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Linear discriminant analysis (LDA) is a widely used technique for data classification. The method offers adequate performance in many classification problems, but it becomes inefficient when the data covariance matrix is ill-conditioned. This often occurs when the feature space's dimensionality is higher than or comparable to the training data size. Regularized LDA (RLDA) methods based on regularized linear estimators of the data covariance matrix have been proposed to cope with such a situation. The performance of RLDA methods is well studied, with optimal regularization schemes already proposed. In this paper, we investigate the capability of a positive semidefinite ridge-type estimator of the inverse covariance matrix that coincides with a nonlinear (NL) covariance matrix estimator. The estimator is derived by reformulating the score function of the optimal classifier utilizing linear estimation methods, which eventually results in the proposed NL-RLDA classifier. We derive asymptotic and consistent estimators of the proposed technique's misclassification rate under the assumptions of a double-asymptotic regime and multivariate Gaussian model for the classes. The consistent estimator, coupled with a one-dimensional grid search, is used to set the value of the regularization parameter required for the proposed NL-RLDA classifier. Performance evaluations based on both synthetic and real data demonstrate the effectiveness of the proposed classifier. The proposed technique outperforms state-of-art methods over multiple datasets. When compared to state-of-the-art methods across various datasets, the proposed technique exhibits superior performance., Comment: \c{opyright} 2024 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works

In many biological applications, the primary objective of study is to quantify the magnitude of treatment effect between two groups. Cohens'd or strictly standardized mean difference (SSMD) can be used to measure effect size however, it is sensitive to violation of assumption of normality. Here, we propose an alternative metric of standardized effect size measure to improve robustness and interpretability, based on the overlap between two sample distributions. The proposed method is a non-parametric generalized variant of SSMD (Strictly Standardized Mean Difference). We characterized proposed measure in various simulation settings to illustrate its behavior. We also investigated finite sample properties on the estimation of effect size and draw some guidelines. As a case study, we applied our measure for hit selection problem in an RNAi experiment and showed superiority of proposed method., Comment: Accepted in International Conference on Bioinformatics and Biomedicine (BIBM) 2020. arXiv admin note: text overlap with arXiv:2001.06384

Channel estimation is an essential part of modern communication systems as it enhances the overall performance of the system. In recent past a variety of adaptive learning methods have been designed to enhance the robustness and convergence speed of the learning process. However, the need for an optimal technique is still there. Herein, for non-Gaussian noisy environment we propose a new class of stochastic gradient algorithm for channel identification. The proposed $q$-least mean fourth ($q$-LMF) is an extension of least mean fourth (LMF) algorithm and it is based on the $q$-calculus which is also known as Jackson derivative. The proposed algorithm utilizes a novel concept of error-correlation energy and normalization of signal to ensure high convergence rate, better stability and low steady-state error. Contrary to the conventional LMF, the proposed method has more freedom for large step-sizes. Extensive experiments show significant gain in the performance of the proposed $q$-LMF algorithm in comparison to the contemporary techniques.