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Sameer A Alkubati,1,2 Khaled M Al-Sayaghi,3,4 Basma Salameh,5 Abdulsalam M Halboup,6,7 Waled A Ahmed,8 Mohannad J Alkuwaisi,1 Mohamed A Zoromba9,10 1Department of Medical Surgical Nursing, University of Hail, Hail, Saudi Arabia; 2Department of Nursing, Hodeida University, Hodeida, Yemen; 3Department of Medical Surgical Nursing, Taibah University, Al‐Madinah Al‐Munawarah, Saudi Arabia; 4Nursing Division, Sana’a University, Sana’a, Yemen; 5Department of Nursing, Arab American University, Jenin, Palestine; 6Department of Clinical Pharmacy and Pharmacy Practice, University of Science and Technology, Sana’a, Yemen; 7Discipline of Clinical Pharmacy, Universiti Sains Malaysia, Penang, Malaysia; 8Community Health Nursing Department, Al-Baha University, Al-Baha, Saudi Arabia; 9Department of Nursing, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; 10Department of Psychiatric and Mental Health Nursing, Mansoura University, Mansoura, EgyptCorrespondence: Abdulsalam M Halboup, Departments of Clinical Pharmacy and Pharmacy Practice, University of Science and Technology, Sana’a, Yemen, Tel +967774960247, Email a.halboup@ust.edu.ye

Sameer A Alkubati,1,2 Khaled M Al-Sayaghi,3,4 Basma Salameh,5 Abdulsalam M Halboup,6,7 Waled AM Ahmed,8 Mohannad J. Alkuwaisi,1 Mohamed A Zoromba9,10 1Department of Medical Surgical Nursing, University of Hail, Hail, Saudi Arabia; 2Department of Nursing, Hodeida University, Hodeida, Yemen; 3Department of Medical Surgical Nursing, Taibah University, Al‐Madinah Al‐Munawarah, Saudi Arabia; 4Nursing Division, Sana’a University, Sana’a, Yemen; 5Department of Nursing, Arab American University, Jenin, Palestine; 6Department of Clinical Pharmacy and Pharmacy Practice, University of Science and Technology, Sana’a, Yemen; 7Discipline of Clinical Pharmacy, Universiti Sains Malaysia, Penang, Malaysia; 8Community Health Nursing Department, Al-Baha University, Al-Baha, Saudi Arabia; 9Department of Nursing, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; 10Department of Psychiatric and Mental Health Nursing, Mansoura University, Mansoura, EgyptCorrespondence: Abdulsalam M Halboup, Departments of Clinical Pharmacy and Pharmacy Practice, University of Science and Technology, Sana’a, Yemen, Tel +967774960247, Email a.halboup@ust.edu.yeBackground: Depression has a negative impact on the health outcomes of hemodialysis (HD) patients, including decreased quality of life and increased morbidity and mortality rates. Therefore, this study aimed to determine the prevalence of depression and its associated factors among HD patients in Hodeida city, Yemen.Methods: A cross-sectional study involving 200 HD patients at the Dialysis Center in Hodeida was conducted from February to May 2022. Data on depression were collected using the 9-item Patient Health Questionnaire (PHQ-9). Association of sociodemographic characteristics of patients with depression were assessed using chi-square, subsequently by multivariable logistic regression. Statistical significance was set at P-values < 0.05.Results: The response rate was 98% (200/204).