Search

Your search keyword '"Al-Qaisieh B"' showing total 187 results
Start Over Author "Al-Qaisieh B"
187 results on '"Al-Qaisieh B"'

9. Multicentre, deep learning, synthetic-CT generation for ano-rectal MR-only radiotherapy treatment planning

Author

Bird, D, Nix, MG, McCallum, H, Teo, M, Gilbert, A, Casanova, N, Cooper, R, Buckley, DL, Sebag-Montefiore, D, Speight, R, Al-Qaisieh, B, and Henry, AM

Abstract

Background and purpose Comprehensive dosimetric analysis is required prior to the clinical implementation of pelvic MR-only sites, other than prostate, due to the limited number of site specific synthetic-CT (sCT) dosimetric assessments in the literature. This study aims to provide a comprehensive assessment of a deep learning-based, conditional generative adversarial network (cGAN) model for a large ano-rectal cancer cohort. The following challenges were investigated; T2-SPACE MR sequences, patient data from multiple centres and the impact of sex and cancer site on sCT quality. Method RT treatment position CT and T2-SPACE MR scans, from two centres, were collected for 90 ano-rectal patients. A cGAN model trained using a focal loss function, was trained and tested on 46 and 44 CT-MR ano-rectal datasets, paired using deformable registration, respectively. VMAT plans were created on CT and recalculated on sCT. Dose differences and gamma indices assessed sCT dosimetric accuracy. A linear mixed effect (LME) model assessed the impact of centre, sex and cancer site. Results A mean PTV D95% dose difference of 0.1% (range: −0.5% to 0.7%) was found between CT and sCT. All gamma index (1%/1 mm threshold) measurements were >99.0%. The LME model found the impact of modality, cancer site, sex and centre was clinically insignificant (effect ranges: −0.4% and 0.3%). The mean dose difference for all OAR constraints was 0.1%. Conclusion Focal loss cGAN models using T2-SPACE MR sequences from multiple centres can produce generalisable, dosimetrically accurate sCTs for ano-rectal cancers.

Published
2021

12. OC-0524 Evidence supporting anal and rectal cancer MR-only radiotherapy planning clinical implementation

Author

Bird, D., primary, Nix, M., additional, Tyyger, M., additional, Beasley, M., additional, McCallum, H., additional, Teo, M., additional, Casanova, N., additional, Cooper, R., additional, Gilbert, A., additional, Buckley, D., additional, Sebag-Montefiore, D., additional, Henry, A., additional, Speight, R., additional, and Al-Qaisieh, B., additional

Published
2021
Full Text
View/download PDF

22. A Systematic Review of the Clinical Implementation of Pelvic Magnetic Resonance Imaging (MR)-Only Planning for External Beam Radiation Therapy

Author

Bird, D, Henry, AM, Sebag-Montefiore, D, Buckley, DL, Al-Qaisieh, B, and Speight, R

Abstract

The use of magnetic resonance imaging (MRI) scans alone for radiotherapy treatment planning (MR-only planning) has been highlighted as one method of improving patient outcomes. Recent technological advances have meant that introducing MR-only planning to the clinic is now becoming a reality, with several specialist radiotherapy clinics treating patients with this technique. As such, substantial efforts are being made to introduce this technique into wide-spread clinical implementation. A systematic review of publications investigating the clinical implementation of pelvic MR-only radiotherapy treatment planning was undertaken following the PRISMA guidelines. The Medline, Embase, Scopus, Science Direct, CINAHL and Web of Science databases were searched (timespan: all years to 2nd January 2019). Twenty six articles met the inclusion criteria. The studies were grouped into the following categories: 1. MR acquisition and synthetic-CT generation verification, 2. MR distortion quantification and phantom development, 3. Clinical validation of patient treatment positioning in an MR-only workflow and 4. MR-only commissioning processes. Key conclusions from this review are: i) MR-only planning has been clinically implemented for prostate cancer treatments; ii) A substantial amount of work remains to translate MR-only planning into wide spread clinical implementation for all pelvic sites; iii) MR scanner distortions are no longer a barrier to MR-only planning; however they must be managed appropriately; iv) MR-only based patient positioning verification shows promise, however limited evidence is reported in the literature and further investigation is required; and v) a number of MR-only commissioning processes have been reported which can aid centres as they undertake local commissioning, however this needs to be formalised in guidance from national bodies.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results