248 results on '"Al-Karadaghi, Salam"'
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2. Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds
3. Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface
4. Crystal structure of DNA polymerase I from Thermus phage G20c
5. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety
6. Crystal structure and initial characterization of a novel archaeal-like Holliday junction-resolving enzyme from Thermus thermophilus phage Tth15-6
7. Recessiveness and Dominance in Barley Mutants Deficient in Mg-Chelatase Subunit D, an AAA Protein Involved in Chlorophyll Biosynthesis
8. Ribosomal Proteins and Their Structural Transitions on and off the Ribosome
9. The States, Conformational Dynamics, and Fusidic Acid-Resistant Mutants of Elongation Factor G
10. Going to extremes – a metagenomic journey into the dark matter of life
11. The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia
12. Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
13. Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase
14. Substrate-binding Model of the Chlorophyll Biosynthetic Magnesium Chelatase BchH Subunit
15. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety
16. Transmembrane topology of FRO2, a ferric chelate reductase from Arabidopsis thaliana
17. Amino acid residues His183 and Glu264 in Bacillus subtilis Ferrochelatase direct and facilitate the insertion of metal ion into protoporphyrin IX
18. Magnesium Chelatase: The Molecular Motor of Chlorophyll Biosynthesis
19. Chelatases: distort to select?
20. Metal binding to Bacillus subtilis ferrochelatase and interaction between metal sites
21. Metal binding to Saccharomyces cerevisiae ferrochelatase
22. In vivo and in vitro studies of Bacillus subtilis ferrochelatase mutants suggest substrate channeling in the heme biosynthesis pathway
23. Molecular Characterization of a Novel Lytic Enzyme LysC from Clostridium intestinale URNW and Its Antibacterial Activity Mediated by Positively Charged N-Terminal Extension
24. Crystal structures of theBacillus subtilisprophage lytic cassette proteins XepA and YomS
25. A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors
26. Crystal Structure of Thermotoga maritima Ribosome Recycling Factor: A tRNA Mimic
27. N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK† †Electronic supplementary information (ESI) available: Additional biochemical data, chemistry, NMR characterization of final compounds, and biochemical protocols. See DOI: 10.1039/c8md00068a
28. In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase (hDHODH) inhibitors
29. Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation
30. Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors
31. Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS.
32. Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors
33. N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK
34. Iron-induced oligomerization of human FXN81-210 and bacterial CyaY frataxin and the effect of iron chelators
35. The Structure of the Complex between Yeast Frataxin and Ferrochelatase: CHARACTERIZATION AND PRE-STEADY STATE REACTION OF FERROUS IRON DELIVERY AND HEME SYNTHESIS*
36. Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
37. The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
38. Structural basis of the iron storage function of frataxin from single particle reconstruction of the iron loaded oligomer
39. SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY
40. 4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade
41. Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery
42. Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery
43. The Structure of the Complex between Yeast Frataxin and Ferrochelatase
44. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model
45. Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design.
46. Iron-induced oligomerization of human FXN81-210 and bacterial CyaY frataxin and the effect of iron chelators.
47. Three-dimensional structures ofPlasmodium falciparumspermidine synthase with bound inhibitors suggest new strategies for drug design
48. ATP-Induced Conformational Dynamics in the AAA plus Motor Unit of Magnesium Chelatase
49. The AAA(+) motor complex of subunits CobS and CobT of cobaltochelatase visualized by single particle electron microscopy
50. A new cryo-EM single-particle ab initio reconstruction method visualizes secondary structure elements in an ATP-fueled AAA+ motor
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