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203 results on '"Akkermans, Louis M. A."'

1. Early versus On-Demand Nasoenteric Tube Feeding in Acute Pancreatitis

Author

Bakker, Olaf J., van Brunschot, Sandra, van Santvoort, Hjalmar C., Besselink, Marc G., Bollen, Thomas L., Boermeester, Marja A., Dejong, Cornelis H., van Goor, Harry, Bosscha, Koop, Ali, Usama Ahmed, Bouwense, Stefan, van Grevenstein, Wilhelmina M., Heisterkamp, Joos, Houdijk, Alexander P., Jansen, Jeroen M., Karsten, Thom M., Manusama, Eric R., Nieuwenhuijs, Vincent B., Schaapherder, Alexander F., van der Schelling, George P., Schwartz, Matthijs P., Spanier, Marcel B.W., Tan, Adriaan, Vecht, Juda, Weusten, Bas L., Witteman, Ben J., Akkermans, Louis M., Bruno, Marco J., Dijkgraaf, Marcel G., van Ramshorst, Bert, and Gooszen, Hein G.

Published
2014
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5. Measurement of Gastrointestinal Transit

Author

Ams Task Force Committee on Gastrointestinal Transit, Lin, Henry C., Prather, Charlene, Fisher, Robert S., Meyer, James H., Summers, Robert W., Pimentel, Mark, Mccallum, Richard W., Akkermans, Louis M. A., and Loening-Baucke, Vera

Published
2005
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7. Gastric Function

Author

Horowitz, Michael, primary, Jones, Karen L., additional, Akkermans, Louis M. A., additional, and Samsom, Melvin, additional

Published
2005
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8. Probiotics in surgery

Author

van Santvoort, Hjalmar C., Besselink, Marc G., Timmerman, Harro M., van Minnen, L. Paul, Akkermans, Louis M., and Gooszen, Hein G.

Published
2008

14. Measurement of Gastrointestinal Transit

Author

LIN, HENRY C., PRATHER, CHARLENE, FISHER, ROBERT S., MEYER, JAMES H., SUMMERS, ROBERT W., PIMENTEL, MARK, McCALLUM, RICHARD W., AKKERMANS, LOUIS M. A., and LOENING-BAUCKE, VERA

Published
2005

18. Pancreatitis, very early compared with normal start of enteral feeding (PYTHON trial): design and rationale of a randomised controlled multicenter trial

Author

Schaapherder Alexander F, van Ramshorst Bert, Nieuwenhuijs Vincent B, Manusama Eric R, Karsten Thom M, Jansen Jeroen M, Houdijk Alexander P, Heisterkamp Joos, van Goor Harry, van Geenen Erwin J, Dejong Cornelis H, Brink Menno A, Bosscha Koop, Bollen Thomas L, Boermeester Marja A, Besselink Marc G, Ali Usama, van Brunschot Sandra, van Santvoort Hjalmar C, Bakker Olaf J, van der Schelling George P, Spanier Marcel BM, Tan Adriaan, Vecht Juda, Weusten Bas L, Witteman Ben J, Akkermans Louis M, and Gooszen Hein G

Subjects
Medicine (General), R5-920
Abstract

Abstract Background In predicted severe acute pancreatitis, infections have a negative effect on clinical outcome. A start of enteral nutrition (EN) within 24 hours of onset may reduce the number of infections as compared to the current practice of starting an oral diet and EN if necessary at 3-4 days after admission. Methods/Design The PYTHON trial is a randomised controlled, parallel-group, superiority multicenter trial. Patients with predicted severe acute pancreatitis (Imrie-score ≥ 3 or APACHE-II score ≥ 8 or CRP > 150 mg/L) will be randomised to EN within 24 hours or an oral diet and EN if necessary, after 72 hours after hospital admission. During a 3-year period, 208 patients will be enrolled from 20 hospitals of the Dutch Pancreatitis Study Group. The primary endpoint is a composite of mortality or infections (bacteraemia, infected pancreatic or peripancreatic necrosis, pneumonia) during hospital stay or within 6 months following randomisation. Secondary endpoints include other major morbidity (e.g. new onset organ failure, need for intervention), intolerance of enteral feeding and total costs from a societal perspective. Discussion The PYTHON trial is designed to show that a very early (< 24 h) start of EN reduces the combined endpoint of mortality or infections as compared to the current practice of an oral diet and EN if necessary at around 72 hours after admission for predicted severe acute pancreatitis. Trial Registration ISRCTN: ISRCTN18170985

Published
2011
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21. Impact of Global Fxr Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the FXR Locus in Human Acute Pancreatitis

Author

Nijmeijer, Rian M, Schaap, Frank G, Smits, Alexander J J, Kremer, Andreas E, Akkermans, Louis M A, Kroese, A.B., Rijkers, Ger T, Schipper, Marguerite E I, Verheem, André, Wijmenga, Cisca, Gooszen, Hein G, van Erpecum, Karel J, Dep IRAS, Sub IRAS Tox CMT/NTX, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Surgery, RS: NUTRIM - R2 - Gut-liver homeostasis, Other departments, Dep IRAS, Sub IRAS Tox CMT/NTX, Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA1

Subjects
Male, Gene Expression, Receptors, Cytoplasmic and Nuclear, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Gene Knockout Techniques, Medizinische Fakultät, GROWTH-FACTOR 19, Medicine and Health Sciences, Electric Impedance, Intestinal Mucosa, Receptor, Mice, Knockout, Multidisciplinary, Pancreatitis, Acute Necrotizing, EXOCRINE PANCREAS, Animal Models, NUCLEAR RECEPTOR FXR, INTESTINAL BARRIER DYSFUNCTION, Acute pancreatitis, Medicine, medicine.symptom, Anatomy, ORGAN FAILURE, Research Article, EXPRESSION, medicine.medical_specialty, Science, Inflammation, Endocrine System, Mouse Models, Gastroenterology and Hepatology, Biology, BINDING PROTEIN, Research and Analysis Methods, Polymorphism, Single Nucleotide, Model Organisms, Ileum, Internal medicine, medicine, Genetics, Animals, Humans, ddc:610, Pancreas, Genetic Association Studies, FGF15, Biology and Life Sciences, FGF19, Human Genetics, medicine.disease, Fibroblast Growth Factors, Mice, Inbred C57BL, MICE, Endocrinology, GALLSTONE DISEASE, Nuclear receptor, Pancreatitis, Case-Control Studies, Genetics of Disease, BILE, Farnesoid X receptor, Gene Function
Abstract

Contains fulltext : 170664.PDF (Publisher’s version ) (Open Access) BACKGROUND: Infectious complications often occur in acute pancreatitis, related to impaired intestinal barrier function, with prolonged disease course and even mortality as a result. The bile salt nuclear receptor farnesoid X receptor (FXR), which is expressed in the ileum, liver and other organs including the pancreas, exhibits anti-inflammatory effects by inhibiting NF-kappaB activation and is implicated in maintaining intestinal barrier integrity and preventing bacterial overgrowth and translocation. Here we explore, with the aid of complementary animal and human experiments, the potential role of FXR in acute pancreatitis. METHODS: Experimental acute pancreatitis was induced using the CCK-analogue cerulein in wild-type and Fxr-/- mice. Severity of acute pancreatitis was assessed using histology and a semi-quantitative scoring system. Ileal permeability was analyzed in vitro by Ussing chambers and an in vivo permeability assay. Gene expression of Fxr and Fxr target genes was studied by quantitative RT-PCR. Serum FGF19 levels were determined by ELISA in acute pancreatitis patients and healthy volunteers. A genetic association study in 387 acute pancreatitis patients and 853 controls was performed using 9 tagging single nucleotide polymorphisms (SNPs) covering the complete FXR gene and two additional functional SNPs. RESULTS: In wild-type mice with acute pancreatitis, ileal transepithelial resistance was reduced and ileal mRNA expression of Fxr target genes Fgf15, SHP, and IBABP was decreased. Nevertheless, Fxr-/- mice did not exhibit a more severe acute pancreatitis than wild-type mice. In patients with acute pancreatitis, FGF19 levels were lower than in controls. However, there were no associations of FXR SNPs or haplotypes with susceptibility to acute pancreatitis, or its course, outcome or etiology. CONCLUSION: We found no evidence for a major role of FXR in acute human or murine pancreatitis. The observed altered Fxr activity during the course of disease may be a secondary phenomenon.

Published
2014

22. Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis

Author

Besselink, Marc G., van Santvoort, Hjalmar C., Renooij, Willem, de Smet, Martin B., Boermeester, Marja A., Fischer, Kathelijn, Timmerman, Harro M., Ali, Usama Ahmed, Cirkel, Geert A., Bollen, Thomas L., van Ramshorst, Bert, Schaapherder, Alexander F., Witteman, Ben J., Ploeg, Rutger J., van Goor, Harry, van Laarhoven, Cornelis J., Tan, Adriaan C., Brink, Menno A., van der Harst, Erwin, Wahab, Peter J., van Eijck, Casper H., Dejong, Cornelis H., van Erpecum, Karel J., Akkermans, Louis M., Gooszen, Hein G., Consten, Esther, Groningen Institute for Organ Transplantation (GIOT), Surgery, Algemene Heelkunde, RS: NUTRIM - R2 - Gut-liver homeostasis, Other departments, AII - Amsterdam institute for Infection and Immunity, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Graduate School

Subjects
medicine.medical_specialty, Pathology, Pancreatic disease, Bacteremia, Fatty Acid-Binding Proteins, Nitric Oxide, Gastroenterology, Permeability, law.invention, Polyethylene Glycols, Excretion, Probiotic, Double-Blind Method, law, Internal medicine, PEG ratio, medicine, Humans, Molecular gastro-enterology and hepatology [IGMD 2], Intestinal permeability, business.industry, Probiotics, medicine.disease, Intestines, Enterocytes, Pancreatitis, Evaluation of complex medical interventions [NCEBP 2], Bacterial Translocation, Acute Disease, Acute pancreatitis, Surgery, business
Abstract

Contains fulltext : 80110.pdf (Publisher’s version ) (Closed access) OBJECTIVES: To determine the relation between intestinal barrier dysfunction, bacterial translocation, and clinical outcome in patients with predicted severe acute pancreatitis and the influence of probiotics on these processes. SUMMARY OF BACKGROUND DATA: Randomized, placebo-controlled, multicenter trial on probiotic prophylaxis (Ecologic 641) in patients with predicted severe acute pancreatitis (PROPATRIA). METHODS: Excretion of intestinal fatty acid binding protein (IFABP, a parameter for enterocyte damage), recovery of polyethylene glycols (PEGs, a parameter for intestinal permeability), and excretion of nitric oxide (NOx, a parameter for bacterial translocation) were assessed in urine of 141 patients collected 24 to 48 h after start of probiotic or placebo treatment and 7 days thereafter. RESULTS: IFABP concentrations in the first 72 hours were higher in patients who developed bacteremia (P = 0.03), infected necrosis (P = 0.01), and organ failure (P = 0.008). PEG recovery was higher in patients who developed bacteremia (PEG 4000, P = 0.001), organ failure (PEG 4000, P < 0.0001), or died (PEG 4000, P = 0.009). Probiotic prophylaxis was associated with an increase in IFABP (median 362 vs. 199 pg/mL; P = 0.02), most evidently in patients with organ failure (P = 0.001), and did not influence intestinal permeability. Overall, probiotics decreased NOx (P = 0.05) but, in patients with organ failure, increased NOx (P = 0.001). CONCLUSIONS: Bacteremia, infected necrosis, organ failure, and mortality were all associated with intestinal barrier dysfunction early in the course of acute pancreatitis. Overall, prophylaxis with this specific combination of probiotic strains reduced bacterial translocation, but was associated with increased bacterial translocation and enterocyte damage in patients with organ failure.

Published
2009

23. Probiotic prophylaxis in predicted severe acute pancreatitis - Reply

Author

Besselink, Marc G., van Santvoort, Hjalmar C., Buskens, Erik, Akkermans, Louis M., Gooszen, Hein G., Faculteit Medische Wetenschappen/UMCG, Science in Healthy Ageing & healthcaRE (SHARE), and Methods in Medicines evaluation & Outcomes research (M2O)

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ENTERAL NUTRITION, BACTERIAL-INFECTION RATES, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), DOUBLE-BLIND TRIAL
Published
2008

26. Correlation between Protection against Sepsis by Probiotic Therapy and Stimulation of a Novel Bacterial Phylotype

Author

Gerritsen, Jacoline, primary, Timmerman, Harro M., additional, Fuentes, Susana, additional, van Minnen, L. Paul, additional, Panneman, Henk, additional, Konstantinov, Sergey R., additional, Rombouts, Frans M., additional, Gooszen, Hein G., additional, Akkermans, Louis M. A., additional, Smidt, Hauke, additional, and Rijkers, Ger T., additional

Published
2011
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30. T1820 Altered Expression of Fibroblast Growth Factor 15 (FGF15) in Acute Pancreatitis: Potential Consequences for Bacterial Translocation and Infection Risk

Author

Nijmeijer, Rian M., primary, Akkermans, Louis M., additional, Schaap, Frank G., additional, Jansen, Peter L., additional, ter Linde, Jose J., additional, Verheem, Andre, additional, Kroese, Alfons B., additional, Besselink, Marc G., additional, Schipper, Marguerite E.I., additional, Gooszen, Hein G., additional, and Van Erpecum, Karel J., additional

Published
2009
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32. Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of Ileal Mucosal Glutathione Biosynthesis

Author

Lutgendorff, Femke, primary, Nijmeijer, Rian M., additional, Sandström, Per A., additional, Trulsson, Lena M., additional, Magnusson, Karl-Eric, additional, Timmerman, Harro M., additional, van Minnen, L. Paul, additional, Rijkers, Ger T., additional, Gooszen, Hein G., additional, Akkermans, Louis M. A., additional, and Söderholm, Johan D., additional

Published
2009
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49. Ileoneorectal Anastomosis

Author

van Laarhoven, Cees J. H. M., primary, Andriesse, Gunnar I., additional, Schipper, Marguerite E. I., additional, Akkermans, Louis M. A., additional, van Vroonhoven, Theo. J. M. V., additional, and Gooszen, Hein G., additional

Published
1999
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