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44 results on '"Al-Ajlan, Fahad S."'

1. Golden Hour Intravenous Thrombolysis for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis.

Author

Al‐Ajlan, Fahad S., Alkhiri, Ahmed, Alamri, Aser F., Alghamdi, Basil A., Almaghrabi, Ahmed A., Alharbi, Abdullah R., Alansari, Nayef, Almilibari, Ahmed Z., Hussain, M. Shazam, Audebert, Heinrich J., Grotta, James C., Shuaib, Ashfaq, Saver, Jeffrey L., and Alhazzani, Adel

Subjects
*ISCHEMIC stroke, *TREATMENT effectiveness, *CEREBRAL hemorrhage, *SCIENCE databases, *WEB databases
Abstract

Objectives: The benefits of intravenous thrombolysis are time‐dependent, with maximum efficacy when administered within the first "golden" hour after onset. Nevertheless, the impact of golden hour thrombolysis has not been well quantified. Methods: Medline, Embase, and Web of Science databases were systematically searched from inception to August 27, 2023. We included studies that reported safety and efficacy outcomes of ischemic stroke patients treated with intravenous thrombolysis in the golden hour versus later treatment window. The primary outcome was an excellent functional outcome, defined as a modified Rankin Scale score of 0–1 at 90 days. The secondary efficacy outcome was a good functional outcome (defined as modified Rankin Scale score of 0–2). The main safety outcome was symptomatic intracerebral hemorrhage. Results: Seven studies involving 78,826 patients met the selection criteria. Golden hour thrombolysis was associated with higher odds of 90‐day excellent functional outcomes (OR 1.40, 95% CI 1.16–1.67) and 90‐day good functional outcomes (OR 1.38, 95% CI 1.13–1.69) compared with thrombolysis outside the golden hour. The number needed to treat to benefit for golden hour thrombolysis to reduce disability by at least 1 level on the modified Rankin Scale per patient was 2.6. Rates of symptomatic intracerebral hemorrhage and mortality were similar between groups. Interpretation: Golden hour thrombolysis significantly improved acute ischemic stroke outcomes. The findings provide rationale for intensive efforts aimed at expediting thrombolytic therapy within the golden hour window following the onset of acute ischemic stroke. ANN NEUROL 2024;96:582–590 [ABSTRACT FROM AUTHOR]

Published
2024
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3. Time Course of Early Hematoma Expansion in Acute Spot-Sign Positive Intracerebral Hemorrhage: Prespecified Analysis of the SPOTLIGHT Randomized Clinical Trial

Author

Al-Ajlan, Fahad S., Gladstone, David J., Song, Dongbeom, Thorpe, Kevin E., Swartz, Rick H., Butcher, Kenneth S., del Campo, Martin, Dowlatshahi, Dar, Gensicke, Henrik, Lee, Gloria Jooyoung, Flaherty, Matthew L., Hill, Michael D., Aviv, Richard I., Demchuk, Andrew M., Swartz, Richard H., Gladstone, David J., Boyle, Karl, Braganza, Maria, Fedasko, Nadia, Golob, Dolores, Bardi, Edith, Senyshyn, Samantha, Cayley, Megan, Colavecchia, Connie, Demchuk, Andrew M., Hill, Michael D., Coutts, Shelagh, Klein, Gary, Menon, Bijoy, Watson, Tim, Smith, Eric, Subramaniam, Suresh, Bal, Simerpreet, Barber, Philip, Camden, Marie-Christine, Horton, Myles, Mishra, Sachin, Nambiar, Vivek, Torres, Andres Venegas, Adatia, Sweta, Alseraya, Amjad, Desai, Jamsheed, Mandzia, Jennifer, Shamy, Michel, Trivedi, Anurag, Choi, Philip, Dubuc, Veronique, Klourfeld, Evgenia, Field, Thalia, Singh, Dilip, Musuka, Tapuwa, Bloujney, Sarah, Nikneshan, Davar, Imoukhuede, Oje, Yu, Amy, Appireddy, Ramana, Evans, Jamie, Ryckborst, Karla, Calvert, Carly, Dowlatshahi, Dariush, Stotts, Grant, Sharma, Mukul, Robert, Sohail, Mortensen, Melodie, Shamloul, Rany, Campo, Martin Del, Silver, Frank L., Casaubon, Leanne, Jaigobin, Cheryl, Perez, Yael, Kalman, Libby, Abraham, Jemini, Wiegner, Relu, Cayley, Anne, Riediger, Victoria, Butcher, Ken, Kate, Mahesh, Jeerakathil, Thomas, Shuaib, Ashfaq, Gaucher, Sylvia, Sivakumar, Leka, Yip, Samuel, Teal, Philip, Woolfenden, Andrew, Benavente, Oscar, Beckman, Jeff, Murphy, Colleen, Field, Thalia, Asdaghi, Negar, Villaluna-MurrVay, Karina, Sahlas, Demetrios J., Algird, Almunder, Knapman, Jordan, Macmillan, Sue, Sancan, Janice, Mehdiratta, Manu, Perez, Yael, John, Verity, Dhanani, AlNoor, Temple, Bryan, Douen, Andre, Selchen, Daniel, Saposnik, Gustavo, Kostyrko, Pawel, Chan, Richard, Young, Bryan, Kumar, Balagopal, Soros, Peter, Hesser, Kimberley, Wright, Mary, Frank, Connie, Amato-Marziali, Belinda, Deschaintre, Yan, Poppe, Alexandre, Lapierre, Marlene, Boulanger, Jean-Martin, Berger, Leo, Blais, Lise, Simard, Christel, Teitelbaum, Jeanne, Campbell, Natasha, Jin, Al, Breen, Adriana, and Bickford, Suzanne

Published
2023
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4. Diagnostic accuracy of large and medium vessel occlusions in acute stroke imaging by neurology residents and stroke fellows: A comparison of CT angiography alone and CT angiography with CT perfusion.

Author

Alotaibi, Fawaz F, Alshahrani, Asma, Mohamed, Gamal, AlShamrani, Mohamed A, Bin Amir, Hussain, Alsaeed, Ali, Heji, Alaa, Alghanmi, Suwaidi, Alqurishi, Mohammed, Alanazi, Azhar, Aldraye, Hamad, Asiri, Muhannad, Alqahtani, Mohammed, Alreshaid, Abdulrahman A, AlKawi, Ammar, AlHazzani, Adel, AlZawahmah, Mohamed, Alokaili, Riyadh N, Shuaib, Ashfaq, and Al-Ajlan, Fahad S

Published
2024
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9. Diagnostic accuracy of large and medium vessel occlusions in acute stroke imaging by neurology residents and stroke fellows: A comparison of CT angiography alone and CT angiography with CT perfusion

Author

Alotaibi, Fawaz F, primary, Alshahrani, Asma, additional, Mohamed, Gamal, additional, AlShamrani, Mohamed A, additional, Bin Amir, Hussain, additional, Alsaeed, Ali, additional, Heji, Alaa, additional, Alghanmi, Suwaidi, additional, Alqurishi, Mohammed, additional, Alanazi, Azhar, additional, Aldraye, Hamad, additional, Asiri, Muhannad, additional, Alqahtani, Mohammed, additional, Alreshaid, Abdulrahman A, additional, AlKawi, Ammar, additional, AlHazzani, Adel, additional, AlZawahmah, Mohamed, additional, Alokaili, Riyadh N, additional, Shuaib, Ashfaq, additional, and Al-Ajlan, Fahad S, additional

Published
2023
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10. Use of Thick Maximum‐Intensity Projection Brain Computed Tomography Angiography for Evaluation of Baseline Collateral Status Improves Interrater Agreement

Author

Al‐Shamrani, Mohamed A., primary, Bin Amir, Hussain, additional, Alotaibi, Fawaz F., additional, Mohamed, Gamal, additional, Alokaili, Riyadh N., additional, Al‐Kawi, Ammar, additional, Alreshaid, Abdulrahman A., additional, Al‐Zawahmah, Mohamed, additional, Al‐Hazzani, Adel, additional, Demchuk, Andrew M., additional, Shuaib, Ashfaq, additional, and Al‐Ajlan, Fahad S., additional

Published
2023
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12. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author

Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, Amato-Marzialli, B, Boulton, M, Lopez-Ojeda, P, Sharma, M, Lownie, S, Chan, R, Swartz, R, Howard, P, Golob, D, Gladstone, D, Boyle, K, Boulos, M, Hopyan, J, Yang, V, Da Costa, L, Holmstedt, CA, Turk, AS, Navarro, R, Jauch, E, Ozark, S, Turner, R, Phillips, S, Shankar, J, Jarrett, J, Gubitz, G, Maloney, W, Vandorpe, R, Schmidt, M, Heidenreich, J, Hunter, G, Kelly, M, Whelan, R, Peeling, L, Burns, PA, Hunter, A, Wiggam, I, Kerr, E, Watt, M, Fulton, A, Gordon, P, Rennie, I, Flynn, P, Smyth, G, O'Leary, S, Gentile, N, Linares, G, McNelis, P, Erkmen, K, Katz, P, Azizi, A, Weaver, M, Jungreis, C, Faro, S, Shah, P, Reimer, H, Kalugdan, V, Saposnik, G, Bharatha, A, Li, Y, Kostyrko, P, Marotta, T, Montanera, W, Sarma, D, Selchen, D, Spears, J, Heo, JH, Jeong, K, Kim, DJ, Kim, BM, Kim, YD, Song, D, Lee, K-J, Yoo, J, Bang, OY, Rho, S, Lee, J, Jeon, P, Kim, KH, Cha, J, Kim, SJ, Ryoo, S, Lee, MJ, Sohn, S-I, Kim, C-H, Ryu, H-G, Hong, J-H, Chang, H-W, Lee, C-Y, Rha, J, Davis, Stephen M, Donnan, Geoffrey A, Campbell, Bruce CV, Mitchell, Peter J, Churilov, Leonid, Yan, Bernard, Dowling, Richard, Yassi, Nawaf, Oxley, Thomas J, Wu, Teddy Y, Silver, Gabriel, McDonald, Amy, McCoy, Rachael, Kleinig, Timothy J, Scroop, Rebecca, Dewey, Helen M, Simpson, Marion, Brooks, Mark, Coulton, Bronwyn, Krause, Martin, Harrington, Timothy J, Steinfort, Brendan, Faulder, Kenneth, Priglinger, Miriam, Day, Susan, Phan, Thanh, Chong, Winston, Holt, Michael, Chandra, Ronil V, Ma, Henry, Young, Dennis, Wong, Kitty, Wijeratne, Tissa, Tu, Hans, Mackay, Elizabeth, Celestino, Sherisse, Bladin, Christopher F, Loh, Poh Sien, Gilligan, Amanda, Ross, Zofia, Coote, Skye, Frost, Tanya, Parsons, Mark W, Miteff, Ferdinand, Levi, Christopher R, Ang, Timothy, Spratt, Neil, Kaauwai, Lara, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Barber, P. Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, MS, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, RD, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, LS, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given II, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, JT, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-FM, Zaidat, O, Lynch, JR, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Arenillas Lara, JF, Martínez Galdámez, M, Calleja Sanz, AI, Cortijo Garcia, E, Garcia Bermejo, P, Perez, S, Mulero Carrillo, P, Crespo Vallejo, E, Ruiz Piñero, M, Lopez Mesonero, L, Reyes Muñoz, FJ, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ruiz de Morales Ayudarte, N, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, JG, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, LH, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, BD, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, ML, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henniger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, JD, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, Ribó, M, Sanjuan, E, Rubiera, M, Pagola, J, Flores, A, Muchada, M, Meler, P, Huerga, E, Gelabert, S, Coscojuela, P, Tomasello, A, Rodriguez, D, Santamarina, E, Maisterra, O, Boned, S, Seró, L, Rovira, A, Molina, CA, Millán, M, Muñoz, L, Pérez de la Ossa, N, Gomis, M, Dorado, L, López-Cancio, E, Palomeras, E, Munuera, J, García Bermejo, P, Remollo, S, Castaño, C, García-Sort, R, Cuadras, P, Puyalto, P, Hernández-Pérez, M, Jiménez, M, Martínez-Piñeiro, A, Lucente, G, Dávalos, A, Chamorro, A, Urra, X, Obach, V, Cervera, A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Brown, Martin M, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Román, Luis San, Menon, Bijoy K, Blasco, Jordi, Hernández-Pérez, María, Dávalos, Antoni, Majoie, Charles B L M, Campbell, Bruce C V, Guillemin, Francis, Lingsma, Hester, Epstein, Jonathan, Marquering, Henk, Wong, John H, Lopes, Demetrius, Reimann, Gernot, Dippel, Diederik W J, Coutts, Shelagh, du Mesnil de Rochemont, Richard, Yavagal, Dileep, Ferre, Jean Christophe, Roos, Yvo B W E M, Liebeskind, David S, Lenthall, Robert, Molina, Carlos, Al Ajlan, Fahad S, Reddy, Vivek, Dowlatshahi, Dar, Sourour, Nader-Antoine, Oppenheim, Catherine, Mitha, Alim P, Weimar, Christian, van Oostenbrugge, Robert J, Cobo, Erik, Demchuk, Andrew M, Boers, Anna M M, Ford, Gary A, Brown, B Scott, Jovin, Tudor, van Zwam, Wim H, Hill, Michael D, White, Phil, and Bracard, Serge

Published
2018
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13. Thrombus Migration and Fragmentation After Intravenous Alteplase Treatment: The INTERRSeCT Study

Author

Ohara, Tomoyuki, Menon, Bijoy K., Al-Ajlan, Fahad S., Horn, MacKenzie, Najm, Mohamed, Al-Sultan, Abdulaziz, Puig, Josep, Dowlatshahi, Dar, Calleja Sanz, Ana I., Sohn, Sung-Il, Ahn, Seong H., Poppe, Alexandre Y., Mikulik, Robert, Asdaghi, Negar, Field, Thalia S., Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Letteri, Federica, Dey, Sadanand, Evans, James W., Goyal, Mayank, Hill, Michael D., Almekhlafi, Mohammed, and Demchuk, Andrew M.

Published
2021
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16. Use of Noncontrast Computed Tomography and Computed Tomographic Perfusion in Predicting Intracerebral Hemorrhage After Intravenous Alteplase Therapy

Author

Batchelor, Connor, Pordeli, Pooneh, d’Esterre, Christopher D., Najm, Mohamed, Al-Ajlan, Fahad S., Boesen, Mari E., McDougall, Connor, Hur, Lisa, Fainardi, Enrico, Shankar, Jai Jai Shiva, Rubiera, Marta, Khaw, Alexander V., Hill, Michael D., Demchuk, Andrew M., Sajobi, Tolulope T., Goyal, Mayank, Lee, Ting-Yim, Aviv, Richard I., and Menon, Bijoy K.

Published
2017
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17. Infarct in a New Territory After Treatment Administration in the ESCAPE Randomized Controlled Trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times)

Author

Ganesh, Aravind, Al-Ajlan, Fahad S., Sabiq, Farahna, Assis, Zarina, Rempel, Jeremy L., Butcher, Kenneth, Thornton, John, Kelly, Peter, Roy, Daniel, Poppe, Alexandre Y., Jovin, Tudor G., Devlin, Thomas, Baxter, Blaise W., Krings, Timo, Casaubon, Leanne K., Frei, Donald F., Choe, Hana, Tampieri, Donatella, Teitelbaum, Jeanne, Lum, Cheemun, Mandzia, Jennifer, Phillips, Stephen J., Bang, Oh Young, Almekhlafi, Mohammed A., Coutts, Shelagh B., Barber, Philip A., Sajobi, Tolulope, Demchuk, Andrew M., Eesa, Muneer, Hill, Michael D., Goyal, Mayank, and Menon, Bijoy K.

Published
2016
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18. Intra-Arterial Therapy and Post-Treatment Infarct Volumes: Insights From the ESCAPE Randomized Controlled Trial

Author

Al-Ajlan, Fahad S., Goyal, Mayank, Demchuk, Andrew M., Minhas, Priyanka, Sabiq, Farahna, Assis, Zarina, Willinsky, Robert, Montanera, Walter J., Rempel, Jeremy L., Shuaib, Ashfaq, Thornton, John, Williams, David, Roy, Daniel, Poppe, Alexandre Y., Jovin, Tudor G., Sapkota, Biggya L., Baxter, Blaise W., Krings, Timo, Silver, Frank L., Frei, Donald F., Fanale, Christopher, Tampieri, Donatella, Teitelbaum, Jeanne, Lum, Cheemun, Dowlatshahi, Dar, Shankar, Jai J., Barber, Philip A., Hill, Michael D., and Menon, Bijoy K.

Published
2016
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19. Discrepancy between post-treatment infarct volume and 90-day outcome in the ESCAPE randomized controlled trial

Author

Ganesh, Aravind, primary, Menon, Bijoy K, additional, Assis, Zarina A, additional, Demchuk, Andrew M, additional, Al-Ajlan, Fahad S, additional, Al-Mekhlafi, Mohammed A, additional, Rempel, Jeremy L, additional, Shuaib, Ashfaq, additional, Baxter, Blaise W, additional, Devlin, Thomas, additional, Thornton, John, additional, Williams, David, additional, Poppe, Alexandre Y, additional, Roy, Daniel, additional, Krings, Timo, additional, Casaubon, Leanne K, additional, Kashani, Nima, additional, Hill, Michael D, additional, and Goyal, Mayank, additional

Published
2020
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20. Thrombus Migration is a Common Phenomenon With IV TPA and May Have Negative Effects on Outcome When TPA Treatment is Given Before Endovascular Thrombectomy in Proximal Occlusions

Author

Ohara, Tomoyuki, Menon, Bijoy K., Al-Ajlan, Fahad S., Horn, Mackenzie, Al Sultan, Abdulaziz S., Letteri, Federica, Dey, Sadanand, Evans, James, Najm, Mohamed, Puig, Josep, Dowlatshahi, Dar, Calleja, Ana, Sohn, Sung-Il, Ahn, Seong H., Poppe, Alex, Mikulik, Robert, Asdaghi, Negar, Field, Thalia S., Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Goyal, Mayank, Michael Hill, Almekhlafi, Mohammed, Demchuk, Andrew M., and ASİL, Talip

Subjects
Ohara T., Menon B. K. , Al-Ajlan F. S. , Horn M., Al Sultan A. S. , Letteri F., Dey S., Evans J., Najm M., Puig J., et al., -Thrombus Migration is a Common Phenomenon With IV TPA and May Have Negative Effects on Outcome When TPA Treatment is Given Before Endovascular Thrombectomy in Proximal Occlusions.-, American-Heart-Association/American-Stroke-Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium, Hawaii, Amerika Birleşik Devletleri, 6 - 08 Şubat 2019, cilt.50
Published
2019

21. Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke

Author

Boers, Anna M. M., Jansen, Ivo G. H., Brown, Scott, Lingsma, Hester F., Beenen, Ludo F. M., Devlin, Thomas G., San Roman, Luis, Heo, Ji-Hoe, Ribo, Marc, Almekhlafi, Mohammed A., Liebeskind, David S., Teitelbaum, Jeanne, Cuadras, Patricia, de Rochemont, Richard du Mesnil, Beaumont, Marine, Brown, Martin M., Yoo, Albert J., Donnan, Geoffrey A., Mas, Jean Louis, Oppenheim, Catherine, Dowling, Richard J., Moulin, Thierry, Agrinier, Nelly, Lopes, Demetrius K., Aja Rodriguez, Lucia, Compagne, Kars C. J., Al-Ajlan, Fahad S., Madigan, Jeremy, Albers, Gregory W., Soize, Sebastien, Blasco, Jordi, Davis, Stephen M., Nogueira, Raul G., Davalos, Antoni, Menon, Bijoy K., van der Lugt, Aad, Muir, Keith W., Roos, Yvo B. W. E. M., White, Phil, Mitchell, Peter J., Demchuk, Andrew M., van Zwam, Wim H., Jovin, Tudor G., van Oostenbrugge, Robert J., Dippel, Diederik W. J., Campbell, Bruce C. V., Guillemin, Francis, Bracard, Serge, Hill, Michael D., Goyal, Mayank, Marquering, Henk A., Majoie, Charles B. L. M., Boers, Anna M. M., Jansen, Ivo G. H., Brown, Scott, Lingsma, Hester F., Beenen, Ludo F. M., Devlin, Thomas G., San Roman, Luis, Heo, Ji-Hoe, Ribo, Marc, Almekhlafi, Mohammed A., Liebeskind, David S., Teitelbaum, Jeanne, Cuadras, Patricia, de Rochemont, Richard du Mesnil, Beaumont, Marine, Brown, Martin M., Yoo, Albert J., Donnan, Geoffrey A., Mas, Jean Louis, Oppenheim, Catherine, Dowling, Richard J., Moulin, Thierry, Agrinier, Nelly, Lopes, Demetrius K., Aja Rodriguez, Lucia, Compagne, Kars C. J., Al-Ajlan, Fahad S., Madigan, Jeremy, Albers, Gregory W., Soize, Sebastien, Blasco, Jordi, Davis, Stephen M., Nogueira, Raul G., Davalos, Antoni, Menon, Bijoy K., van der Lugt, Aad, Muir, Keith W., Roos, Yvo B. W. E. M., White, Phil, Mitchell, Peter J., Demchuk, Andrew M., van Zwam, Wim H., Jovin, Tudor G., van Oostenbrugge, Robert J., Dippel, Diederik W. J., Campbell, Bruce C. V., Guillemin, Francis, Bracard, Serge, Hill, Michael D., Goyal, Mayank, Marquering, Henk A., and Majoie, Charles B. L. M.

Abstract

IMPORTANCE The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke.OBJECTIVE To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke.DESIGN, SETTING, AND PARTICIPANTS Patient data from 7 randomized multicenter trialswere pooled. These trials were conducted between December 2010 and April 2015 and included 1764 patients randomly assigned to receive either EVT or standard care (control). Follow-up infarct volume was assessed on computed tomography ormagnetic resonance imaging after stroke onset. Mediation analysis was performed to examine the potential causal chain in which FIV may mediate the relationship between EVT and functional outcome. A total of 1690 patients met the inclusion criteria. Twenty-five additional patients were excluded, resulting in a total of 1665 patients, including 821 (49.3%) in the EVT group and 844 (50.7%) in the control group. Data were analyzed from January to June 2017.MAIN OUTCOME AND MEASURE The 90-day functional outcome via the modified Rankin Scale (mRS).RESULTS Among 1665 patients, the median (interquartile range [IQR]) age was 68 (57-76) years, and 781 (46.9%) were female. The median (IQR) time to FIV measurement was 30 (24-237) hours. The median (IQR) FIV was 41 (14-120) mL. Patients in the EVT group had significantly smaller FIVs compared with patients in the control group (median [IQR] FIV, 33 [11-99] vs 51 [18-134] mL; P =.007) and lower mRS scores at 90 days (median [IQR] score, 3 [1-4] vs 4 [2-5]). Follow-up infarct volume was a predictor of functional outcome (adjusted common odds ratio, 0.46; 95% CI, 0.39-0.54; PCONCLUSIONS AND RELEVANCE In this analysis, follow-up infarct v

Published
2019

22. Discrepancy between post-treatment infarct volume and 90-day outcome in the ESCAPE randomized controlled trial.

Author

Ganesh, Aravind, Menon, Bijoy K, Assis, Zarina A, Demchuk, Andrew M, Al-Ajlan, Fahad S, Al-Mekhlafi, Mohammed A, Rempel, Jeremy L, Shuaib, Ashfaq, Baxter, Blaise W, Devlin, Thomas, Thornton, John, Williams, David, Poppe, Alexandre Y, Roy, Daniel, Krings, Timo, Casaubon, Leanne K, Kashani, Nima, Hill, Michael D, and Goyal, Mayank

Subjects
ISCHEMIC stroke, FUNCTIONAL assessment, ENDOVASCULAR surgery, BARTHEL Index, AGE differences
Abstract

Background: Some patients with ischemic stroke have poor outcomes despite small infarcts after endovascular thrombectomy, while others with large infarcts sometimes fare better. Aims: We explored factors associated with such discrepancies between post-treatment infarct volume (PIV) and functional outcome. Methods: We identified patients with small PIV (volume ≤ 25th percentile) and large PIV (volume ≥ 75th percentile) on 24–48-h CT/MRI in the ESCAPE randomized-controlled trial. Demographics, comorbidities, baseline, and 24–48-h stroke severity (NIHSS), stroke location, treatment type, post-stroke complications, and other outcome scales like Barthel Index, and EQ-5D were compared between "discrepant cases" – those with 90-day modified Rankin Scale(mRS) ≤ 2 despite large PIV or mRS ≥ 3 despite small PIV – and "non-discrepant cases". Multi-variable logistic regression was used to identify pre-treatment and post-treatment factors associated with small-PIV/mRS ≥ 3 and large-PIV/mRS ≤ 2. Sensitivity analyses used different definitions of small/large PIV and good/poor outcome. Results: Among 315 patients, median PIV was 21 mL; 27/79 (34.2%) patients with PIV ≤ 7 mL (25th percentile) had mRS ≥ 3; 12/80 (15.0%) with PIV ≥ 72 mL (75th percentile) had mRS ≤ 2. Discrepant cases did not differ by CT versus MRI-based PIV ascertainment, or right versus left-hemisphere involvement (p = 0.39, p = 0.81, respectively, for PIV ≤ 7 mL/mRS ≥ 3). Pre-treatment factors independently associated with small-PIV/mRS ≥ 3 included older age (p = 0.010), cancer, and vascular risk-factors; post-treatment factors included 48-h NIHSS (p = 0.007) and post-stroke complications (p = 0.026). Absence of vascular risk-factors (p = 0.004), CT-based lentiform nucleus sparing (p = 0.002), lower 24-hour NIHSS (p = 0.001), and absence of complications (p = 0.013) were associated with large-PIV/mRS ≤ 2. Sensitivity analyses yielded similar results. Conclusions: Discrepancies between functional ability and PIV are likely explained by differences in age, comorbidities, and post-stroke complications, emphasizing the need for high-quality post-thrombectomy stroke care. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT01778335. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Factors Associated with Discrepancy Between Post-treatment Infarct Volume and 90-day Functional Outcome in the ESCAPE Randomized Controlled Trial (S47.008)

Author

Ganesh, Aravind, primary, Menon, Bijoy K., additional, Assis, Zarina, additional, Demchuk, Andrew M., additional, Al-Ajlan, Fahad S., additional, Almekhlafi, Mohammed A., additional, Rempel, Jeremy L., additional, Baxter, Blaise W., additional, Thornton, John, additional, Kashani, Nima, additional, Hill, Michael D., additional, and Goyal, Mayank, additional

Published
2019
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25. Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke

Author

Boers, Anna M. M., primary, Jansen, Ivo G. H., additional, Brown, Scott, additional, Lingsma, Hester F., additional, Beenen, Ludo F. M., additional, Devlin, Thomas G., additional, Román, Luis San, additional, Heo, Ji-Hoe, additional, Ribó, Marc, additional, Almekhlafi, Mohammed A., additional, Liebeskind, David S., additional, Teitelbaum, Jeanne, additional, Cuadras, Patricia, additional, du Mesnil de Rochemont, Richard, additional, Beaumont, Marine, additional, Brown, Martin M., additional, Yoo, Albert J., additional, Donnan, Geoffrey A., additional, Mas, Jean Louis, additional, Oppenheim, Catherine, additional, Dowling, Richard J., additional, Moulin, Thierry, additional, Agrinier, Nelly, additional, Lopes, Demetrius K., additional, Aja Rodríguez, Lucía, additional, Compagne, Kars C. J., additional, Al-Ajlan, Fahad S., additional, Madigan, Jeremy, additional, Albers, Gregory W., additional, Soize, Sebastien, additional, Blasco, Jordi, additional, Davis, Stephen M., additional, Nogueira, Raul G., additional, Dávalos, Antoni, additional, Menon, Bijoy K., additional, van der Lugt, Aad, additional, Muir, Keith W., additional, Roos, Yvo B. W. E. M., additional, White, Phil, additional, Mitchell, Peter J., additional, Demchuk, Andrew M., additional, van Zwam, Wim H., additional, Jovin, Tudor G., additional, van Oostenbrugge, Robert J., additional, Dippel, Diederik W. J., additional, Campbell, Bruce C. V., additional, Guillemin, Francis, additional, Bracard, Serge, additional, Hill, Michael D., additional, Goyal, Mayank, additional, Marquering, Henk A., additional, and Majoie, Charles B. L. M., additional

Published
2019
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26. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author

Roman, Luis San, Menon, Bijoy K., Blasco, Jordi, Hernandez-Perez, Maria, Davalos, Antoni, Majoie, Charles B. L. M., Campbell, Bruce C. V., Guillemin, Francis, Lingsma, Hester, Anxionnat, Rene, Epstein, Jonathan, Saver, Jeffrey L., Marquering, Henk, Wong, John H., Lopes, Demetrius, Reimann, Gernot, Desal, Hubert, Dippel, Diederik W. J., Coutts, Shelagh, de Rochemont, Richard du Mesnil, Yavagal, Dileep, Ferre, Jean Christophe, Roos, Yvo B. W. E. M., Liebeskind, David S., Lenthall, Robert, Molina, Carlos, Al Ajlan, Fahad S., Reddy, Vivek, Dowlatshahi, Dar, Nader-Antoine, Sourour, Oppenheim, Catherine, Mitha, Alim P., Davis, Stephen M., Weimar, Christian, van Oostenbrugge, Robert J., Cobo, Erik, Kleinig, Timothy J., Donnan, Geoffrey A., van der Lugt, Aad, Demchuk, Andrew M., Berkhemer, Olvert A., Boers, Anna M. M., Ford, Gary A., Muir, Keith W., Brown, B. Scott, Jovin, Tudor, van Zwam, Wim H., Mitchell, Peter J., Hill, Michael D., White, Phil, Bracard, Serge, Goyal, Mayank, HERMES Collaboration, Roman, Luis San, Menon, Bijoy K., Blasco, Jordi, Hernandez-Perez, Maria, Davalos, Antoni, Majoie, Charles B. L. M., Campbell, Bruce C. V., Guillemin, Francis, Lingsma, Hester, Anxionnat, Rene, Epstein, Jonathan, Saver, Jeffrey L., Marquering, Henk, Wong, John H., Lopes, Demetrius, Reimann, Gernot, Desal, Hubert, Dippel, Diederik W. J., Coutts, Shelagh, de Rochemont, Richard du Mesnil, Yavagal, Dileep, Ferre, Jean Christophe, Roos, Yvo B. W. E. M., Liebeskind, David S., Lenthall, Robert, Molina, Carlos, Al Ajlan, Fahad S., Reddy, Vivek, Dowlatshahi, Dar, Nader-Antoine, Sourour, Oppenheim, Catherine, Mitha, Alim P., Davis, Stephen M., Weimar, Christian, van Oostenbrugge, Robert J., Cobo, Erik, Kleinig, Timothy J., Donnan, Geoffrey A., van der Lugt, Aad, Demchuk, Andrew M., Berkhemer, Olvert A., Boers, Anna M. M., Ford, Gary A., Muir, Keith W., Brown, B. Scott, Jovin, Tudor, van Zwam, Wim H., Mitchell, Peter J., Hill, Michael D., White, Phil, Bracard, Serge, Goyal, Mayank, and HERMES Collaboration

Abstract

Background Evidence regarding whether imaging can be used effectively to select patients for endovascular thrombectomy (EVT) is scarce. We aimed to investigate the association between baseline imaging features and safety and efficacy of EVT in acute ischaemic stroke caused by anterior large-vessel occlusion. Methods In this meta-analysis of individual patient-level data, the HERMES collaboration identified in PubMed seven randomised trials in endovascular stroke that compared EVT with standard medical therapy, published between Jan 1, 2010, and Oct 31, 2017. Only trials that required vessel imaging to identify patients with proximal anterior circulation ischaemic stroke and that used predominantly stent retrievers or second-generation neurothrombectomy devices in the EVT group were included. Risk of bias was assessed with the Cochrane handbook methodology. Central investigators, masked to clinical information other than stroke side, categorised baseline imaging features of ischaemic change with the Alberta Stroke Program Early CT Score (ASPECTS) or according to involvement of more than 33% of middle cerebral artery territory, and by thrombus volume, hyperdensity, and collateral status. The primary endpoint was neurological functional disability scored on the modified Rankin Scale (mRS) score at 90 days after randomisation. Safety outcomes included symptomatic intracranial haemorrhage, parenchymal haematoma type 2 within 5 days of randomisation, and mortality within 90 days. For the primary analysis, we used mixed-methods ordinal logistic regression adjusted for age, sex, National Institutes of Health Stroke Scale score at admission, intravenous alteplase, and time from onset to randomisation, and we used interaction terms to test whether imaging categorisation at baseline modifies the association between treatment and outcome. This meta-analysis was prospectively designed by the HERMES executive committee but has not been registered. Findings Among 1764 pooled patie

Published
2018

27. Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials

Author

Boers, Anna M. M., Jansen, Ivo G. H., Beenen, Ludo F. M., Devlin, Thomas G., San Roman, Luis, Heo, Ji Hoe, Ribo, Marc, Brown, Scott, Almekhlafi, Mohammed A., Liebeskind, David S., Teitelbaum, Jeanne, Lingsma, Hester F., van Zwam, Wim H., Cuadras, Patricia, de Rochemont, Richard du Mesnil, Beaumont, Marine, Brown, Martin M., Yoo, Albert J., van Oostenbrugge, Robert J., Menon, Bijoy K., Donnan, Geoffrey A., Mas, Jean Louis, Roos, Yvo B. W. E. M., Oppenheim, Catherine, van der Lugt, Aad, Dowling, Richard J., Hill, Michael D., Davalos, Antoni, Moulin, Thierry, Agrinier, Nelly, Demchuk, Andrew M., Lopes, Demetrius K., Aja Rodriguez, Lucia, Dippel, Diederik W. J., Campbell, Bruce C. V., Mitchell, Peter J., Al-Ajlan, Fahad S., Jovin, Tudor G., Madigan, Jeremy, Albers, Gregory W., Soize, Sebastien, Guillemin, Francis, Reddy, Vivek K., Bracard, Serge, Blasco, Jordi, Muir, Keith W., Nogueira, Raul G., White, Phil M., Goyal, Mayank, Davis, Stephen M., Marquering, Henk A., Majoie, Charles B. L. M., Boers, Anna M. M., Jansen, Ivo G. H., Beenen, Ludo F. M., Devlin, Thomas G., San Roman, Luis, Heo, Ji Hoe, Ribo, Marc, Brown, Scott, Almekhlafi, Mohammed A., Liebeskind, David S., Teitelbaum, Jeanne, Lingsma, Hester F., van Zwam, Wim H., Cuadras, Patricia, de Rochemont, Richard du Mesnil, Beaumont, Marine, Brown, Martin M., Yoo, Albert J., van Oostenbrugge, Robert J., Menon, Bijoy K., Donnan, Geoffrey A., Mas, Jean Louis, Roos, Yvo B. W. E. M., Oppenheim, Catherine, van der Lugt, Aad, Dowling, Richard J., Hill, Michael D., Davalos, Antoni, Moulin, Thierry, Agrinier, Nelly, Demchuk, Andrew M., Lopes, Demetrius K., Aja Rodriguez, Lucia, Dippel, Diederik W. J., Campbell, Bruce C. V., Mitchell, Peter J., Al-Ajlan, Fahad S., Jovin, Tudor G., Madigan, Jeremy, Albers, Gregory W., Soize, Sebastien, Guillemin, Francis, Reddy, Vivek K., Bracard, Serge, Blasco, Jordi, Muir, Keith W., Nogueira, Raul G., White, Phil M., Goyal, Mayank, Davis, Stephen M., Marquering, Henk A., and Majoie, Charles B. L. M.

Abstract

Background Follow-up infarct volume (FIV) has been recommended as an early indicator of treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal imaging approach for FIV measurement. Objective To examine the association of FIV with 90-day modified Rankin Scale (mRS) score and investigate its dependency on acquisition time and modality. Methods Data of seven trials were pooled. FIV was assessed on follow-up (12 hours to 2 weeks) CT or MRI. Infarct location was defined as laterality and involvement of the Alberta Stroke Program Early CT Score regions. Relative quality and strength of multivariable regression models of the association between FIV and functional outcome were assessed. Dependency of imaging modality and acquisition time (48 hours) was evaluated. Results Of 1665 included patients, 83% were imaged with CT. Median FIV was 41 mL (IQR 14-120). A large FIV was associated with worse functional outcome (OR=0.88(95% CI 0.87 to 0.89) per 10 mL) in adjusted analysis. A model including FIV, location, and hemorrhage type best predicted mRS score. FIV of >= 133 mL was highly specific for unfavorable outcome. FIV was equally strongly associated with mRS score for assessment on CT and MRI, even though large differences in volume were present (48 mL (IQR 15-131) vs 22 mL (IQR 8-71), respectively). Associations of both early and late FIV assessments with outcome were similar in strength (rho=0.60(95% CI 0.56 to 0.64) and rho=0.55(95% CI 0.50 to 0.60), respectively). Conclusions In patients with an acute ischemic stroke due to a proximal intracranial occlusion of the anterior circulation, FIV is a strong independent predictor of functional outcome and can be assessed before 48 hours, oneither CT or MRI.

Published
2018

28. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author

Román, Luis San, primary, Menon, Bijoy K, additional, Blasco, Jordi, additional, Hernández-Pérez, María, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, Campbell, Bruce C V, additional, Guillemin, Francis, additional, Lingsma, Hester, additional, Anxionnat, René, additional, Epstein, Jonathan, additional, Saver, Jeffrey L, additional, Marquering, Henk, additional, Wong, John H, additional, Lopes, Demetrius, additional, Reimann, Gernot, additional, Desal, Hubert, additional, Dippel, Diederik W J, additional, Coutts, Shelagh, additional, du Mesnil de Rochemont, Richard, additional, Yavagal, Dileep, additional, Ferre, Jean Christophe, additional, Roos, Yvo B W E M, additional, Liebeskind, David S, additional, Lenthall, Robert, additional, Molina, Carlos, additional, Al Ajlan, Fahad S, additional, Reddy, Vivek, additional, Dowlatshahi, Dar, additional, Sourour, Nader-Antoine, additional, Oppenheim, Catherine, additional, Mitha, Alim P, additional, Davis, Stephen M, additional, Weimar, Christian, additional, van Oostenbrugge, Robert J, additional, Cobo, Erik, additional, Kleinig, Timothy J, additional, Donnan, Geoffrey A, additional, van der Lugt, Aad, additional, Demchuk, Andrew M, additional, Berkhemer, Olvert A, additional, Boers, Anna M M, additional, Ford, Gary A, additional, Muir, Keith W, additional, Brown, B Scott, additional, Jovin, Tudor, additional, van Zwam, Wim H, additional, Mitchell, Peter J, additional, Hill, Michael D, additional, White, Phil, additional, Bracard, Serge, additional, Goyal, Mayank, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez-Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, Gladstone, D, additional, Boyle, K, additional, Boulos, M, additional, Hopyan, J, additional, Yang, V, additional, Da Costa, L, additional, Holmstedt, CA, additional, Turk, AS, additional, Navarro, R, additional, Jauch, E, additional, Ozark, S, additional, Turner, R, additional, Phillips, S, additional, Shankar, J, additional, Jarrett, J, additional, Gubitz, G, additional, Maloney, W, additional, Vandorpe, R, additional, Schmidt, M, additional, Heidenreich, J, additional, Hunter, G, additional, Kelly, M, additional, Whelan, R, additional, Peeling, L, additional, Burns, PA, additional, Hunter, A, additional, Wiggam, I, additional, Kerr, E, additional, Watt, M, additional, Fulton, A, additional, Gordon, P, additional, Rennie, I, additional, Flynn, P, additional, Smyth, G, additional, O'Leary, S, additional, Gentile, N, additional, Linares, G, additional, McNelis, P, additional, Erkmen, K, additional, Katz, P, additional, Azizi, A, additional, Weaver, M, additional, Jungreis, C, additional, Faro, S, additional, Shah, P, additional, Reimer, H, additional, Kalugdan, V, additional, Saposnik, G, additional, Bharatha, A, additional, Li, Y, additional, Kostyrko, P, additional, Marotta, T, additional, Montanera, W, additional, Sarma, D, additional, Selchen, D, additional, Spears, J, additional, Heo, JH, additional, Jeong, K, additional, Kim, DJ, additional, Kim, BM, additional, Kim, YD, additional, Song, D, additional, Lee, K-J, additional, Yoo, J, additional, Bang, OY, additional, Rho, S, additional, Lee, J, additional, Jeon, P, additional, Kim, KH, additional, Cha, J, additional, Kim, SJ, additional, Ryoo, S, additional, Lee, MJ, additional, Sohn, S-I, additional, Kim, C-H, additional, Ryu, H-G, additional, Hong, J-H, additional, Chang, H-W, additional, Lee, C-Y, additional, Rha, J, additional, Campbell, Bruce CV, additional, Churilov, Leonid, additional, Yan, Bernard, additional, Dowling, Richard, additional, Yassi, Nawaf, additional, Oxley, Thomas J, additional, Wu, Teddy Y, additional, Silver, Gabriel, additional, McDonald, Amy, additional, McCoy, Rachael, additional, Scroop, Rebecca, additional, Dewey, Helen M, additional, Simpson, Marion, additional, Brooks, Mark, additional, Coulton, Bronwyn, additional, Krause, Martin, additional, Harrington, Timothy J, additional, Steinfort, Brendan, additional, Faulder, Kenneth, additional, Priglinger, Miriam, additional, Day, Susan, additional, Phan, Thanh, additional, Chong, Winston, additional, Holt, Michael, additional, Chandra, Ronil V, additional, Ma, Henry, additional, Young, Dennis, additional, Wong, Kitty, additional, Wijeratne, Tissa, additional, Tu, Hans, additional, Mackay, Elizabeth, additional, Celestino, Sherisse, additional, Bladin, Christopher F, additional, Loh, Poh Sien, additional, Gilligan, Amanda, additional, Ross, Zofia, additional, Coote, Skye, additional, Frost, Tanya, additional, Parsons, Mark W, additional, Miteff, Ferdinand, additional, Levi, Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Sharma, Gagan, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Bonafé, Alain, additional, Mendes Pereira, Vitor, additional, Jahan, Reza, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jansen, Olav, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, Rüdiger, additional, Smith, Wade, additional, Turjman, Francis, additional, Hamilton, Scott, additional, Chiacchierini, Richard, additional, Amar, Arun, additional, Sanossian, Nerses, additional, Loh, Yince, additional, Baxter, B, additional, Reddy, VK, additional, Horev, A, additional, Star, M, additional, Siddiqui, A, additional, Hopkins, LN, additional, Snyder, K, additional, Sawyer, R, additional, Hall, S, additional, Costalat, V, additional, Riquelme, C, additional, Machi, P, additional, Omer, E, additional, Arquizan, C, additional, Mourand, I, additional, Charif, M, additional, Ayrignac, X, additional, Menjot de Champfleur, N, additional, Leboucq, N, additional, Gascou, G, additional, Moynier, M, additional, du Mesnil de Rochemont, R, additional, Singer, O, additional, Berkefeld, J, additional, Foerch, C, additional, Lorenz, M, additional, Pfeilschifer, W, additional, Hattingen, E, additional, Wagner, M, additional, You, SJ, additional, Lescher, S, additional, Braun, H, additional, Dehkharghani, S, additional, Belagaje, SR, additional, Anderson, A, additional, Lima, A, additional, Obideen, M, additional, Haussen, D, additional, Dharia, R, additional, Frankel, M, additional, Patel, V, additional, Owada, K, additional, Saad, A, additional, Amerson, L, additional, Horn, C, additional, Doppelheuer, S, additional, Schindler, K, additional, Lopes, DK, additional, Chen, M, additional, Moftakhar, R, additional, Anton, C, additional, Smreczak, M, additional, Carpenter, JS, additional, Boo, S, additional, Rai, A, additional, Roberts, T, additional, Tarabishy, A, additional, Gutmann, L, additional, Brooks, C, additional, Brick, J, additional, Domico, J, additional, Reimann, G, additional, Hinrichs, K, additional, Becker, M, additional, Heiss, E, additional, Selle, C, additional, Witteler, A, additional, Al-Boutros, S, additional, Danch, M-J, additional, Ranft, A, additional, Rohde, S, additional, Burg, K, additional, Weimar, C, additional, Zegarac, V, additional, Hartmann, C, additional, Schlamann, M, additional, Göricke, S, additional, Ringlestein, A, additional, Wanke, I, additional, Mönninghoff, C, additional, Dietzold, M, additional, Budzik, R, additional, Davis, T, additional, Eubank, G, additional, Hicks, WJ, additional, Pema, P, additional, Vora, N, additional, Mejilla, J, additional, Taylor, M, additional, Clark, W, additional, Rontal, A, additional, Fields, J, additional, Peterson, B, additional, Nesbit, G, additional, Lutsep, H, additional, Bozorgchami, H, additional, Priest, R, additional, Ologuntoye, O, additional, Barnwell, S, additional, Dogan, A, additional, Herrick, K, additional, Takahasi, C, additional, Beadell, N, additional, Brown, B, additional, Jamieson, S, additional, Hussain, MS, additional, Russman, A, additional, Hui, F, additional, Wisco, D, additional, Uchino, K, additional, Khawaja, Z, additional, Katzan, I, additional, Toth, G, additional, Cheng-Ching, E, additional, Bain, M, additional, Man, S, additional, Farrag, A, additional, George, P, additional, John, S, additional, Shankar, L, additional, Drofa, A, additional, Dahlgren, R, additional, Bauer, A, additional, Itreat, A, additional, Taqui, A, additional, Cerejo, R, additional, Richmond, A, additional, Ringleb, P, additional, Bendszus, M, additional, Möhlenbruch, M, additional, Reiff, T, additional, Amiri, H, additional, Purrucker, J, additional, Herweh, C, additional, Pham, M, additional, Menn, O, additional, Ludwig, I, additional, Acosta, I, additional, Villar, C, additional, Morgan, W, additional, Sombutmai, C, additional, Hellinger, F, additional, Allen, E, additional, Bellew, M, additional, Gandhi, R, additional, Bonwit, E, additional, Aly, J, additional, Ecker, RD, additional, Seder, D, additional, Morris, J, additional, Skaletsky, M, additional, Belden, J, additional, Baker, C, additional, Connolly, LS, additional, Papanagiotou, P, additional, Roth, C, additional, Kastrup, A, additional, Politi, M, additional, Brunner, F, additional, Alexandrou, M, additional, Merdivan, H, additional, Ramsey, C, additional, Given II, C, additional, Renfrow, S, additional, Deshmukh, V, additional, Sasadeusz, K, additional, Vincent, F, additional, Thiesing, JT, additional, Putnam, J, additional, Bhatt, A, additional, Kansara, A, additional, Caceves, D, additional, Lowenkopf, T, additional, Yanase, L, additional, Zurasky, J, additional, Dancer, S, additional, Freeman, B, additional, Scheibe-Mirek, T, additional, Robison, J, additional, Roll, J, additional, Clark, D, additional, Rodriguez, M, additional, Fitzsimmons, B-FM, additional, Zaidat, O, additional, Lynch, JR, additional, Lazzaro, M, additional, Larson, T, additional, Padmore, L, additional, Das, E, additional, Farrow-Schmidt, A, additional, Hassan, A, additional, Tekle, W, additional, Cate, C, additional, Jansen, O, additional, Cnyrim, C, additional, Wodarg, F, additional, Wiese, C, additional, Binder, A, additional, Riedel, C, additional, Rohr, A, additional, Lang, N, additional, Laufs, H, additional, Krieter, S, additional, Remonda, L, additional, Diepers, M, additional, Añon, J, additional, Nedeltchev, K, additional, Kahles, T, additional, Biethahn, S, additional, Lindner, M, additional, Chang, V, additional, Gächter, C, additional, Esperon, C, additional, Guglielmetti, M, additional, Arenillas Lara, JF, additional, Martínez Galdámez, M, additional, Calleja Sanz, AI, additional, Cortijo Garcia, E, additional, Garcia Bermejo, P, additional, Perez, S, additional, Mulero Carrillo, P, additional, Crespo Vallejo, E, additional, Ruiz Piñero, M, additional, Lopez Mesonero, L, additional, Reyes Muñoz, FJ, additional, Brekenfeld, C, additional, Buhk, J-H, additional, Krützelmann, A, additional, Thomalla, G, additional, Cheng, B, additional, Beck, C, additional, Hoppe, J, additional, Goebell, E, additional, Holst, B, additional, Grzyska, U, additional, Wortmann, G, additional, Starkman, S, additional, Duckwiler, G, additional, Jahan, R, additional, Rao, N, additional, Sheth, S, additional, Ng, K, additional, Noorian, A, additional, Szeder, V, additional, Nour, M, additional, McManus, M, additional, Huang, J, additional, Tarpley, J, additional, Tateshima, S, additional, Gonzalez, N, additional, Ali, L, additional, Liebeskind, D, additional, Hinman, J, additional, Calderon-Arnulphi, M, additional, Liang, C, additional, Guzy, J, additional, Koch, S, additional, DeSousa, K, additional, Gordon-Perue, G, additional, Elhammady, M, additional, Peterson, E, additional, Pandey, V, additional, Dharmadhikari, S, additional, Khandelwal, P, additional, Malik, A, additional, Pafford, R, additional, Gonzalez, P, additional, Ramdas, K, additional, Andersen, G, additional, Damgaard, D, additional, Von Weitzel-Mudersbach, P, additional, Simonsen, C, additional, Ruiz de Morales Ayudarte, N, additional, Poulsen, M, additional, Sørensen, L, additional, Karabegovich, S, additional, Hjørringgaard, M, additional, Hjort, N, additional, Harbo, T, additional, Sørensen, K, additional, Deshaies, E, additional, Padalino, D, additional, Swarnkar, A, additional, Latorre, JG, additional, Elnour, E, additional, El-Zammar, Z, additional, Villwock, M, additional, Farid, H, additional, Balgude, A, additional, Cross, L, additional, Hansen, K, additional, Holtmannspötter, M, additional, Kondziella, D, additional, Hoejgaard, J, additional, Taudorf, S, additional, Soendergaard, H, additional, Wagner, A, additional, Cronquist, M, additional, Stavngaard, T, additional, Cortsen, M, additional, Krarup, LH, additional, Hyldal, T, additional, Haring, H-P, additional, Guggenberger, S, additional, Hamberger, M, additional, Trenkler, J, additional, Sonnberger, M, additional, Nussbaumer, K, additional, Dominger, C, additional, Bach, E, additional, Jagadeesan, BD, additional, Taylor, R, additional, Kim, J, additional, Shea, K, additional, Tummala, R, additional, Zacharatos, H, additional, Sandhu, D, additional, Ezzeddine, M, additional, Grande, A, additional, Hildebrandt, D, additional, Miller, K, additional, Scherber, J, additional, Hendrickson, A, additional, Jumaa, M, additional, Zaidi, S, additional, Hendrickson, T, additional, Snyder, V, additional, Killer-Oberpfalzer, M, additional, Mutzenbach, J, additional, Weymayr, F, additional, Broussalis, E, additional, Stadler, K, additional, Jedlitschka, A, additional, Malek, A, additional, Mueller-Kronast, N, additional, Beck, P, additional, Martin, C, additional, Summers, D, additional, Day, J, additional, Bettinger, I, additional, Holloway, W, additional, Olds, K, additional, Arkin, S, additional, Akhtar, N, additional, Boutwell, C, additional, Crandall, S, additional, Schwartzman, M, additional, Weinstein, C, additional, Brion, B, additional, Prothmann, S, additional, Kleine, J, additional, Kreiser, K, additional, Boeckh-Behrens, T, additional, Poppert, H, additional, Wunderlich, S, additional, Koch, ML, additional, Biberacher, V, additional, Huberle, A, additional, Gora-Stahlberg, G, additional, Knier, B, additional, Meindl, T, additional, Utpadel-Fischler, D, additional, Zech, M, additional, Kowarik, M, additional, Seifert, C, additional, Schwaiger, B, additional, Puri, A, additional, Hou, S, additional, Wakhloo, A, additional, Moonis, M, additional, Henniger, N, additional, Goddeau, R, additional, Massari, F, additional, Minaeian, A, additional, Lozano, JD, additional, Ramzan, M, additional, Stout, C, additional, Patel, A, additional, Tunguturi, A, additional, Onteddu, S, additional, Carandang, R, additional, Howk, M, additional, Ribó, M, additional, Sanjuan, E, additional, Rubiera, M, additional, Pagola, J, additional, Flores, A, additional, Muchada, M, additional, Meler, P, additional, Huerga, E, additional, Gelabert, S, additional, Coscojuela, P, additional, Tomasello, A, additional, Rodriguez, D, additional, Santamarina, E, additional, Maisterra, O, additional, Boned, S, additional, Seró, L, additional, Rovira, A, additional, Molina, CA, additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Albers, Gregory W, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Ducrocq, Xavier, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Richard, Sébastien, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Raoult, Hélène, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Naggara, Olivier, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, White, Philip, additional, Brown, Martin M, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Dixit, Anand, additional, Cloud, Geoffrey, additional, Clifton, Andrew, additional, Madigan, Jeremy, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional

Published
2018
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29. Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials

Author

Boers, Anna M M, primary, Jansen, Ivo G H, additional, Beenen, Ludo F M, additional, Devlin, Thomas G, additional, San Roman, Luis, additional, Heo, Ji Hoe, additional, Ribó, Marc, additional, Brown, Scott, additional, Almekhlafi, Mohammed A, additional, Liebeskind, David S, additional, Teitelbaum, Jeanne, additional, Lingsma, Hester F, additional, van Zwam, Wim H, additional, Cuadras, Patricia, additional, du Mesnil de Rochemont, Richard, additional, Beaumont, Marine, additional, Brown, Martin M, additional, Yoo, Albert J, additional, van Oostenbrugge, Robert J, additional, Menon, Bijoy K, additional, Donnan, Geoffrey A, additional, Mas, Jean Louis, additional, Roos, Yvo B W E M, additional, Oppenheim, Catherine, additional, van der Lugt, Aad, additional, Dowling, Richard J, additional, Hill, Michael D, additional, Davalos, Antoni, additional, Moulin, Thierry, additional, Agrinier, Nelly, additional, Demchuk, Andrew M, additional, Lopes, Demetrius K, additional, Aja Rodríguez, Lucia, additional, Dippel, Diederik W J, additional, Campbell, Bruce C V, additional, Mitchell, Peter J, additional, Al-Ajlan, Fahad S, additional, Jovin, Tudor G, additional, Madigan, Jeremy, additional, Albers, Gregory W, additional, Soize, Sebastien, additional, Guillemin, Francis, additional, Reddy, Vivek K, additional, Bracard, Serge, additional, Blasco, Jordi, additional, Muir, Keith W, additional, Nogueira, Raul G, additional, White, Phil M, additional, Goyal, Mayank, additional, Davis, Stephen M, additional, Marquering, Henk A, additional, and Majoie, Charles B L M, additional

Published
2018
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31. Abstract WP62: Favorable Clot Characteristics Predict Smaller Infarct Volume in Acute Ischemic Stroke Patients Treated With Reperfusion Therapy

Author

Al Sultan, Abdulaziz S, primary, Al-Ajlan, Fahad S, additional, Najm, Mohammed, additional, Casault, Colin, additional, Neweduk, Anneliese, additional, Horn, MacKenzie, additional, Field, Thalia S, additional, Puig, Josep, additional, Castellanos, Mar, additional, Dowlatshahi, Dar, additional, Sohn, Sung-II, additional, Ahn, Seong H, additional, Poppe, Alex, additional, Mikulik, Robert, additional, Asdaghi, Negar, additional, Boulanger, Jean-Martin, additional, Asil, Talip, additional, Calleja, Ana I, additional, Goyal, Mayank, additional, Hill, Michael D, additional, Demchuk, Andrew M, additional, and Menon, Bijoy K, additional

Published
2018
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35. Selective intra-arterial hypothermia combined with endovascular thrombectomy for large vessel occlusion: A systematic review and meta-analysis

Author

Alturki, Fahad, Alkhiri, Ahmed, Alsulami, Bander, Alotaibi, Fawaz F., Alamri, Aser F., AlRuhaymi, Bader, Bakhuraybah, Elyas M., Al-Ajlan, Fahad S., Alhazzani, Adel, and Almekhlafi, Mohammed A.

Abstract

Background Systemic therapeutic hypothermia may improve outcomes after acute ischemic stroke but increases complications. Selective intra-arterial hypothermia at the ischemic site during endovascular thrombectomy (EVT) theoretically offers benefits with fewer risks. However, there is little clinical evidence to support this approach.Methods We searched Medline/PubMed, Embase and Cochrane electronic databases for studies evaluating the safety and feasibility of selective intra-arterial hypothermia as an adjunct to EVT for large vessel occlusion (LVO). Effect sizes with 95% confidence intervals (CIs) were pooled using the fixed-effect model. Odds ratios (ORs) were computed for binary variables, while the mean differences (MDs) were pooled for continuous data.Results Of identified records, five clinical studies involving 463 LVO patients (62.9% male) were included. Of those, 224 (48.4%) patients received adjuvant selective intra-arterial hypothermia, while 239 (51.6%) received EVT alone. Selective intra-arterial hypothermia resulted in higher rates of good functional outcome (modified Rankin scale [mRS] 0–2 at 90-days) (OR 2.07, [95% CI, 1.36 to 3.16]), and lower final infarct volume (MD, −20.96 ml [95% CI, −26.17 to −15.75]) and lower rates of severe disability (mRS 3–5 at 90 days) (OR 0.44 [95% CI, 0.26 to 0.75]). Safety parameters including rates of symptomatic intracerebral hemorrhage, mortality, pneumonia, coagulation abnormalities, and arterial spasm were comparable between groups.Conclusions The initial evidence supports the safety and feasibility of selective intra-arterial hypothermia when combined with EVT for LVO. This approach shows promise for advancing research on neuroprotective strategies for ischemic stroke.

Published
2024
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36. Abstract TP45: One Threshold Does not Fit All: Hounsfield Unit Thresholds to Segment Clot on NCCT are Patient Specific

Author

Qazi, Emmad, primary, Wilson, Alexis T, additional, McDougall, Connor, additional, Boesen, Mari, additional, Al-Ajlan, Fahad S, additional, Pordeli, Pooneh, additional, Batchelor, Connor, additional, Khan, Khayam, additional, Sajobi, Tolulope T, additional, Lee, Ting-Yim, additional, Hill, Michael D, additional, Demchuk, Andrew M, additional, Goyal, Mayank, additional, d'Esterre, Christopher D, additional, Menon, Bijoy K, additional, and Forkert, Nils D, additional

Published
2016
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37. The future of endovascular treatment: Insights from the ESCAPE investigators

Author

Klourfeld, Evgenia, primary, Zerna, Charlotte, additional, Al-Ajlan, Fahad S, additional, Kamal, Noreen, additional, Randhawa, Privia, additional, Yu, Amy Y, additional, Dowlatshahi, Dar, additional, Thornton, John, additional, Williams, David, additional, Holmstedt, Christine, additional, Kelly, Michael, additional, Frei, Donald, additional, Baxter, Blaise, additional, Linares, Guillermo, additional, Bang, Oh Young, additional, Poppe, Alexandre Y, additional, Montanera, Walter, additional, Rempel, Jeremy, additional, Eesa, Muneer, additional, Menon, Bijoy K, additional, Demchuk, Andrew M, additional, Goyal, Mayank, additional, and Hill, Michael D, additional

Published
2016
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38. Association of Clinical, Imaging, and Thrombus Characteristics With Recanalization of Visible Intracranial Occlusion in Patients With Acute Ischemic Stroke.

Author

Menon, Bijoy K., Al-Ajlan, Fahad S., Najm, Mohamed, Puig, Josep, Castellanos, Mar, Dowlatshahi, Dar, Calleja, Ana, Sohn, Sung-Il, Ahn, Seong H., Poppe, Alex, Mikulik, Robert, Asdaghi, Negar, Field, Thalia S., Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Smith, Eric E., Coutts, Shelagh B., Barber, Phil A., and Bal, Simerpreet

Subjects
*THROMBOSIS, *STROKE, *COMPUTED tomography, *ANGIOGRAPHY, *DIAGNOSTIC imaging, *TISSUE plasminogen activator, *CEREBRAL ischemia, *COMBINED modality therapy, *COMPARATIVE studies, *INTRAVENOUS therapy, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *VEIN surgery, *EVALUATION research, *TREATMENT effectiveness, *THERAPEUTICS, THERAPEUTIC use of fibrinolytic agents
Abstract

Importance: Recanalization of intracranial thrombus is associated with improved clinical outcome in patients with acute ischemic stroke. The association of intravenous alteplase treatment and thrombus characteristics with recanalization over time is important for stroke triage and future trial design.Objective: To examine recanalization over time across a range of intracranial thrombus occlusion sites and clinical and imaging characteristics in patients with ischemic stroke treated with intravenous alteplase or not treated with alteplase.Design, Setting, and Participants: Multicenter prospective cohort study of 575 patients from 12 centers (in Canada, Spain, South Korea, the Czech Republic, and Turkey) with acute ischemic stroke and intracranial arterial occlusion demonstrated on computed tomographic angiography (CTA).Exposures: Demographics, clinical characteristics, time from alteplase to recanalization, and intracranial thrombus characteristics (location and permeability) defined on CTA.Main Outcomes and Measures: Recanalization on repeat CTA or on first angiographic acquisition of affected intracranial circulation obtained within 6 hours of baseline CTA, defined using the revised arterial occlusion scale (rAOL) (scores from 0 [primary occlusive lesion remains the same] to 3 [complete revascularization of primary occlusion]).Results: Among 575 patients (median age, 72 years [IQR, 63-80]; 51.5% men; median time from patient last known well to baseline CTA of 114 minutes [IQR, 74-180]), 275 patients (47.8%) received intravenous alteplase only, 195 (33.9%) received intravenous alteplase plus endovascular thrombectomy, 48 (8.3%) received endovascular thrombectomy alone, and 57 (9.9%) received conservative treatment. Median time from baseline CTA to recanalization assessment was 158 minutes (IQR, 79-268); median time from intravenous alteplase start to recanalization assessment was 132.5 minutes (IQR, 62-238). Successful recanalization occurred at an unadjusted rate of 27.3% (157/575) overall, including in 30.4% (143/470) of patients who received intravenous alteplase and 13.3% (14/105) who did not (difference, 17.1% [95% CI, 10.2%-25.8%]). Among patients receiving alteplase, the following factors were associated with recanalization: time from treatment start to recanalization assessment (OR, 1.28 for every 30-minute increase in time [95% CI, 1.18-1.38]), more distal thrombus location, eg, distal M1 middle cerebral artery (39/84 [46.4%]) vs internal carotid artery (10/92 [10.9%]) (OR, 5.61 [95% CI, 2.38-13.26]), and higher residual flow (thrombus permeability) grade, eg, hairline streak (30/45 [66.7%]) vs none (91/377 [24.1%]) (OR, 7.03 [95% CI, 3.32-14.87]).Conclusions and Relevance: In patients with acute ischemic stroke, more distal thrombus location, greater thrombus permeability, and longer time to recanalization assessment were associated with recanalization of arterial occlusion after administration of intravenous alteplase; among patients who did not receive alteplase, rates of arterial recanalization were low. These findings may help inform treatment and triage decisions in patients with acute ischemic stroke. [ABSTRACT FROM AUTHOR]

Published
2018
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40. Minimally Invasive Surgery for Spontaneous Intracerebral Hemorrhage: Meta‐Analysis of High‐Quality Randomized Clinical Trials.

Author

Alkhiri, Ahmed, Alamri, Aser F., Almaghrabi, Ahmed A., Alturki, Fahad, Alghamdi, Basil A., Alharbi, Abdullah, Salamatullah, Hassan K., Alzawahmah, Mohamed, Al‐Otaibi, Faisal, Alturki, Abdulrahman Y., Dowlatshahi, Dar, Demchuk, Andrew M., Ziai, Wendy C., Kellner, Christopher P., Alhazzani, Adel, and Al‐Ajlan, Fahad S.

Subjects
*MINIMALLY invasive procedures, *CEREBRAL hemorrhage, *CLINICAL trials, *THERAPEUTICS, *DEATH rate, *INTRACEREBRAL hematoma
Abstract

Objectives Methods Results Interpretation Spontaneous intracerebral hemorrhage (ICH) poses high mortality and morbidity rates with limited evidence‐based therapeutic approaches. We aimed to evaluate the current evidence for the role of minimally invasive surgery (MIS) in the management of ICH.This systematic review and meta‐analysis followed recommended guidelines and protocols. Medline, Embase, Scopus, and the Cochrane Library were searched from inception up to April 12, 2024. The inclusion was restricted to randomized clinical trials (RCTs) of high quality, ensuring they were not deemed to have a high risk of bias in any of the Cochrane risk of bias tool (RoB2) domains. Primary outcomes were good functional outcome (modified Rankin scale, 0–3) and mortality beyond 90 days. Secondary outcomes were early mortality within 30 days and rebleeding rates. We pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) using random‐effects models.Fourteen high‐quality RCTs were included. There were 3,027 patients with ICH (1,475 randomized to MIS, and 1,452 randomized to medical management or craniotomy). Of included patients, 1,899 (62.7%) were males. MIS resulted in higher odds of achieving long‐term good functional outcome (OR, 1.51 [95% CI, 1.25–1.82]), lower odds of long‐term mortality (OR, 0.72 [95% CI, 0.57–0.90]) and lower odds of early mortality (OR, 0.73 [95% CI, 0.56–0.95]). Rebleeding rates were similar (OR, 1.10 [95% CI, 0.55–2.19]). The treatment effect of MIS was consistent across multiple sensitivity and subgroup analyses, including individuals with deep ICH.This meta‐analysis provides high‐quality clinical trial evidence supporting the use of MIS as a primary treatment strategy in the management of ICH. ANN NEUROL 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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41. Favorable Clot Characteristics Predict Smaller Infarct Volume in Acute Ischemic Stroke Patients Treated With Reperfusion Therapy

Author

Al Sultan, Abdulaziz S., Al-Ajlan, Fahad S., Najm, Mohammed, Casault, Colin, Neweduk, Anneliese, Horn, Mackenzie, Field, Thalia S., Puig, Josep, Castellanos, Mar, Dowlatshahi, Dar, Sohn, Sung-Ii, Ahn, Seong H., Poppe, Alex, Mikulik, Robert, Asdaghi, Negar, Boulanger, Jean-Martin, Asil, Talip, Calleja, Ana I., Goyal, Mayank, Michael Hill, Demchuk, Andrew M., and Menon, Bijoy K.

44. Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study.

Author

Gensicke H, Evans JW, Al Ajlan FS, Dowlatshahi D, Najm M, Calleja AL, Puig J, Sohn SL, Ahn SH, Poppe AY, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Hill MD, Goyal M, Demchuk AM, and Menon BK

Subjects
Aged, Aged, 80 and over, Bayes Theorem, Computed Tomography Angiography methods, Female, Humans, Male, Middle Aged, Prospective Studies, Fibrinolytic Agents therapeutic use, Intracranial Thrombosis diagnostic imaging, Intracranial Thrombosis drug therapy, Tissue Plasminogen Activator therapeutic use, Tomography, X-Ray Computed methods
Abstract

Purpose: To compare the association of different measures of intracranial thrombus permeability on non-contrast computerized tomography (NCCT) and computed tomography angiography (CTA) with recanalization with or without intravenous alteplase., Methods: Patients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus permeability was measured on non-contrast CT and CTA using the following methods: [1] automated method, mean attenuation increase on co-registered thin (< 2.5 mm) CTA/NCCT; [2] semi-automated method, maximum attenuation increase on non-registered CTA/NCCT (ΔHUmax); [3] manual method, maximum attenuation on CTA (HUmax); and [4] visual method, residual flow grade. Primary outcome was recanalization with intravenous alteplase on the revised AOL scale (2b/3). Regression models were compared using C-statistic, Akaike (AIC), and Bayesian information criterion (BIC)., Results: Four hundred eighty patients were included in this analysis. Statistical models using methods 2, 3, and 4 were similar in their ability to discriminate recanalizers from non-recanalizers (C-statistic 0.667, 0.683, and 0.634, respectively); method 3 had the least information loss (AIC = 483.8; BIC = 492.2). A HU max ≥ 89 measured with method 3 provided optimal sensitivity and specificity in discriminating recanalizers from non-recanalizers [recanalization 55.4% (95%CI 46.2-64.6) when HU max > 89 vs. 16.8% (95%CI 13.0-20.6) when HU max ≤ 89]. In sensitivity analyses restricted to patients with co-registered CTA/NCCT (n = 88), methods 1-4 predicted recanalization similarly (C-statistic 0.641, 0.688, 0.640, 0.648, respectively) with Method 2 having the least information loss (AIC 104.8, BIC 109.8)., Conclusion: Simple methods that measure thrombus permeability are as reliable as complex image processing methods in discriminating recanalizers from non-recanalizers.

Published
2020
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