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3. Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status.

Author

Maguire, Sinead, Al-Emadi, Samar, Alba, Paula, Aguiar, Mathia, Al Lawati, Talal, Alle, Gelsomina, Bermas, Bonnie, Bhana, Suleman, Branimir, Anic, Bulina, Inita, Clowse, Megan, Cogo, Karina, Colunga, Iris, Cook, Claire, Cortez, Karen, Dao, Kathryn, Gianfrancesco, Milena, Gore-Massey, Monique, Gossec, Laure, Grainger, Rebecca, Hausman, Jonathon, Hsu, Tiffany, Hyrich, Kimme, Isnardi, Carolina, Kawano, Yumeko, Kilding, Rachael, Kusevich, Daria, Lawson-Tovey, Saskia, Liew, Jean, McCarthy, Eoghan, Montgumery, Anna, Moyano, Sebastian, Nasir, Noreen, Padjen, Ivan, Papagoras, Charalampos, Patel, Naomi, Pera, Mariana, Pisoni, Cecilia, Pons-Estel, Guillermo, Quiambao, Antonio, Quintana, Rosana, Ruderman, Eric, Sattui, Sebastian, Savio, Veronica, Sciascia, Savino, Sencarova, Marieta, Morales, Rosa, Siddique, Faizah, Sirotich, Emily, Sparks, Jeffrey, Strangfeld, Anja, Sufka, Paul, Tanner, Helen, Tissera, Yohana, Wallace, Zachary, Werner, Marina, Wise, Leanna, Worthing, Angus, Zell, JoAnn, Zepa, Julija, Machado, Pedro, Yazdany, Jinoos, Robinson, Philip, and Conway, Richard

Subjects
COVID-19, patient outcomes, pregnancy, rheumatic disease, vaccination, women’s health, Pregnancy, Infant, Newborn, Female, Humans, COVID-19 Vaccines, COVID-19, COVID-19 Testing, Rheumatic Diseases, Premature Birth, Vaccination
Abstract

OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fishers exact test. RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2% (n = 2). CONCLUSIONS: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

Published
2023

4. Development of a Prediction Model for COVID‐19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry

Author

Izadi, Zara, Gianfrancesco, Milena A, Aguirre, Alfredo, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson‐Tovey, Saskia, Kearsley‐Fleet, Lianne, Schaefer, Martin, Seet, Andrea M, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Al‐Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y‐T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte‐García, Alí, Valenzuela‐Almada, Maria O, Ugarte‐Gil, Manuel F, Ribeiro, Sandra Lúcia Euzébio, de Oliveira Marinho, Adriana, de Azevedo Valadares, Lilian David, Di Giuseppe, Daniela, Hasseli, Rebecca, Richter, Jutta G, Pfeil, Alexander, Schmeiser, Tim, Isnardi, Carolina A, Torres, Alvaro A Reyes, Alle, Gelsomina, Saurit, Verónica, Zanetti, Anna, Carrara, Greta, Labreuche, Julien, Barnetche, Thomas, Herasse, Muriel, Plassart, Samira, Santos, Maria José, Rodrigues, Ana Maria, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Costello, Wendy, Wallace, Zachary S, Yazdany, Jinoos, and Registry, Global Rheumatology Alliance

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Prevention, Rare Diseases, Arthritis, Autoimmune Disease, Good Health and Well Being, Global Rheumatology Alliance Registry, Clinical sciences
Abstract

ObjectiveSome patients with rheumatic diseases might be at higher risk for coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS). We aimed to develop a prediction model for COVID-19 ARDS in this population and to create a simple risk score calculator for use in clinical settings.MethodsData were derived from the COVID-19 Global Rheumatology Alliance Registry from March 24, 2020, to May 12, 2021. Seven machine learning classifiers were trained on ARDS outcomes using 83 variables obtained at COVID-19 diagnosis. Predictive performance was assessed in a US test set and was validated in patients from four countries with independent registries using area under the curve (AUC), accuracy, sensitivity, and specificity. A simple risk score calculator was developed using a regression model incorporating the most influential predictors from the best performing classifier.ResultsThe study included 8633 patients from 74 countries, of whom 523 (6%) had ARDS. Gradient boosting had the highest mean AUC (0.78; 95% confidence interval [CI]: 0.67-0.88) and was considered the top performing classifier. Ten predictors were identified as key risk factors and were included in a regression model. The regression model that predicted ARDS with 71% (95% CI: 61%-83%) sensitivity in the test set, and with sensitivities ranging from 61% to 80% in countries with independent registries, was used to develop the risk score calculator.ConclusionWe were able to predict ARDS with good sensitivity using information readily available at COVID-19 diagnosis. The proposed risk score calculator has the potential to guide risk stratification for treatments, such as monoclonal antibodies, that have potential to reduce COVID-19 disease progression.

Published
2022

5. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Tanten, Romina, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Marques, Claudia D Lopes, Pileggi, Gecilmara CS, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, Yazdany, Jinoos, Registry, COVID-19 Global Rheumatology Alliance, Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Coello, Vanessa V Castro, Salinas, María J Haye, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Ficco, Hernán Maldonado, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Elkin, Maria S Gálvez, Medina, María A, Savio, Veronica, Tessel, Romina Rojas, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, and Lucero, Luciana Gonzalez

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Women's Health, Social Determinants of Health, Infectious Diseases, Coronaviruses, Emerging Infectious Diseases, Good Health and Well Being, COVID-19 Global Rheumatology Alliance Registry, Clinical sciences
Abstract

BackgroundDifferences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally.MethodsIn this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death.Findings14 044 patients from 23 countries were included in the analyses. 10 178 (72·5%) individuals were female and 3866 (27·5%) were male, with a mean age of 54·4 years (SD 15·6). Air pollution (odds ratio 1·10 per 10 μg/m3 [95% CI 1·01-1·17]; p=0·0105), proportion of the population aged 65 years or older (1·19 per 1% increase [1·10-1·30]; p

Published
2022

6. Characteristics associated with poor COVID-19 outcomes in individuals with systemic lupus erythematosus: data from the COVID-19 Global Rheumatology Alliance

Author

Ugarte-Gil, Manuel Francisco, Alarcón, Graciela S, Izadi, Zara, Duarte-García, Ali, Reátegui-Sokolova, Cristina, Clarke, Ann Elaine, Wise, Leanna, Pons-Estel, Guillermo J, Santos, Maria Jose, Bernatsky, Sasha, Ribeiro, Sandra Lúcia Euzébio, Al Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Gilbert, Emily L, Valenzuela-Almada, Maria O, Jönsen, Andreas, Landolfi, Gianpiero, Fredi, Micaela, Goulenok, Tiphaine, Devaux, Mathilde, Mariette, Xavier, Queyrel, Viviane, Romão, Vasco C, Sequeira, Graca, Hasseli, Rebecca, Hoyer, Bimba, Voll, Reinhard E, Specker, Christof, Baez, Roberto, Castro-Coello, Vanessa, Ficco, Hernan Maldonado, Neto, Edgard Torres Reis, Ferreira, Gilda Aparecida Aparecida, Monticielo, Odirlei Andre André, Sirotich, Emily, Liew, Jean, Hausmann, Jonathan, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Costello, Wendy, Wallace, Zachary S, Jacobsohn, Lindsay, Taylor, Tiffany, Ja, Clairissa, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schäfer, Martin, Machado, Pedro M, Robinson, Philip C, Gianfrancesco, Milena, and Yazdany, Jinoos

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Infectious Diseases, Lupus, Emerging Infectious Diseases, Minority Health, Coronaviruses, Autoimmune Disease, Women's Health, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Inflammatory and immune system, Good Health and Well Being, COVID-19, Humans, Lupus Erythematosus, Systemic, Male, Prednisone, Rheumatology, Severity of Illness Index, lupus erythematosus, systemic, epidemiology, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

AimTo determine characteristics associated with more severe outcomes in a global registry of people with systemic lupus erythematosus (SLE) and COVID-19.MethodsPeople with SLE and COVID-19 reported in the COVID-19 Global Rheumatology Alliance registry from March 2020 to June 2021 were included. The ordinal outcome was defined as: (1) not hospitalised, (2) hospitalised with no oxygenation, (3) hospitalised with any ventilation or oxygenation and (4) death. A multivariable ordinal logistic regression model was constructed to assess the relationship between COVID-19 severity and demographic characteristics, comorbidities, medications and disease activity.ResultsA total of 1606 people with SLE were included. In the multivariable model, older age (OR 1.03, 95% CI 1.02 to 1.04), male sex (1.50, 1.01 to 2.23), prednisone dose (1-5 mg/day 1.86, 1.20 to 2.66, 6-9 mg/day 2.47, 1.24 to 4.86 and ≥10 mg/day 1.95, 1.27 to 2.99), no current treatment (1.80, 1.17 to 2.75), comorbidities (eg, kidney disease 3.51, 2.42 to 5.09, cardiovascular disease/hypertension 1.69, 1.25 to 2.29) and moderate or high SLE disease activity (vs remission; 1.61, 1.02 to 2.54 and 3.94, 2.11 to 7.34, respectively) were associated with more severe outcomes. In age-adjusted and sex-adjusted models, mycophenolate, rituximab and cyclophosphamide were associated with worse outcomes compared with hydroxychloroquine; outcomes were more favourable with methotrexate and belimumab.ConclusionsMore severe COVID-19 outcomes in individuals with SLE are largely driven by demographic factors, comorbidities and untreated or active SLE. Patients using glucocorticoids also experienced more severe outcomes.

Published
2022

7. Standards for structured reporting of dual-energy X-ray absorptiometry scans: best practice recommendations by the Pan Arab Osteoporosis Society

Author

El Miedany, Yasser, El Gaafary, Maha, Gadallah, Naglaa, Sulimani, Riad, AlAli, Nadia S., Alzoubi, Ziad, Azim, Atef Abdel, Abdulateef, Nizar, Adib, Gemma, Elwy, Mohamed, Al Izzi, Mustafa Khalid, El Maghraoui, Abdellah, Mahran, Safaa, Masri, Basel K., Al Emadi, Samar, Abu-Zaid, Mohammed Hassan, Saba, Elias, Hassan, Waleed, El Rakaawi, Manal, Otom, Ali, and Elwakil, Walaa

Published
2023
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8. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Author

Sattui, Sebastian E, Conway, Richard, Putman, Michael S, Seet, Andrea M, Gianfrancesco, Milena A, Beins, Kaley, Hill, Catherine, Liew, David, Mackie, Sarah L, Mehta, Puja, Neill, Lorna, Gomez, Gimena, Salinas, Maria Isabel Haye, Maldonado, Federico Nicolas, Mariz, Henrique Ataide, de Sousa Studart, Samia Araujo, Araujo, Nafice Costa, Knight, Ann, Rozza, Davide, Quartuccio, Luca, Samson, Maxime, Bally, Stéphane, Maria, Alexandre TJ, Chazerain, Pascal, Hasseli, Rebecca, Müller-Ladner, Ulf, Hoyer, Bimba F, Voll, Reinhard, Torres, Rita Pinheiro, Luis, Mariana, Ribeirio, Sandra Lucia Euzebio, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, D’Silva, Kristin M, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Almada, Maria Valenzuela, Duarte-García, Alí, Ugarte-Gil, Manuel, Jacobsohn, Lindsay, Izadi, Zara, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Sirotich, Emily, Hausmann, Jonathan S, Sufka, Paul, Bhana, Suleman, Liew, Jean W, Grainger, Rebecca, Machado, Pedro M, Wallace, Zachary S, Yazdany, Jinoos, Robinson, Philip C, Alliance, Global Rheumatology, Dahou, Brahim, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Ribeiro, Francinne Machado, Ribeiro, Sandra Lucia Euzebio, Pinheiro, Marcelo, Quintana, Rosana, Gómez, Gimena, Roberts, Karen, Baez, Roberto Miguel, Coello, Vanessa Castro, Salinas, María J Haye, Torres, Alvaro Andres Reyes, Alle, Gelsomina, Tanten, Romina, Ficco, Hernán Maldonado, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan Alejandro, Schmid, Maria Marcela, Cosatti, Micaela, Gamba, Maria Julieta, Leandro, Carlevaris, Cusa, María Alejandra, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Elkin, Maria Soledad Gálvez, Medina, María Alejandra, and Savio, Veronica

Subjects
Aging, Arthritis, Autoimmune Disease, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Inflammatory and immune system, Global Rheumatology Alliance
Abstract

BackgroundPatients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica.MethodsIn this retrospective cohort study, adult patients (aged ≥18 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Behçet's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease.FindingsOf 1202 eligible patients identified in the registry, 733 (61·0%) were women and 469 (39·0%) were men, and their mean age was 63·8 years (SD 17·1). A total of 374 (31·1%) patients had polymyalgia rheumatica, 353 (29·4%) had ANCA-associated vasculitis, 183 (15·2%) had giant cell arteritis, 112 (9·3%) had Behçet's syndrome, and 180 (15·0%) had other vasculitis. Of 1020 (84·9%) patients with outcome data, 512 (50·2%) were not hospitalised, 114 (11·2%) were hospitalised and did not receive supplemental oxygen, 239 (23·4%) were hospitalised and received ventilation or supplemental oxygen, and 155 (15·2%) died. A higher odds of poor COVID-19 outcomes were observed in patients who were older (per each additional decade of life OR 1·44 [95% CI 1·31-1·57]), were male compared with female (1·38 [1·05-1·80]), had more comorbidities (per each additional comorbidity 1·39 [1·23-1·58]), were taking 10 mg/day or more of prednisolone compared with none (2·14 [1·50-3·04]), or had moderate, or high or severe disease activity compared with those who had disease remission or low disease activity (2·12 [1·49-3·02]). Risk factors varied among different disease subtypes.InterpretationAmong patients with primary systemic vasculitis and polymyalgia rheumatica, severe COVID-19 outcomes were associated with variable and largely unmodifiable risk factors, such as age, sex, and number of comorbidities, as well as treatments, including high-dose glucocorticoids. Our results could be used to inform mitigation strategies for patients with these diseases.FundingAmerican College of Rheumatology and the European Alliance of Associations for Rheumatology.

Published
2021

9. Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry

Author

Yazdany, Jinoos, Ware, Anna, Wallace, Zachary S., Bhana, Suleman, Grainger, Rebecca, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Hausmann, Jonathan S., Liew, Jean W., Sirotich, Emily, Jacobsohn, Lindsay, Strangfeld, Anja, Mateus, Elsa F., Hyrich, Kimme L., Gossec, Laure, Carmona, Loreto, Lawson‐Tovey, Saskia, Kearsley‐Fleet, Lianne, Schaefer, Martin, Ribeiro, Sandra Lucia Euzebio, Al‐Emadi, Samar, Hasseli, Rebecca, Müller‐Ladner, Ulf, Specker, Christof, Schulze‐Koops, Hendrik, Bernardes, Miguel, Fraga, Vanessa Machado, Rodrigues, Ana Maria, Sparks, Jeffrey A., Ljung, Lotta, Di Giuseppe, Daniela, Tidblad, Liselotte, Wise, Leanna, Duarte‐García, Alí, Ugarte‐Gil, Manuel F., Colunga‐Pedraza, Iris Jazmín, Martínez‐Martínez, Marco Ulises, Alpizar‐Rodriguez, Deshire, Xavier, Ricardo Machado, Isnardi, Carolina A., Pera, Mariana, Pons‐Estel, Guillermo, Izadi, Zara, Gianfrancesco, Milena A., Carrara, Greta, Scirè, Carlo Alberto, Zanetti, Anna, and Machado, Pedro M.

Published
2024
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10. Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry

Author

Sparks, Jeffrey A, Wallace, Zachary S, Seet, Andrea M, Gianfrancesco, Milena A, Izadi, Zara, Hyrich, Kimme L, Strangfeld, Anja, Gossec, Laure, Carmona, Loreto, Mateus, Elsa F, Lawson-Tovey, Saskia, Trupin, Laura, Rush, Stephanie, Katz, Patricia, Schmajuk, Gabriela, Jacobsohn, Lindsay, Wise, Leanna, Gilbert, Emily L, Duarte-García, Ali, Valenzuela-Almada, Maria O, Pons-Estel, Guillermo J, Isnardi, Carolina A, Berbotto, Guillermo A, Hsu, Tiffany Y-T, D’Silva, Kristin M, Patel, Naomi J, Kearsley-Fleet, Lianne, Schäfer, Martin, Ribeiro, Sandra Lúcia Euzébio, Al Emadi, Samar, Tidblad, Liselotte, Scirè, Carlo Alberto, Raffeiner, Bernd, Thomas, Thierry, Flipo, René-Marc, Avouac, Jérôme, Seror, Raphaèle, Bernardes, Miguel, Cunha, Maria Margarida, Hasseli, Rebecca, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Specker, Christof, de Souza, Viviane Angelina, da Mota, Licia Maria Henrique, Gomides, Ana Paula Monteiro, Dieudé, Philippe, Nikiphorou, Elena, Kronzer, Vanessa L, Singh, Namrata, Ugarte-Gil, Manuel F, Wallace, Beth, Akpabio, Akpabio, Thomas, Ranjeny, Bhana, Suleman, Costello, Wendy, Grainger, Rebecca, Hausmann, Jonathan S, Liew, Jean W, Sirotich, Emily, Sufka, Paul, Robinson, Philip C, Machado, Pedro M, Yazdany, Jinoos, Dahou, Brahim, Quintana, Rosana, Gómez, Gimena, Roberts, Karen, Baez, Roberto Miguel, Coello, Vanessa Castro, Salinas, María Haye, Maldonado, Federico Nicolas, Reyes, Alvaro Andres, Alle, Gelsomina, Tanten, Romina, Ficco, Hernán Maldonado, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan Alejandro, Schmid, Maria Marcela, Cosatti, Micaela, Gamba, Maria Julieta, Leandro, Carlevaris, Cusa, María Alejandra, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Elkin, Maria Soledad, Medina, María Alejandra, Savio, Veronica, Tessel, Ivana Romina, Alamino, Rodolfo Perez, Werner, Marina Laura, Ornella, Sofía, and Casalla, Luciana

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Rheumatoid Arthritis, Emerging Infectious Diseases, Coronaviruses, Arthritis, Autoimmune Disease, 6.1 Pharmaceuticals, Inflammatory and immune system, Good Health and Well Being, Aged, Antirheumatic Agents, Arthritis, Rheumatoid, COVID-19, Female, Humans, Male, Middle Aged, Registries, SARS-CoV-2, Severity of Illness Index, COVID-19 Global Rheumatology Alliance, Covid-19, abatacept, rheumatoid arthritis, rituximab, tumour necrosis factor inhibitors, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectiveTo investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA).MethodsWe analysed the COVID-19 Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD use for RA at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 inhibitors (IL-6i) or tumour necrosis factor inhibitors (TNFi, reference group). The ordinal COVID-19 severity outcome was (1) no hospitalisation, (2) hospitalisation without oxygen, (3) hospitalisation with oxygen/ventilation or (4) death. We used ordinal logistic regression to estimate the OR (odds of being one level higher on the ordinal outcome) for each drug class compared with TNFi, adjusting for potential baseline confounders.ResultsOf 2869 people with RA (mean age 56.7 years, 80.8% female) on b/tsDMARD at the onset of COVID-19, there were 237 on ABA, 364 on RTX, 317 on IL-6i, 563 on JAKi and 1388 on TNFi. Overall, 613 (21%) were hospitalised and 157 (5.5%) died. RTX (OR 4.15, 95% CI 3.16 to 5.44) and JAKi (OR 2.06, 95% CI 1.60 to 2.65) were each associated with worse COVID-19 severity compared with TNFi. There were no associations between ABA or IL6i and COVID-19 severity.ConclusionsPeople with RA treated with RTX or JAKi had worse COVID-19 severity than those on TNFi. The strong association of RTX and JAKi use with poor COVID-19 outcomes highlights prioritisation of risk mitigation strategies for these people.

Published
2021

11. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Castro Coello, Vanessa V, Haye Salinas, María J, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria S, Medina, María A, Savio, Veronica, Rojas Tessel, Romina, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Maria A, Rodriguez Gil, Gustavo F, Risueño, Fabian, Quaglia, Maria I, Scafati, Julia, Cuchiaro, Natalia L, Rebak, Jonathan E, Pineda, Susana I, Calvo, María E, Picco, Eugenia, Yanzi, Josefina G, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta S, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José L, Kisluk, Boris, Castaños Menescardi, Maria S, Gallo, Rosana, Martire, María V, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina S, Aeschlimann, Carolina, Subils, Gisela, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra L, Pinheiro, Marcelo, Ibáñez, Sebastián, Chassin Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešić, Marko, Anić, Branimir, Ćulo, Melanie-Ivana, Pavelić, Tea A, Stranski, Kristina K, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela M, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zazueta Montiel, Beatriz E, Castillo Ortiz, Angel A, Zamora Tehozol, Erick, Vega Morales, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez Reyna, Tatiana S, Rull Gabayet, Marina, Alpízar Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte Gil, Manuel, Nowakowski, Jarosław, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria M, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Mičeková, Dagmar, Capova, Lubica, Macejova, Zelmira, Šteňová, Emőke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Senčarová, Marieta, Žlnayová, Soňa, Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre Rubio, Natalia, Alegre Sancho, Juan J, Corteguera Coro, Montserrat, Cobeta Garcia, Juan C, Torres Martin, Maria C, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd K, Akar, Servet, Icacan, Ozan C, ÇELİK, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline M, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, Todd, Derrick, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio, Karen, Webb Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Ezzati, Fatemeh, Parks, Deborah, Karp, David, Quiceno, Guillermo, Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Lopes Marques, Claudia D, Pileggi, Gecilmara C S, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, and Yazdany, Jinoos

Published
2022
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12. Telehealth in rheumatology: the 2021 Arab League of Rheumatology Best Practice Guidelines

Author

Ziade, Nelly, Hmamouchi, Ihsane, el Kibbi, Lina, Daou, Melissa, Abdulateef, Nizar, Abutiban, Fatemah, Elzorkany, Bassel, Dahou-Makhloufi, Chafia, Hamdi, Wafa, Al Emadi, Samar, Halabi, Hussein, Alnaqbi, Khalid A., Abu Al Saoud, Sima, Hashad, Soad, Niamane, Radouane, El Rakawi, Manal, Kazkaz, Layla, Saad, Sahar, Eissa, Mervat, Fraser, Ilanca, and Masri, Basel

Published
2022
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14. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Author

Dahou, Brahim, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra Lucia, Pinheiro, Marcelo, Quintana, Rosana, Gómez, Gimena, Roberts, Karen, Baez, Roberto Miguel, Castro Coello, Vanessa, Haye Salinas, María J., Maldonado, Federico Nicolas, Reyes Torres, Alvaro Andres, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan Alejandro, Schmid, Maria Marcela, Cosatti, Micaela, Gamba, Maria Julieta, Leandro, Carlevaris, Cusa, María Alejandra, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria Soledad, Medina, María Alejandra, Savio, Veronica, Rojas Tessel, Ivana Romina, Perez Alamino, Rodolfo, Werner, Marina Laura, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Ma. Alicia, Rodriguez Gil, Gustavo Fabián, Risueño, Fabian, Quaglia, Maria Isabel, Scafati, Julia, Cuchiaro, Natalia Lili, Rebak, Jonathan Eliseo, Pineda, Susana Isabel, Calvo, María Elena, Picco, Eugenia, Gallino Yanzi, Josefina, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta Silvana, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José Luis, Kisluk, Boris, Castaños Menescardi, Maria Sol, Gallo, Rosana, Martire, María Victoria, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina Solange, Aeschlimann, Carolina, Subils, Gisela, Ibáñez, Sebastián, Chassin-Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešic, Marko, Anic, Branimir, Culo, Melanie-Ivana, Pavelic, Tea Ahel, Kovacevic Stranski, Kristina, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela Maria, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir-Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zaueta, Beatriz, Castillo Ortiz, Angel Alejandro, Zamora Tehozol, Erick, Vega, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez-Reyna, Tatiana Sofia, Rull Gabayet, Marina, Alpízar-Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts-van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al-Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte-Gil, Manuel, Nowakowski, Jaroslaw, Al-Emadi, Samar, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria Magdelena, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Miceková, Dagmar, Capova, Lubica, Macejova, Zelmira, Štenová, Emoke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Sencarová, Marieta, Žlnayová, Sona, Anna Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre-Rubio, Natalia, Alegre Sancho, Juan José, Corteguera Coro, Montserrat, Cobeta Garcia, Juan Carlos, Torres Martin, Maria Carmen, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd Kubra, Akar, Servet, Icacan, Ozan Cemal, Çelik, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline Mulvaney, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, D'Silva, Kristin, Hsu, Tiffany, Patel, Naomi, Sparks, Jeffrey, Todd, Derrick, Wallace, Zachary, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Wise, Leanna, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio Toribio, Karen, Webb-Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Fatemeh, Ezzati, Parks, Deborah, Karp, David, Quiceno, Guillermo, Sattui, Sebastian E, Putman, Michael S, Seet, Andrea M, Gianfrancesco, Milena A, Beins, Kaley, Hill, Catherine, Liew, David, Mackie, Sarah L, Mehta, Puja, Neill, Lorna, Gomez, Gimena, Salinas, Maria Isabel Haye, Mariz, Henrique Ataide, de Sousa Studart, Samia Araujo, Araujo, Nafice Costa, Knight, Ann, Rozza, Davide, Quartuccio, Luca, Samson, Maxime, Bally, Stéphane, Maria, Alexandre TJ, Chazerain, Pascal, Hasseli, Rebecca, Müller-Ladner, Ulf, Hoyer, Bimba F, Voll, Reinhard, Torres, Rita Pinheiro, Luis, Mariana, Ribeirio, Sandra Lucia Euzebio, Sparks, Jeffrey A, Hsu, Tiffany Y-T, D’Silva, Kristin M, Patel, Naomi J, Gilbert, Emily, Almada, Maria Valenzuela, Duarte-García, Alí, Jacobsohn, Lindsay, Izadi, Zara, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Sirotich, Emily, Hausmann, Jonathan S, Sufka, Paul, Bhana, Suleman, Liew, Jean W, Grainger, Rebecca, Machado, Pedro M, Wallace, Zachary S, Yazdany, Jinoos, and Robinson, Philip C

Published
2021
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15. Impact of Spondyloarthritis on Pregnancy Outcome: A Descriptive Analysis from a Specialized Center in Qatar

Author

Al Emadi,Samar, Hadwan,Nawal, Saleh,Rawan, Satti,Eman, Singh,Rajvir, Al Emadi,Samar, Hadwan,Nawal, Saleh,Rawan, Satti,Eman, and Singh,Rajvir

Abstract

Samar Al Emadi,1 Nawal Nouman Hadwan,1 Rawan Saleh,1 Eman Satti,1 Rajvir Singh2 1Department of Rheumatology, Hamad Medical Corporation, Doha, Qatar; 2Medical Research Center, Statistics, Hamad Medical Corporation, Doha, QatarCorrespondence: Samar Al Emadi, Department of Rheumatology, Hamad General Hospital, PO Box 3050, Doha, Qatar, Tel +974 55550087, Email salemadi@hamad.qaIntroduction: Spondyloarthritis (SpA) most commonly presents at childbearing age; thus, pregnancy is of concern. However, data on pregnancy outcomes in these patients are limited.Purpose: This study aimed to retrospectively describe pregnancy outcomes in patients with SpA from the Middle East.Patients and Methods: We reviewed the electronic health records of all pregnant women attending a specialized pregnancy and rheumatic disease clinic between 2016 and 2022. All pregnant patients diagnosed with axial spondyloarthritis (axSpA) and peripheral SpA were included. Data on adverse maternal and fetal outcomes were collected.Results: Fifty-seven eligible pregnancies were identified from hospital records: 10 pregnancies ended in early miscarriage. Forty-seven pregnancies resulted in live singleton births, 25 in patients with peripheral SpA and 22 with axSpA. Human leukocyte antigen B27 was positive in 7 (15%) patients and only in women with axSpA. Twenty-nine (64%) patients received treatment throughout pregnancy. Consistent biologic disease-modifying antirheumatic drug (bDMARD) use was high, in eight (32%) patients with peripheral SpA and in nine (41%) with axSpA. A conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) was used as treatment in 11 (50%) patients with peripheral SpA and two (8%) with axSpA. Twenty-two (53%) neonates were delivered by cesarean section, 19 (40%) by normal vaginal delivery and three (6%) by assisted delivery. Additionally, 44 (94%) deliveries were at term, and 42 (91%) neonates had a normal birth weight. Exploration of a subgroup showed no difference in re

Published
2024

17. Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People with Rheumatic Diseases

Author

Yazdany, Jinoos, primary, Ware, Anna, additional, Wallace, Zachary S, additional, Bhana, Suleman, additional, Grainger, Rebecca, additional, Hachulla, Eric, additional, Richez, Christophe, additional, Cacoub, Patrice, additional, Hausmann, Jonathan S, additional, Liew, Jean W, additional, Sirotich, Emily, additional, Jacobsohn, Lindsay, additional, Strangfeld, Anja, additional, Mateus, Elsa F, additional, Hyrich, Kimme L, additional, Gossec, Laure, additional, Carmona, Loreto, additional, Lawson‐Tovey, Saskia, additional, Kearsley‐Fleet, Lianne, additional, Schaefer, Martin, additional, Ribeiro, Sandra Lucia Euzebio, additional, Al‐Emadi, Samar, additional, Hasseli, Rebecca, additional, Müller‐Ladner, Ulf, additional, Specker, Christof, additional, Schulze‐Koops, Hendrik, additional, Bernardes, Miguel, additional, Machado Fraga, Vanessa, additional, Rodrigues, Ana Maria, additional, Sparks, Jeffrey A., additional, Ljung, Lotta, additional, Di Giuseppe, Daniela, additional, Tidblad, Liselotte, additional, Wise, Leanna, additional, Duarte‐García, Alí, additional, Ugarte‐Gil, Manuel F., additional, Colunga‐Pedraza, Iris Jazmín, additional, Martínez‐Martínez, Marco Ulises, additional, Alpizar‐Rodriguez, Deshire, additional, Xavier, Ricardo Machado, additional, Isnardi, Carolina A, additional, Pera, Mariana, additional, Pons‐Estel, Guillermo, additional, Izadi, Zara, additional, Gianfrancesco, Milena A, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Zanetti, Anna, additional, and Machado, Pedro M, additional

Published
2023
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18. Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines

Author

Arayssi, Thurayya, Harfouche, Manale, Darzi, Andrea, Al Emadi, Samar, A. Alnaqbi, Khalid, Badsha, Humeira, Al Balushi, Farida, Dib, Carole, Elzorkany, Bassel, Halabi, Hussein, Hammoudeh, Mohammed, Hazer, Wissam, Masri, Basel, Merashli, Mira, Omair, Mohammed, Salloum, Nelly, Uthman, Imad, Zahirovic, Sumeja, Ziade, Nelly, Bannuru, Raveendhara R., McAlindon, Timothy, Nomier, Mohamed A., Singh, Jasvinder A., Christensen, Robin, Tugwell, Peter, Schünemann, Holger, and Akl, Elie A.

Published
2018
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19. Diagnosis and management of osteoporosis in postmenopausal women in Gulf Cooperation Council (GCC) countries: consensus statement of the GCC countries’ osteoporosis societies under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)

Author

Al-Saleh, Yousef, Al-Daghri, Nasser M., Sabico, Shaun, Alessa, Thamer, Al Emadi, Samar, Alawadi, Fatheya, Al Qasaabi, Salim, Alfutaisi, Abdullah, Al Izzi, Mustafa, Mukhaimer, Jameela, Suhaili, Abdul Rahim, Reginster, Jean-Yves, and Sulimani, Riad

Published
2020
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20. Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction

Author

Sakaue, Saori, Hirata, Jun, Kanai, Masahiro, Suzuki, Ken, Akiyama, Masato, Lai Too, Chun, Arayssi, Thurayya, Hammoudeh, Mohammed, Al Emadi, Samar, Masri, Basel K., Halabi, Hussein, Badsha, Humeira, Uthman, Imad W., Saxena, Richa, Padyukov, Leonid, Hirata, Makoto, Matsuda, Koichi, Murakami, Yoshinori, Kamatani, Yoichiro, and Okada, Yukinori

Published
2020
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22. Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey

Author

Ramos-Remus, Cesar, Ramirez-Gomez, Andrea, Brambila-Barba, Victor, Barajas-Ochoa, Aldo, Castillo-Ortiz, Jose D., Adebajo, Adewale O., Espinoza, Luis R., Aceves-Avila, Francisco J., Sánchez-González, Jorge M., Boudersa, Nadia, Slimani, Samy, Ladjouze-Rezig, Aicha, Diaz, Mónica P., Kirmayr, Karin I., Asnal, Cecilia A., Catoggio, Luis J., Citera, Gustavo, Casado, Gustavo C., Alvarez, Analia P., Pisoni, Cecilia N., Benavente, Emilio, Lopez-Cabanillas, Adriana, Baez, Roberto M., Pons-Estel, Bernardo A., Sacnún, Mónica P., Cavallasca, Javier A., Paniego, Raúl H., Proudman, Susanna M., Thomas, Ranjeny, Major, Gabor, Mathers, David M., Schrieber, Leslie, Haq, Syed A., Islam, Nazrul, Dessein, Patrick H., von Muhlen, Carlos A., Bianchi, Washington A., da R. Castelar-Pinheiro, Geraldo, Feldman-Pollak, Daniel, Cossermelli, Waldenise, Bonfiglioli, Karina R., Giorgi, Rina D., Zabsonre-Tiendrebeogo, Wendlassida J., Russell, Anthony S., Olaru, Lilia, Karsh, Jacob, Fuentealba, Carlos, Aguilera, Sergio, Castro-Esparza, Irene H., Burgos, Paula I., Neira, Oscar, Li, Zhan-guo, Tam, Lai-Shan, Mok, Mo Y., Medina, Yimy F., Moreno-Alvarez, Mario J., Zúñiga-Vera, Andrés E., Vera, Claudia, Quezada, Ivonne, Moreno, Iván M., Calapaqui, Wendy, El-Mardenly, Ghada, Salama, M. Salah, Ragab, Gaafar, Hadidi, Tahsin, Gado, Kamel, Leirisalo-Repo, Marjatta, Tuompo, Riitta, Koivuniemi, Riitta, Berenbaum, Francis, Allanore, Yannick, Constantin, Arnaud, Buttgereit, Frank, Schulze-Koops, Hendrik, Liz, Myriam, Dey, Dzifa, Alonzo-Borjas, Hugo D., Santiago-Pastelín, Carlos B., Cuéllar-Cruz, Víctor, Dharmanand, Balebail G., Yathish, G. C., Akerkar, Shashank M., Malaviya, Anand N., Ahmadzadeh, Arman, Hasunuma, Tomoko, Owino, Benard O., Pacheco-Tena, César, Frausto-Arenas, Aaron, De la Madrid-Cernas, Adrián A., Cardona-Cabrera, Román, Centeno-Valadez, Juan D., Rodríguez-Torres, Isaura M., Vaidya, Binit, Gupta, Arun K., Harrison, Andrew A., Grainger, Rebecca, Nwankwo, Henry M., Diamantopoulos, Andreas P., Mæland, Elisabeth, Besada, Emilio, Gorriz, Luis, Duarte, Margarita, Albrecht, Maria T. Romero-de, Cabrera-Villalba, Sonia, Segami, María I., García-Poma, Augusto, Pérez-Medina, Wilkerson, Ramos, María P., Navarra, Sandra V., Racaza, Geraldine Z., Penserga, Ester G., Manapat-Reyes, Bernadette H., Dianongco, Maria L., Lichauco, Juan J., Torralba, Tito P., Al-Emadi, Samar, Hammoudeh, Mohammed, Botchkova, Anna G., AlSaeedi, Sabri H., Almoallim, Hani, Al-Arfaj, Hussein F., Koh, Wei H., Leung, Ying Y., Whitelaw, David A., Hodkinson, Bridget, García-Miguel, Javier, Duro, Juan C., Andreu, José L., Martin-Mola, Emilio, Ahijón-Lana, María, Finckh, Axel, Alpízar-Rodríguez, Deshiré, Osiri, Manathip, Kasitanon, Nuntana, Louthrenoo, Worawit, de Vries, Niek, van Denderen, Christiaan, Gerritsen, Martjin, van Vollenhoven, Ronald F., Jansen, Tim L., van Riel, Piet, Núñez-Sotelo, Concepción M., Villegas-Morales, Sol, and GEO-RA Group

Published
2017
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23. Development of a Prediction Model for COVID-19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases

Author

Izadi, Zara, Gianfrancesco, Milena A., Aguirre, Alfredo, Strangfeld, Anja, Mateus, Elsa F., Hyrich, Kimme L., Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Seet, Andrea M., Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Al-Emadi, Samar, Sparks, Jeffrey A., Hsu, Tiffany Y.T., Patel, Naomi J., Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O., Ugarte-Gil, Manuel F., Ribeiro, Sandra Lúcia Euzébio, de Oliveira Marinho, Adriana, de Azevedo Valadares, Lilian David, Giuseppe, Daniela Di, Hasseli, Rebecca, Richter, Jutta G., Pfeil, Alexander, Schmeiser, Tim, Isnardi, Carolina A., Reyes Torres, Alvaro A., Alle, Gelsomina, Saurit, Verónica, Zanetti, Anna, Carrara, Greta, Labreuche, Julien, Barnetche, Thomas, Herasse, Muriel, Plassart, Samira, Santos, Maria José, Rodrigues, Ana Maria, Robinson, Philip C., Machado, Pedro M., Sirotich, Emily, Liew, Jean W., Hausmann, Jonathan S., NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
Rheumatology
Abstract

Funding Information: We acknowledge financial support from the ACR and EULAR. The ACR and EULAR were not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2022 The Authors. ACR Open Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. Objective: Some patients with rheumatic diseases might be at higher risk for coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS). We aimed to develop a prediction model for COVID-19 ARDS in this population and to create a simple risk score calculator for use in clinical settings. Methods: Data were derived from the COVID-19 Global Rheumatology Alliance Registry from March 24, 2020, to May 12, 2021. Seven machine learning classifiers were trained on ARDS outcomes using 83 variables obtained at COVID-19 diagnosis. Predictive performance was assessed in a US test set and was validated in patients from four countries with independent registries using area under the curve (AUC), accuracy, sensitivity, and specificity. A simple risk score calculator was developed using a regression model incorporating the most influential predictors from the best performing classifier. Results: The study included 8633 patients from 74 countries, of whom 523 (6%) had ARDS. Gradient boosting had the highest mean AUC (0.78; 95% confidence interval [CI]: 0.67-0.88) and was considered the top performing classifier. Ten predictors were identified as key risk factors and were included in a regression model. The regression model that predicted ARDS with 71% (95% CI: 61%-83%) sensitivity in the test set, and with sensitivities ranging from 61% to 80% in countries with independent registries, was used to develop the risk score calculator. Conclusion: We were able to predict ARDS with good sensitivity using information readily available at COVID-19 diagnosis. The proposed risk score calculator has the potential to guide risk stratification for treatments, such as monoclonal antibodies, that have potential to reduce COVID-19 disease progression. publishersversion published

Published
2022

24. Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status

Author

Maguire, Sinead, primary, Al-Emadi, Samar, additional, Alba, Paula, additional, Aguiar, Mathia Cecilia, additional, Al Lawati, Talal, additional, Alle, Gelsomina, additional, Bermas, Bonnie, additional, Bhana, Suleman, additional, Branimir, Anic, additional, Bulina, Inita, additional, Clowse, Megan, additional, Cogo, Karina, additional, Colunga, Iris, additional, Cook, Claire, additional, Cortez, Karen J, additional, Dao, Kathryn, additional, Gianfrancesco, Milena, additional, Gore-Massey, Monique, additional, Gossec, Laure, additional, Grainger, Rebecca, additional, Hausman, Jonathon, additional, Hsu, Tiffany Y T, additional, Hyrich, Kimme, additional, Isnardi, Carolina, additional, Kawano, Yumeko, additional, Kilding, Rachael, additional, Kusevich, Daria A, additional, Lawson-Tovey, Saskia, additional, Liew, Jean, additional, McCarthy, Eoghan, additional, Montgumery, Anna, additional, Moyano, Sebastian, additional, Nasir, Noreen, additional, Padjen, Ivan, additional, Papagoras, Charalampos, additional, Patel, Naomi J, additional, Pera, Mariana, additional, Pisoni, Cecilia, additional, Pons-Estel, Guillermo, additional, Quiambao, Antonio L, additional, Quintana, Rosana, additional, Ruderman, Eric, additional, Sattui, Sebastian, additional, Savio, Veronica, additional, Sciascia, Savino, additional, Sencarova, Marieta, additional, Morales, Rosa Serrano, additional, Siddique, Faizah, additional, Sirotich, Emily, additional, Sparks, Jeffrey, additional, Strangfeld, Anja, additional, Sufka, Paul, additional, Tanner, Helen, additional, Tissera, Yohana, additional, Wallace, Zachary, additional, Werner, Marina L, additional, Wise, Leanna, additional, Worthing, Angus B, additional, Zell, JoAnn, additional, Zepa, Julija, additional, Machado, Pedro M, additional, Yazdany, Jinoos, additional, Robinson, Philip, additional, and Conway, Richard, additional

Published
2022
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25. Correction to: Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines

Author

Arayssi, Thurayya, Harfouche, Manale, Darzi, Andrea, Al Emadi, Samar, Alnaqbi, Khalid A., Badsha, Humeira, Al Balushi, Farida, Dib, Carole, Elzorkany, Bassel, Halabi, Hussein, Hammoudeh, Mohammed, Hazer, Wissam, Masri, Basel, Merashli, Mira, Omair, Mohammed, Salloum, Nelly, Uthman, Imad, Zahirovic, Sumeja, Ziade, Nelly, Bannuru, Raveendhara R., McAlindon, Timothy, Nomier, Mohamed A., Singh, Jasvinder A., Christensen, Robin, Tugwell, Peter, Schünemann, Holger, and Akl, Elie A.

Published
2018
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29. SARS-CoV-2 breakthrough infections among vaccinated individuals with rheumatic disease: results from the COVID-19 Global Rheumatology Alliance provider registry

Author

Liew, Jean, primary, Gianfrancesco, Milena, additional, Harrison, Carly, additional, Izadi, Zara, additional, Rush, Stephanie, additional, Lawson-Tovey, Saskia, additional, Jacobsohn, Lindsay, additional, Ja, Clairissa, additional, Hyrich, Kimme L, additional, Gossec, Laure, additional, Strangfeld, Anja, additional, Carmona, Loreto, additional, Schäfer, Martin, additional, Frãzao-Mateus, Elsa, additional, Bulina, Inita, additional, Stafford, Frances, additional, Tufan, Abdurrahman, additional, Graver, Christine, additional, Yardımcı, Gözde Kübra, additional, Zepa, Julija, additional, Al Emadi, Samar, additional, Cook, Claire, additional, Abutiban, Fatemah, additional, Dey, Dfiza, additional, Katigbak, Genevieve, additional, Kaufman, Lauren, additional, Kowalski, Emily, additional, Martínez-Martínez, Marco Ulises, additional, Patel, Naomi J, additional, Reyes-Cordero, Greta, additional, Salido, Evelyn, additional, Smith, Ellison, additional, Snow, David, additional, Sparks, Jeffrey, additional, Wise, Leanna, additional, Bhana, Suleman, additional, Gore-Massy, Monique, additional, Grainger, Rebecca, additional, Hausmann, Jonathan, additional, Sirotich, Emily, additional, Sufka, Paul, additional, Wallace, Zachary, additional, Machado, Pedro M, additional, Robinson, Philip C, additional, and Yazdany, Jinoos, additional

Published
2022
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31. Country-Level Factors Associated With COVID-19-Related Death in People With Rheumatic Disease: Results From the COVID-19 Global Rheumatology Alliance Registry

Author

Izadi, Zara, primary, Gianfrancesco, Milena A., additional, Schmajuk, Gabriela, additional, Jacobsohn, Lindsay, additional, Katz, Patricia, additional, Rush, Stephanie, additional, Ja, Clairissa, additional, Taylor, Tiffany, additional, Shidara, Kie, additional, Danila, Maria I., additional, Wysham, Katherine D., additional, Strangfeld, Anja, additional, Frãzao Mateus, Elsa, additional, Hyrich, Kimme L., additional, Gossec, Laure, additional, Carmona, Loreto, additional, Lawson-Tovey, Saskia, additional, Kearsley-Fleet, Lianne, additional, Schaefer, Martin, additional, Al-Emadi, Samar, additional, Sparks, Jeffrey A., additional, Hsu, Tiffany Y-T, additional, Patel, Naomi J., additional, Wise, Leanna, additional, Gilbert, Emily, additional, Duarte-García, Alí, additional, Valenzuela-Almada, Maria O., additional, Ugarte-Gil, Manuel F., additional, Ljung, Lotta, additional, Scirè, Carlo A., additional, Carrara, Greta, additional, Hachulla, Eric, additional, RICHEZ, Christophe, additional, CACOUB, Patrice, additional, Thomas, Thierry, additional, Santos, Maria J., additional, Bernardes, Miguel, additional, Hasseli, Rebecca, additional, Regierer, Anne, additional, Schulze-Koops, Hendrik, additional, Müller-Ladner, Ulf, additional, Pons-Estel, Guillermo, additional, Tanten, Romina, additional, Nieto, Romina E., additional, Pisoni, Cecilia Nora, additional, Tissera, Yohana S., additional, Xavier, Ricardo, additional, Marques, Claudia D. Lopes, additional, Pileggi, Gecilmara Cristina Salviato, additional, Robinson, Philip C., additional, Machado, Pedro M., additional, Sirotich, Emily, additional, Liew, Jean W., additional, Hausmann, Jonathan S., additional, Sufka, Paul, additional, Grainger, Rebecca, additional, Bhana, Suleman, additional, Gore-Massy, Monique, additional, Wallace, Zachary S., additional, Yazdany, Jinoos, additional, and Registry, Global Rheumatology Alliance, additional

Published
2022
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33. COVID-19 in Pregnant Women With Rheumatic Disease: Data From the COVID-19 Global Rheumatology Alliance

Author

Bermas, Bonnie L., primary, Gianfrancesco, Milena, additional, Tanner, Helen L., additional, Seet, Andrea M., additional, Aguiar, Mathia C., additional, Al Adhoubi, Nasra K., additional, Al Emadi, Samar, additional, Cunha, Bernardo M., additional, Flood, Rachael, additional, Kusevich, Daria A., additional, McCarthy, Eoghan M., additional, Patel, Naomi J., additional, Ruderman, Eric M., additional, Sattui, Sebastian E., additional, Sciascia, Savino, additional, Siddique, Faizah, additional, Valenzuela-Almada, Maria O., additional, Wise, Leanna M., additional, Worthing, Angus B., additional, Zell, JoAnn, additional, Bhana, Suleman, additional, Costello, Wendy, additional, Duarte-Garcia, Ali, additional, Grainger, Rebecca, additional, Gossec, Laure, additional, Hausmann, Jonathan S., additional, Hyrich, Kimme, additional, Lawson-Tovey, Saskia, additional, Liew, Jean W., additional, Sirotich, Emily, additional, Sparks, Jeffrey A., additional, Sufka, Paul, additional, Wallace, Zachary S., additional, Machado, Pedro M., additional, Strangfeld, Anja, additional, Clowse, Megan E.B., additional, Yazdany, Jinoos, additional, and Robinson, Philip C., additional

Published
2021
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34. Challenges and opportunities in the early diagnosis and optimal management of rheumatoid arthritis in Africa and the Middle East

Author

Halabi, Hussein, Alarfaj, Abdurhman, Alawneh, Khaldoon, Alballa, Soliman, Alsaeid, Khalid, Badsha, Humeira, Benitha, Romela, Bouajina, Elyes, Al Emadi, Samar, El Garf, Ayman, El Hadidi, Khaled, Laatar, Ahmed, Makhloufi, Chafia D., Masri, Abdel F., Menassa, Jeanine, Al Shaikh, Ahmed, Swailem, Ramiz Al, and Dougados, Maxime

Published
2015
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35. Suboptimal management of rheumatoid arthritis in the Middle East and Africa: could the EULAR recommendations be the start of a solution?

Author

El Zorkany, Bassel, AlWahshi, Humaid A., Hammoudeh, Mohamed, Al Emadi, Samar, Benitha, Romela, Al Awadhi, Adel, Bouajina, Elyes, Laatar, Ahmed, El Badawy, Samir, Al Badi, Marzooq, Al-Maini, Mustafa, Al Saleh, Jamal, Alswailem, Ramiz, Ally, Mahmood Moosa Tar Mahomed, Batha, Wafaa, Djoudi, Hachemi, El Garf, Ayman, El Hadidi, Khaled, El Marzouqi, Mohamed, Hadidi, Musa, Maharaj, Ajesh Basantharan, Masri, Abdel Fattah, Mofti, Ayman, Nahar, Ibrahim, Pettipher, Clive Allan, Spargo, Catherine Elizabeth, and Emery, Paul

Published
2013
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36. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry : a retrospective cohort study

Author

Sattui, Sebastian E., Conway, Richard, Putman, Michael S., Seet, Andrea M., Gianfrancesco, Milena A., Beins, Kaley, Hill, Catherine, Liew, David, Mackie, Sarah L., Mehta, Puja, Neill, Lorna, Gomez, Gimena, Salinas, Maria Isabel Haye, Maldonado, Federico Nicolas, Mariz, Henrique Ataide, Studart, Samia Araujo de Sousa, Araujo, Nafice Costa, Knight, Ann, Rozza, Davide, Quartuccio, Luca, Samson, Maxime, Bally, Stephane, Maria, Alexandre T. J., Chazerain, Pascal, Hasseli, Rebecca, Muller-Ladner, Ulf, Hoyer, Bimba F., Voll, Reinhard, Torres, Rita Pinheiro, Luis, Mariana, Ribeirio, Sandra Lucia Euzebio, Al-Emadi, Samar, Sparks, Jeffrey A., Hsu, Tiffany Y-T, D'Silva, Kristin M., Patel, Naomi J., Wise, Leanna, Gilbert, Emily, Almada, Maria Valenzuela, Duarte-Garcia, Ali, Ugarte-Gil, Manuel, Jacobsohn, Lindsay, Izadi, Zara, Strangfeld, Anja, Mateus, Elsa F., Hyrich, Kimme L., Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Sirotich, Emily, Hausmann, Jonathan S., Sufka, Paul, Bhana, Suleman, Liew, Jean W., Grainger, Rebecca, Machado, Pedro M., Wallace, Zachary S., Yazdany, Jinoos, Robinson, Philip C., Sattui, Sebastian E., Conway, Richard, Putman, Michael S., Seet, Andrea M., Gianfrancesco, Milena A., Beins, Kaley, Hill, Catherine, Liew, David, Mackie, Sarah L., Mehta, Puja, Neill, Lorna, Gomez, Gimena, Salinas, Maria Isabel Haye, Maldonado, Federico Nicolas, Mariz, Henrique Ataide, Studart, Samia Araujo de Sousa, Araujo, Nafice Costa, Knight, Ann, Rozza, Davide, Quartuccio, Luca, Samson, Maxime, Bally, Stephane, Maria, Alexandre T. J., Chazerain, Pascal, Hasseli, Rebecca, Muller-Ladner, Ulf, Hoyer, Bimba F., Voll, Reinhard, Torres, Rita Pinheiro, Luis, Mariana, Ribeirio, Sandra Lucia Euzebio, Al-Emadi, Samar, Sparks, Jeffrey A., Hsu, Tiffany Y-T, D'Silva, Kristin M., Patel, Naomi J., Wise, Leanna, Gilbert, Emily, Almada, Maria Valenzuela, Duarte-Garcia, Ali, Ugarte-Gil, Manuel, Jacobsohn, Lindsay, Izadi, Zara, Strangfeld, Anja, Mateus, Elsa F., Hyrich, Kimme L., Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Sirotich, Emily, Hausmann, Jonathan S., Sufka, Paul, Bhana, Suleman, Liew, Jean W., Grainger, Rebecca, Machado, Pedro M., Wallace, Zachary S., Yazdany, Jinoos, and Robinson, Philip C.

Abstract

Background Patients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica. Methods In this retrospective cohort study, adult patients (aged >= 18 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Behcet's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease. Findings Of 1202 eligible patients identified in the registry, 733 (61.0%) were women arid 469 (39.0%) were men, and their mean age was 63.8 years (SD 17.1). A total of 374 (31.1%) patients had polymyalgia rheumatica, 353 (29.4%) had ANCA-associated vasculitis, 183 (15.2%) had giant cell arteritis, 112 (9.3%) had Behcet's syndrome, and 180 (15.0%) had other vasculitis. Of 1020 (84. 9%) patients with outcome data, 512 (S0.2%) were not hospitalised, 114 (11.2%) were hospitalised and did not receive supplemental oxygen, 239 (23 - 4%) were hospitalised and received

Published
2021
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37. Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19.

Author

UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, Izadi, Zara, Brenner, Erica J, Mahil, Satveer K, Dand, Nick, Yiu, Zenas Z N, Yates, Mark, Ungaro, Ryan C, Zhang, Xian, Agrawal, Manasi, Colombel, Jean-Frederic, Gianfrancesco, Milena A, Hyrich, Kimme L, Strangfeld, Anja, Carmona, Loreto, Mateus, Elsa F, Lawson-Tovey, Saskia, Klingberg, Eva, Cuomo, Giovanna, Caprioli, Marta, Cruz-Machado, Ana Rita, Mazeda Pereira, Ana Carolina, Hasseli, Rebecca, Pfeil, Alexander, Lorenz, Hanns-Martin, Hoyer, Bimba Franziska, Trupin, Laura, Rush, Stephanie, Katz, Patricia, Schmajuk, Gabriela, Jacobsohn, Lindsay, Seet, Andrea M, Al Emadi, Samar, Wise, Leanna, Gilbert, Emily L, Duarte-García, Alí, Valenzuela-Almada, Maria O, Isnardi, Carolina A, Quintana, Rosana, Soriano, Enrique R, Hsu, Tiffany Y-T, D'Silva, Kristin M, Sparks, Jeffrey A, Patel, Naomi J, Xavier, Ricardo Machado, Marques, Claudia Diniz Lopes, Kakehasi, Adriana Maria, Flipo, René-Marc, Claudepierre, Pascal, Cantagrel, Alain, Goupille, Philippe, Wallace, Zachary S, Bhana, Suleman, Costello, Wendy, Grainger, Rebecca, Hausmann, Jonathan S, Liew, Jean W, Sirotich, Emily, Sufka, Paul, Robinson, Philip C, Machado, Pedro M, Griffiths, Christopher E M, Barker, Jonathan N, Smith, Catherine H, Yazdany, Jinoos, Kappelman, Michael D, Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection, Rahier, Jean-François, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, Izadi, Zara, Brenner, Erica J, Mahil, Satveer K, Dand, Nick, Yiu, Zenas Z N, Yates, Mark, Ungaro, Ryan C, Zhang, Xian, Agrawal, Manasi, Colombel, Jean-Frederic, Gianfrancesco, Milena A, Hyrich, Kimme L, Strangfeld, Anja, Carmona, Loreto, Mateus, Elsa F, Lawson-Tovey, Saskia, Klingberg, Eva, Cuomo, Giovanna, Caprioli, Marta, Cruz-Machado, Ana Rita, Mazeda Pereira, Ana Carolina, Hasseli, Rebecca, Pfeil, Alexander, Lorenz, Hanns-Martin, Hoyer, Bimba Franziska, Trupin, Laura, Rush, Stephanie, Katz, Patricia, Schmajuk, Gabriela, Jacobsohn, Lindsay, Seet, Andrea M, Al Emadi, Samar, Wise, Leanna, Gilbert, Emily L, Duarte-García, Alí, Valenzuela-Almada, Maria O, Isnardi, Carolina A, Quintana, Rosana, Soriano, Enrique R, Hsu, Tiffany Y-T, D'Silva, Kristin M, Sparks, Jeffrey A, Patel, Naomi J, Xavier, Ricardo Machado, Marques, Claudia Diniz Lopes, Kakehasi, Adriana Maria, Flipo, René-Marc, Claudepierre, Pascal, Cantagrel, Alain, Goupille, Philippe, Wallace, Zachary S, Bhana, Suleman, Costello, Wendy, Grainger, Rebecca, Hausmann, Jonathan S, Liew, Jean W, Sirotich, Emily, Sufka, Paul, Robinson, Philip C, Machado, Pedro M, Griffiths, Christopher E M, Barker, Jonathan N, Smith, Catherine H, Yazdany, Jinoos, Kappelman, Michael D, Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection, and Rahier, Jean-François

Abstract

Although tumor necrosis factor (TNF) inhibitors are widely prescribed globally because of their ability to ameliorate shared immune pathways across immune-mediated inflammatory diseases (IMIDs), the impact of COVID-19 among individuals with IMIDs who are receiving TNF inhibitors remains insufficiently understood. To examine the association between the receipt of TNF inhibitor monotherapy and the risk of COVID-19-associated hospitalization or death compared with other commonly prescribed immunomodulatory treatment regimens among adult patients with IMIDs. This cohort study was a pooled analysis of data from 3 international COVID-19 registries comprising individuals with rheumatic diseases, inflammatory bowel disease, and psoriasis from March 12, 2020, to February 1, 2021. Clinicians directly reported COVID-19 outcomes as well as demographic and clinical characteristics of individuals with IMIDs and confirmed or suspected COVID-19 using online data entry portals. Adults (age ≥18 years) with a diagnosis of inflammatory arthritis, inflammatory bowel disease, or psoriasis were included. Treatment exposure categories included TNF inhibitor monotherapy (reference treatment), TNF inhibitors in combination with methotrexate therapy, TNF inhibitors in combination with azathioprine/6-mercaptopurine therapy, methotrexate monotherapy, azathioprine/6-mercaptopurine monotherapy, and Janus kinase (Jak) inhibitor monotherapy. The main outcome was COVID-19-associated hospitalization or death. Registry-level analyses and a pooled analysis of data across the 3 registries were conducted using multilevel multivariable logistic regression models, adjusting for demographic and clinical characteristics and accounting for country, calendar month, and registry-level correlations. A total of 6077 patients from 74 countries were included in the analyses; of those, 3215 individuals (52.9%) were from Europe, 3563 individuals (58.6%) were female, and the mean (SD) age was 48.8 (16.5) years. The mo

Published
2021

38. The practical value of biologics registries in Africa and Middle East: challenges and opportunities

Author

Hajjaj-Hassouni, Najia, Al-Badi, Marzooq, Al-Heresh, Ala’, Al-Emadi, Samar, El Bawendi, Ahmed, El Garf, Ayman, El Hadidi, Khaled, Halabi, Hussein, Hammoudeh, Mohammed, El Hassani, Selma, Al Maaini, Mustafa, Nahar, Ibrahim, Ladjouze Rezig, Aïcha, Sellami, Slaheddine, Sweiri, Wafaa, Alswailem, Ramiz, Traub, Beverly, Uthman, Imad, van Duuren, Elsa, Zakraoui, Leith, El Zorkany, Bassel, Carmona, Loreto, and Dougados, Maxime

Published
2012
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43. COVID-19 in Pregnant Women With Rheumatic Disease: Data From the COVID-19 Global Rheumatology Alliance.

Author

Bermas, Bonnie L., Gianfrancesco, Milena, Tanner, Helen L., Seet, Andrea M., Aguiar, Mathia C., Al Adhoubi, Nasra K., Al Emadi, Samar, Cunha, Bernardo M., Flood, Rachael, Kusevich, Daria A., McCarthy, Eoghan M., Patel, Naomi J., Ruderman, Eric M., Sattui, Sebastian E., Sciascia, Savino, Siddique, Faizah, Valenzuela-Almada, Maria O., Wise, Leanna M., Worthing, Angus B., and Zell, JoAnn

Published
2022
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46. Correction to:Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines (Clinical Rheumatology, (2018), 37, 11, (2947-2959), 10.1007/s10067-018-4245-5)

Author

Arayssi, Thurayya, Harfouche, Manale, Darzi, Andrea, Al Emadi, Samar, Alnaqbi, Khalid A, Badsha, Humeira, Al Balushi, Farida, Dib, Carole, Elzorkany, Bassel, Halabi, Hussein, Hammoudeh, Mohammed, Hazer, Wissam, Masri, Basel, Merashli, Mira, Omair, Mohammed, Salloum, Nelly, Uthman, Imad, Zahirovic, Sumeja, Ziade, Nelly, Bannuru, Raveendhara R, McAlindon, Timothy, Nomier, Mohamed A, Singh, Jasvinder A, Christensen, Robin, Tugwell, Peter, Schünemann, Holger, and Akl, Elie A

Abstract

In the original version of this article the first name of the co-author was incorrectly spelled as "Khaled A. Alnaqbi". The correct spelling should have been "Khalid A. Alnaqbi". This is now presented correctly in this article.

Published
2018

47. Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients

Author

Dargham, Soha R., Zahirovic, Sumeja, Hammoudeh, Mohammed, Al Emadi, Samar, Masri, Basel K., Halabi, Hussein, Badsha, Humeira, Uthman, Imad, Mahfoud, Ziyad R., Ashour, Hadil, Gad El Haq, Wissam, Bayoumy, Karim, Kapiri, Marianthi, Saxena, Richa, Plenge, Robert M., Kazkaz, Layla, and Arayssi, Thurayya

Subjects
Arabic People, Asia, Science, Immunology, Social Sciences, Rheumatoid Arthritis, Autoimmune Diseases, Geographical Locations, Habits, Rheumatology, Medicine and Health Sciences, Smoking Habits, Ethnicities, Psychology, Lebanon, Qatar, Pharmacology, Behavior, Organic Compounds, Arthritis, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Drugs, Chemistry, Methotrexate, People and Places, Physical Sciences, Medicine, Clinical Immunology, Population Groupings, Steroids, Clinical Medicine, Research Article
Abstract

Objectives There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the demographic characteristics, clinical profile, and treatment patterns of patients of Arab ancestry with RA. Methods This is a cross sectional study of 895 patients with established rheumatoid arthritis enrolled from five sites (Jordan, Lebanon, Qatar, Kingdom of Saudi Arabia (KSA), and United Arab Emirates). Demographic characteristics, clinical profile, and treatment patterns are compared between the five countries. Results The majority of our patients are women, have an average disease duration of 10 years, are married and non-smokers, with completed secondary education. We report a high (>80%) ever-use of methotrexate (MTX) and steroids among our RA population, while the ever-use of disease modifying anti-rheumatic drugs (DMARDs) and TNF-inhibitors average around 67% and 33%, respectively. There are variations in RA treatment use between the five country sites. Highest utilization of steroids is identified in Jordan and KSA (p-value < 0.001), while the highest ever-use of TNF-inhibitors is reported in KSA (p-value < 0.001). Conclusion Disparities in usage of RA treatments among Arab patients are noted across the five countries. National gross domestic product (GDP), as well as some other unique features in each country likely affect these. Developing treatment guidelines specific to this region could contribute in delivering standardized therapies to RA patients.

Published
2018

48. Correction: Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients

Author

Dargham, Soha R., primary, Zahirovic, Sumeja, additional, Hammoudeh, Mohammed, additional, Al Emadi, Samar, additional, Masri, Basel K., additional, Halabi, Hussein, additional, Badsha, Humeira, additional, Uthman, Imad, additional, Mahfoud, Ziyad R., additional, Ashour, Hadil, additional, El Haq, Wissam Gad, additional, Bayoumy, Karim, additional, Kapiri, Marianthi, additional, Saxena, Richa, additional, Plenge, Robert M., additional, Kazkaz, Layla, additional, and Arayssi, Thurayya, additional

Published
2019
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49. Characteristics of patients with systemic sclerosis living in Qatar.

Author

Alam, Fiaz, Abdulaziz, Hani Malallah, Ul Haq, Irfan, Mahdy, Salah Mohamed, Mohammed Siam, Abdul Rahim, Chandra, Prem, and Al Emadi, Samar

Subjects
SYSTEMIC scleroderma, SCLERODERMA (Disease), CALCINOSIS, RAYNAUD'S disease, ANTINUCLEAR factors, INTERSTITIAL lung diseases, GASTROINTESTINAL system
Abstract

Objective: The aim of this study was to determine the demographic, clinical, and immunological characteristics of patients with systemic sclerosis living in Qatar. Method: This retrospective study included 42 patients with systemic sclerosis who attended Rheumatology Clinics at Hamad General Hospital in Doha, Qatar, between January 2000 and December 2014. All patients fulfilled the 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis. Results: The 42 consecutively recruited patients of mixed ethnicities consisted of 37 (88.1%) females and 5 (11.9%) males. Of the total 42 patients, 22 (52.4%) had diffuse cutaneous systemic sclerosis (dcSSc) and 20 (47.6%) had limited cutaneous systemic sclerosis (lcSSc). Mean age at onset of first symptoms was 34.5 + 12 years, and mean age at diagnosis was 36.1 + 11.5 years. During follow-up, Raynaud's phenomenon occurred in 36 (85.7%) patients, sclerodactyly in 39 (92.9%) patients, digital ulcers in 16 (38.1%) patients, calcinosis in 6 (14.3%) patients, telangiectasia in 16 (38.1%) patients, and arthritis in 13 (31%) patients. The gastrointestinal and respiratory systems were the most frequently affected internal organs. Gastrointestinal involvement was present in 36 (85.7%) patients, and respiratory involvement was found in 30 (71.4%) patients. The majority of patients had positive antinuclear antibodies (ANA; 97.6%). Anti-Scl-70 antibody was found in 66.7% and anti-centromere antibody (ACA) was detected in 14.3% of the patients. Conclusion: To our knowledge, this is the first study that describes the clinical and immunological profile of patients with systemic sclerosis living in Qatar. This study cohort showed an earlier age of disease onset and diagnosis than that reported in other international studies. Furthermore, in contrast to several other studies, the diffuse type of scleroderma was more commonly observed than the limited type, which resulted in a high frequency of anti-Scl-70 antibody and interstitial lung disease. [ABSTRACT FROM AUTHOR]

Published
2019
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50. A Multinational Arab Genome‐Wide Association Study Identifies New Genetic Associations for Rheumatoid Arthritis

Author

Saxena, Richa, primary, Plenge, Robert M., additional, Bjonnes, Andrew C., additional, Dashti, Hassan S., additional, Okada, Yukinori, additional, Gad El Haq, Wessam, additional, Hammoudeh, Mohammed, additional, Al Emadi, Samar, additional, Masri, Basel K., additional, Halabi, Hussein, additional, Badsha, Humeira, additional, Uthman, Imad W., additional, Margolin, Lauren, additional, Gupta, Namrata, additional, Mahfoud, Ziyad R., additional, Kapiri, Marianthi, additional, Dargham, Soha R., additional, Aranki, Grace, additional, Kazkaz, Layla A., additional, and Arayssi, Thurayya, additional

Published
2017
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