Search

Simple Summary: Our study conducted at King Abdullah University Hospital (KAUH) in Jordan offers a comprehensive exploration of the correlation between specific Single Nucleotide Polymorphisms (SNPs) in the Serpin B family and the prognosis of Glioblastoma Multiforme (GBM) patients. We reveal that individuals with the G/T genotype of the rs4940595 (Serpinb11) SNP experience worse prognostic outcomes in Jordan compared to those with the G/G-T/T genotype. Additionally, we introduce a Serpin B-related 5-gene risk score and employ bioinformatics analyses with the TCGA-GBM cohort, highlighting the significant association of the Serpin B family with implications for predicting progression-free survival. Pioneering in investigating Serpinb11 SNPs in the Jordanian population, our study establishes a foundation for future research into targeted therapies and precision medicine, closing the gap between genetic variations and clinical outcomes in the context of GBM. Serpins are serine proteinase inhibitors, with several serpins being overexpressed in cancer cells. Thus, we aim to analyze the single-nucleotide polymorphism (SNP) of Serpinb11 and its association with GBM survival. A cohort of 63 GBM patients recruited from King Abdullah University Hospital in Jordan underwent polymorphism analysis and overall survival (OS) assessments. The Cancer Genome Atlas (GBM) cohort was useful for validation. We constructed a risk score using the principal component analysis for the following Serpin genes: Serpinb3, Serpinb5, Serpinb6, Serpinb11, and Serpinb12, and patients were grouped into high- vs. low-risk groups based on the median cutoff. Univariable Cox models were used to study the survival outcomes. We identified a significant association between rs4940595 and survival. In the TCGA cohort, Serpinb3 alterations showed worse OS. Univariable Cox showed worse PFS outcomes with higher SERPINB5 and SERPINB6 expression. A Serpin B 5-gene risk score showed a trend towards worse PFS in the high-risk group. Upregulated DEGs showed GO enrichment in cytokine regulation and production, positive regulation of leukocyte activation, and the MAPK cascade. The high-risk group showed a significantly higher infiltration of M2 macrophages and activated mast cells. Our findings showed a significant role of the Serpin B family in GBM survival in the Jordanian population. [ABSTRACT FROM AUTHOR]

The appeal shall be considered by means of the objection of the non-adversary a way of challenging the judicial decisions and a decision to protect the rights of third parties affected by the effects of the judicial decisions. It is considered to be a legal system of a special nature requesting reconsideration of the first sentence with a view to amending or canceling it and replacing it with another guaranteeing that its legal status and personal interest will not be affected. This study has shown the different legislative trends on the challenge of objecting to the judgments of administrative courts and after detailed research in the legislation under study, we found that the French legislator explicitly allowed third parties to challenge the provisions of the administrative court of the rights of his rights in the codification of administrative justice of the new French, while the Egyptian legislator did not explicitly state that it is permissible to appeal by means of objection by others to the rulings of the administrative courts. This led the jurisprudence and the judiciary to address this issue in order to show different trends that we have analyzed in the research until we reached the conclusion that the Egyptian legislator considered the appeal of the third party is a case to be challenged by way of seeking reconsideration. As for the position of our Jordanian legislator, the provisions of the appeal were organized through the objection of others in the Code of Civil Procedure, and we tried very hard to express an opinion on the applicability of the provisions of the said code to the disputes before the administrative courts. This way of appeal, as well as finding any judicial judgment or diligence is the subject of research in the Jordanian legal library. [ABSTRACT FROM AUTHOR]

Copyright of Dirasat: Shar'ia & Law Sciences is the property of University of Jordan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The primary objective is to evaluate the safety and effectiveness of Stryker second generation Target ® Nano Coils in the treatment of ruptured and unruptured small (<7 mm) intracranial aneurysms., Methods: The TARGET Registry is a prospective, two-arm study with independent medical event monitoring and core-lab adjudication. This paper describes the second arm of the TARGET registry. Patients with de novo intracranial aneurysms were embolized with 2nd generation TARGET Nano coils in 12 US centers. The primary efficacy outcome was adequate aneurysm occlusion (RR occlusion grade I-II) on follow-up. Primary safety outcome was treatment-related morbidity and mortality. Secondary outcomes included aneurysm packing density immediately post-procedure, immediate adequate occlusion, aneurysm re-access rate, retreatment rate and clinical outcomes using modified ranking scale. A secondary analysis investigated the influence of using Nano-predominant coils (≥2/3 of total coil-length) vs. non-Nano-predominant coils (<2/3 of total length)., Results: 150 patients with 155 aneurysms met the inclusion and exclusion criteria. (31%) patients with ruptured and (69%) with unruptured aneurysms were treated using TARGET coils. Median age was 58.8 (SD 12.7), 74.7% were females, and 80% were Caucasians. Mean follow-up was 5.23 (SD 2.27) months. Peri-procedural mortality was seen in 2.0% of patients. Good outcome at discharge (mRS 0-2) was seen in 81.3% of the cohort. The median packing density (SD) was 29.4% (14.9). Mid-term complete/near complete occlusion rate was seen in 96% of aneurysms and complete obliteration was seen in 75.2% of aneurysms. Patients treated predominantly with Nano coils had higher PD (32.6% vs. 26.1%, p  < 0.001). There was no significant difference in clinical and angiographic outcomes. The mid-term mRS0-2 was achieved in 106/109 (97.2%) patients. All-cause mortality was 5/115 (4.3%)., Conclusion: In the multicenter TARGET Registry, 75.8% of aneurysms achieved mid-term complete occlusion, and 96% achieved complete/near complete occlusion with excellent independent functional outcome., Competing Interests: CL was employed by MedX Cro LLC. AP discloses that she is a consultant for Microvention and Penumbra. OZ reports Grant/research support from Genentech, Medtronic Neurovascular and Stryker; is Consultant for Codman, Medtronic Neurovascular, (NIH) StrokeNet, Penumbra, Stryker; honoraria from Codman, Medtronic Neurovascular, Penumbra, and Stryker; and has ownership interest Galaxy Therapeutics, LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Ashouri, Paul, Puri, Liaw, Majjhoo, Taqi, Rai, Badruddin, Alshekhlee, Naravetla, Rayes, Lawson, Al Masaid, Langerford, Shah, Beaty, Lin, Gray-Duvall, Olvany, Slight, Chaubal, Bushnaq, Tan, Al Majali, Elijovich, Sunenshine and Zaidat.)