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Your search keyword '"Al-Eidi, Hamad"' showing total 19 results
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19 results on '"Al-Eidi, Hamad"'

8. Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies

Author

Alghamdi, Khalid, primary, Alehaideb, Zeyad, additional, Kumar, Ashok, additional, Al-Eidi, Hamad, additional, Alghamdi, Sahar S., additional, Suliman, Rasha, additional, Ali, Rizwan, additional, Almourfi, Feras, additional, Alghamdi, Saleh M., additional, Boudjelal, Mohamed, additional, and Matou-Nasri, Sabine, additional

Published
2023
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10. Achillea fragrantissima (Forssk.) Sch.Bip Flower Dichloromethane Extract Exerts Anti-Proliferative and Pro-Apoptotic Properties in Human Triple-Negative Breast Cancer (MDA-MB-231) Cells: In Vitro and In Silico Studies

Author

Alshuail, Nora, primary, Alehaideb, Zeyad, additional, Alghamdi, Sahar, additional, Suliman, Rasha, additional, Al-Eidi, Hamad, additional, Ali, Rizwan, additional, Barhoumi, Tlili, additional, Almutairi, Mansour, additional, Alwhibi, Mona, additional, Alghanem, Bandar, additional, Alamro, Abir, additional, Alghamdi, Amani, additional, and Matou-Nasri, Sabine, additional

Published
2022
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12. Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

Author

Matou-Nasri, Sabine, primary, Najdi, Maria, additional, AlSaud, Nouran Abu, additional, Alhaidan, Yazeid, additional, Al-Eidi, Hamad, additional, Alatar, Ghada, additional, AlWadaani, Deemah, additional, Trivilegio, Thadeo, additional, AlSubait, Arwa, additional, AlTuwaijri, Abeer, additional, Abudawood, Manal, additional, and Almuzzaini, Bader, additional

Published
2022
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13. Bursatella leachii Purple Ink Secretion Concentrate Exerts Cytotoxic Properties against Human Hepatocarcinoma Cell Line (HepG2): In Vitro and In Silico Studies

Author

Alehaideb, Zeyad I., primary, Venkatraman, Anuradha, additional, Kokane, Mahadev, additional, Mohamed, Syed Ali, additional, Rameshbabu, Saranya, additional, Suliman, Rasha S., additional, Alghamdi, Sahar S., additional, Al-Eidi, Hamad, additional, Alghanem, Bandar, additional, Abdulla, Maha-Hamadien, additional, and Matou-Nasri, Sabine, additional

Published
2022
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16. Anti-Proliferative and Pro-Apoptotic Effects ofCalligonum comosum(L’Her.) Methanolic Extract in Human Triple-Negative MDA-MB-231 Breast Cancer Cells

Author

Alehaideb, Zeyad, primary, AlGhamdi, Saleh, additional, Yahya, Wesam Bin, additional, Al-Eidi, Hamad, additional, Alharbi, Mashael, additional, Alaujan, Monira, additional, Albaz, Abeer, additional, Tukruni, Muruj, additional, Nehdi, Atef, additional, Abdulla, Maha-Hamadien, additional, and Matou-Nasri, Sabine, additional

Published
2020
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17. Anti-Proliferative and Pro-Apoptotic Effects of Calligonum comosum (L'Her.) Methanolic Extract in Human Triple-Negative MDA-MB-231 Breast Cancer Cells.

Author

Alehaideb, Zeyad, AlGhamdi, Saleh, Yahya, Wesam Bin, Al-Eidi, Hamad, Alharbi, Mashael, Alaujan, Monira, Albaz, Abeer, Tukruni, Muruj, Nehdi, Atef, Abdulla, Maha-Hamadien, and Matou-Nasri, Sabine

Subjects
CELL proliferation, REACTIVE oxygen species, APOPTOSIS, BREAST tumors, CELL cycle, CELL death, CELL lines, DRUG toxicity, FLAVONOIDS, FLOW cytometry, GENE expression, HIGH performance liquid chromatography, METHANOL, MITOCHONDRIA, RESEARCH funding, SCANNING electron microscopy, T-test (Statistics), WESTERN immunoblotting, PLANT extracts, CASPASES, CELL survival, PROTEIN kinase inhibitors, DESCRIPTIVE statistics, PHARMACODYNAMICS
Abstract

Triple-negative breast cancer (TNBC), the most aggressive subtype, does not respond to targeted therapy due to the lack of hormone receptors. There is an urgent need for alternative therapies, including natural product-based anti-cancer drugs, at lower cost. We investigated the impact of a Calligonum comosum L'Hér. methanolic extract (CcME) on the TNBC MDA-MB-231 cell line proliferation and related cell death mechanisms performing cell viability and cytotoxicity assays, flow cytometry to detect apoptosis and cell cycle analysis. The apoptosis-related protein array and cellular reactive oxygen species (ROS) assay were also carried out. We showed that the CcME inhibited the TNBC cell viability, in a dose-dependent manner, with low cytotoxic effects. The CcME-treated TNBC cells underwent apoptosis, associated with a concomitant increase of apoptosis-related protein expression, including cytochrome c, cleaved caspase-3, cyclin-dependent kinase inhibitor p21, and the anti-oxidant enzyme catalase, compared with the untreated cells. The CcME also enhanced the mitochondrial transition pore opening activity and induced G0/G1 cell growth arrest, which confirmed the cytochrome c release and the increase of the p21 expression detected in the CcME-treated TNBC cells. The CcME-treated TNBC cells resulted in intracellular ROS production, which, when blocked with a ROS scavenger, did not reduce the CcME-induced apoptosis. In conclusion, CcME exerts anti-proliferative effects against TNBC cells through the induction of apoptosis and cell growth arrest. In vivo studies are justified to verify the CcME anti-proliferative activities and to investigate any potential anti-metastatic activities of CcME against TNBC development and progression. [ABSTRACT FROM AUTHOR]

Published
2020
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18. Corrigendum to ‘CD95-mediated apoptosis in Burkitt's lymphoma B-cells is associated with Pim-1 down-regulation’[Biochimica et Biophysica Acta 1863/1 (2017) 239–252]

Author

Matou-Nasri, Sabine, primary, Rabhan, Zaki, additional, Albuayjan, Haya, additional, Al-Eidi, Hamad, additional, Yahya, Wesam Bin, additional, Al Abdulrahman, Abdelkareem, additional, Almobadel, Nasser, additional, Alsubeai, Mona, additional, Al Ghamdi, Saleh, additional, Alaskar, Ahmed, additional, AlBalwi, Mohammed, additional, Alzahrani, Mohsen, additional, and Alabdulkareem, Ibrahim, additional

Published
2018
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19. Anti-Proliferative and Pro-Apoptotic Effects of Calligonum comosum(L’Her.) Methanolic Extract in Human Triple-Negative MDA-MB-231 Breast Cancer Cells

Author

Alehaideb, Zeyad, AlGhamdi, Saleh, Yahya, Wesam Bin, Al-Eidi, Hamad, Alharbi, Mashael, Alaujan, Monira, Albaz, Abeer, Tukruni, Muruj, Nehdi, Atef, Abdulla, Maha-Hamadien, and Matou-Nasri, Sabine

Abstract

Triple-negative breast cancer (TNBC), the most aggressive subtype, does not respond to targeted therapy due to the lack of hormone receptors. There is an urgent need for alternative therapies, including natural product-based anti-cancer drugs, at lower cost. We investigated the impact of a Calligonum comosumL’Hér. methanolic extract (CcME) on the TNBC MDA-MB-231 cell line proliferation and related cell death mechanisms performing cell viability and cytotoxicity assays, flow cytometry to detect apoptosis and cell cycle analysis. The apoptosis-related protein array and cellular reactive oxygen species (ROS) assay were also carried out. We showed that the CcME inhibited the TNBC cell viability, in a dose-dependent manner, with low cytotoxic effects. The CcME-treated TNBC cells underwent apoptosis, associated with a concomitant increase of apoptosis-related protein expression, including cytochrome c, cleaved caspase-3, cyclin-dependent kinase inhibitor p21, and the anti-oxidant enzyme catalase, compared with the untreated cells. The CcME also enhanced the mitochondrial transition pore opening activity and induced G0/G1cell growth arrest, which confirmed the cytochrome c release and the increase of the p21 expression detected in the CcME-treated TNBC cells. The CcME-treated TNBC cells resulted in intracellular ROS production, which, when blocked with a ROS scavenger, did not reduce the CcME-induced apoptosis. In conclusion, CcME exerts anti-proliferative effects against TNBC cells through the induction of apoptosis and cell growth arrest. In vivostudies are justified to verify the CcME anti-proliferative activities and to investigate any potential anti-metastatic activities of CcME against TNBC development and progression.

Published
2020
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