Zinka Matkovic, Ivan Mitrecic, Marie-Laure Bouchy Jacobsson, Anette Bro Christensen, Uffe Christian Heitmann Bødtger, Christian Niels Meyer, Andreas Vestergaard Jensen, Gertrud Baunbæk-Knudsen, Pelle Trier Petersen, Stine Andersen, Ibrahim El-Said Abd El-Wahhab, Nesreen Elsayed Morsy, Hanaa Shafiek, Eman Sobh, Kedir Abdella Abdulsemed, Fabrice Bertrand, Christian Brun-Buisson, Etienne de Montmollin, Muriel Fartoukh, Jonathan Messika, Pierre Tattevin, Abdo Khoury, Bernard Ebruke, Michael Dreher, Martin Kolditz, Matthias Meisinger, Mathias W Pletz, Stefan Hagel, Jan Rupp, Tom Schaberg, Marc Spielmanns, Petra Creutz, Norton Suttorp, Beatrice Siaw-Lartey, Dimosthenis Papapetrou, Evdoxia Tsigou, Dimitrios Ampazis, Evangelos Kaimakamis, Mohit Bhatia, Raja Dhar, George D'Souza, Rajiv Garg, Parvaiz A Koul, P A Mahesh, B S Jayaraj, Kiran Vishnu Narayan, Hirennappa B Udnur, Shashi Bhaskara Krishnamurthy, Surya Kant, Rajesh Swarnakar, Sneha Limaye, Sundeep Salvi, Keihan Golshani, Vera M Keatings, Ignacio Martin-Loeches, Yasmin Maor, Jacob Strahilevitz, Paola Faverio, Salvatore Battaglia, Maria Carrabba, Piero Ceriana, Marco Confalonieri, Antonella d'Arminio Monforte, Bruno Del Prato, Marino De Rosa, Riccardo Fantini, Giuseppe Fiorentino, Maria Antonia Gammino, Francesco Menzella, Giuseppe Milani, Stefano Nava, Gerardo Palmiero, Barbra Gabrielli, Paolo Rossi, Claudio Sorino, Gundi Steinhilber, Alessandro Zanforlin, Ospedale San Luca, Fabio Franzetti, Manuela Carugati, Manuela Morosi, Elisa Monge, Mauro Carone, Vincenzo Patella, Simone Scarlata, Andrea Comel, Kiyoyasu Kurahashi, Zeina Aoun Bacha, Daniel Barajas Ugalde, Omar Ceballos Zuñiga, José F Villegas, Milic Medenica, Deebya Raj Mihsra, Poojan Shrestha, Elliott Ridgeon, Babatunde Ishola Awokola, Ogonna N O Adefuye Bolanle Olufunlola, Segaolu Olumide, Kingsley N Ukwaja, Muhammad Irfan, Lukasz Minarowski, Skoczyński Szymon, Felipe Froes, Pedro Leuschner, Mariana Meireles, Cláudia Ferrão, João Neves, Abel Salazar, Sofia B Ravara, Victoria Brocovschii, Doina Rusu, Cristina Toma, Daniela Chirita, Carmen Mihaela Dorobat, Alexei Birkun, Anna Kaluzhenina, Abdullah Almotairi, Zakeya Abdulbaqi Ali Bukhary, Jameela Edathodu, Amal Fathy, Abdullah Mushira Abdulaziz Enani, Nazik Eltayeb Mohamed, Jawed Ulhadi Memon, Abdelhaleem Bella, Serbia Nada Bogdanović, Branislava Milenkovic, Dragica Pesut, Luis Borderìas, Noel Manuel Bordon Garcia, Hugo Cabello Alarcón, Catia Cilloniz, Antoni Torres, Vicens Diaz-Brito, Xavier Casas, Alicia Encabo González, Maria Luisa Fernández-Almira, Medicina Interna, Miguel Gallego, Inmaculada Gaspar-GarcÍa, Juan González Del Castillo, Patricia Javaloyes Victoria, Elena Laserna Martínez, Rosa Malo de Molina, Pedro J Marcos, Rosario Menéndez, Ana Pando-Sandoval, Cristina Prat Aymerich, Alicia Lacoma de la Torre, Ignasi García-Olivé, Jordi Rello, Silvia Moyano, Ana Rodrigo-Troyano, Jordi Solé-Violán, Ane Uranga, Job Fm van Boven, Ester Vendrell Torra, Jordi Almirall Pujol, Charles Feldman, Ho Kee Yum, Inje Univ Arnauld Attannon Fiogbe, Ferdaous Yangui, Semra Bilaceroglu, Izmir Dr Levent Dalar, Ufuk Yilmaz, Artemii Bogomolov, Naheed Elahi, Devesh J Dhasmana, Andrew Feneley, Adam T Hill, Banu Rudran, Silvia Ruiz-Buitrago, Marion Campbell, Paul Whitaker, Alexander Youzguin, Anika Singanayagam, C Hancock, David Villafuerte, Karen S Allen, Veronica Brito, Jessica Dietz, Claire E Dysart, Susan M Kellie, Clement J Ricardo A Franco-Sadud, Garnet Meier, Mina Gaga, Thomas L Holland, Stephen P Bergin, Fayez Kheir, Mark Landmeier, Manuel Lois, Girish B Nair, Hemali Patel, Katherine Reyes, William Rodriguez-Cintron, Shigeki Saito, Julio Noda, Cecilia I Hinojosa, Stephanie M Levine, Luis F Reyes, Luis F Angel, K Scott Whitlow, John Hipskind, Kunal Sukhija, Vicken Totten, Richard G Wunderink, Ray D Shah, Kondwelani John Mateyo, Lorena Noriega, Ezequiel Alvarado, Mohamed Aman, Lucía Labra, Marin-Corral J., Pascual-Guardia S., Amati F., Aliberti S., Masclans J.R., Soni N., Rodriguez A., Sibila O., Sanz F., Sotgiu G., Anzueto A., Dimakou K., Petrino R., van de Garde E., Restrepo M.I., Aruj P.K., Attorri S., Barimboim E., Caeiro J.P., Garzon M.I., Cambursano V.H., Adrian Ceccato V.H.D.C.A., Chertcoff J., Lascar F., Di Tulio F., Diaz A.C., de Vedia L., Ganaha M.C., Lambert S., Lopardo G., Luna C.M., Malberti A.G., Morcillo N., Tartara S., Pensotti C., Pereyra B., Scapellato P.G., Stagnaro J.P., Shah S., Lotsch F., Thalhammer F., Anseeuw K., Francois C.A., Van Braeckel E., Vincent J.L., Djimon M.Z., Bashi J., Dodo R., Nouer S.A., Chipev P., Encheva M., Miteva D., Petkova D., Balkissou A.D., Pefura Yone E.W., Mbatchou Ngahane B.H., Shen N., Xu J.-F., Bustamante Rico C.A., Buitrago R., Pereira Paternina F.J., Kayembe Ntumba J.-M., Carevic V.V., Jakopovic M., Jankovic M., Matkovic Z., Mitrecic I., Bouchy Jacobsson M.-L., Christensen A.B., Heitmann Bodtger U.C., Meyer C.N., Jensen A.V., Baunbaek-knudsen G., Petersen P.T., Andersen S., El-Said Abd El-Wahhab I., Morsy N.E., Shafiek H., Sobh E., Abdulsemed K.A., Bertrand F., Brun-Buisson C., de Montmollin E., Fartoukh M., Messika J., Tattevin P., Khoury A., Ebruke B., Dreher M., Kolditz M., Meisinger M., Pletz M.W., Hagel S., Rupp J., Schaberg T., Spielmanns M., Creutz P., Suttorp N., Siaw-Lartey B., Papapetrou D., Tsigou E., Ampazis D., Kaimakamis E., Bhatia M., Dhar R., D'Souza G., Garg R., Koul P.A., Mahesh P.A., Jayaraj B.S., Narayan K.V., Udnur H.B., Krishnamurthy S.B., Kant S., Swarnakar R., Limaye S., Salvi S., Golshani K., Keatings V.M., Martin-Loeches I., Maor Y., Strahilevitz J., Faverio P., Battaglia S., Carrabba M., Ceriana P., Confalonieri M., Monforte A.D., Del Prato B., De Rosa M., Fantini R., Fiorentino G., Gammino M.A., Menzella F., Milani G., Nava S., Palmiero G., Gabrielli B., Rossi P., Sorino C., Steinhilber G., Zanforlin A., San Luca O., Franzetti F., Carugati M., Morosi M., Monge E., Carone M., Patella V., Scarlata S., Comel A., Kurahashi K., Bacha Z.A., Ugalde D.B., Zuniga O.C., Villegas J.F., Medenica M., Mihsra D.R., Shrestha P., Ridgeon E., Awokola B.I., Adefuye Bolanle Olufunlola O.N.O., Olumide S., Ukwaja K.N., Irfan M., Minarowski L., Szymon S., Froes F., Leuschner P., Meireles M., Ferrao C., Neves J., Abel Salazar, Ravara S.B., Brocovschii V., Rusu D., Toma C., Chirita D., Dorobat C.M., Birkun A., Kaluzhenina A., Almotairi A., Ali Bukhary Z.A., Edathodu J., Fathy A., Abdulaziz Enani A.M., Mohamed N.E., Memon J.U., Bella A., Bogdanovic S.N., Milenkovic B., Pesut D., Borderias L., Bordon Garcia N.M., Alarcon H.C., Cilloniz C., Torres A., Diaz-Brito V., Casas X., Gonzalez A.E., Fernandez-Almira M.L., Interna M., Gallego M., Gaspar-GarcIa I., Gonzalez del Castillo J., Victoria P.J., Martinez E.L., Malo de Molina R., Marcos P.J., Menendez R., Pando-Sandoval A., Aymerich C.P., Lacoma de la Torre A., Garcia-Olive I., Rello J., Moyano S., Rodrigo-Troyano A., Sole-Violan J., Uranga A., van Boven J.F., Torra E.V., Pujol J.A., Feldman C., Yum H.K., Arnauld Attannon Fiogbe I.U., Yangui F., Bilaceroglu S., Levent Dalar I.D., Yilmaz U., Bogomolov A., Elahi N., Dhasmana D.J., Feneley A., Hill A.T., Rudran B., Ruiz-Buitrago S., Campbell M., Whitaker P., Youzguin A., Singanayagam A., Hancock C., Villafuerte D., Allen K.S., Brito V., Dietz J., Dysart C.E., Kellie S.M., Ricardo A. Franco-Sadud C.J., Meier G., Gaga M., Holland T.L., Bergin S.P., Kheir F., Landmeier M., Lois M., Nair G.B., Patel H., Reyes K., Rodriguez-Cintron W., Saito S., Noda J., Hinojosa C.I., Levine S.M., Reyes L.F., Angel L.F., Whitlow K.S., Hipskind J., Sukhija K., Totten V., Wunderink R.G., Shah R.D., Mateyo K.J., Noriega L., Alvarado E., Aman M., Labra L., Marin-Corral, Judith, Pascual-Guardia, Sergi, Amati, Francesco, Aliberti, Stefano, R Masclans, Joan, Soni, Nilam, Rodriguez, Alejandro, Sibila, Oriol, Sanz, Francisco, Sotgiu, Giovanni, Anzueto, Antonio, Dimakou, Katerina, Petrino, Roberta, van de Garde, Ewoudt, I Restrepo, Marco, Investigators, Glimp, Karina Aruj, Patricia, Attorri, Silvia, Barimboim, Enrique, Pablo Caeiro, Juan, I Garzón, María, Hugo Cambursano, Victor, A Adrian Ceccato, V H Dr Cazaux, Chertcoff, Julio, Lascar, Florencia, Di Tulio, Fernando, Cordon Díaz, Ariel, de Vedia, Lautaro, Cristina Ganaha, Maria, Lambert, Sandra, Lopardo, Gustavo, M Luna, Carlo, Gerardo Malberti, Alessio, Morcillo, Nora, Tartara, Silvina, Pensotti, Claudia, Pereyra, Betiana, Gustavo Scapellato, Pablo, Pablo Stagnaro, Juan, Shah, Sonali, Lötsch, Felix, Thalhammer, Florian, Anseeuw, Kurt, A Francois, Camille, Van Braeckel, Eva, Louis Vincent, Jean, Zannou Djimon, Marcel, Bashi, Jule, Dodo, Roger, Aranha Nouér, Simone, Chipev, Peter, Encheva, Milena, Miteva, Darina, Petkova, Diana, Dodo Balkissou, Adamou, Walter Pefura Yone, Eric, Hugo Mbatchou Ngahane, Bertrand, Shen, Ning, Xu, Jin-Fu, Andres Bustamante Rico, Carlo, Buitrago, Ricardo, Jose Pereira Paternina, Fernando, Kayembe Ntumba, Jean-Marie, Vladic Carevic, Vesna, Jakopovic, Marko, Jankovic, Mateja, Matkovic, Zinka, Mitrecic, Ivan, Bouchy Jacobsson, Marie-Laure, Bro Christensen, Anette, Christian Heitmann Bødtger, Uffe, Niels Meyer, Christian, Vestergaard Jensen, Andrea, Baunbæk-Knudsen, Gertrud, Trier Petersen, Pelle, Andersen, Stine, El-Said Abd El-Wahhab, Ibrahim, Elsayed Morsy, Nesreen, Shafiek, Hanaa, Sobh, Eman, Abdella Abdulsemed, Kedir, Bertrand, Fabrice, Brun-Buisson, Christian, de Montmollin, Etienne, Fartoukh, Muriel, Messika, Jonathan, Tattevin, Pierre, Khoury, Abdo, Ebruke, Bernard, Dreher, Michael, Kolditz, Martin, Meisinger, Matthia, W Pletz, Mathia, Hagel, Stefan, Rupp, Jan, Schaberg, Tom, Spielmanns, Marc, Creutz, Petra, Suttorp, Norton, Siaw-Lartey, Beatrice, Papapetrou, Dimostheni, Tsigou, Evdoxia, Ampazis, Dimitrio, Kaimakamis, Evangelo, Bhatia, Mohit, Dhar, Raja, D'Souza, George, Garg, Rajiv, A Koul, Parvaiz, A Mahesh, P, S Jayaraj, B, Vishnu Narayan, Kiran, B Udnur, Hirennappa, Bhaskara Krishnamurthy, Shashi, Kant, Surya, Swarnakar, Rajesh, Limaye, Sneha, Salvi, Sundeep, Golshani, Keihan, M Keatings, Vera, Martin-Loeches, Ignacio, Maor, Yasmin, Strahilevitz, Jacob, Faverio, Paola, Battaglia, Salvatore, Carrabba, Maria, Ceriana, Piero, Confalonieri, Marco, d'Arminio Monforte, Antonella, Del Prato, Bruno, De Rosa, Marino, Fantini, Riccardo, Fiorentino, Giuseppe, Antonia 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Amal, Mushira Abdulaziz Enani, Abdullah, Eltayeb Mohamed, Nazik, Ulhadi Memon, Jawed, Bella, Abdelhaleem, Nada Bogdanović, Serbia, Milenkovic, Branislava, Pesut, Dragica, Borderìas, Lui, Manuel Bordon Garcia, Noel, Cabello Alarcón, Hugo, Cilloniz, Catia, Torres, Antoni, Diaz-Brito, Vicen, Casas, Xavier, Encabo González, Alicia, Luisa Fernández-Almira, Maria, Interna, Medicina, Gallego, Miguel, Gaspar-GarcÍa, Inmaculada, González Del Castillo, Juan, Javaloyes Victoria, Patricia, Laserna Martínez, Elena, Malo de Molina, Rosa, J Marcos, Pedro, Menéndez, Rosario, Pando-Sandoval, Ana, Prat Aymerich, Cristina, Lacoma de la Torre, Alicia, García-Olivé, Ignasi, Rello, Jordi, Moyano, Silvia, Rodrigo-Troyano, Ana, Solé-Violán, Jordi, Uranga, Ane, Fm van Boven, Job, Vendrell Torra, Ester, Almirall Pujol, Jordi, Feldman, Charle, Kee Yum, Ho, Univ Arnauld Attannon Fiogbe, Inje, Yangui, Ferdaou, Bilaceroglu, Semra, Dr Levent Dalar, Izmir, Yilmaz, Ufuk, Bogomolov, Artemii, Elahi, Naheed, J Dhasmana, 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Barimboim, E, Caeiro, J, Garzon, M, Cambursano, V, Adrian Ceccato, V, Chertcoff, J, Lascar, F, Di Tulio, F, Diaz, A, de Vedia, L, Ganaha, M, Lambert, S, Lopardo, G, Luna, C, Malberti, A, Morcillo, N, Tartara, S, Pensotti, C, Pereyra, B, Scapellato, P, Stagnaro, J, Shah, S, Lotsch, F, Thalhammer, F, Anseeuw, K, Francois, C, Van Braeckel, E, Vincent, J, Djimon, M, Bashi, J, Dodo, R, Nouer, S, Chipev, P, Encheva, M, Miteva, D, Petkova, D, Balkissou, A, Pefura Yone, E, Mbatchou Ngahane, B, Shen, N, Xu, J, Bustamante Rico, C, Buitrago, R, Pereira Paternina, F, Kayembe Ntumba, J, Carevic, V, Jakopovic, M, Jankovic, M, Matkovic, Z, Mitrecic, I, Bouchy Jacobsson, M, Christensen, A, Heitmann Bodtger, U, Meyer, C, Jensen, A, Baunbaek-knudsen, G, Petersen, P, Andersen, S, El-Said Abd El-Wahhab, I, Morsy, N, Shafiek, H, Sobh, E, Abdulsemed, K, Bertrand, F, Brun-Buisson, C, de Montmollin, E, Fartoukh, M, Messika, J, Tattevin, P, Khoury, A, Ebruke, B, Dreher, M, Kolditz, M, Meisinger, M, Pletz, M, 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S, Ricardo, A, Meier, G, Gaga, M, Holland, T, Bergin, S, Kheir, F, Landmeier, M, Lois, M, Nair, G, Patel, H, Reyes, K, Rodriguez-Cintron, W, Saito, S, Noda, J, Hinojosa, C, Levine, S, Reyes, L, Angel, L, Whitlow, K, Hipskind, J, Sukhija, K, Totten, V, Wunderink, R, Shah, R, Mateyo, K, Noriega, L, Alvarado, E, Aman, M, and Labra, L

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.drug_class, Aspiration risk, Antibiotics, Nursing home resident, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Critical Care and Intensive Care Medicine, Microbiology, anaerobic, aspiration, bacteria, pneumonia, risk factors, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Community-acquired pneumonia, Taverne, Anti-Bacterial Agent, medicine, Humans, Community-Acquired Infection, 030212 general & internal medicine, Stroke, Aged, Aged, 80 and over, business.industry, Respiratory Aspiration, Middle Aged, medicine.disease, Antibiotic coverage, Anti-Bacterial Agents, Community-Acquired Infections, Hospitalization, Pneumonia, 030228 respiratory system, Risk factors, risk factor, Female, Underweight, medicine.symptom, business, Cardiology and Cardiovascular Medicine
Abstract

Background: Aspiration community-acquired pneumonia (ACAP) and community-acquired pneumonia (CAP) in patients with aspiration risk factors (AspRFs) are infections associated with anaerobes, but limited evidence suggests their pathogenic role. Research Question: What are the aspiration risk factors, microbiology patterns, and empiric anti-anaerobic use in patients hospitalized with CAP? Study Design and Methods: This is a secondary analysis of GLIMP, an international, multicenter, point-prevalence study of adults hospitalized with CAP. Patients were stratified into three groups: (1) ACAP, (2) CAP/AspRF+ (CAP with AspRF), and (3) CAP/AspRF- (CAP without AspRF). Data on demographics, comorbidities, microbiological results, and anti-anaerobic antibiotics were analyzed in all groups. Patients were further stratified in severe and nonsevere CAP groups. Results: We enrolled 2,606 patients with CAP, of which 193 (7.4%) had ACAP. Risk factors independently associated with ACAP were male, bedridden, underweight, a nursing home resident, and having a history of stroke, dementia, mental illness, and enteral tube feeding. Among non-ACAP patients, 1,709 (70.8%) had CAP/AspRF+ and 704 (29.2%) had CAP/AspRF-. Microbiology patterns including anaerobes were similar between CAP/AspRF-, CAP/AspRF+ and ACAP (0.0% vs 1.03% vs 1.64%). Patients with severe ACAP had higher rates of total gram-negative bacteria (64.3% vs 44.3% vs 33.3%, P =.021) and lower rates of total gram-positive bacteria (7.1% vs 38.1% vs 50.0%, P 50% in all groups) independent of AspRFs or ACAP received specific or broad-spectrum anti-anaerobic coverage antibiotics. Interpretation: Hospitalized patients with ACAP or CAP/AspRF+ had similar anaerobic flora compared with patients without aspiration risk factors. Gram-negative bacteria were more prevalent in patients with severe ACAP. Despite having similar microbiological flora between groups, a large proportion of CAP patients received anti-anaerobic antibiotic coverage.

Published
2021

33. Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial.

Author

Arabi YM, Asiri AY, Assiri AM, Aziz Jokhdar HA, Alothman A, Balkhy HH, AlJohani S, Al Harbi S, Kojan S, Al Jeraisy M, Deeb AM, Memish ZA, Ghazal S, Al Faraj S, Al-Hameed F, AlSaedi A, Mandourah Y, Al Mekhlafi GA, Sherbeeni NM, Elzein FE, Almotairi A, Al Bshabshe A, Kharaba A, Jose J, Al Harthy A, Al Sulaiman M, Mady A, Fowler RA, Hayden FG, Al-Dawood A, Abdelzaher M, Bajhmom W, and Hussein MA

Subjects
Antiviral Agents adverse effects, Coronavirus Infections diagnosis, Coronavirus Infections mortality, Coronavirus Infections virology, Data Interpretation, Statistical, Double-Blind Method, Drug Combinations, Host-Pathogen Interactions, Humans, Interferon beta-1b adverse effects, Lopinavir adverse effects, Middle East Respiratory Syndrome Coronavirus pathogenicity, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Ritonavir adverse effects, Saudi Arabia, Time Factors, Treatment Outcome, Antiviral Agents therapeutic use, Coronavirus Infections drug therapy, Interferon beta-1b therapeutic use, Lopinavir therapeutic use, Middle East Respiratory Syndrome Coronavirus drug effects, Ritonavir therapeutic use
Abstract

The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. The MIRACLE trial is designed as a recursive, two-stage, group sequential, multicenter, placebo-controlled, double-blind randomized controlled trial. The aim of this article is to describe the statistical analysis plan for the MIRACLE trial. The primary outcome is 90-day mortality. The primary analysis will follow the intention-to-treat principle. The MIRACLE trial is the first randomized controlled trial for MERS treatment. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02845843. Registered on 27 July 2016.

Published
2020
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