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9 results on '"Akinola, N.O."'

1. Acceptability of prenatal diagnosis of sickle cell anemia (SCA) by female patients and parents of SCA patients in Nigeria

Author

Durosinmi, M.A., Odebiyi, A.I., Adediran, I.A., Akinola, N.O., Adegorioye, D.E., and Okunade, M.A.

Subjects
Nigeria -- Health aspects, Sickle cell anemia in children -- Diagnosis, Prenatal diagnosis -- Evaluation, Health attitudes -- Surveys, Health, Social sciences
Abstract

The acceptability of prenatal diagnosis (PND) of sickle cell anaemia (SCA) as a means of controlling sickle cell disorder in Nigeria was examined using a structured questionnaire. The respondents were comprised of 92 adult female patients with SCA, aged 15-20 (23 [+ or -] 6) years; 53 HbAS mothers, aged 20-61 (37 [+ or -] 11) years and 48 HbAS fathers, aged 33-65 (46 [+ or -] 8) years. More than 85% of the respondents would like PND to be offered in Nigeria and 92% of the HbAS mothers as well as 86% of the fathers would like to have the investigation or allow their wives to go through the procedure, respectively. Only 35% of the patients as compared to 63% of the mothers and 51% of the fathers would opt for termination of an affected pregnancy. Fear of the complications of abortion and religious convictions were the two most frequently cited reasons for opposing pregnancy termination. The high percentage of parents who would opt for termination of an affected pregnancy was associated with the societal emphasis on perfection and on previous experience in management of SCA patients. It is interesting that most of the respondents still favoured effective genetic counselling as the best means of controlling SCA.

Published
1995

3. In vitro Evaluation of Moringa oleifera Leaf Extracts Used in Managing Sickle Cell Patients in South West Nigeria

Author

Cyril-Olutayo, M.C., Agbedahunsi, J.M., and Akinola, N.O.

Subjects
Anti-sickling, Polymerization, Membrane stability, Red Cell density
Abstract

Background: Moringa oleifera Lam. (Moringaceae) cultivated in South West Nigeria has been used locally in the treatment of iron deficiency anaemia, and especially in the management of sickle cell anaemia whose treatment is mainly palliative. Moringa oleifera is a nutritious vegetable and attention is now being given to such plant materials which can serve as both food and medicine in the management of sickle cell anaemia. This study therefore investigated the antisickling properties as well as the mode of action of the leaf extract of Moringa oleifera grown in South West Nigeria.Materials and method: The anti-sickling properties of M. oleifera leaf ethanol extracts and various fractions were evaluated using nitrogen gas to induce hypoxial state in vitro. The mechanisms of action were examined using different in vitro models, which include red cell density, membrane stability, haemoglobin HbS polymerization as well as antioxidant assays at various concentrations.Results: Moringa oleifera at 4 mg/mL caused 95.6 ± 2.47% inhibition and 79.4 ± 1.93% reversal of HbS sickling and purification of the crude extract enhanced activity. The extract showed a change in density of 14.74 ± 0.90% and a dose dependent membrane stabilizing property, which was significantly higher (p < 0.05) than the positive control. Moringa oleifera exhibited metal chelating activity and low inhibition of nitric oxide, which is important in the prevention of the onset of vaso-occlusive crisis in sickle cell patients.Conclusion: This study therefore justifies the use of Moringa. oleifera in the management of sickle cell anaemia and therefore a candidate plant in the development of antisickling drug.Keywords: Anti-sickling, Polymerization, Membrane stability, Red Cell density

Published
2018

4. Assessment of serum Cystatin-C based eGFR equations and kidney dysfunction in patients with sickle cell anaemia: a single centre evaluation of cases and healthy controls

Author

Bolarinwa, R.A., Ojewumi, T.K., Akinlade, K.S., and Akinola, N.O.

Abstract

Background: Serum creatinine and its estimated glomerular filtration rate (eGFR) may be imprecise in assessing renal impairment of patients with sickle cell anaemia (SCA).Objective: To evaluate serum Cystatin-C and Cystatin-C eGF Requationsin the assessment of kidney dysfunction in Nigerians with SCA and controls.Design: A prospective, cross-sectional and case-control studySetting: The study was conducted at the haematology units of the Obafemi Awolowo University Teaching hospital complex, Ile-Ife and the Ring Road State Hospital, Ibadan in the South Western Nigeria,Subjects: The study participants included 46 sickle cell anaemia patients (HbSS) and 36 HbAA healthy controls in whiche GFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI, 2009 and 2012) equations for Creatinine, cystatin-C and Creatine and cystatin-C combined.Results: Mean serum cys-C was similar in patients and control group [0.29 (0.09) vs 0.26 (0.07) mg/L] while albuminuria occurred in 44.4% of patients only. Twice the number of patients with hyper filtration using CKD-EPI Cr equation was identified by CKD-EPI Cr-cys-C equation andnone by CKD-EPI cys-C. CKD-EPI cys-C identified more patients with eGFR 60 mL/min/1.73m2 than the creatinine based only and/or Cr-cys-C equations. Patients with CKD stage 3 were identified by CKD-EPI Cr and CKD-EPI cys-C at 2.2% and 8.7% respectively. Age 19 years, male sex, low eGFR and albuminuria were predictive of having high levels of serum cystatin C.Conclusion: Serum Cystatin C values appear lower for the sickled cell anaemia patients and healthy controls in the Nigerian population. Of the CKD-EPI equations, CKD-EPI cystatin-C equation best identified SCA patients with low eGFR (eGFR < 60 mL/min/1.73m2)

Published
2018

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