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Activities of succinate dehydrogenase (SDH), alpha-glycerophosphate dehydrogenase (alpha-GPDH), and nonspecific esterase (NE) were studied in blood lymphocytes of healthy men and chronic alcoholics. SDH activity was notably decreased, while the levels of alpha-GPDH and NE were increased in alcoholics. The detected metabolic changes suggest lymphocyte dysfunction and hence, impairment of neuroimmune relationships, which may be the central component in the pathogenesis of chronic alcoholism.

The metabolic state of rat liver was studied in vivo 1, 6, and 18 h after single hyperthermia (42 degrees C). It was shown that intracellular compensatory reactions involved in restoration of the energy state and realization of endogenous cytoprotective mechanisms play a role during recovery.

The metabolic changes in rat liver were studied during a reduction period after the overheating (25 min, 42 degrees C) using the isolated organ perfusion. First six hours after the treatment were characterised by a decrease of the respiration rate, the activation of glycolysis and an exhaustion of hepatic carbohydrate resources. The development of adaptive reaction resulted in the recovery of respiration rate to 18 h. This may provide subsequent restoration of hepatic metabolism and normalisation of the organ functioning.