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This study was undertaken to observe the effects of spirulina (Spirulina platensis) and riboflavin in hematological and biochemical parameters against arsenic toxicity in Long Evans rat. Sixty male rats were taken to perform the study. Experimental rats were divided into five equal groups. Each group consists of 12 rats. Animals of T0 group were given normal feed and water and kept as control. Rats of T1, were given arsenic trioxide @ 100 mg/L drinking water orally. Rats of group T2 were given arsenic trioxide @ 100 mg/L drinking water and with spirulina @ 1 gm/kg feed. Group T3 were given arsenic trioxide @ 100 mg/L with riboflavin @ 10mg /kg body weight. Group T4 were given arsenic trioxide and spirulina and riboflavin with same dose up to 45 days respectively. Four rats from each group (T0, T1, T2, T3 and T4) were sacrificed at 15 days interval to determine body weight, hematological and biochemical parameters. Result showed that in group T1, body weight gain was minimum, whereas in group T2, T3 and T4 the body weight gain in rats were better. Reduction of TEC, Hb values were significant (P