1. Influence of cisapride on food-stimulated gastro-oesophageal reflux: a radiological study
- Author
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Gelineck, J, Aksglade, K, Funch-Jensen, Peter, and Thommesen, P
- Subjects
Adult ,Male ,Cisapride ,Clinical Trials as Topic ,digestive, oral, and skin physiology ,Middle Aged ,digestive system ,digestive system diseases ,Double-Blind Method ,Piperidines ,Gastroesophageal Reflux ,Humans ,Female ,Serotonin Antagonists ,Barium Sulfate ,Esophagitis, Peptic ,Aged - Abstract
The influence of Cisapride on food-stimulated gastro-oesophageal reflux mechanisms was studied in a double-blind cross-over investigation in 24 consecutive patients selected by endoscopy, 12 with microscopical evidence of gastro-oesophageal reflux and 12 with additional macroscopic oesophagitis. 63% had food-stimulated gastro-oesophageal reflux, and Cisapride significantly reduced the tendency to gastro-oesophageal reflux and mucosal contact time between gastric content and the oesophageal mucosa in 73% of these patients. It is concluded that Cisapride could be valuable in the treatment of gastro-oesophageal reflux.
- Published
- 1990