85 results on '"Aksoyek S"'
Search Results
2. No Evidence of Cardiac Autonomic Involvement in Ankylosing Spondylitis, as Assessed by Heart Rate Variability
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Yildirir, A., Aksoyek, S., Calguneri, M., Aytemir, K., Apras, S., Kiraz, S., Kabakci, G., Ovunc, K., Oto, A., and Kes, S.
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- 2001
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3. cTnT can be a useful marker for early detection of anthracycline cardiotoxicity
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Kilickap, S., Barista, I., Akgul, E., Aytemir, K., Aksoyek, S., Aksoy, S., Celik, I., Kes, S., and Tekuzman, G.
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- 2005
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4. Treatment of intestinal pseudo obstruction by segmental resection
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Nayci, A., Avlan, D., Polat, A., and Aksoyek, S.
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- 2003
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5. Effect of an additional atropine injection during dobutamine infusion for myocardial SPET
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CANER, B., KARANFIL, A., UYSAL, U., TOKGOZOGLU, L., AKSOYEK, S., UGUR, O., CCIFTCI, I., ATALAR, E., KES, S., and BEKDIK, C.
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- 1997
6. Congenital granular-cell tumor of the gingiva
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Tokar, B., Boneval, C., MirapogElu, S., Tetikkurt, S., Aksoyek, S., Salman, T., and Celik, A.
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Health - Abstract
Byline: B. Tokar (1), C. Boneval (2), S. MirapogElu (2), S. Tetikkurt (3), S. Aksoyek (2), T. Salman (2), A. Celik (2) Keywords: Key words Congenital granular-cell tumor; Myoblastoma; Epulis; Gingiva Abstract: Congenital granular cell tumors of the gingiva (synonyms: congenital myoblastoma, congenital epulis) originate from the alveolar ridge in newborns. They are rare granular-cell tumors with benign histology. The main differential diagnosis is epignathus (oral teratoma). Early surgical excision is recommended due to a risk of airway obstruction and difficulty feeding. Author Affiliation: (1) Yunusemre Cad. Ufuk Apt. 63-18 26090 TR-EskiAehir, Turkey, TR (2) Department of Pediatric Surgery, University of Istanbul, Istanbul School of Medicine, Capa 34390 Istanbul, Turkey, TR (3) Department of Pathology, University of Istanbul, Istanbul School of Medicine, Capa 34390 Istanbul, Turkey, TR Article note: Accepted: 5 August 1997
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- 1998
7. Increased Troponin-T level is associated with anthracycline-induced diastolic dysfunction of the left ventricle
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Kilickap, S., primary, Barista, I., additional, Akgul, E., additional, Aytemir, K., additional, Aksoyek, S., additional, Celik, I., additional, Kes, S. S., additional, and Tekuzman, G., additional
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- 2004
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8. 865 Hyperthomocysteinemia is associated with the presence of left atrial spontenous echo contrast and or thrombus in stroke patients with nonvalvular atrial fibrillation
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OZER, N, primary, KYLYC, H, additional, ARSAVA, E, additional, ATALAR, E, additional, AY, H, additional, AKSOYEK, S, additional, OVUNC, K, additional, TOKGOZOOLU, L, additional, SARYBAS, O, additional, and KES, S, additional
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- 2003
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9. 870 Assessment of left atrial appendage wall velocities in patients with stroke
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OZER, N, primary, KYLIC, H, additional, ABALY, G, additional, AY, H, additional, ATALAR, E, additional, AKSOYEK, S, additional, OVUNC, K, additional, TOKGOZOOLU, L, additional, OZMEN, F, additional, and KES, S, additional
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- 2003
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10. Treatment of intestinal pseudo obstruction by segmental resection
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Nayci, A., primary, Avlan, D., additional, Polat, A., additional, and Aksoyek, S., additional
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- 2002
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11. QT dispersion as a predictor of arrhythmic events in patients with ankylosing spondylitis
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Yildirir, A., primary, Aksoyek, S., additional, Calguneri, M., additional, Aytemir, K., additional, Kabakci, G., additional, Ovunc, K., additional, Nazlı, N., additional, Ozmen, F., additional, Oto, A., additional, and Kes, S., additional
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- 2000
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12. 652 Decreased flow velocity in the left atrial appendage function is a risk factor for stroke in patients with the sinus rhythm
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OZER, N, primary, TOKGOZOGLU, L, additional, OVUNC, K, additional, KABAKCY, G, additional, AKSOYEK, S, additional, AYTEMIR, K, additional, and KES, S, additional
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- 1999
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13. 613 Effect of diastolic dysfunction on signal- averaged EKG P wave duration in patients with essential hypertension
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OZER, N, primary, AYTEMIR, K, additional, AKSOYEK, S, additional, OVUNC, K, additional, ATALAR, E, additional, KES, S, additional, and OTO, A, additional
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- 1999
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14. 600 Left ventricular diastolic functions in chronic renal failure patients with left ventricular hypertrophy
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OZER, N, primary, AYTEMIR, K, additional, ALTUN, B, additional, SADE, E, additional, AKSOYEK, S, additional, ERDEM, Y, additional, OVUNC, K, additional, and KES, S, additional
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- 1999
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15. Ischemic preconditioning reduces intestinal apoptosis in rodents
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Cinel, I, Avlan, D, Cinel, L, Polat, G, Atici, s, Serinol, H, Aksoyek, S, and Oral, U
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Meeting Abstract - Published
- 2002
16. Increased dispersion of ventricular repolarisation during stress test induced ischaemia
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AYTEMIR, K., primary, OZER, N., additional, and AKSOYEK, S., additional
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- 1999
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17. Holter monitoring for 24 hours in patients with thromboembolic stroke and sinus rhythm diagnosed in the emergency department.
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Gunalp M, Atalar E, Coskun F, Yilmaz A, Aksoyek S, Aksu NM, Sivri B, Gunalp, Muge, Atalar, Enver, Coskun, Figen, Yilmaz, Arda, Aksoyek, Serdar, Aksu, Nalan Metin, and Sivri, Bulent
- Abstract
It is well known that patients with ischemic stroke show ST-T abnormalities and various rhythm abnormalities on an electrocardiogram (ECG). The most commonly encountered rhythm abnormality is atrial fibrillation. It was recently shown that paroxysmal atrial fibrillation (PAF) is an important causative factor in patients with stroke. Detection of PAF is important in identifying the cause, prognosis, and treatment in patients with thromboembolic stroke. Investigators in the present study followed patients with thromboembolic stroke who had been admitted to the emergency department in sinus rhythm; 24-h Holter monitoring was used, and patients were assessed at referral and every 6 h for 24 h with ECG, which was used to detect rhythm disturbances, especially PAF. In 26 patients with stroke who came to the emergency department, acute thromboembolic stroke was diagnosed on the basis of magnetic resonance imaging; no rhythm abnormalities were noted on Holter monitoring. Eighteen patients were male and 8 were female (mean age: 66+/-13 y). Arrhythmia was identified on ECG in 3 patients (11%) and on 24-h Holter monitoring in 24 patients (92%). PAF was diagnosed in 3 patients (11%) on ECG and in 11 patients (42%) on Holter monitoring. In 2 patients, nonsustained ventricular tachycardia was detected only on Holter monitoring, which was found to be significantly superior to ECG for the detection of arrhythmias (P<.001). Investigators found no significant relationship between PAF and variables such as hypertension, diabetes, coronary artery disease, history of myocardial infarction, ST-T changes, and elevations in cardiac markers. However, a significant relationship (P<.01) was seen between nonsustained ventricular tachycardia and a history of myocardial infarction. No relationship was discerned between arrhythmia and stroke localization. Study results suggested that (1) PAF is a commonly diagnosed rhythm abnormality, and (2) Holter monitoring is superior to routine ECG for the detection of arrhythmias such as PAF in patients anticipated to have thromboembolic stroke with sinus rhythm. [ABSTRACT FROM AUTHOR]
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- 2006
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18. Doppler Tissue Evaluation of Intra-atrial and Interatrial Electromechanical Delay and Comparison with P-wave Dispersion in Patients with Mitral Stenosis
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Ozer, N., Yavuz, B., Can, I., Atalar, E., Aksoyek, S., Ovunc, K., Ozmen, F., and Kes, S.
- Abstract
Objective: The aim of our study was to: (1) measure atrial electromechanical delay in patients with mitral stenosis (MS) and in a control group; (2) find the echocardiographic parameters that affect atrial electromechanical delay; and (3) examine the correlation between atrial electromechanical delay and P-wave dispersion (PWD). Methods: A total of 25 patients with pure MS (age 43 +/- 10 years; 18 women, 7 men) and 16 control subjects (age 41 +/- 8 years; 9 women, 7 men) were studied. Interatrial and intra-atrial electromechanical delay was measured with Doppler tissue echocardiography. From the 12-lead electrocardiograms, PWD was calculated. Results: Interatrial electromechanical delay was 71.2 +/- 33 in the MS group and 40.5 +/- 21.0 in the control group (P = .01). In the MS group, PWD was 50 +/- 7 and in the control group it was 29 +/- 5 (P = .03). A positive correlation was detected between interatrial electromechanical delay and PWD (r = 0.6, P = .03). Conclusion: This study shows that interatrial electromechanical delay gets longer in MS and is correlated with PWD. Atrial electromechanical delay is related with left atrial size but not with severity of MS.
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- 2005
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19. Increased plasma levels of soluble selectins in patients with unstable angina
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Atalar, E., Aytemir, K., Haznedaroglu, I., Ozer, N., Ovunc, K., Aksoyek, S., Kes, S., Kirazl, S., and Ozmen, F.
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- 2001
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20. A retrospective review of 228 episodes of infective endocarditis where rheumatic valvular disease is still common
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Cetinkaya, Y., Akova, M., Akaln, H. E., Ascoglu, S., Hayran, M., Uzuns, O., Aksoyek, S., Tokgozoglu, L., Oto, A., and Kes, S.
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- 2001
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21. Increased QT dispersion in the absence of QT prolongation in patients with Behcet's disease and ventricular arrhythmias
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Aytemir, K., Ozer, N., Aksoyek, S., Ozcebe, O., Kabakci, G., and Oto, A.
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- 1998
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22. QT dispersion and autonomic nervous system function in patients with type 1 diabetes
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Aytemir, K., Aksoyek, S., Ozer, N., Gurlek, A., and Oto, A.
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- 1998
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23. Prediction of atrial fibrillation recurrence after cardioversion by P wave signal-averaged electrocardiography^1
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Aytemir, K., Aksoyek, S., Yildirir, A., Ozer, N., and Oto, A.
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- 1999
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24. Atrial fibrillation after coronary artery bypass surgery: P wave signal averaged ECG, clinical and angiographic variables in risk assessment
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Aytemir, K., Aksoyek, S., Ozer, N., Aslamaci, S., and Oto, A.
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- 1999
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25. Right ventricular outflow tract thrombus in a case of Behcet's disease
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Ozer, N., Ciftci, O., Demirci, M., Atalar, E., Ovunc, K., Aksoyek, S., Ozmen, F., and Kes, S.
- Abstract
Behcet's disease is known as a chronic systemic vasculitic syndrome, the hallmark of which is recurrent oral aphthous and genital ulcerations and uveitis. Vascular involvement, mainly thrombosis, reportedly affects as many as one-third of patients. Cardiac involvement, however, is very rare. We present in this report a young female patient developing right ventricular thrombus while being treated medically.
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- 2005
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26. Sex hormone concentrations in men do not predict the presence and extent of angiographically assessed coronary artery disease
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Aylin YILDIRIR, Kabakci, G., Can, I., Erbas, B., Unsal, I., Tokgozoglu, L., Aksoyek, S., Ovunc, K., Oto, A., Ozmen, F., and Kes, S.
27. Effects of blood pressure control on ventricular arrhythmias and related non-invasive electrocardiologic parameters in hypertensive patients
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Batur, Mk, Onalan, O., Aylin YILDIRIR, Cagrikul, R., Kabakci, G., Aksoyek, S., Ozkutlu, H., and Oto, A.
28. Melatonin rhythms in type 2 diabetes mellitus with respect to cardiac autonomic functions
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Neslihan Bascil Tutuncu, Koray, Z., Deger, A., Batur, Mk, Yildirir, A., Onalan, O., Aksoyek, S., Kabakci, G., and Erbas, T.
29. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Ad Darts Memo, Morris For The Collaboration, Juhl, C., Porksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th, Muller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Bjorn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H-M, Oksanen, L., Tuomainen, T-P, Kontula, K., Salonen, J. T., Dekker, J. M., Boks, P., Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., Macalpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M. Jr, Kozakova, H., Kaas, A., Kofronova, O., Tlaskalova-Hogenova, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sorensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Hasko, G., Szabo, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H-H, Genediab, Study Group, Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabak, A. Gy, Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Canton, A., Burgos, R., Hernandez, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simo, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., Mcdermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y-S, Sternesjo, J., Sandler, S., Chen, M-C, Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Breant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessieres-Lacombe, S., Gedec, Study Group, Tauber, J-P, Home, P. D., Lindholm, A., Riis, A., European Insulin Aspart Study Group, Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Us Dm, Study Group Of Insulin Glargine In Type, Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Hvidore Study group on Childhood Diabetes, Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Ukpds, Group, Steiner, G., Dais, Project Group, Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Verges, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph, Benko, B., Ljubic, S., Turk, Z., Granic, M., Marz, W., Wollschlager, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O Rahilly, S., Hattersley, A. T., Mccarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Siman, C., Wisse, Bert, Gittenberger-De Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ozegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rosc, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Skrha, J., Kvasnicka, J., Kalvodova, B., Hilgertova, J., Schatteman, K., Goossens, F., Scharpe, S., Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Haring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., Mckinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnas, A. M., Andersen, N. Aa, Osterhoff, M., Mohlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Furnsinn, C., Nowotny, P., Waldhausl, W., Roden, M., Neeft, M., Meijer, A. J., Bavenholm, P., Pigon, J., Efendic, S., Kastenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovska, A., Kasalicky, P., Hosova, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefebvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valero, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., Galan, B., Netea, M. G., Hancu, N., Smits, P., Meer, J. W. M., Osterbye, T., Jorgensen, K. H., Tranum-Jensen, J., Fredman, P., Hoy, M., Bokvist, K., Olsen, H. L., Horn, T., Gromada, J., Laub, R., Lohmann, T., Hahn, H. J., Adler, T., Emmrich, F., Rabuazzo, A. M., Lupi, R., Dotta, F., Patane, G., Marselli, L., Realacci, M., Piro, S., Del Guerra, S., Santangelo, C., Navalesi, R., Purrello, F., Marchetti, P., Vos, P., Visser, L., Haan, B. J., Klok, P., Schilfgaarde, R., Poppema, S., Juang, J-H, Kuo, C-H, Hsu, B. R-S, Nacher, V., Perez, M., Biarnes, M., Raurell, M., Soler, J., Montanya, E., Ritzel, R., Maubach, J., Busing, M., Becker, T., Klempnauer, J., Hucking, K., Schmiegel, W. H., Nauck, M. A., Boucek, P., Saudek, F., Adamec, M., Kozitarova, R., Jedinakova, T., Vlasakova, Z., Bartos, V., Maffi, P., Bertuzzi, F., Aldrighetti, L., Taglietti, M. V., Castelnuovo, A., Pozza, G., Di Carlo, V., Secchi, A., Renier, G., Mamputu, J-C, Gillespie, J. S., Mcmaster, D., Mercer, C., Trimble, E. R., Lecomte, M., Vericel, E., Paget, C., Ruggiero, D., Lagarde, M., Wiernsperger, N., Pricci, F., Leto, G., Amadio, L., Cordone, S., Iacobini, C., Catalano, S., Violi, F., Rotella, C. M., Pugliese, G., Zicari, A., Gradini, R., Sale, P., Pala, L., Cresci, B., Giannini, S., Manuelli, C., Dahlfors, G., Arnqvist, H. J., Gonelle-Gispert, C., Halnan, P. A., Sadoul, K., Wolter, S., Lang, J., Niwa, T., Yu, W., Hidaka, H., Senda, T., Niki, I., Fukasawa, T., Renstrom, E., Barg, S., Seward, E., Rorsman, P., Rutter, G. A., Molinete, M., Lilla, V., Ravazzola, M., Halban, P. A., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Zwiller, J., Berggren, P-O, Msengul, A., Salman, F., Sargrn, M., Ozer, E., Karsidaǧ, K., Salman, S., Gedik, S., Satman, I., Dinccaǧ, N., Yilmaz, M. T., Lloyd, A., Hopkinson, P. K., Testa, M. A., Blonde, L., Turner, R. 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W., Kowalska, I., Telejko, B., Bachorzewska-Gajewska, A., Prokop, J., Kochman, W., Musial, W., Naskret, D., Oleksa, R., Zozulinska, D., Sowinski, J., Wierusz-Wysocka, B., Klamann, A., Jonas, M., Muller-Lung, U., Heuser, L., Launhardt, V., Valensi, P., Paries, J., Torremocha, F., Brulport, V., Sachs, R. N., Vanzetto, G., Levy, M., Lormeau, B., Halimi, S., Perfornis, A., Boumal, D., Zimmermann, C., Bernard, Y., Sabbah, A., Meneveau, N., Gautier, S., Bassand, J. P., Andel, M., Kraml, P., Potockova, J., Dvorakova, H., Treslova, L., Nuttall, S. L., Martin, U., Kendall, M. J., Schiaffini, R., Pantaleo, A., Battocletti, T., Vaccari, V., Brufani, C., Martuscelli, E., Gargiulo, P., Nieszner, E., Posa, I., Kocsis, E., Preda, I., Pogatsa, G., Koltai, M. Z. S., Stefanidis, A., Manoussakis, S., Handanis, S., Zairis, M., Vitalis, D., Dadiotis, L., Fiorina, P., La Rocca, E., Astorri, E., Rossetti, C., Lucignani, G., Giudici, D., Castoldi, R., Mazarakis, N., Giagiakou, E., Karavidas, A., Agellou, A., Karamani, O., Matsakas, E., Caviezel, F., Morricone, L., Ranucci, M., Denti, S., Cazzaniga, A., Enrini, R., Isgro, G., Gonzalez Molina, F. J., Sala, J., Masia, R., Marrugat, J., Kruszewski, P., Wolnik, B., Bieniaszewski, L., Swierblewska, E., Semetkowska-Jurkiewicz, E., Krupa-Wojciechowska, B., Vasilikos, P. G., Alaveras, A. E. G., Anastasopoulos, N. G., Chala, E., Sidira, M., Christakopoulos, P. D., Poulsen, P. L., Hansen, K. W., Ebbehoj, E., Knudsen, S. T., Mogensen, C. E., Ramu, Y., Vidyullatha, Y., Strojek, K., Gorska, J., Morawin, E., Ritz, E., Ciavarella, A., Malini, P. L., Strocchi, E., Fiumi, N., Ambrosioni, E., Idzior-Walus, B., Stevens, L., Mceneny, J., O Kane, M. J., Moles, K. W., Mcmaster, C., Young, I. S., Leonhardt, W., Konstadelou, E., Gurlek, Alper, Soedamah-Muthu, S., Taskinen, M. R., Ehnholm, C., Wagner, A., Bayen, Laia, Rigla, M., Ortega, E., Caixas, A., Mestron, A., Ordonez, J., Perez, A., Sotiropoulou, G., Servais, P. L., Bertolotto, A., Pilo, M., Suchankova, G., Andratschke, S., Tschop, M., Strasburger, C-J, Rizzo, L., Aerts, P., Vinckx, M., Ansquer, J. C., Ryan, M., Buter, H., Navis, G. J., Jong, P. E., Zeeuw, D., Carreras, G., Gimenez, G., Pou, J. M., Howorka, K., Gabriel, M., Pumprla, J., Koves, A., Bhowmik, N. B., Haque, A., Rahman, A., Paleari, F., Gamba, P., Mauri, G., Rovaris, G., Giannattasio, C., Piatti, M. L., Zincone, A., Cavaletti, G., Mancia, G., Lan, S., Arezzo, J., Gerber, R. A., Klioze, S. S., Saponara, C., Tartaglione, T., Cercone, S., Caputo, S., Meloni, T., Brunetti, D., Di Lazzaro, V., Xu, G., Jiang, H. Y., Shy, M. E., Sugimoto, K., Zhang, W-X, Kuchmerovskaya, T., Donchenko, G., Shymansky, I., Kuchmerovsky, N., Pakyrbaeva, L., Cameron, N. E., Keegan, A., Cotter, M. A., Mirrlees, D., Smale, S. E., Biessels, G. J., Duis, S. E. J., Kamal, A., Gispen, W. H., Carrington, A., Carman, S., Smiarowski, H., Lavoie, D., Sawicki, D., Sabetta, A., Litchfield, J., Zandt, M., Sredy, J., Smirnova, V., Strokov, I., Ivanova, L., Ichunina, A., Nakamura, J., Nakayama, M., Hamada, Y., Chaya, S., Kato, K., Kasuya, Y., Mizubayashi, R., Miwa, K., Yasuda, Y., Kamiya, H., Hotta, N., Biro, K., Kukorelli, T., Szilagyi, N., Kurthy, M., Komaromy, A., Mogyorosi, T., Nagy, K., Cakir, M., Baskal, N., Gullu, S., Elhan, A. H., Erdogan, G., Ziegler, D., Piolot, R., Neubauer, J., Senesi, B., Bonetti, R., Napolitano, A., Canepa, F., Ottonello, P., Schabmann, A., Gimenez-Perez, G., Arroyo, J. A., Lopez, T., Ponz, E., Mauricio, D., Diem, P., Zanchin, L., Suter, S. L., Lefrandt, J. D., Smit, A., Roon, A. M., Dullaart, R., Voita, D., Mackevics, V., Vitols, A., Lengyel, Cs, Farkas, Gy, Torok, T., Legrady, P., Varkonyi, T. T., Kardos, A., Gingl, Z., Kempler, P., Rudas, L., Lonovics, J., Marchand, M., Stevens, L. K., Tarnas, Gy, Eurodiab Iddm, Study Group, Estrella, F., Christensen, N. J., Keresztes, K., Barna, I., Hermanyi, Zs, Vargha, P., Bonnevie, L., Chanudet, X., Larroque, P., Tutuncu, N. Bascil, Deger, A., Batur, M. K., Yildirir, A., Onalan, O., Aksoyek, S., Kabakciota, G., Erbas, T., Galicka-Latala, D., Surdacki, A., Gerritsen, J., Tenvoorde, B. J., Heethaar, R. M., Tagawa, T. S., Kodama, M., Yoshioka, R., Yamasaki, Y., Didangelos, T., Athyros, V., Kontopoulos, A., Papageorgiou, A., Karamitsos, D., Lacigova, S., Rusavy, Z., Karova, R., Perrild, H., Kay, L., Jorgensen, T., Bien, A. I., Witek, P., Geraldes, Elizabete, Rodrigues, D., Pereira, L., Domenech, A., Leitao, P., Anagnostopoulos, D., Foster, A. V. M., Nag, S., Barsoum, M., Lewis, G., Dunlop, N., Connolly, V., Bilous, R., Kelly, W., Chantelau, E., Gede, A., Sharman, D., O Halloran, D., Best, C., Abbas, Z. G., Lutale, J., Gill, G. V., Jarvis, W. R., Archibald, L. K., Corcoran, S., Mansell, J., Pibworth, L., Terada, H., Shiba, T., Utugi, N., Utugi, T., Blum, M., Strobel, J., Hoffken, K., Razvi, F. M., Kritzinger, E. E., Taylor, K., Jones, S., Illahi, W., Grubetaer, M., Hartmann, P., Hoffstadt, K., Leiden, H. A., Moll, A. C., Polak, B. C. P., Pietragalla, G. B., Maurino, M., Montanaro, M., Karadeniz, S., Tommasini, P., Quadrini, C., Demiraj, V., Rispoli, E., Ota, A., Takama, H., Saito, N., Hemandez, C., Lepore, D., Antico, L., Giardina, B., Franconi, F., Michoud, E., Chamot, S., Riva, Ch, Hammes, H-P, Renner, O., Breier, G., Lin, J., Alt, A., Betzholtz, C., Bretzel, R. G. Rd, Manti, R., Gallo, M., Molinar Hin, A., Brignardello, E., Boccuzzi, G., Li, Shanfang, Xiang, Kunsan, Zhang, Rugeng, Shangguan, Xinhong, Wu, Jianrong, Donnan, P. T., Broomhall, J., Hunter, K., Morris, A. D., Darts Memo, Collaboration, Ioannidis, G., Peppa, M., Rontogianni, E., Kallifronas, M., Lekatsas, I., Chrysanthopoulou, G., Anthopoulos, L., Kesse, M., Thalassinos, N., Neves, C., Medina, J. L., Lopes, F., Guvener, N., Guvener, M., Kocagoz, T., Boke, E., Pasaoglu, I., Bascil Tutuncu, N., Oto, A., Karvonen, M. K., Koulu, M., Pesonen, U., Mercuri, M., Rauramaa, R., Pittsburgh Epidemiology of Diabetes Complications (EDC) Study, Rutter, M. K., Kestevan, P., Mccomb, J. M., Marshall, S. M., Sobieska, M., Wiktorowicz, K., Kanters, S. D. J. M., Banga, J. D., Algra, A., Frijns, C. J. M., Beutler, J. J., Fijnheer, R., Nicoloff, G., Baydanoff, S., Stanimirova, N., Petrova, Ch, Lario, S., Campistol, J. M., Cases, A., Claria, J., Inigo, P., Esmatjcs, E., Sarman, B., Toth, M., Kocsis, I., Somogyi, A., Bumbure, A., Jachimowicz, K., Samson, J., Tomasiak, M., Sobol, A., Stanczyk, L., Watala, C., Stradina, P., Wisniewska-Jarosinska, M., Marciniak, D., Wieclawska, B., Golanski, J., Zinnat, R., Mahmud, I., Buyukasik, Yahya, Demiroglu, H., Szczepanik, A., Skowronski, M., Murawska, A., Meeking, D. R., Allard, S., Munday, J., Chowienczyk, P., Shaw, K. M., Cummings, M. H., Simkova, R., Jirsa, M., Hadoke, P. W. F., Mcintyre, C. A., Jones, G. C., Williams, B. C., Elliott, A. I., Mcknight, J. A., Pernow, J., Bombonato, G. C., Finucci, G. F., Zotta, L., Senses, V., Ozyazgan, S., Ince, E., Tuncdemir, M., Sultuybek, G., Akkan, A. G., Unlucerci, Y., Bekpinar, S., Meyer, M. F., Lee, B. C., Shore, A. C., Humphreys, J. M., Tooke, J. E., Omo, G., Giovannitti, G., Caricato, F., Mariani, M., Pedrinelli, R., Kiviet-Boehm, C., Schwelling, V., Pfohl, M., Mcinerney, D., Itoh, H., Ohno, T., Katoh, N., Baumgartner-Parzer, S., Artwohl, M., Graier, W., Ludwig, C., Tachi, Y., Bannai, C., Shinohara, M., Shimpuku, H., Ohura, K., Bertacca, A., Sasvari, M., Szaleczki, E., Pusztai, P., Boes, U., Klaus, E., Dittrich, P., Wagner, Z., Wittmann, I., Poto, L., Wagner, L., Mazak, I., Nagy, J., Feletto, F., Taboga, C., Tonutti, L., Lizzio, S., Russo, A., Selmo, V., Ceriello, A., Lekakis, J., Papamichael, C. M., Stamatelopoulos, K., Stamatelopoulos, S., Yillar, D. O., Gay, M., Lillaz, E., Passaro, A., Vanini, A., Calzoni, F., D Elia, K., Carantoni, M., Zuliani, G., Fellin, R., Solini, A., Chwatko, G., Bald, E., Dramais, A-S, Wallemacq, P. E., Vandeleene, B., Ciaria, M. V., Ariano, M., Strom, R., Gibney, J., Weiss, U., Turner, B., O Gorman, P., Watts, G., Powrie, J., Crook, M., Shaw, K., and Cummings, M.
30. Increased dispersion of ventricular repolarisation during stress test induced ischaemia
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Ayternir, K, Ozer, N, and Aksoyek, S
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- 1999
31. New insights into the mechanisms of diastolic dysfunction in patients with type 2 diabetes.
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Bayraktar A, Canpolat U, Demiri E, Kunak AU, Ozer N, Aksoyek S, Ovunc K, Ozkan A, Yildiz OB, and Atalar E
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- Adult, Blood Glucose analysis, Body Mass Index, Female, Heart Failure, Diastolic physiopathology, Humans, Male, Middle Aged, Statistics as Topic, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 diagnosis, Glycation End Products, Advanced metabolism, Receptor for Advanced Glycation End Products blood, Ventricular Dysfunction, Left blood, Ventricular Dysfunction, Left etiology, Ventricular Dysfunction, Left physiopathology
- Abstract
Background: Little is known about the role of advanced glycation end products (AGEs) and their receptor (RAGE) in diabetic cardiovascular complications. Therefore, we aimed to evaluate the association of serum soluble RAGE (sRAGE) levels and left ventricular (LV) diastolic dysfunction in patients with type 2 diabetes., Methods: Our study consisted of 40 patients with type 2 diabetes and 40 age- and sex-matched healthy control group. Subjects with age ≥ 50 years old and any cardiovascular risk factors or conditions were excluded from the study. Serum sRAGE levels determined by enzyme-linked immunosorbent assay and LV diastolic dysfunction were evaluated according to current American Society of Echocardiography guidelines., Results: Baseline characteristics were similar between groups except body mass index, waist-hip ratio, and fasting glucose levels. Serum sRAGE level was significantly lower in diabetic group compared with control group (676 ± 128 vs. 1044 ± 344, p < 0.05). Diastolic dysfunction was observed in 50% of diabetic patients (40% grade I and 10% grade II). Correlation analysis showed that serum sRAGE was negatively correlated with duration of diabetes, septal E'/A', lateral E'/A', and average E/E'. In multivariate regression analysis, serum sRAGE level was strongly associated with diastolic dysfunction in patients with type 2 diabetes., Conclusion: Our study showed that serum sRAGE level was significantly lower in type 2 diabetic patients aged < 50 years old. Also, sRAGE has negative correlation with the duration of diabetes and it was significantly associated with the presence of diastolic dysfunction in type 2 diabetes.
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- 2015
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32. Are the conventional cutoff values adequate to define hypertension in young women?
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Atalar E, Okutucu S, Aksoy H, Demiri E, and Aksoyek S
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- Adult, Body Weight, Family Health, Female, Humans, Male, Sex Factors, Smoking epidemiology, Turkey epidemiology, Blood Pressure physiology, Hypertension epidemiology
- Abstract
Background: Women have lower systolic blood pressure (SBP) levels than men during early adulthood. Diastolic blood pressure (DBP) tends to be just marginally lower in women than men regardless of age., Objective: Aims of this study were (i) to determine 95th percentile value of SBP, DBP, and mean arterial blood pressure in healthy women, and (ii) to evaluate the effects of basal demographic and anthropometric features on blood pressure., Methods: Six hundred and fifty-four consecutive participants (18-35 years old) were initially enrolled in the study but among them 54 (8.2%) cases were excluded. Demographic features, relevant personal and family history data about hypertension, smoking habits, and use of medications were interviewed using a questionnaire. Blood pressure, height, weight, and waist circumference of every case were measured., Results: Of the 600 patients (mean age, 24.6±4.0 years), 124 (20.7%) were currently smokers, 20 (3.3%) had history of hypertension during pregnancy, and 291 (48.5%) had family history of hypertension in women (mean age, 61.0±9.51 years). Reference ranges of 5th and 95th percentile values for SBP were determined as 74 and 115 mmHg, for mean arterial blood pressure as 57 and 85 mmHg, for DBP as 45 and 72 mmHg, respectively., Conclusion: In conclusion, cutoff values of hypertension in healthy women, which were determined by our study, are lower than the standard cutoff values for definition of hypertension in adults. However, clinical importance of these findings should be investigated in further studies involving larger population with prospective follow-up.
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- 2010
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33. Intron 4 VNTR polymorphism of eNOS gene is protective for cardiac syndrome X.
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Sinici I, Atalar E, Kepez A, Hayran M, Aksoyek S, Tokgozoglu L, and Ozmen F
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- Adult, Aged, Female, Humans, Male, Microvascular Angina prevention & control, Middle Aged, Introns, Microvascular Angina genetics, Minisatellite Repeats, Nitric Oxide Synthase Type III genetics
- Abstract
Microvascular abnormalities caused by endothelial dysfunction seem to be responsible for the myocardial ischemia in patients with cardiac syndrome X (CSX). Nitric oxide is a key mediator of endothelial function and is synthesized by endothelial nitric oxide synthase (eNOS). We investigated if the 3 potential polymorphisms of the eNOS gene (VNTR in intron 4, T786C polymorphism in the promoter region, and G894T polymorphism in exon 7) are independent risk factors for CSX. Sixty-nine patients with CSX and 73 healthy controls were studied. Genotypes were determined through polymerase chain reaction with or without restriction endonuclease digestions. Genotype distribution was significantly different between patients with CSX and controls for intron 4aa (allele for 4 repeats of 27 bp), intron 4aa genotype frequency being 3.2% and 6.8%, respectively. The presence of intron 4a is 3.2 (odds ratio) times protective (95% confidence interval, 1.5-6.8) for the risk of CSX disease. The protective effect of intron 4a polymorphism also holds after adjustment for age and sex and when the study group is limited to those without hypertension and hyperlipidemia. No significant difference was observed in genotype distribution of G894T and T786C polymorphism between patients with CSX and controls. In conclusion, intron 4aa genotype of eNOS gene is protective for CSX. No association was found between promoter and exon 7 polymorphisms of eNOS gene and CSX.
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- 2010
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34. Association of plasma osteopontin levels with coronary calcification evaluated by tomographic coronary calcium scoring.
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Aryan M, Kepez A, Atalar E, Hazirolan T, Haznedaroglu I, Akata D, Ozer N, Aksoyek S, Ovunc K, and Ozmen F
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- Anticholesteremic Agents pharmacology, Female, Humans, Male, Middle Aged, Renin-Angiotensin System drug effects, Calcinosis blood, Calcinosis diagnostic imaging, Calcium metabolism, Cardiomyopathies blood, Cardiomyopathies diagnostic imaging, Osteopontin blood, Tomography, X-Ray Computed
- Abstract
Evidence indicates that proteins controlling bone mineralization are also involved in the regulation of coronary calcification. The aim of the present study is to evaluate the association between plasma osteopontin (OPN) levels and coronary calcification quantified by using tomographic coronary calcium scoring. Plasma OPN levels were measured from samples of 80 intermediate-risk asymptomatic patients (56 +/- 10 years) who underwent tomographic coronary calcium scoring via multislice computed tomography for incremental risk stratification. There was no significant difference regarding OPN levels between patients with and without coronary calcification in the whole study population. Of 49 patients not receiving renin-angiotensin system inhibitors and/or statins, plasma OPN levels of patients with coronary calcification (38.7%) were significantly higher than those without coronary calcification (61.3%) (8.88 +/- 2.85 vs. 6.79 +/- 2.41, P = 0.008, respectively). On a binary logistic regression model, only age and plasma OPN level were found to be significant independent associated variables for the presence of coronary calcification in patients not receiving these medications (odds ratio for age, 1.15, P = 0.017; for plasma OPN levels, 1.63, P = 0.014). Our results indicate that plasma OPN levels may be predictive of coronary calcification, suggesting an important role of OPN in the atherosclerotic calcification pathogenesis.
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- 2009
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35. Early electrocardiographic diagnosis of acute coronary ischemia on the paced electrocardiogram.
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Kilic H, Atalar E, Ozer N, Ovunc K, Aksoyek S, Ozmen F, and Akdemir R
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- Humans, Electrocardiography, Myocardial Ischemia diagnosis
- Abstract
Background: Twelve-lead electrocardiography (ECG) is the most important source for the early diagnosis of an acute myocardial ischemia. However, its diagnostic value when the sequence of ventricular activation is altered by ventricular pacing is unknown. The aim of the study was to evaluate the ECG changes on the paced ECG during percutaneous coronary intervention (PCI) by doing temporary pacing., Methods and Results: Standard 12 lead baseline and temporary pacing ECG records were taken before the intervention in elective PCI patients. Standard 12 lead and temporary pacing ECG records were repeated during the balloon inflation. Fifteen (12 men and 3 women; age 57.2+/-9.7 years) subjects who were undergoing routine PCI were studied. Mean Delta ST deviation on the normal conduction ECG during inflation was 1.03+/-1.02 mV and mean Delta ST deviation on the paced ECG during inflation was 1.7+/-1.6 mV. The pre-inflation mean QRS duration on the paced ECG was 143.2+/-2.8 ms and during inflation mean QRS duration was 157.8+/-12.5 ms. The mean QRS prolongation was 14.6+/-13.6 ms on the paced ECG. Despite the presence of paced ECG abnormalities, significant ischemic ST segment deviations were seen after referencing the ST segment deviations to the pre-PCI. Also, there is significant QRS prolongation on the paced ECG during ischemia., Conclusions: The present study extends the correlation between normal and paced ECG during ischemia and the QRS prolongation could be a marker of myocardial ischemia on the paced electrocardiogram.
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- 2008
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36. B-type natriuretic peptide (BNP) levels in female systemic lupus erythematosus patients: what is the clinical significance?
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Karadag O, Calguneri M, Yavuz B, Atalar E, Akdogan A, Kalyoncu U, Kiraz S, Aksoyek S, Ozmen F, and Ertenli AI
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- Adult, Age Factors, Blood Pressure, Cardiovascular Diseases diagnosis, Echocardiography methods, Female, Humans, Inflammation, Lupus Erythematosus, Systemic diagnosis, Middle Aged, Models, Statistical, Prognosis, Prospective Studies, Risk Factors, Lupus Erythematosus, Systemic blood, Natriuretic Peptide, Brain blood
- Abstract
Cardiovascular disease is a major cause of death in patients with systemic lupus erythematosus (SLE) especially during the late phase of the disease. This study was conducted to evaluate B-type natriuretic peptide (BNP) levels in female SLE patients without cardiac symptoms and to investigate whether BNP levels correlated with echocardiographic findings. We studied 59 women with SLE and 33 healthy women. SLE patients with history of cardiac disease, diabetes mellitus, hypertension, and other inflammatory diseases were excluded from the study. All subjects had a complete history and physical examination. Overall disease activity assessment in SLE patients at the time of the study were derived by calculation of SLE disease activity index (SLEDAI). BNP levels were determined, and transthoracic echocardiography were performed in all subjects. There was no difference between SLE patients and controls in terms of age, blood pressure, smoking status, plasma glucose, creatinine levels, and lipid profiles. Nine patients had SLEDAI score greater than 5. All subjects had an EF greater than 55%. Diastolic dysfunction was more frequent in lupus patients than in controls (15 [25.4%] vs. 2 [6%]; p = 0.022). BNP levels of SLE patients were significantly higher than controls (median 17.9 range [5-211] pg/ml vs. median 14.7 range [5-39.7] pg/ml; p = 0.033). Twenty-seven of the SLE patients (46%) and seven of the controls (21%) had BNP levels greater than or equal to 20 pg/ml (p = 0.019). There were no differences in BNP levels of SLE patients with and without diastolic dysfunction (median 17.8 range [5-117] pg/ml vs. median 18.5 range [5-211] pg/mL; p = NS). BNP levels were positively correlated with left atrium diameter (r (2) = 0.39, p = 0.001). BNP levels did not correlate with erythrocyte sedimentation rate/C-reactive protein levels, SLEDAI scores, total steroid dosage used, or other echocardigraphic parameters. BNP levels were increased in female SLE patients without cardiac symptoms as compared to healthy controls. Although none of the SLE patients in our study had clinical signs of ischemic heart disease, increased levels of BNP in SLE patients might be a reflection of a ischemic myocardial tissue.
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- 2007
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37. QT interval dispersion changes according to the vessel involved during percutaneous coronary angioplasty.
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Kilic H, Atalar E, Necla O, Ovunc K, Aksoyek S, and Ozmen F
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- Aged, Coronary Artery Disease diagnosis, Female, Humans, Male, Middle Aged, Angioplasty, Balloon, Coronary, Coronary Artery Disease physiopathology, Coronary Artery Disease therapy, Coronary Vessels physiopathology, Electrocardiography
- Abstract
Increased QT dispersion (QTd) is a noninvasive marker of an electrophysiologic abnormality associated with high mortality in coronary artery disease. The purposes of this study were to measure changes in QTd and ST-segment changes immediately before, during and after intracoronary balloon inflation and to determine whether the coronary artery vessel involved and/or the duration of inflation affect(s) QTd. A total of 45 patients (32 men, 13 women, mean age 58 +/- 11 years) who were referred for elective percutaneous transluminal coronary angioplasty were included. The mean QT interval dispersions for all patients before the inflation, during the balloon inflation at 60 sec and after the balloon deflation at 5 min were 68 +/- 13 ms, 82 +/- 16 ms and 71 +/- 13 ms, respectively. There was no significant difference between baseline and 5 min after deflation. The increase in QTd during the balloon inflation was significant (p<0.01). There was no significant QTd change in patients with left circumflex artery (Cx) lesions during inflation and after deflation compared with baseline. The differences were statistically significant only in patients with left anterior descending (LAD) lesions and right coronary artery (RCA) lesions at 60 sec during balloon inflation (p=0.001 vs. p=0.04). Acute reversible myocardial ischemia induced by balloon inflation causes an increase in QTd limited to the LAD and RCA vessels. Therefore, when using QTd as a marker of myocardial repolarization abnormality due to acute reversible ischemia, the involved coronary artery vessel must be taken into account.
- Published
- 2007
38. Effects of acute exercise on fibrinolysis and coagulation in patients with coronary artery disease.
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Acil T, Atalar E, Sahiner L, Kaya B, Haznedaroglu IC, Tokgozoglu L, Ovunc K, Aytemir K, Ozer N, Oto A, Ozmen F, Nazli N, Kes S, and Aksoyek S
- Subjects
- Agglutination Tests, Coronary Angiography, Coronary Disease diagnosis, Coronary Disease physiopathology, Echocardiography, Female, Follow-Up Studies, Humans, Immunoenzyme Techniques, Male, Middle Aged, Peptide Fragments blood, Prognosis, Prothrombin, Severity of Illness Index, Stroke Volume physiology, Ventricular Function, Left physiology, Blood Coagulation physiology, Coronary Disease blood, Exercise physiology, Exercise Test methods, Fibrinolysis physiology
- Abstract
Acute physical exertion may trigger an acute coronary syndrome. Furthermore, acute physical exercise may influence hemostatic markers in healthy individuals. However, the effect of acute exercise on blood fibrinolysis and coagulation in patients with coronary artery disease (CAD) is still not well understood. Nineteen untrained patients with angiographically proven CAD (age, 58 +/- 9 years, 12 males), and 25 age- and sex-matched controls without CAD (age, 56 +/- 6 years, 16 males) underwent a treadmill exercise test. Global fibrinolytic capacity (GFC) and prothrombin fragment 1 + 2 (F 1 + 2) levels were measured before exercise, at peak exercise, and 2 hours after recovery. There were no differences between the groups with respect to left ventricular ejection fraction, history of hypertension, body mass index, and serum lipids. Before exercise, GFC was significantly lower in patients with CAD when compared with controls (1.40 +/- 0.43 versus 3.28 +/- 1.19 microg/mL, respectively; P < 0.001). In patients with CAD, F 1 + 2 levels were significantly higher than those of controls (1.15 +/- 0.43 versus 0.79 +/- 0.10 nmol/L, respectively; P = 0.002). In both study groups, GFC levels increased significantly at peak exercise and decreased to baseline values 2 hours after recovery. At peak exercise, F 1 + 2 levels significantly increased in both study groups. However, while F 1 + 2 levels of controls decreased to baseline values 2 hours after recovery (0.79 +/- 0.10 versus 0.80 +/- 0.10 nmol/L; P > 0.05), F 1 + 2 levels of patients with CAD were still significantly elevated (1.15 +/- 0.43 versus 1.84 +/- 0.06 nmol/L; P = 0.002). Acute exercise increases coagulation and fibrinolysis both in untrained subjects with and without CAD. However, in patients with CAD, the equilibrium between fibrinolysis and coagulation during peak exercise is disturbed in favor of coagulation after recovery.
- Published
- 2007
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39. Aorta-right atrial fistula: a rare complication of prosthetic aortic valvular endocarditis.
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Ozer N, Deniz A, Atalar E, Aksoyek S, Ovunc K, and Kes SS
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- Adult, Aorta, Thoracic, Aortic Diseases diagnostic imaging, Aortic Valve Insufficiency surgery, Diagnosis, Differential, Echocardiography, Transesophageal, Endocarditis diagnostic imaging, Endocarditis microbiology, Female, Heart Valve Prosthesis Implantation adverse effects, Humans, Prosthesis-Related Infections diagnostic imaging, Prosthesis-Related Infections microbiology, Staphylococcal Infections diagnostic imaging, Staphylococcal Infections microbiology, Staphylococcus aureus isolation & purification, Vascular Fistula diagnostic imaging, Aortic Diseases etiology, Endocarditis complications, Heart Atria, Heart Valve Prosthesis microbiology, Prosthesis-Related Infections complications, Staphylococcal Infections complications, Vascular Fistula etiology
- Abstract
Aortic root abscess is a well-known complication of aortic valve endocarditis but intracardiac fistulas are rarely seen. This report describes a patient with prosthetic valve endocarditis who had an aortic root abscess that ruptured into the right atrium creating an aortic-right atrial fistula and causing a highly mobile vegetative mass in the right atrium.
- Published
- 2007
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40. Plasma soluble osteopontin concentrations are increased in patients with rheumatic mitral stenosis and associated with the severity of mitral valve calcium.
- Author
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Atalar E, Ozturk E, Ozer N, Haznedaroglu IC, Kepez A, Coskun S, Aksoyek S, Ovunc K, Kes S, Kirazli S, and Ozmen F
- Subjects
- Adult, Biomarkers blood, C-Reactive Protein analysis, Calcinosis diagnostic imaging, Echocardiography, Female, Humans, Male, Mitral Valve diagnostic imaging, Osteopontin, Rheumatic Heart Disease complications, Rheumatic Heart Disease diagnostic imaging, Rheumatic Heart Disease pathology, Calcinosis pathology, Mitral Valve pathology, Rheumatic Heart Disease blood, Sialoglycoproteins blood
- Abstract
Although the severity of valvular calcification is an important prognostic indicator, the cellular mechanisms of the calcification process are unknown. Osteopontin modulates inflammation and biomineralization, and increased osteopontin expression has been demonstrated in calcified degenerative or rheumatic cardiac valves. The present study evaluated soluble plasma osteopontin in 32 patients with echocardiographically determined rheumatic mitral stenosis and compared the results to those of a control group of 22 healthy patients. Patients were evaluated with routine echocardiographic techniques, Wilkins scoring, and 2-dimensional echocardiographic calcium scoring. Patients with rheumatic involvement other than in the mitral valve were excluded. Plasma osteopontin and high-sensitivity C-reactive protein levels in patients with mitral stenosis were significantly higher those of the control group (p = 0.006 and p = 0.0001, respectively). A significant correlation was found between plasma osteopontin levels and the severity of mitral valve calcification (p = 0.003) and also between high-sensitivity C-reactive protein levels and Wilkins score (p = 0.009). There was a stepwise and statistically significant increase in soluble plasma osteopontin levels in association with the severity of mitral valve calcification. In conclusion, increased osteopontin levels were correlated with the severity of mitral valve calcification in patients with rheumatic mitral stenosis, suggesting an important role of osteopontin in the modulation of valvular calcification. Elevated levels of high-sensitivity C-reactive protein concentrations suggest the presence of ongoing inflammation in those patients.
- Published
- 2006
- Full Text
- View/download PDF
41. Simvastatin treatment improves endothelial function and increases fibrinolysis in patients with hypercholestrolemia.
- Author
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Guven GS, Atalar E, Yavuz B, Beyazit Y, Kekilli M, Kilicarslan A, Sahiner L, Oz G, Ozer N, Aksoyek S, Haznedaroglu IC, and Sozen T
- Subjects
- Endothelium, Vascular drug effects, Endothelium, Vascular physiopathology, Female, Fibrinolysis drug effects, Humans, Hypercholesterolemia physiopathology, Male, Middle Aged, Prospective Studies, Anticholesteremic Agents therapeutic use, Hypercholesterolemia drug therapy, Simvastatin therapeutic use
- Abstract
Objectives: Statins reduce cardiovascular events by cholesterol-lowering as well as nonlipid-related actions. Thrombin activatable fibrinolysis inhibitor (TAFI) is a recently identified independent risk factor of thrombosis. Endothelial dysfunction is also a strong predictor of cardiovascular events. The aim of this study was to assess the effects of simvastatin treatment on circulating TAFI concentrations and endothelial function in patients with hypercholesterolemia., Methods: Thirty-five patients (19 female, mean age 48 +/- 7 years) with hyperlipidemia were recruited into the study. Simvastatin was administered, 40 mg daily, for eight weeks to all subjects. Study subjects did not receive any medication except for lipid-lowering therapy during the follow-up period. Endothelial function was evaluated by flow-mediated dilation (FMD) from the brachial artery of the patients. Plasma lipid parameters, TAFI levels and endothelial function were measured before and after simvastatin treatment., Results: Treatment with simvastatin showed a significant decrement in plasma total cholesterol, LDL cholesterol and triglyceride levels (p<0.05). Plasma TAFI levels were also significantly decreased after simvastatin treatment [median 17.0 (range 0.4-93.7) mcg/mL versus median 6.9 (range 0.8-63.0) mcg/mL, p<0.001]. Mean FMD was measured 7.7 +/- 2.5% at baseline and significantly improved after treatment (13.0 +/- 1.4%) (p=0.001)., Conclusion: Our findings of decreased TAFI levels may reflect the beneficial effect of simvastatin treatment on fibrinolysis, and improved endothelial function may suggest the improved future cardiovascular events in hyperlipidemic patients.
- Published
- 2006
42. Increased soluble glycoprotein V concentration during the acute onset of unstable angina pectoris in association with chronic cigarette smoking.
- Author
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Atalar E, Haznedaroglu IC, Kilic H, Ozer N, Coskun S, Ozturk E, Aksoyek S, Ovunc K, Kirazli S, and Ozmen F
- Subjects
- Acute Disease, Angina, Unstable complications, Angina, Unstable diagnostic imaging, Coronary Angiography, Coronary Stenosis complications, Coronary Stenosis diagnostic imaging, Female, Humans, Male, Middle Aged, Platelet Activation drug effects, Platelet Count, Solubility, Angina, Unstable blood, Coronary Stenosis blood, Platelet Glycoprotein GPIb-IX Complex analysis, Smoking adverse effects, Smoking blood
- Abstract
Platelet hyperactivity is important in the pathobiology of acute coronary syndromes. Glycoprotein V (GPV) is an integral membrane protein of platelets in the function of the GPIb-V-IX receptor for vWf/shear-dependent platelet adhesion in arteries. Soluble GPV is a novel marker of platelet activation. The aim of this study is to assess circulating soluble GPV levels in unstable angina pectoris (UA). Twenty-one patients (15 men, six women, aged 52+/-7 years) with UA pectoris were studied. The inclusion criteria were angina at rest lasting >20 min during the preceding 6 h, with transient ST segment depression and/or T wave inversion and no evidence of myocardial infarction detected with the use of cardiac troponin-T. Coronary artery stenosis was angiographically confirmed in all patients. Twenty age- and sex-matched healthy adults (14 men, six women, aged 48+/-7 years) served as controls. There were no significant differences among the studied groups with respect to age, sex, obesity, smoking, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride and platelet counts. Plasma-soluble GPV concentrations were higher in the UA patient group (126+/-46 ng/ml) than those in the healthy controls (82+/-15 ng/ml) (P=0.001). There was a significant correlation only between plasma-soluble GPV levels and smoking (r=0.526, P=0.0001). Smoker UA patients had higher levels of soluble GPV than the non-smoker patients (139+/-40 vs. 113+/-50 ng/ml, respectively, P=0.02). However, soluble GPV levels were similar in smoker and non-smoker healthy controls (P=0.2). It is concluded that soluble GPV concentrations are significantly increased during the acute clinical course of unstable angina pectoris, indicating that soluble GPV may be useful marker of platelet activation in those patients. The level of the molecule is significantly affected from smoking in those patients.
- Published
- 2005
- Full Text
- View/download PDF
43. Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy.
- Author
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Tutuncu NB, Batur MK, Yildirir A, Tutuncu T, Deger A, Koray Z, Erbas B, Kabakci G, Aksoyek S, and Erbas T
- Subjects
- Autonomic Nervous System Diseases etiology, Blood Pressure, Circadian Rhythm, Diabetes Mellitus, Type 2 complications, Diabetic Neuropathies etiology, Female, Humans, Male, Middle Aged, Autonomic Nervous System Diseases blood, Diabetes Mellitus, Type 2 blood, Diabetic Neuropathies blood, Melatonin blood
- Abstract
The present study has been designed to determine melatonin levels in type 2 diabetic patients and test the relationship between the autonomic nervous system and melatonin dynamics. Thirty-six type 2 diabetic patients and 13 age-matched healthy subjects were recruited for the study. Circadian rhythm of melatonin secretion was assessed by measuring serum melatonin concentrations between 02:00-04:00 and 16:00-18:00 hr. Melatonin dynamics were re-evaluated with respect to autonomic nervous system in diabetic patients with autonomic neuropathy who were diagnosed by the cardiovascular reflex tests, heart rate variability (HRV), and 24-hr blood pressure monitoring. Nocturnal melatonin levels and the nocturnal melatonin surge were low in the diabetic group (P = 0.027 and 0.008 respectively). Patients with autonomic neuropathy revealed decreased melatonin levels both at night and during day when compared with healthy controls (P < 0.001 and 0.004 respectively) while the melatonin dynamics were similar to controls in patients without autonomic neuropathy. Nocturnal melatonin level was positively correlated with nocturnal high and low frequency components of HRV (P = 0.005 and 0.011 respectively) and systolic and diastolic blood pressures at night (P = 0.002 and 0.004 respectively) in patients with autonomic neuropathy. We found a negative correlation between nocturnal melatonin levels and the degree of systolic blood pressure decrease at night (r = -0.478, P = 0.045). As a conclusion this study has shown that circadian rhythm of melatonin secretion is blunted in type 2 diabetic patients and there is a complex relationship between various components of autonomic nervous system and melatonin secretion at night. Among the patients with autonomic neuropathy those with more preserved HRV and the systolic nondippers (<10% reduction in blood pressure during the night relative to daytime values) have more pronounced melatonin surge at night.
- Published
- 2005
- Full Text
- View/download PDF
44. Bilateral adrenal cystic neuroblastoma with massive hepatomegaly and intracystic hemorrhage.
- Author
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Duzovali O, Ozer C, Turhan AH, Arslankoylu AE, Yilgor E, Polat A, and Aksoyek S
- Subjects
- Adrenal Gland Neoplasms complications, Adrenal Gland Neoplasms therapy, Diagnosis, Differential, Female, Hemorrhage diagnosis, Hemorrhage etiology, Hepatomegaly etiology, Humans, Infant, Newborn, Neuroblastoma complications, Neuroblastoma therapy, Adrenal Gland Neoplasms diagnosis, Neuroblastoma diagnosis
- Published
- 2005
- Full Text
- View/download PDF
45. Immediate effects of fluvastain on circulating soluble endothelial protein C and free tissue factor pathway inhibitor in acute coronary syndromes.
- Author
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Atalar E, Coskun S, Haznedaroglu IC, Yücel N, Ozer N, Sivri B, Aksoyek S, Ovunc K, and Ozmen F
- Subjects
- Acute Disease, Adult, Aged, Antigens, CD, Blood Coagulation Factors, Coronary Disease blood, Endothelial Protein C Receptor, Female, Fluvastatin, Humans, Male, Middle Aged, Antigens blood, Coronary Disease drug therapy, Fatty Acids, Monounsaturated pharmacology, Glycoproteins blood, Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology, Indoles pharmacology, Lipoproteins blood, Receptors, Cell Surface blood
- Abstract
Background: Statins promptly lower rates of adverse cardiovascular events in patients with acute coronary syndromes (ACS). These therapeutic properties may be mediated by the effects of statins on key hemostatic factors. This study examined the immediate effects of fluvastatin on plasma free tissue factor pathway inhibitor (fTFPI) and soluble endothelial protein C receptor (sEPCR) concentrations in patients with unstable angina or non-ST segment elevation myocardial infarction., Methods: We studied 57 patients consecutively admitted to our emergency department and randomly assigned to placebo (n = 29) versus fluvastatin, 80 mg, p.o. (n = 28). All patients were treated with aspirin and metoprolol p.o., nitroglycerin i.v., and subcutaneous enoxaparin. Venous blood was sampled as soon as possible upon admission, before and 6 h after administration of study drug and standard anti-ischemic therapy., Results: Mean sEPCR concentrations decreased significantly in patients treated with fluvastatin (-8.1 +/- 6.7% from baseline) and was unchanged in the placebo group (-2.3 +/- 14.4%, P = 0.007 vs. fluvastatin). Though fTFPI increased significantly after the administration of both fluvastatin and placebo, the mean increase after fluvastatin (450+/-436%) was significantly greater than after placebo (155+/-141%, P = 0.001)., Conclusions: Treatment with fluvastatin significantly modified key hemostatic factors toward an antithrombotic effect within 6 h. These properties may, in part, explain the early salutary effects of fluvastatin in patients with ACS.
- Published
- 2005
- Full Text
- View/download PDF
46. Ileal atresia associated with a congenital vascular band anomaly: observations on pathogenesis.
- Author
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Nayci A, Avlan D, Polat A, and Aksoyek S
- Subjects
- Female, Humans, Infant, Newborn, Intestinal Atresia etiology, Ileum abnormalities, Intestinal Atresia complications, Intestinal Obstruction etiology, Vitelline Duct abnormalities
- Abstract
We report the case of a newborn, who developed intestinal obstruction soon after birth. Exploratory laparotomy revealed a congenital vascular band anomaly extending from the antimesenteric border of the terminal ileum to the gallbladder in association with ileal atresia. Surgical intervention was performed for correction of the disorder. A review of the embryology and congenital vascular bands is presented together with discussion as to possible etiopathogenesis leading to small bowel atresia.
- Published
- 2003
- Full Text
- View/download PDF
47. Patients with paroxysmal atrial fibrillation but not paroxysmal supraventricular tachycardia display evidence of platelet activation during arrhythmia.
- Author
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Atalar E, Haznedaroglu IC, Acil T, Ozer N, Kilic H, Ovunc K, Aksoyek S, Nazli N, Kes S, Kabakçi G, Kirazli S, and Ozmen F
- Subjects
- Adult, Arrhythmias, Cardiac blood, Arrhythmias, Cardiac physiopathology, Atrial Fibrillation blood, Blood Platelets metabolism, Electric Countershock, Female, Humans, Male, Middle Aged, Platelet Factor 4 analysis, Tachycardia, Paroxysmal blood, Tachycardia, Supraventricular blood, beta-Thromboglobulin analysis, Atrial Fibrillation physiopathology, Platelet Activation physiology, Tachycardia, Paroxysmal physiopathology, Tachycardia, Supraventricular physiopathology
- Abstract
It is well known that chronic atrial fibrillation (CAF) and paroxysmal atrial fibrillation (PAF) are associated with hypercoagulable state. However, pathological hemostatic changes during the paroxysmal supraventricular tachycardia (PSVT) have not yet been elucidated. To determine platelet activity in patients with PSVT, PAF and CAF, we examined the levels of beta-thromboglobulin (BTG) and platelet factor 4 (PF4) during tachyarrhythmia attacks. We measured the levels of BTG and PF4, as an index of platelet activation in 15 patients with PAF (9 men, mean age 45+/-11), and 14 patients with PSVT (8 men, mean age 40+/-10). Levels were compared to 22 age and sex matched healthy controls in sinus rhythm and with 25 patients with CAF (16 men, mean age 51+/-12). Blood samples were taken during arrhythmia and 24 hours after conversion to sinus rhythm. Patients taking medications or have clinical conditions that may affect the BTG and PF4 levels were excluded. In patients with PAF, BTG and PF4 levels were significantly higher than in controls (p<0.009, and p=0.002, respectively), and in patients with PSVT (p<0.004, and p=0.009, respectively), however, BTG and PF4 levels were significantly lower than CAF patients (p=0.002, and p=0.02, respectively). Moreover, BTG and PF4 levels were significantly decreased 24 hours after conversion to sinus rhythm (p<0.0001), and p=0.004, respectively). Although BTG and PF4 levels in patients with PSVT were significantly lower than in patients with PAF (p=0.04, and p=0.009, respectively) and CAF (p=0.0001, and p=0.0001, respectively), BTG and PF4 levels were similar to controls and did not change significantly after recovery to sinus rhythm (p=NS for all). These results indicate that there was no platelet activation in patients with PSVT during tachyarrhythmia but significantly increased platelet activity in PAF and CAF patients. There was a significant decrement of the platelet activity to a level of control subjects twenty-four hours after cardioversion of PAF.
- Published
- 2003
- Full Text
- View/download PDF
48. The role of the spleen on colonic anastomotic healing.
- Author
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Nayci A, Cakmak M, Comelekoglu U, Renda N, and Aksoyek S
- Subjects
- Animals, Models, Animal, Rats, Spleen surgery, Anastomosis, Surgical, Colon surgery, Spleen physiology, Splenectomy, Wound Healing physiology
- Abstract
The role of the spleen on wound healing remains unclear. This study investigates the effect of splenectomy on the healing of colonic anastomoses. Twenty-six Wistar rats were assigned into four groups: sham, splenectomy, anastomoses, and splenectomy and anastomoses. The rats underwent a standardized left colonic resection and primary anastomoses, and/or splenectomy. Bursting pressure and hydroxyproline content were used to evaluate anastomotic healing, five days postoperatively. No differences were found in the bursting pressure and hydroxyproline content between the groups. The present results indicate that splenectomy has no negative effect on the healing of colonic anastomoses in rats.
- Published
- 2003
49. Ischemic preconditioning reduces intestinal epithelial apoptosis in rats.
- Author
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Cinel I, Avlan D, Cinel L, Polat G, Atici S, Mavioglu I, Serinol H, Aksoyek S, and Oral U
- Subjects
- Animals, Coloring Agents, Eosine Yellowish-(YS), Hematoxylin, Immunohistochemistry, Ischemic Preconditioning, Male, Proto-Oncogene Proteins c-bcl-2 genetics, Proto-Oncogene Proteins c-bcl-2 metabolism, Rats, Rats, Wistar, Apoptosis physiology, Intestinal Mucosa blood supply, Intestinal Mucosa cytology, Reperfusion Injury prevention & control
- Abstract
Recent experimental studies have described protective effect of ischemic preconditioning (IPC) on ischemia-reperfusion (I/R) injury of the intestine. We hypothesize that to reach a new point of view on the effect of IPC in intestinal barrier function, the relationship between I/R-induced mucosal injury and apoptosis must first be clarified. The present study was undertaken to investigate the role of IPC on intestinal apoptosis and probable contributions of bcl-2 expression to this process. We also investigated the effect of intestinal IPC on ileal malondyaldihyde levels. Forty-four male Wistar rats were randomized into four groups each consisting of 11 rats: sham-operated control, I/R group (30 min of superior mesenteric artery occlusion), IPC-I/R group (10 min of temporary artery occlusion prior before an ischemic insult of 30 min), and IPC alone group (10 min of preconditioning). Twenty-four hours later, ileum samples were obtained. Ileal malondyaldihyde levels were increased in the I/R group (31.9 +/- 18.8 vs. 106.8 +/- 39.8) but not in the IPC alone and IPC-I/R groups (38.1 +/- 13.6 and 44.7 +/- 12.7; P < 0.01). The number of apoptotic cells was significantly lower in IPC-I/R group than that of I/R group, and these findings were further supported by DNA laddering and M30 findings. Diminished bcl-2 expression observed in the ileal specimens of I/R group was prevented by IPC. Our results indicate that IPC may provide a protective effect on ileal epithelium and that this effect is probably the result of a significant increase in the expression of bcl-2 after the insult. The reversal of apoptosis by IPC might help preserving the vitality of intestinal structures that have a critical function, cessation of which often leads to multiorgan dysfunction syndrome.
- Published
- 2003
- Full Text
- View/download PDF
50. Effect of electromagnetic fields and early postoperative 5-fluorouracil on the healing of colonic anastomoses.
- Author
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Nayci A, Cakmak M, Renda N, Aksoyek S, and Yucesan S
- Subjects
- Animals, Fluorouracil administration & dosage, Hydroxyproline analysis, Injections, Intraperitoneal, Male, Random Allocation, Rats, Rats, Wistar, Anastomosis, Surgical, Colon surgery, Electromagnetic Phenomena, Fluorouracil pharmacology, Wound Healing drug effects, Wound Healing physiology
- Abstract
Background and Aims: Studies have indicated a deleterious effect of perioperative 5-fluorouracil (5-FU) administration on the healing of intestinal anastomoses. This study examined the effect of early postoperative 5-FU on the healing of colonic anastomoses and investigated the effect of electromagnetic fields (EMF) on colonic anastomotic repair under normal physiological conditions and in the presence of 5-FU therapy in a rat model., Materials and Methods: Forty male Wistar rats were randomly assigned into four groups and underwent a standardized left colonic resection and anastomoses. The animals then served as control or received intraperitoneal 5-FU (20 mg/kg per day, 5 days), EMF stimulation (10.76 mT, 50 Hz; 2-h on/10-h off cycles, 7 days) or both, starting on the day of surgery. After 7 days anastomotic healing was assessed by measurement of hydroxyproline content and breaking strength., Results: Hydroxyproline content increased in EMF exposed group (1.53+/-0.11 to 1.92+/-0.11 microg/mg) and in EMF + 5-FU group (1.53+/-0.11 to 1.89+/-0.12 microg/mg). Breaking strength also increased in the EMF group (0.23+/-0.02 to 0.27+/-0.01 MPa) and in the EMF + 5-FU group (0.23+/-0.02 to 0.28+/-0.01 MPa. No differences were found in hydroxyproline content or breaking strength between the 5-FU group and controls., Conclusion: Early postoperative 5-FU administration did not impair the healing of colonic anastomoses in rats. Additionally, EMF stimulation provided a significant gain in colonic anastomotic strength, in rat intestines in control animals and in animals exposed to 5-FU.
- Published
- 2003
- Full Text
- View/download PDF
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