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This study was conducted to determine the efficacy of metformin vs placebo in women with polycystic ovary syndrome (PCOS) undergoing IVF treatment. A total of 66 CC-resistant patients were studied prospectively. The women were randomly assigned to receive 850 mg of metformin (n = 34) or placebo (n = 32) twice daily that started 1 month before commencing the IVF treatment and continued to the day of the pregnancy test. Compared with the metformin-treated group, women who received a placebo had a significant increase in terms of days of stimulation with HMG, number of HMG ampoules, number of follicles >14 mm, number of oocytes retrieved, number of mature eggs, fertilisation rate and oestradiol level on the day of hCG administration. Similarly, women in the placebo group showed a significant increase in poor quality embryos, cancellation rate and the rate of ovarian hyperstimulation syndrome, as compared with the metformin-treated group. On the other hand, women who received metformin showed a significantly higher number of good quality embryos and implantation rate when compared with the placebo controls. Despite the transfer of a similar number of embryos, an insignificant increased in the pregnancy rate along with significant reduction in the abortion rate was observed in the metformin-treated group as compared with the placebo controls. No fetal abnormalities were encountered in the babies born in the metformin-treated group. It is concluded that metformin affects positively the quality of both oocytes and embryos without a significant increase in the pregnancy rate. It decreases significantly the rates of abortion and ovarian hyperstimulation syndrome. [ABSTRACT FROM AUTHOR]

In this paper,the effect of troidal magnetic field is studied in standard self-gravitating thin disks with β priscription. By applying the magnetic field, we expect to see different behaviors compared to a non-magnetic field case. The study reveals self-similar solutions for radial infall velocity, rotation velocity, surface density and mass accretion rate. Our results also show that by increasing the magnetic field, the radial velocity and mass accretion rate, at least in the inner regions of the disk,become slow and low, respectively. By contrast, in the outer regions, the azimuthal velocity and surface density become fast and high, respectively. [ABSTRACT FROM AUTHOR]