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10 results on '"Akiyama, Fumihiro"'

1. Association of a single-nucleotide polymorphism in the immunoglobulin μ-binding protein 2 gene with immunoglobulin A nephropathy

Author

Ohtsubo, Shigeru, Iida, Aritoshi, Nitta, Kosaku, Tanaka, Toshihiro, Yamada, Ryo, Ohnishi, Yozo, Maeda, Shiro, Tsunoda, Tatsuhiko, Takei, Takashi, Obara, Wataru, Akiyama, Fumihiro, Ito, Kyoko, Honda, Kazuho, Uchida, Keiko, Tsuchiya, Ken, Yumura, Wako, Ujiie, Takashi, Nagane, Yutaka, Miyano, Satoru, Suzuki, Yasushi, Narita, Ichiei, Gejyo, Fumitake, Fujioka, Tomoaki, Nihei, Hiroshi, and Nakamura, Yusuke

Published
2005
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2. Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients

Author

Obara, Wataru, Iida, Aritoshi, Suzuki, Yasushi, Tanaka, Toshihiro, Akiyama, Fumihiro, Maeda, Shiro, Ohnishi, Yozo, Yamada, Ryo, Tsunoda, Tatsuhiko, Takei, Takashi, Ito, Kyoko, Honda, Kazuho, Uchida, Keiko, Tsuchiya, Ken, Yumura, Wako, Ujiie, Takashi, Nagane, Yutaka, Nitta, Kosaku, Miyano, Satoru, Narita, Ichiei, Gejyo, Fumitake, Nihei, Hiroshi, Fujioka, Tomoaki, and Nakamura, Yusuke

Published
2003
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7. Association of a single-nucleotide polymorphism in the immunoglobulin μ-binding protein 2 gene with immunoglobulin A nephropathy

Author

Ohtsubo, Shigeru, primary, Iida, Aritoshi, additional, Nitta, Kosaku, additional, Tanaka, Toshihiro, additional, Yamada, Ryo, additional, Ohnishi, Yozo, additional, Maeda, Shiro, additional, Tsunoda, Tatsuhiko, additional, Takei, Takashi, additional, Obara, Wataru, additional, Akiyama, Fumihiro, additional, Ito, Kyoko, additional, Honda, Kazuho, additional, Uchida, Keiko, additional, Tsuchiya, Ken, additional, Yumura, Wako, additional, Ujiie, Takashi, additional, Nagane, Yutaka, additional, Miyano, Satoru, additional, Suzuki, Yasushi, additional, Narita, Ichiei, additional, Gejyo, Fumitake, additional, Fujioka, Tomoaki, additional, Nihei, Hiroshi, additional, and Nakamura, Yusuke, additional

Published
2004
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9. Chronic portal-systemic shunt encephalopathy in a hemodialysis patient treated with balloon-occluded retrograde transvenous obliteration.

Author

Yasukawa R, Akiyama F, Tsukishiro T, and Narita I

Abstract

We report a case of chronic portal-systemic shunt encephalopathy in a 79-year-old female hemodialysis patient with end-stage renal disease. Approximately 1 month before admission, she occasionally had a discrepant conversation. It was considered that hepatic encephalopathy was caused by an increase in the ammonia level in the blood flow of the shunt, which had been diagnosed 7 years previously between the splenic vein and the left renal vein. On admission, disturbed consciousness and an elevated serum ammonia level (221 μg/dl) were observed. No change in the shunt diameter was noted. Consciousness improved with conservative treatment, whereas hyperammonemia remained. Balloon-occluded retrograde transvenous obliteration (B-RTO) was performed on the shunt. As a result, hyperammonemia resolved immediately, and the level of ammonia was maintained at approximately 60 μg/dl. The patient often complained of drug-induced constipation; therefore, an increase in the intra-abdominal pressure in addition to ammonia production in the intestinal tract was suspected as the cause of encephalopathy. More than 23 months have passed since the B-RTO therapy, and no symptoms of encephalopathy have been observed yet.

Published
2013
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10. Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy.

Author

Akiyama F, Tanaka T, Yamada R, Ohnishi Y, Tsunoda T, Maeda S, Takei T, Obara W, Ito K, Honda K, Uchida K, Tsuchiya K, Nitta K, Yumura W, Nihei H, Ujiie T, Nagane Y, Miyano S, Suzuki Y, Fujioka T, Narita I, Gejyo F, and Nakamura Y

Subjects
Adult, Alleles, Case-Control Studies, Chromosomes, Human, Pair 6 genetics, Female, Genetic Predisposition to Disease, Genotype, HLA-DR alpha-Chains, Humans, Japan, Linkage Disequilibrium genetics, Male, Middle Aged, Odds Ratio, Genes, MHC Class II genetics, Glomerulonephritis, IGA genetics, HLA-DR Antigens genetics, Polymorphism, Single Nucleotide genetics
Abstract

Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis of unknown etiology and pathogenesis. Immunogenetic studies have not conclusively indicated that human leukocyte antigen (HLA) is involved. As a first step in investigating a possible relationship between HLA class II genes and IgAN, we analyzed the extent of linkage disequilibrium (LD) in this region of chromosome 6p21.3 in a Japanese test population and found extended LD blocks within the class II locus. We designed a case-control association study of single-nucleotide polymorphisms (SNPs) in each of those LD blocks, and determined that SNPs located in the HLA- DRA gene were significantly associated with an increased risk of IgAN ( P = 0.000001, odds ratio = 1.91 [95% confidence interval 1.46-2.49]); SNPs in other LD blocks were not. Our data imply that some haplotype of the HLA- DRA locus has an important role in the development of IgAN in Japanese patients.

Published
2002
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