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1. Identifying plasma proteomic signatures from health to heart failure, across the ejection fraction spectrum

Author

Andrzejczyk, Karolina, Abou Kamar, Sabrina, van Ommen, Anne-Mar, Canto, Elisa Dal, Petersen, Teun B., Valstar, Gideon, Akkerhuis, K. Martijn, Cramer, Maarten Jan, Umans, Victor, Rutten, Frans H., Teske, Arco, Boersma, Eric, Menken, Roxana, van Dalen, Bas M., Hofstra, Leonard, Verhaar, Marianne, Brugts, Jasper, Asselbergs, Folkert, den Ruijter, Hester, and Kardys, Isabella

Published
2024
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3. Targeted proteomics and metabolomics for biomarker discovery in abdominal aortic aneurysm and post-EVAR sac volume

Author

Vanmaele, Alexander, Bouwens, Elke, Hoeks, Sanne E, Kindt, Alida, Lamont, Lieke, Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Ijpma, Arne S, van Lier, Felix, Akkerhuis, K. Martijn, Majoor-Krakauer, Danielle F, Hankemeier, Thomas, de Rijke, Yolanda, Verhagen, Hence JM, Boersma, Eric, and Kardys, Isabella

Published
2024
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7. Proteomic biomarkers related to obesity in heart failure with reduced ejection fraction and their associations with outcome.

Author

Petersen, Teun B., Suthahar, Navin, Asselbergs, Folkert W., de Bakker, Marie, Akkerhuis, K. Martijn, Constantinescu, Alina A., van Ramshorst, Jan, Katsikis, Peter D., van der Spek, Peter J., Umans, Victor A., de Boer, Rudolf A., Boersma, Eric, Rizopoulos, Dimitris, and Kardys, Isabella

Abstract

Objective: Heart failure (HF) pathophysiology in patients with obesity may be distinct. To study these features, we identified obesity‐related biomarkers from 4210 circulating proteins in patients with HF with reduced ejection fraction (HFrEF) and examined associations of these proteins with HF prognosis and biological mechanisms. Methods: In 373 patients with trimonthly blood sampling during a median follow‐up of 2.1 (25th–75th percentile: 1.1–2.6) years, we applied an aptamer‐based multiplex approach measuring 4210 proteins in baseline samples and the last two samples before study end. Associations between obesity (BMI > 30 kg/m2) and baseline protein levels were analyzed. Subsequently, associations of serially measured obesity‐related proteins with biological mechanisms and the primary endpoint (PEP; composite of cardiovascular mortality, HF hospitalization, left ventricular assist device implantation, and heart transplantation) were examined. Results: Obesity was identified in 26% (96/373) of patients. A total of 30% (112/373) experienced a PEP (with obesity: 26% [25/96] vs. without obesity: 31% [87/277]). A total of 141/4210 proteins were linked to obesity, reflecting mechanisms of neuron projection development, cell adhesion, and muscle cell migration. A total of 50/141 proteins were associated with the PEP, of which 12 proteins related to atherosclerosis or hypertrophy provided prognostic information beyond clinical characteristics, N‐terminal pro‐B‐type natriuretic peptide, and high‐sensitivity troponin T. Conclusions: Patients with HFrEF and obesity show distinct proteomic profiles compared to patients with HFrEF without obesity. Obesity‐related proteins are independently associated with HF outcome. These proteins carry potential to improve management of obesity‐related HF and could be leads for future research. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Abstract 12012: Subphenotypes of Heart Failure With Reduced Ejection Fraction Based on Repeated Measurements of 4210 Circulating Proteins Are Driven by Protein Subsets Reflecting Different Biological Mechanisms

Author

Petersen, Teun B, de Bakker, Marie, Asselbergs, Folkert W, Akkerhuis, K. Martijn, Brugts, Jasper J, van Ramshorst, Jan, Lumbers, Tom, Ostroff, Rachel, Katsikis, Peter D, van der Spek, Peter J, Umans, Victor A, Boersma, Eric, Rizopoulos, Dimitris, and Kardys, Isabella

Published
2022
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12. Machine learning–based biomarker profile derived from 4210 serially measured proteins predicts clinical outcome of patients with heart failure

Author

de Bakker, Marie, primary, Petersen, Teun B, additional, Rueten-Budde, Anja J, additional, Akkerhuis, K Martijn, additional, Umans, Victor A, additional, Brugts, Jasper J, additional, Germans, Tjeerd, additional, Reinders, Marcel J T, additional, Katsikis, Peter D, additional, van der Spek, Peter J, additional, Ostroff, Rachel, additional, She, Ruicong, additional, Lanfear, David, additional, Asselbergs, Folkert W, additional, Boersma, Eric, additional, Rizopoulos, Dimitris, additional, and Kardys, Isabella, additional

Published
2023
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16. Sex‐specific cardiovascular protein levels and their link with clinical outcome in heart failure.

Author

de Bakker, Marie, Loncq de Jong, Mylène, Petersen, Teun, de Lange, Iris, Akkerhuis, K. Martijn, Umans, Victor A., Rizopoulos, Dimitris, Boersma, Eric, Brugts, Jasper J., and Kardys, Isabella

Subjects
HEART assist devices, FATTY acid-binding proteins, HEART failure, MATRIX metalloproteinases, TREFOIL factors, HEART transplantation
Abstract

Aims: This study aims to provide insight into sex‐specific cardiovascular protein profiles and their associations with adverse outcomes, which may contribute to a better understanding of heart failure (HF) pathophysiology and the optimal use of circulating proteins for prognostication in women and men. Methods and results: In 250 stable patients with HF with reduced ejection fraction (HFrEF), we performed trimonthly blood sampling (median follow‐up: 26 [17–30] months). We selected all baseline samples and two samples closest to the primary endpoint (PEP; composite of cardiovascular death, heart transplantation, left ventricular assist device implantation, and HF hospitalization) or one sample closest to censoring and applied the Olink Cardiovascular III panel. We used linear regression to study sex‐based differences in baseline levels and joint models to study differences in the prognostic value of serially measured proteins. In 66 women and 184 men (mean age of 66 and 67 years, respectively), 21% and 28% reached the PEP, respectively. Mean baseline levels of fatty acid‐binding protein 4, secretoglobin family 3A member 2, paraoxonase 3, and trefoil factor 3 were higher in women (Pinteraction: 0.001, 0.007, 0.018, and 0.049, respectively), while matrix metalloproteinase‐3, interleukin 1 receptor‐like 1, and myoglobin were higher in men (Pinteraction: <0.001, 0.001, and 0.049, respectively), independent of clinical characteristics. No significant differences between sexes were observed in the longitudinal associations of proteins with the PEP. Only peptidoglycan recognition protein 1 showed a suggestive interaction with sex for the primary outcome (Pinteraction = 0.028), without multiple testing correction, and was more strongly associated with adverse outcome in women {hazard ratio [HR] 3.03 [95% confidence interval (CI), 1.42 to 6.68], P = 0.008} compared with men [HR 1.18 (95% CI, 0.84 to 1.66), P = 0.347]. Conclusions: Although multiple cardiovascular‐related proteins show sex differences at baseline, temporal associations with the adverse outcome do not differ between women and men with HFrEF. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, primary, Vanmaele, Alexander, additional, Hoeks, Sanne E, additional, Verhagen, Hence JM, additional, Fioole, Bram, additional, Moelker, Adriaan, additional, ten Raa, Sander, additional, Hussain, Burhan, additional, Oliveira-Pinto, José, additional, Bastos Gonçalves, Frederico, additional, Ijpma, Arne S, additional, Hoefer, Imo E, additional, van Lier, Felix, additional, Akkerhuis, K Martijn, additional, Majoor-Krakauer, Danielle F, additional, Boersma, Eric, additional, and Kardys, Isabella, additional

Published
2023
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18. Effects of Ticagrelor, Prasugrel, or Clopidogrel on Endothelial Function and Other Vascular Biomarkers: A Randomized Crossover Study

Author

Frigoli, Enrico, Monti, Monia, Ciociano, Nestor, Karagiannis, Alexios, Heg, Dik, Valgimigli, Marco, Leonardi, Sergio, Brugaletta, Salvatore, Rizzotti, Diego, Mandurino Mirizzi, Alessandro, Van Royen, Niels, van Leeuwen, Maarten, Janssens, Gladys, Räber, Lorenz, Ariotti, Sara, Windecker, Stephan, Rimoldi, Stefano F., Rexhaj, Emrush, Sabaté, Manel, Ortega-Paz, Luis, Akkerhuis, K. Martijn, van den Berge, Jan C., and Gianni, Umberto

Published
2018
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19. Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, Vanmaele, Alexander, Hoeks, Sanne E., Verhagen, Hence J.M., Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Bastos Gonçalves, Frederico, Ijpma, Arne S., Hoefer, Imo E., van Lier, Felix, Akkerhuis, K. Martijn, Majoor-Krakauer, Danielle F., Boersma, Eric, Kardys, Isabella, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
endovascular aneurysm repair, SDG 3 - Good Health and Well-being, biomarkers, Cardiology and Cardiovascular Medicine, abdominal aortic aneurysm (AAA), cardiovascular diseases
Abstract

Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work is supported by Stichting Lijf en Leven. The sponsor had no role in study design, methods, subject recruitment, data collection or analysis, or preparation of the manuscript. Publisher Copyright: © The Author(s) 2023. Background: Surveillance programs in abdominal aortic aneurysms (AAA) are mainly based on imaging and leave room for improvement to timely identify patients at risk for AAA growth. Many biomarkers are dysregulated in patients with AAA, which fuels interest in biomarkers as indicators of disease progression. We examined associations of 92 cardiovascular disease (CVD)-related circulating biomarkers with AAA and sac volume. Methods: In a cross-sectional analysis, we separately investigated (1) 110 watchful waiting (WW) patients (undergoing periodic surveillance imaging without planned intervention) and (2) 203 patients after endovascular aneurysm repair (EVAR). The Cardiovascular Panel III (Olink Proteomics AB, Sweden) was used to measure 92 CVD-related circulating biomarkers. We used cluster analyses to investigate protein-based subphenotypes, and linear regression to examine associations of biomarkers with AAA and sac volume on CT scans. Results: Cluster analyses revealed two biomarker-based subgroups in both WW and EVAR patients, with higher levels of 76 and 74 proteins, respectively, in one subgroup versus the other. In WW patients, uPA showed a borderline significant association with AAA volume. Adjusting for clinical characteristics, there was a difference of −0.092 (−0.148, −0.036) loge mL in AAA volume per SD uPA. In EVAR patients, after multivariable adjustment, four biomarkers remained significantly associated with sac volume. The mean effects on sac volume per SD difference were: LDLR: −0.128 (−0.212, −0.044), TFPI: 0.139 (0.049, 0.229), TIMP4: 0.110 (0.023, 0.197), IGFBP-2: 0.103 (0.012, 0.194). Conclusion: LDLR, TFPI, TIMP4, and IGFBP-2 were independently associated with sac volume after EVAR. Subgroups of patients with high levels of the majority of CVD-related biomarkers emphasize the intertwined relationship between AAA and CVD. ClinicalTrials.gov Identifier: NCT03703947. publishersversion epub_ahead_of_print

Published
2023

20. Serially Measured hs-cTnT, NT-proBNP, hs-CRP and GDF-15 for Risk Assessment After Acute Coronary Syndrome: the BIOMArCS Cohort

Author

Gürgöze, Muhammed T, primary, Akkerhuis, K Martijn, additional, Oemrawsingh, Rohit M, additional, Umans, Victor A W M, additional, Kietselaer, Bas, additional, Schotborgh, Carl E, additional, Ronner, Eelko, additional, Lenderink, Timo, additional, Aksoy, Ismail, additional, van der Harst, Pim, additional, Asselbergs, Folkert W, additional, Maas, Arthur C, additional, Ophuis, Anton J Oude, additional, Krenning, Boudewijn, additional, de Winter, Robbert J, additional, The, Salem H K, additional, Wardeh, Alexander J, additional, Hermans, Walter R M, additional, Cramer, G Etienne, additional, van Gorp, Ina, additional, de Rijke, Yolanda B, additional, van Schaik, Ron H N, additional, and Boersma, Eric, additional

Published
2023
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24. Prognostic value of temporal patterns of global longitudinal strain in patients with chronic heart failure

Author

Abou Kamar, Sabrina, primary, Aga, Yaar S., additional, de Bakker, Marie, additional, van den Berg, Victor J., additional, Strachinaru, Mihai, additional, Bowen, Dan, additional, Frowijn, René, additional, Akkerhuis, K. Martijn, additional, Brugts, Jasper, additional, Manintveld, Olivier, additional, Umans, Victor, additional, Geleijnse, Marcel L., additional, Boersma, Eric, additional, van Dalen, Bas M., additional, and Kardys, Isabella, additional

Published
2023
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26. Multimarker Analysis of Serially Measured GDF-15, NT-proBNP, ST2, GAL-3, cTnI, Creatinine, and Prognosis in Acute Heart Failure

Author

Gürgöze, Muhammed T., primary, van Vark, Laura C., additional, Baart, Sara J., additional, Kardys, Isabella, additional, Akkerhuis, K. Martijn, additional, Manintveld, Olivier C., additional, Postmus, Douwe, additional, Hillege, Hans L., additional, Lesman-Leegte, Ivonne, additional, Asselbergs, Folkert W., additional, Brunner-la-Rocca, Hans-Peter, additional, van den Bos, Ewout J., additional, Orsel, Joke G., additional, de Ridder, Stijn P.J., additional, Pinto, Yigal M., additional, and Boersma, Eric, additional

Published
2023
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29. sj-pdf-3-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, Vanmaele, Alexander, Hoeks, Sanne E, Verhagen, Hence JM, Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Bastos Gonçalves, Frederico, Ijpma, Arne S, Hoefer, Imo E, van Lier, Felix, Akkerhuis, K Martijn, Majoor-Krakauer, Danielle F, Boersma, Eric, and Kardys, Isabella

Subjects
Cardiology, Surgery
Abstract

Supplemental material, sj-pdf-3-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine

Published
2023
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30. sj-pdf-2-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, Vanmaele, Alexander, Hoeks, Sanne E, Verhagen, Hence JM, Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Bastos Gonçalves, Frederico, Ijpma, Arne S, Hoefer, Imo E, van Lier, Felix, Akkerhuis, K Martijn, Majoor-Krakauer, Danielle F, Boersma, Eric, and Kardys, Isabella

Subjects
Cardiology, Surgery
Abstract

Supplemental material, sj-pdf-2-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine

Published
2023
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31. sj-pdf-1-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, Vanmaele, Alexander, Hoeks, Sanne E, Verhagen, Hence JM, Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Bastos Gonçalves, Frederico, Ijpma, Arne S, Hoefer, Imo E, van Lier, Felix, Akkerhuis, K Martijn, Majoor-Krakauer, Danielle F, Boersma, Eric, and Kardys, Isabella

Subjects
Cardiology, Surgery
Abstract

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine

Published
2023
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32. Additional file 1 of Sex-based differences in cardiovascular proteomic profiles and their associations with adverse outcomes in patients with chronic heart failure

Author

de Bakker, Marie, Petersen, Teun B., Akkerhuis, K. Martijn, Harakalova, Magdalena, Umans, Victor A., Germans, Tjeerd, Caliskan, Kadir, Katsikis, Peter D., van der Spek, Peter J., Suthahar, Navin, de Boer, Rudolf A., Rizopoulos, Dimitris, Asselbergs, Folkert W., Boersma, Eric, and Kardys, Isabella

Abstract

Additional file 1. Supplemental materials.

Published
2023
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33. Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study

Author

Cheng, Jin M., Suoniemi, Matti, Kardys, Isabella, Vihervaara, Terhi, de Boer, Sanneke P.M., Akkerhuis, K. Martijn, Sysi-Aho, Marko, Ekroos, Kim, Garcia-Garcia, Hector M., Oemrawsingh, Rohit M., Regar, Evelyn, Koenig, Wolfgang, Serruys, Patrick W., van Geuns, Robert-Jan, Boersma, Eric, and Laaksonen, Reijo

Published
2015
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34. High-Frequency Biomarker Measurements of Troponin, NT-proBNP, and C-Reactive Protein for Prediction of New Coronary Events After Acute Coronary Syndrome: BIOMArCS Study

Author

Oemrawsingh, Rohit M., Akkerhuis, K. Martijn, de Mulder, Maarten, Umans, Victor A., Kietselaer, Bas, Schotborgh, Carl, Ronner, Eelko, Lenderink, Timo, Liem, Anho, Haitsma, David, van der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur, Oude Ophuis, Anton J., Ilmer, Ben, Dijkgraaf, Rene, de Winter, Robbert J., Kie The, S. Hong, Wardeh, Alexander J., Hermans, Walter, Cramer, Etienne, van Schaik, Ron H., Hoefer, Imo E., Doevendans, Pieter A., Simoons, Maarten L., and Boersma, Eric

Published
2019
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35. Serially measured high-sensitivity cardiac troponin T, N-terminal-pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and growth differentiation factor 15 for risk assessment after acute coronary syndrome: the BIOMArCS cohort.

Author

Gürgöze, Muhammed T, Akkerhuis, K Martijn, Oemrawsingh, Rohit M, Umans, Victor A W M, Kietselaer, Bas, Schotborgh, Carl E, Ronner, Eelko, Lenderink, Timo, Aksoy, Ismail, van der Harst, Pim, Asselbergs, Folkert W, Maas, Arthur C, Oude Ophuis, Anton J, Krenning, Boudewijn, de Winter, Robbert J, The, Salem H K, Wardeh, Alexander J, Hermans, Walter R M, Cramer, G Etienne, and van Gorp, Ina

Published
2023
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36. Prognostic value of syntax score, intravascular ultrasound and near-infrared spectroscopy to identify low-risk patients with coronary artery disease 5-year results from the ATHEROREMO and IBIS-3 cohorts

Author

Vlieger, Selina, primary, Oemrawsingh, Rohit M., additional, Cheng, Jin M., additional, Schuurman, Anne-Sophie, additional, Vroegindewey, Maxime, additional, Kardys, Isabella, additional, Van Geuns, Robert-Jan, additional, Daemen, Joost, additional, Van Mieghem, Nicolaas M., additional, Akkerhuis, K. Martijn, additional, and Boersma, Eric, additional

Published
2022
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38. Relation of C-Reactive Protein to Coronary Plaque Characteristics on Grayscale, Radiofrequency Intravascular Ultrasound, and Cardiovascular Outcome in Patients With Acute Coronary Syndrome or Stable Angina Pectoris (from the ATHEROREMO-IVUS Study)

Author

Cheng, Jin M., Oemrawsingh, Rohit M., Garcia-Garcia, Hector M., Akkerhuis, K. Martijn, Kardys, Isabella, de Boer, Sanneke P.M., Langstraat, Jannette S., Regar, Evelyn, van Geuns, Robert-Jan, Serruys, Patrick W., and Boersma, Eric

Published
2014
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44. Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy)

Author

Anroedh, Sharda S., Akkerhuis, K. Martijn, Oemrawsingh, Rohit M., Garcia-Garcia, Hector M., Brankovic, Milos, Regar, Evelyn, van Geuns, Robert-Jan, Serruys, Patrick W., Daemen, Joost, van Mieghem, Nicolas M., Boersma, Eric, and Kardys, Isabella

Published
2018
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47. Relation of Iron Status to Prognosis After Acute Coronary Syndrome

Author

Gürgöze, Muhammed T., primary, Kardys, Isabella, additional, Akkerhuis, K. Martijn, additional, Oemrawsingh, Rohit M., additional, Groot, Hilde E., additional, van der Harst, Pim, additional, Umans, Victor A., additional, Kietselaer, Bas, additional, Ronner, Eelko, additional, Lenderink, Timo, additional, Asselbergs, Folkert W., additional, Manintveld, Olivier C., additional, and Boersma, Eric, additional

Published
2022
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48. Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events

Author

van den Berg, Victor. J., Vroegindewey, Maxime M., Umans, Victor A., van der Harst, Pim, Asselbergs, Folkert W., Akkerhuis, K. Martijn, Kardys, Isabella, Boersma, Eric, Cardiovascular Centre (CVC), and Cardiology

Subjects
Male, sST2, RISK, NT-PROBNP, Health, Toxicology and Mutagenesis, Clinical Biochemistry, Middle Aged, Prognosis, Interleukin-1 Receptor-Like 1 Protein, Biochemistry, C-REACTIVE PROTEIN, acute coronary syndrome, SDG 3 - Good Health and Well-being, MYOCARDIAL-INFARCTION, MANAGEMENT, IL-33, Humans, atherosclerosis, repeated measurements, SOLUBLE ST2, Biomarkers, secondary prevention, Proportional Hazards Models
Abstract

Purpose: Higher soluble ST2 (sST2) levels at admission are associated with adverse outcome in acute coronary syndrome (ACS) patients. We studied the dynamics of sST2 over time in post-ACS patients prior to a recurrent ACS or cardiac death. Methods: We used the BIOMArCS case cohort, consisting of 187 patients who underwent serial blood sampling during one-year follow-up post-ACS. sST2 was batch-wise quantified after completion of follow-up in a median of 8 (IQR: 5–11) samples per patient. Joint modelling was used to investigate the association between longitudinally measured sST2 and the endpoint, adjusted for gender, GRACE risk score and history of cardiovascular diseases. Results: Median age was 64 years and 79% were men. The 36 endpoint patients had systematically higher sST2 levels than those that remained endpoint free (mean value 29.6 ng/ml versus 33.7 ng/ml, p-value 0.052). The adjusted hazard ratio for the endpoint per standard deviation increase of sST2 was 1.64 (95% confidence interval: 1.09–2.34; p = 0.019) at any time point. We could not identify a steady or sudden increase of sST2 in the run-up to the combined endpoint. Conclusion: Asymptomatic post-ACS patients with persistently higher sST2 levels are at higher risk of recurrent ACS or cardiac death during one-year follow-up.

Published
2022

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