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In this work, implants with enhanced antibacterial and surface properties besides mechanical, biological, and chemical properties were prepared with the replacement of traditional titanium and titanium alloys in the field of biomedical materials. Titanium substrates were coated with chondroitin sulfate (CS) containing (3-glycidoxypropyl)trimethoxysilane (GLYMO) and tetraethoxysilane (TEOS) based thin film using sol-gel technology. Chondroitin sulfate is a preferred material due to its characteristics antioxidative and osseointegresion properties besides its collagen-forming properties. Coated implants were morphologically elucidated with atomic force microscopy (AFM), and scanning electron microscopy (SEM). The structure of the chondroitin sulfate-containing films was investigated with Fourier Transform Infrared Spectroscopy (FTIR) and Energy Dispersive X-Ray Analysis (EDX) techniques. The obtained CS-based sol-gel surface coatings are thermally stable up to ∼200 °C according to TGA and DTA analysis results. The biological and antibacterial properties of the coatings were also determined. The biocompatibility and osseointegration properties of the coatings developed within the scope of the study were, determined by in vivo studies on rats. According to biocompatibility results of CS/Sol-Gel coated surfaces, Cell viability (%) rates of CS-based coatings showed between 89 and 66%. According to the experimental data, it has been claimed that implants improved with antibacterial, stable, homogeneous, and biocompatible coatings can be used as a new alternative product for dental and orthopedic applications. [ABSTRACT FROM AUTHOR]

Background: The successful lowering of the intraocular pressure after glaucoma filtration surgery depends mostly on the nature of the healing response, which is also the single most important modifiable factor. Aims: To evaluate and compare the effectiveness of two oxidated regenerated cellulose material, Interceed and Surgicel on wound healing reaction after glaucoma filtration surgery. Setting and Design: University hospital, prospective study. Materials and Methods: Full thickness filtration surgery was carried out on three groups of rabbits. Interceed and Surgicel was applied in Groups 1 and 2 respectively. The third group was the controls. Intraocular pressure, anterior chamber depth and bleb appearance were checked on the first, third, seventh and 14 th days. The rabbits were sacrificed on the14 th day and the trabeculectomy area with overlying conjunctiva was excised, fixed, stained and evaluated histopathologically. Statistics: The values obtained from the clinical and histopathologic evaluation were statistically analyzed using non-parametric tests (Mann Whitney-U and Kruskall Wallis tests) in SPSS for Windows v-10. P values under 0.05 for statistical significance in comparisons were considered significant. Results: The groups were similar with respect to intraocular pressure, anterior chamber depth, bleb appearance and number of the fibroblasts and neutrophils on the seventh and 14 th days. Mean number of the eosinophils and vessels was significantly less in Groups 1 and 2 ( P = 0.014, P = 0.20 respectively). Macrophages in Group 2 were significantly less than Group 1 ( P = 0.047). Conclusion: Both these agents seem to suppress vascularization. Since they have no significant effect on fibroblast proliferation, it is controversial to talk about wound healing modulation.

Copyright of Journal of Health Academics / Sağlık Akademisyenleri Dergisi is the property of Journal of Health Academics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Current Pediatrics / Guncel Pediatri is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Osteoarthritis (OA) is the most common chronic joint disease, primarily due to aging. Chondroitin sulfate (CS) is a glycosaminoglycan (GAG) commonly used to treat osteoarthritis. CS can delay the progression of pathology or reverse morphological changes in joint structure. Traditionally CS is produced from animal sources. However, due to different reasons such as contamination, ecological risk, and the possibility of infectious diseases, the trend towards microbial sources has increased because of its advantages such as purer, more antiallergic, and lower Molecular Weight (MW) than animal sources. Biochemical analysis of Microbial CS (MCS), which is a new and significant alternative as a source of CS in the OA healing process, has not been evaluated in the literature yet. This study was designed to analyze the biochemical effects of MCS produced by our team from a microbial source, with an MW value of 269 Daltons, on the osteoarthritis healing process compared to the commercial form. We aim to reach data that MCS has a higher antioxidant effect than animal-sourced CS, and in this way, it is a more suitable production for the treatment of osteoarthritis. In this study, knee osteoarthritis was surgically induced in experimental rabbits; and TGF-ip, CAT, MPO, TOS, and OSI parameters measured in blood samples before the operation and after the healing period were analyzed comparatively. After the surgical application, the rabbits were randomly divided into three groups: control, animal-sourced CS, and E. coli sourced MCS. The standard rabbit diet was administered daily to 10 rabbits in Group 1 (control), and CS and MCS were applied daily to the other groups as 17 mg/kg for 12 weeks. Blood samples were taken from rabbits at the 12th week after surgery, and TGF-ip, CAT, MPO, TOS, and OSI parameters were biochemically evaluated. This study has confirmed that the antioxidant properties of MCS and data on its effectiveness in controlling oxidative stress compared to animal-sourced CS. Based on these results, it can be concluded that MCS has a significant potency of nutraceutical and therapeutic agents for OA treatment. [ABSTRACT FROM AUTHOR]