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Understanding the dynamics of molecular communications between cells and intracellular response is crucial to create predictable cellular applications. When the propagation mechanism is diffusion based, the arrival histogram of molecules becomes heavy tailed and the stray molecules create interference for the following symbol slots. Here, we present a model-based framework to design diffusion-based systems using computer simulations. To overcome interference problems, we utilize two different signals with two different molecule types to carry a single bit of data. While the first signal is the actual data carrier, the latter acts as an antagonist to cancel out the heavy tail of the former signal. At the receiver side, these signals are used to control cellular behaviour via a synthetic genetic circuit, which eliminates the effect of stray molecules. This holistic and model-driven design approach combines both intracellular and intercellular dynamics to create novel applications.

3rd Congress of the European-Academy-of-Neurology -- JUN, 2017 -- -- Amsterdam, NETHERLANDS, WOS: 000405530101049, …, European Acad Neurol

L-arginine (L-ARG)-nitric oxide (NO)-cGMP (cyclic guanosine monophosphate) cycle has been determined in various studies to be associated with epilepsy. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5) and increases the level of cGMP. Methylene blue (MB) is a lipophilic agent regulating intracellular electron flow as well as increasing the mitochondrial effectiveness. It also decreases cGMP levels by directly inhibiting guanylate cyclase.The aim of the present study was to evaluate the effects of MB and tadalafil on pentylenetetrazol-induced seizures. MB and tadalafil were administered 30 min prior to PTZ (70 mg/kg, i.p.) injection and the dose-response ratio was determined. Racine's Convulsion Scale and first myoclonic jerk (FMJ) onset time was used to evaluate seizures. Besides, drugs were administered 30 min prior to pentylenetetrazol (35 mg/kg, i.p.) injection and EEG was recorded from cortex and the spike wave discharges was determined in EEG. Plasma cGMP levels were measured in all groups. 5 and 10 mg/kg MB decreased Racine convulsion stage, increased FMJ onset time and decreased cGMP levels when compared with saline. 10 mg/kg tadalafil increased cGMP levels and Racine convulsion stage but decreased FMJ onset time compared with saline. Spike wave discharges were decreased in 5 and 10 mg/kg MB groups and increased in 10 mg/ kg tadalafil group when compared with saline group.The proconvulsant properties of all the agents may be taken into consideration, especially when prescribing PDE5 inhibitors. © Gülhane Tip Fakültesi 2016.

1st Congress of the European-Academy-of-Neurology -- JUN 20-23, 2015 -- Berlin, GERMANY WOS: 000364239000378 … European Acad Neurol

Drug-induced dyskinesias can be seen occasionally in clinical practice. Here we present a 70-year-old patient who developed a noticeable dyskinesia after the use of pramipexole, gabapentin, pregabalin respectively for his restless leg syndrome. Prior to this condition, he was hospitalized in intensive care unit for the myocardial infarction that required cardiopulmonary resuscitation, and he was discharged with no neurological deficits. The case presented here is a good example indicating the importance of being vigilant for drug-induced dyskinesias after hypoxic-ischemic encephalopathy, even though everything else seems right.

10th International Multidisciplinary Scientific GeoConference SGEM 2010 -- JUN 20-26, 2010 -- Albena, BULGARIA, WOS: 000288623600084, In this work, samples were taken from Koyunagili Lignites Company Washing Plant feed and were subjected to extensive research to determine the floatability of lignite fines. The optimum conditions of flotation were determined under the laboratory conditions by using a laboratory type Denver flotation cell. In the flotation experiments particle size distribution, collector type and amount and dispersant amount were tested as variables. After flotation experiments, at optimum conditions, 53.91 % of the sample was floated with 29.54 % ash content., Minist Environm & Water Bulgaria, Bulgarian Acad Sci, Acad Sci Czech Republ, Acad Sci IR Iran, Latvian Acad Sci, Polish Acad Sci, Russian Acad Sci, Serbian Acad Sci & Arts (SASA), Slovak Acad Sci, Natl Acad Sci Ukraine, Bulgarian Ind Assoc