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35 results on '"Al‐Bari, Md. Abdul Alim"'

28. Convergence between global BCG vaccination and COVID‐19 pandemic.

Author

Islam, Md. Zahurul, Zahan, Md. Kudrat‐E, and Al‐Bari, Md. Abdul Alim

Subjects
COVID-19 pandemic, BCG vaccines, COVID-19 vaccines, COVID-19, SARS-CoV-2
Abstract

The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has kept the whole world in tenterhooks due to its severe life‐threatening infectious disease, COVID‐19. The virus is distinct from its cousins, SARS‐CoV and MERS‐CoV in terms of severity of the infection. The obligated killing properties of the SARS‐CoV‐2 virus is mediated by its unique structure. Efforts for developing vaccines for COVID‐19 are ongoing, but it is unlikely to be available in the immediate future. Due to the absence of precise treatment, the investigators are discovering other effective, protective, and healing choices. However, the lower than a predictable number of SARS‐CoV‐2 cases in countries with fragile health systems is mystifying. Recently, there has been a buzz about the protective effect of Bacille Calmette‐Guérin (BCG) vaccine in COVID‐19 through long‐term boosting of trained immunity. Based on epidemiological correlations, we link up that BCG vaccination adopted by different countries might influence the SARS‐CoV‐2 transmission patterns and/or COVID‐19 associated mortality through the vaccine's capacity to confer heterologous protection. A number of clinical studies are underway to investigate this possibility but even if they prove effective‐many questions will remain. Moreover, responsible stewardship of the BCG vaccine in the context of the COVID‐19 epidemic is directly needed. [ABSTRACT FROM AUTHOR]

Published
2021
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34. RETRACTED ARTICLE: Tridax procumbensflavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation

Author

Al Mamun, Md. Abdullah, Hosen, Mohammad Jakir, Khatun, Amina, Alam, M. Masihul, and Al-Bari, Md. Abdul Alim

Abstract

Background: The Tridax procumbensextracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbensflavonoids (TPF) significantly suppressed the RANKL-induced osteoclasts differentiation and bone resorption. The TPF also promoted osteoblasts differentiation and bone formation demonstrated by increasing bone formation markers in cultured mouse primary osteoblasts. However, the effects of the TPF on in vivo bone formation remain unclear. In this study, we investigated the effects of the TPF on in vivo bone formation, injected the TPF (20 mg/kg) twice a day in the low calcium diet mice and killed them after 21 day. Radiographic and histomorphometric analyses were performed on the dissected bones to determine the anabolic effects of the TPF. Results: Bone mineral density and bone mineral content of the TPF-treated mice were significantly increased compared to the control mice. Bone formation-related indices like osteoblast number, osteoblast surface, bone volume, mineralizing surface, mineral apposition rate and bone formation rate were significantly increased in the TPF-treated mice compared to the control mice. Conclusion: Our findings point towards the stimulation of bone formation by TPF, suggested that the TPF could be a potential natural anabolic agent to treat patients with bone loss-associated diseases such as osteoporosis.

Published
2017
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35. Mechanistic insights into fasting-induced autophagy in the aging heart.

Author

Parvaresh H, Paczek K, Al-Bari MAA, and Eid N

Abstract

Autophagy is a prosurvival mechanism for the clearance of accumulated abnormal proteins, damaged organelles, and excessive lipids within mammalian cells. A growing body of data indicates that autophagy is reduced in aging cells. This reduction leads to various diseases, such as myocardial hypertrophy, infarction, and atherosclerosis. Recent studies in animal models of an aging heart showed that fasting-induced autophagy improved cardiac function and longevity. This improvement is related to autophagic clearance of damaged cellular components via either bulk or selective autophagy (such as mitophagy). In this editorial, we summarize the mechanisms of autophagy in normal and aging hearts. In addition, the protective effect of fasting-induced autophagy in cardiac aging has been highlighted., Competing Interests: Conflict-of-interest statement: All the authors declare that they have no conflict of interest to disclose., (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)

Published
2024
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