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Objective: In 2021, the Clinical Genome Resource (ClinGen) amyotrophic lateral sclerosis (ALS) spectrum disorders Gene Curation Expert Panel (GCEP) was established to evaluate the strength of evidence for genes previously reported to be associated with ALS. Through this endeavor, we will provide standardized guidance to laboratories on which genes should be included in clinical genetic testing panels for ALS. In this manuscript, we aimed to assess the heterogeneity in the current global landscape of clinical genetic testing for ALS. Methods: We reviewed the National Institutes of Health (NIH) Genetic Testing Registry (GTR) and members of the ALS GCEP to source frequently used testing panels and compare the genes included on the tests. Results: 14 clinical panels specific to ALS from 14 laboratories covered 4 to 54 genes. All panels report on ANG, SOD1, TARDBP, and VAPB; 50% included or offered the option of including C9orf72 hexanucleotide repeat expansion (HRE) analysis. Of the 91 genes included in at least one of the panels, 40 (44.0%) were included on only a single panel. We could not find a direct link to ALS in the literature for 14 (15.4%) included genes. Conclusions: The variability across the surveyed clinical genetic panels is concerning due to the possibility of reduced diagnostic yields in clinical practice and risk of a missed diagnoses for patients. Our results highlight the necessity for consensus regarding the appropriateness of gene inclusions in clinical genetic ALS tests to improve its application for patients living with ALS and their families.

This study aimed to discover the level of psychological pollution among Irbid university college female student in light of some variables, the sample of the study consisted of (146) female students from Irbid university college. The researchers used the psychological pollution scale that was developed by them and consisted of (40) items. The results of the study revealed that the level of psychological pollution among Irbid university college female student was intermediate with an average (2.51). also, the results revealed that there were statically significant differences related to the psychological pollution due to major variable and in favour of English students. and the results revealed that there were statically significant differences related to the psychological pollution due to level of study and in favour of fourth year students. The study didn't reveal differences in the level of psychological pollution due to the variable of parents education Keywords: psychological pollution, Irbid University College. DOI: 10.7176/JEP/10-20-09 Publication date:July 31st 2019

This study aimed to detect the level of Self- Disclosure at Irbid university college students and its relationship with some variables, the sample of the study consisted of (343) students were selected randomly. The results of the study show that the level of self- Disclosure in this sample was high. The person who was most targeted in disclosure is the parent, friend, the same sex and then parent respectively, as the results showed that the detection of Self- Disclosure influenced by style of upbringing and was in a democratic style, and it was also influenced by location of housing and came in favor of the city. Keywords: Self- Disclosure, Irbid university college students, psychological stress, Democratic, Dictatorial, Jourard questionnaire