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21 results on '"Akihiko KISHIMOTO"'

1. Classification and characterization of human full-length cDNA clones that are difficult to sequence

Author

Ai Wakamatsu, Akihiko Kishimoto, Takao Isogai, Masafumi Yohda, Yukio Ono, Tadashi Ishibashi, Sumio Sugano, Keiichi Kanehori, Nobuo Nomura, and Katsuji Murakawa

Subjects
Genetics, Complementary DNA, Primer walking, Alu element, Phrap, Human genome, Sine, ORFS, Biology, Biochemistry, Sequence (medicine)
Abstract

In the Full-length Human cDNA Sequencing Project, 30,160 cDNA were sequenced. Among them, our group performed sequencing of 3,588 cDNAs, mainly using the primer walking method. The sequences achieved an average Phrap score of 76, which means the average of expected sequence accuracy was 99.9999975%, by sequencing of both strands with the criterion of a Phrap score over 30. In spite of the extremely high sequence reliability, we met with difficulty in sequencing 52 cDNAs, which are termed undecipherable cDNAs. cDNAs of long repeats were considered as a possible source of sequencing difficulty; their maximum repeat length sequenced by the primer walking method was 530 bp, without using the random method, and 81% of long repeat sequences remained in the ORFs. In single repeat regions, the insertion/deletion rates were much larger than in the usual regions. The fraction of SINE/Alu repeats in the cDNAs was 5.4%, half of the fraction of the human genome. The fraction of SINE/Alu in undecipherable cDNAs was up to 10%, the same level of the human genome.

Published
2008
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3. Enzyme System for Improving the Detection Limit in Pyrosequencing

Author

Shigeya Suzuki, Mari Gotou, Hideki Kambara, Guohua Zhou, Tomoharu Kajiyama, and Akihiko Kishimoto

Subjects
Detection limit, Chemistry, Sensitivity and Specificity, Pyrophosphate, DNA sequencing, Enzymes, Analytical Chemistry, chemistry.chemical_compound, DNA sequencer, Biochemistry, Pyrosequencing, A-DNA, Luciferase, DNA
Abstract

Highly sensitive real-time pyrosequencing seems promising for constructing an inexpensive and small DNA sequencer with a low running cost. A DNA sample of a picomole level is usually used in the conventional pyrosequencing based on a luciferase assay coupled with an APS-ATP surfurylase reaction for producing ATP from pyrophosphate (PPi). Although the luminescence intensity could be increased by increasing the amount of luciferase, it was impossible to reduce the target DNA amount because of a large background luminescence due to the luciferase-APS reaction. In this report, a novel approach using a new conversion reaction of PPi to ATP is proposed. This method has a very low background and can produce high signals in the presence of a large amount of luciferase; thus, the sample amount required for sequencing is significantly reduced. The ATP production from PPi is catalyzed with pyruvate orthophosphate dikinase (PPDK) using AMP and phosphoenolpyruvate as the substrates, which are inactive for the luciferase-catalyzed reaction. All of the components in the AMP-PPDK-based pyrosequencing system are suitable for highly sensitive DNA sequencing in one tube. Real-time DNA sequencing with a readable length up to 70 bases was successfully demonstrated by using this system. By increasing the amount of luciferase, as low as 2.5 fmol of DNA templates was accurately sequenced by the proposed method with a novel simple and inexpensive DNA sequencer having a photodiode array as a sensor instead of a PMT or CCD camera. A sample amount as low as 2 orders of magnitude smaller than that used in the conventional pyrosequencer can be used.

Published
2006
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4. Biliary cystadenocarcinoma followed up as benign cystadenoma for 10 years

Author

Kohei Katsumi, Yoshimitsu Ban, Shinichi Takamatsu, Akihiko Kishimoto, Masayuki Iida, Kunio Kobayashi, Kenji Andoh, Eiji Kubota, Nobuo Takahashi, Koutaroh Nakata, and Takashi Joh

Subjects
Male, medicine.medical_specialty, Cystadenoma, Cystadenocarcinoma, Intrahepatic bile ducts, Hepatic Duct, Common, Bile Duct Neoplasm, Hepatic Artery, Internal medicine, Abdomen, medicine, Humans, Diagnostic Errors, Aged, Ultrasonography, medicine.diagnostic_test, business.industry, Liver Neoplasms, Gastroenterology, Hepatology, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Bile Duct Neoplasms, Abdominal ultrasonography, Radiology, Tomography, X-Ray Computed, business, Abdominal surgery
Abstract

We describe a case of biliary cystadenocarcinoma that showed a longterm clinical course. A 69-year-old Japanese man was admitted to our hospital because of abdominal discomfort. The patient had been diagnosed with benign cystadenoma of the liver at another hospital in 1987 and had been followed up for 10 years. Abdominal ultrasonography (US) and computed tomography (CT) scan demonstrated a unilocular cystic lesion, which included multiple conspicuous papillary protrusions in the left hepatic lobe. Left lateral segmentectomy was performed, and intraoperative cholangiography revealed a communication between the cystic tumor and intrahepatic bile duct. The tumor contained clear mucinous fluid and enfolded multiple yellowish papillary projections on the cystic wall. Histological examination showed the tumor to be biliary cystadenocarcinoma. The patient is doing well 4 years after the operation.

Published
2003
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5. A Case of Familial Adenomatous Polyposis Associated with Colon Cancer, Ureteral Cancer and Two Early Gastric Cancers

Author

Makoto Itoh, Akihiko Takeshima, Tomoyuki Shirai, Fumihiro Iwata, Shoji Kojma, Minoru Kato, Toshihiko Takeuchi, Kohei Katsumi, Kumiko Ogawa, Hiromi Kataoka, Yoshimitsu Ban, Hiroshi Suzumura, Akihiko Kishimoto, Takeo Kutsuna, and Tatsuo Itoh

Subjects
medicine.medical_specialty, business.industry, Colorectal cancer, medicine.medical_treatment, Gastroenterology, Cancer, Ureteral cancer, medicine.disease, digestive system diseases, Nephrectomy, Descending colon, Familial adenomatous polyposis, medicine.anatomical_structure, Ureter, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, business, Barium enema
Abstract

A rare case of Familial Adenomatous Polyposis (FAP), associated with colon cancer, ureteral cancer and two early gastric cancers, is reported. A 42-year-old male was admitted to our hospital for evaluation of bloody stools and macrohematuria. There were six FAP patients in his family line, spanning four generations, and five had developed colon cancers. A barium enema revealed diffuse and scattered polyposis throughout the colon and an apple core sign in the descending colon. Abdominal CT disclosed right hydronephrosis with a markedly dilated ureter. Surgery was undertaken and included total colectomy, mucosal proctectomy, ileoanal anastomosis and right nephrectomy with ureteral resection, under a diagnosis of colon cancer and complete right ureteral stenosis. The resected specimens revealed a colon cancer in the descending colon, 50×32×15 mm in size and a ureteral cancer in the lower part of the right ureter, 30×16×16 mm in size. Four years later, he visited our hospital for detailed gastric examination, because gastric abnormalities had been pointed out in a health screening examination. Upper Gl X-ray and endoscopic studies disclosed two cancerous lesions in the gastric antrum, one being a lie lesion in the anterior wall and the other a Ha + lie lesion in the posterior wall. Subtotal gastrectomy was performed and histological study revealed that invasiveness was limited to the submucosa in both lesions. No case of FAP associated with ureteral cancer has previously been reported and only 28 cases with associated gastric cancer have appeared in the Japanese literature.

Published
1995
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6. High-Quality Carbon-Doped Boron Nitride Membrane for X-Ray Lithography Mask

Author

Sadae Yamaguchi, Akihiko Kishimoto, Masahiko Sakakihara, Kozo Mochiji, Hiroaki Oizumi, Shinji Kuniyoshi, and Tetsurou Kawai

Subjects
business.industry, General Engineering, General Physics and Astronomy, Chemical vapor deposition, chemistry.chemical_compound, Membrane, Optics, Quality (physics), chemistry, Chemical engineering, Boron nitride, Radiation damage, X-ray lithography, business, Lithography, Visible spectrum
Abstract

Carbon-doped BN (BNC) membrane was fabricated by low pressure chemical vapor deposition (LPCVD) at a high temperature (750°C). Here, CH3NH2 was used as the reactive gas instead of NH3. The newly developed BNC has tensile stress and is transparent to visible light. A very small hydrogen content (3.3%) leads to the construction of strong atomic networks of B, N, and C, as well as to highly improved radiation stability.

Published
1992
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7. A Case of Pneumonia Associated with Increased Antibody Titers to Simultaneous Mycoplasma pneumoniae and Chlamydia psittaci

Author

Yoshimitsu Miyoshi, Masahito Kato, Yoshimitsu Hayashi, Toshihiko Takeuchi, Toshihisa Fujioka, Masanobu Kawabe, Kazufuto Toyama, Akihiko Kishimoto, and Hirotaka Ohara

Subjects
Male, Chlamydia psittaci, Mycoplasma pneumoniae, Adolescent, biology, business.industry, Antibody titer, Pneumonia, General Medicine, Psittacosis, medicine.disease_cause, biology.organism_classification, medicine.disease, Antibodies, Bacterial, Virology, Pneumonia, Mycoplasma, medicine, Humans, business
Published
1986
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8. A Comparative Study Between Cefminox (MT-141) and Cefotaxime in Respiratory Tract Infections

Author

Fumio MIKI, Eiji INOUE, Masakazu TERAGAKI, Kaname AKIOKA, Minoru YOSHIYAMA, Toru HIRAGA, Tetsuto MURATA, Akira SAITO, Akira UJIIE, Morikuni ABE, Yoshinobu TAKASHIRO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Fumio NAGAHAMA, Takehito NAKABAYASHI, Tetsuji KOROKU, Yomei HIRAGA, Katsuo SUZUKI, Hiroshi KON, Yasumasa YOKOTA, Ryoji OHASHI, Jutaro SHIMOMURA, Yoichi GOCHO, Hisashi NISHIHARA, Kazuo TAKEBE, Mitsuo MASUDA, Seiichi MURAKAMI, Yoshihiro KUMASAKA, Mitsuo NAKAMURA, Tatsuro IRIE, Masashi YONEDA, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyoshi KONNO, Kotaru OIZUMI, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Hisashi TAKIZUKA, Reiko SAITO, Keimei MASHIMO, Tetsuro UKAI, Hiroichi TANIMOTO, Ryuoh NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Hideo IKEMOTO, Kazuyoshi WATANABE, Atsushi SAITO, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Hiroyuki KOBAYASHI, Kota KONO, Kenji TAKAMURA, Hiroshi OSHITANI, Kokichi FUKUSHIMA, Akira ITO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Keinosuke NOSE, Kazufuto FUKAYA, Tadashi TAKIGAMI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Hajimu TAKEDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Katsutaka TORIKAI, Mutsumi ASHIHARA, Tatsuo SUGIHARA, Nobuo MAEKAWA, Michiyasu NAKANISHI, Tsuneo MATSUBARA, Nobuaki IKEDA, Ataka SHIBATA, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Rinzo SOEJIMA, Yoshito NIKI, Chikara NAKAHAMA, Michifumi ADACHI, Osamu KURIMURA, Koji NOMA, Eiro TSUBURA, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Kenichi MATSUBA, Takahiro NAWATA, Masaro KAJI, Yoichiro ICHIKAWA, Nisaburo TANAKA, Toshiharu HAYASHI, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Kohei HARA, Atushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Isao NAKAMURA, Munetaka KOMORI, Ken SHINZATO, Hirofumi OGATA, Naomi ITO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Takashi ITOGA, Masaru NASU, Yoichiro GOTO, Jun GOTO, and Takayoshi TASHIRO

Subjects
Clinical Trials as Topic, medicine.medical_specialty, Cefotaxime, Respiratory tract infections, Cefminox, business.industry, Lung abscess, Pneumonia, General Medicine, medicine.disease, Gastroenterology, Chronic disease, Internal medicine, Chronic Disease, medicine, Humans, Cephamycins, Lung Abscess, business, Respiratory Tract Infections, medicine.drug
Published
1985
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9. Dynamic properties of concentrated suspensions of charged polystyrene spheres

Author

Toshiya Ohtsuki, Akihiko Kishimoto, Shigeki Mitaku, and Koji Okano

Subjects
Polystyrene spheres, Structure formation, Free volume theory, Chemistry, Organic Chemistry, Biophysics, Thermodynamics, Biochemistry, Condensed Matter::Soft Condensed Matter, Crystallography, Rigidity (electromagnetism), Transition point, Newtonian fluid, Quartz, Phase diagram
Abstract

Ordered structure formation of charged polystyrene spheres was studied by measuring the order-disorder phase diagrams as well as the mechanical properties. The phase diagrams indicate that the ordering of polystyrene spheres obeys Lindemann's law of crystal melting, in which the Lindemann's parameter is about 5%. The rigidity of about 10 3 dyn/cm 2 was observed in the ordered suspension of polystyrene spheres as measured by a torsional quartz crystal method. The steady flow properties of suspensions of polystyrene spheres showed a remarkable change from a Bingham body to a Newtonian liquid at the transition point. The limit of elasticity in the ordered phase was about 1 dyn/cm 2 . The viscosity in the disordered phase was well explained by the free volume theory of liquids. It is concluded from these facts that the ordered phase of polystyrene spheres is a real “crystal” whereas the disordered phase is a “liquid”. Properties of ordered structures in biological systems are also discussed.

Published
1980
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10. Studies of Ordered Monodisperse Polystyrene Latexes. I. Shear Ultrasonic Measurements

Author

Akihiko Kishimoto, Koji Okano, Toshiya Ohtsuki, Katsumi Enari, and Shigeki Mitaku

Subjects
Materials science, Aqueous solution, Physics and Astronomy (miscellaneous), Dispersity, General Engineering, Analytical chemistry, General Physics and Astronomy, Dielectric, Crystal, chemistry.chemical_compound, Rigidity (electromagnetism), chemistry, Polymer chemistry, Ultrasonic sensor, Polystyrene, Quartz
Abstract

The rigidity G and the viscosity ? of monodisperse polystyrene latexes were measured by the torsional quartz crystal method at 70 kHz, and an abrupt change in G and ? was found at the order-disorder transition of the latexes. The torsional quartz crystal method was improved for measurements with aqueous conductive samples, and a careful calibration showed that G and ? are obtained if the dielectric constant of the sample is known. In the ordered state of latex with a volume concentration of 9.3%, the apparent rigidity G and the viscosity ? were about 1.5?103 dyne/cm2 and 0.6 cp, respectively, while in the disordered state G was small and ? was 0.95 cp. Ordered latex is a ?crystal? formed by the screened Coulomb repulsion and is a good model not only for crystals but also for ordered structures in some biological systems.

Published
1978
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11. Studies on Composition of Pharyngeal Flora in the Aged

Author

Kazuo Yoshitomo, Toshiyuki Yamamoto, Masahito Kato, Masako Takizawa, Kanzo Suzuki, Joichi Kato, Toshihiko Takeuchi, Motoko Yamamoto, and Akihiko Kishimoto

Subjects
Bacteria, Smoking, Streptococcus, Zoology, General Medicine, Middle Aged, Biology, Gram-Positive Bacteria, Micrococcus, Yeasts, Pharyngeal Flora, Humans, Pharynx, Composition (visual arts), Neisseria, Aged
Published
1984
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12. Optimization of the composition of a new MRS-type negative resist

Author

Akihiko Kishimoto, Toshiharu Matsuzawa, Hiroshi Yanazawa, Takao Iwayanagi, and Hidehito Obayashi

Subjects
Materials science, business.industry, Photoresist, Electronic, Optical and Magnetic Materials, law.invention, Wavelength, Photosensitivity, Resist, Magazine, law, Optoelectronics, Photosensitizer, Electrical and Electronic Engineering, business, Layer (electronics)
Abstract

Sensitizer concentration is optimized for a new negative photoresist, MRL (Micro Resist for Longer wavelengths) with the assistance of computer simulation. The resist, which has photosensitivity in the ordinary UV region, resembles a deep UV resist MRS in terms of light absorption characteristic. It is found that a photosensitizer concentration of 20 wt% (based on the resin) is suitable for a reduction projection exposure system that utilizes UV light at 365 nm. A steep profile resist image of 0.7-µm lines and 0.7-µm spaces in a 1.0-µm thick resist layer is obtained using the MRL of optimized composition and the exposure system.

Published
1983
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13. Meterial Characterization of Polymers

Author

Ichiro Noda, Mitsuru Nagasawa, Hirokazu Kajiura, Akihiko Kishimoto, Teruo Aramaki, Akira Itsubo, Toshihiko Kuroda, Yoshiharu Tsujita, Akira Takizawa, Shuichi Nojima, and Masamitsu Murayama

Subjects
chemistry.chemical_classification, Materials science, chemistry, Mechanics of Materials, Mechanical Engineering, General Materials Science, Nanotechnology, Polymer, Condensed Matter Physics, Characterization (materials science)
Published
1986
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14. Comparative Clinical Study of Cefpiramide (SM-1652) and Cefmetazole for Respiratory Tract Infections by a Double-Blind Method

Author

Hiroyuki KOBAYASHI, Osamu KITAMOTO, Akira SAITO, Yasumichi KATO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Morikuni ABE, Akira UJIIE, Yoshio KINOSHITA, Osamu YAJIMA, Fumio NAGAHAMA, Yuichi SASAKI, Shinya YASUDA, Takehito NAKABAYASHI, Takahisa SAITO, Satoshi YAGUCHI, Kazuo SAOTOME, Yuji IKEDA, Jutaro SHIMOMURA, Mitsuharu OGI, Hiroshi TAKAGI, Akihiko KUZE, Osamu MITSUHASHI, Takashi TAKABORI, Yomei HIRAGA, Kohki KIKUCHI, Hiroshi KAWAI, Kazuo TAKEBE, Kenichi IMAMURA, Yoshihiro KUMASAKA, Kiyohito TAKAHASHI, Hisashi NAKAHATA, Mitsuo NAKAMURA, Takashi CHINOI, Katsuhiro OKAMOTO, Shuichiro YOSHIDA, Naoyoshi MASAKI, Toyokazu TAMURA, Tadashi MIYAZAWA, Hazime WATANABE, Shiro KOSAKA, Makoto NAKAZONO, Tsuneharu BABA, Kazuo SASAKI, Morio SAGARA, Hitoshi YASHIRO, Osamu UEHARA, Masao TAMURA, Ryuji ITO, Taro CHIBA, Kazuki KONISHI, Toshimi SUZUKI, Yoshiaki TAKEZAWA, Yasuo ONO, Hisao KIMURA, Tamotsu TAKISHIMA, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Kikuo ONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Kenichi OKAYAMA, Kunio IMATAKA, Masanori ADACHI, Fuyuhiko HIGASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Junko HIBINO, Yasushi UEDA, Atsushi SAITO, Masanobu KAJI, Tadashi MIYAHARA, Ryozo YONEDA, Mitsuo KAWAMURA, Sumio YAMAOKA, Keimei MASHIMO, Keiichi NAKAGAWA, Masaru KOYAMA, Kentaro WATANABE, Motoichi TANAKA, Shinichi ODAMA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hiroichi TANIMOTO, Akio TACHIBANA, Ippei FUJIMORI, Michinori KOHNO, Yoshio KOBAYASHI, Toshio FUKUI, Kenji MITSUI, Kokichi FUKUSHIMA, Akira ITHO, Kunihiko SHINDO, Shigeki ODAGIRI, Makio KURIHARA, Hideyuki HASEGAWA, Kazufuto FUKAYA, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OHYAMA, Kuniyoshi SUZUKI, Ryusaku SHIMIZU, Toshiyuki YAMAMOTO, Saburo KITAURA, Masahito KATO, Kenzo SUZUKI, Kazuo YOSHITOMO, Motoko YAMAMOTO, Akihiko KISHIMOTO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Mitsuo HASE, Ryoichi AMIYA, Yoichi OSADA, Hiroshi OKUBO, Yuruko OKAMOTO, Yoshihiro UEDA, Keigo MAEHARA, Fumio MIKI, Rinzo SOEJIMA, Yoshito NIKI, Masayasu KAWANISHI, Chikara NAKAHAMA, Yukio NISHIMOTO, Michio YAMAKIDO, Fumiaki TSUKIYAMA, Osamu KURIMURA, Hideo SASAKI, Yoshihiko ARAYA, Yoko KAGAWA, Eiro TSUBURA, Toshihiro GOTO, Yoshihiro TAKISHITA, Yoshiro SAWAE, Kaoru OKADA, Nobuaki SHIGEMATSU, Osamu OGUSHI, Kohei HARA, Tsuneo TSUTSUMI, Kazuhiro OKUNO, Rokushi OKA, Keizo YAMAGUCHI, Youji SUZUYAMA, Toshiyuki OE, Yoshiteru SHIGENO, Naomi ITOH, Hikaru TANAKA, Masao SAI, Keizo MATSUMOTO, Harumi SHISHIDO, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Atsushi SHINODA, Hitoshi NAGANO, Toshiyuki HAYASHI, Haruhiko TOKUOMI, Yasutsugu FUKUDA, and Katsumasa TOKUNAGA

Subjects
Double blind, Clinical study, medicine.medical_specialty, Respiratory tract infections, business.industry, Internal medicine, medicine, General Medicine, Cefpiramide, Cefmetazole, business, Gastroenterology, medicine.drug
Published
1983
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15. A comparative Study Between Aztreonam and Cefoperazone in Respiratory Tract Infections

Author

Atsushi SAITO, Kohya SHIBA, Tadashi MIYAHARA, Yasushi UEDA, Tsugio TERAI, Shosaku ABE, Etsuro YAMAGUCHI, Nozomu OKAZAKI, Yoshikazu KAWAKAMI, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Kiyofumi ISHIKAWA, Akira SUZUKI, Mitsunari NAKAMURA, Hiroshi NATORI, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Sokichi ONODERA, Nobuhiro SASAKI, Fumio NAGAHAMA, Rensuke KURODA, Yuji IKEDA, Kazuo TAKEBE, Shiro KOSAKA, Ken-ichi KIMURA, Masafumi KITAOKA, Shuichiro YOSHIDA, Katsuhiro OKAMOTO, Teruo NAKAMURA, Osamu UEHARA, Shigetoshi YANAGIYA, Toyokazu TAMURA, Hitoshi YASHIRO, Takahiko KAWAGISHI, Masao TAMURA, Takashi ITO, Takehisa MURAKAMI, Kohtaroh ITAKURA, Hiroshi KURAMITSU, Katsura MORIYA, Kazutoshi GOMI, Tamotsu TAKISHIMA, Shiro IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Reiko SASAKI, Izumi HAYASHI, Koichi WADA, Hajimu TAKEDA, Masaaki ARAKAWA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OHYAMA, Kuninori SUZUKI, Hisashi TAKIZUKA, Masato NAKANO, Hajime YAMAGATA, Yumiko MURAYAMA, Kazumichi TSURUMACHI, Hiroichi TANIMOTO, Tatsuo NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Katsunori UENO, Tetsuro UKAI, Kazuaki HANAOKA, Keimei MASHIMO, Keiichi NAKAGAWA, Masaru KOYAMA, Fukuo IIJIMA, Kentaro WATANABE, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kihachiro SHIMIZU, Fumio MATSUMOTO, Kazufuto FUKAYA, Shigeki ODAGIRI, Masanori MATSUMURA, Kaneo SUZUKI, Kou MUROHASHI, Keinosuke NOZE, Shin-ichiro WATANABE, Hisako SUZUKI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Kenzo TAKAGI, Ken-ichi YAMAKI, Shigeki YOKOYAMA, Masao TANO, Hitoshi IWATA, Motohide SASAMOTO, Tatsuo SATAKE, Nobuo MAEKAWA, Fumiyuki KUZE, Michiyasu NAKANISHI, Hideki NISHIYAMA, Hiroyuki TSUJINO, Nobuo INABA, Yoshiro ODA, Akira KAGIOKA, Takekuni IWATA, Kazukiyo OIDA, Hitoshi NAKAI, Hiroko SAKAMOTO, Nobuyuki KATAGAMI, Eiichi MATSUYAMA, Shin-ichi USHIDA, Sadao IKEDA, Kohei AOKI, Kenzo SHIOTA, Yoshio YAMADA, Keiji KOBAYASHI, Kojiro YASUNAGA, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Yoshihiro UEDA, Akira OOKUBO, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Minoru YOSHIYAMA, Tetsuro MURATA, Shin-ichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenji TAKAMATSU, Kazuya HIGASHINO, Toshikazu HADA, Kenji NABESHIMA, Akitaka HIROSAKI, Takashi NAKANO, Rinzo SOEJIMA, Yoshihito NIKI, Yukio NISHIMOTO, Michio YAMAKIDO, Akimitsu KAMITSUNA, Kenji HASEGAWA, Osamu KURIMURA, Yoshihiko ARATANI, Eiro TSUBURA, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Nobuaki SHIGEMATSU, Norichika MATSUMOTO, Reiko KISHIKAWA, Takeo YOKOTA, Hitoshi NAGANO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Kazuhiro OKUNO, Koichi WATANABE, Tsunetoshi KOTEDA, Kenji MORI, Keizo MATSUMOTO, Yoshio UZUKA, Naoto RIKITOMI, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Takashi ITOGA, Masayuki ANDO, Mineharu SUGIMOTO, Moritake SUGA, Akira MIYAZAKI, Shukuro ARAKI, Kazumine KOBARI, Masao NAKATOMI, Yuei IRABU, Tatsuo OHGIMI, and Yutoku KINJO

Subjects
Adult, Male, Adolescent, Respiratory tract infections, business.industry, Cefoperazone, Pneumonia, General Medicine, Aztreonam, Middle Aged, Haemophilus influenzae, Microbiology, chemistry.chemical_compound, chemistry, Humans, Medicine, Female, business, Respiratory Tract Infections, Aged, medicine.drug
Published
1985
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16. [Polymicrobial infection in terminal pneumonia in the aged]

Author

Joichi Kato, Motoko Yamamoto, Akihiko Kishimoto, Kanzo Suzuki, Masahito Kato, Toshiyuki Yamamoto, Yoshimitsu Hayashi, Toshihiko Takeuchi, Mizuo Tsuzuki, and Kazuo Yoshitomo

Subjects
Male, Polymicrobial infection, business.industry, General Medicine, Pneumonia, Middle Aged, medicine.disease, Microbiology, Klebsiella pneumoniae, Terminal (electronics), medicine, Enterococcus faecalis, Escherichia coli, Humans, Female, business, Aged
Published
1984

17. Novel Process For Fabricating Low Distortion X-Ray Masks Of Submicron Gold Patterns

Author

Akihiko Kishimoto, Takashi Soga, Takeshi Kimura, Taroh Ogawa, and Shinji Kuniyoshi

Subjects
Materials science, Fabrication, chemistry, Resist, Proximity effect (electron beam lithography), Plating, Copper plating, chemistry.chemical_element, Nanotechnology, Electroplating, Layer (electronics), Copper
Abstract

A novel process for fabricating x-ray masks of submicron gold patterns using a copper plating base is presented and discussed in detail. In the E-beam writing of x-ray masks, the trilevel resist layers and the metal layer for x-ray absorber patterning cause a proximity effect which determines the masks' resolution. Based on E-beam simulations and experimental results, copper plating base is selected as the best metal-layer material to reduce the above effect. To fabricate submicron gold patterns on the copper base, two gold-electroplating steps are newly introduced. These are strike plating and pulse-current plating. Stress change in the plated gold and positional accuracy changes are also measured throughout the heating process. Finally, sequential steps for the fabrication of x-ray masks with plating base are shown.

Published
1988
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18. [Comparative clinical study of ceftazidime and cefotiam for respiratory tract infections by a double-blind method]

Author

Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Isao NAKAMURA, Toshiro ODA, Kazuhiro OKUNO, Hiromaru IWASAKI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Shinya YASUDA, Takehito NAKABAYASHI, Tetsuji KOROKU, Takahisa SAITO, Hiromichi HORIKAWA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Mitsunari NAKAMURA, Mitsuo ASAKAWA, Akira SUZUKI, Yoshiro ISHII, Kazuo TAKEBE, Morio SAGARA, Shuichiro YOSHIDA, Toyokazu TAMURA, Hideya MURABAYASHI, Naoki TAMAZAWA, Tomio ONUMA, Osamu UEHARA, Gen ENOOKA, Katsuhiro OKAMOTO, Naoyoshi MASAKI, Shigetoshi YANAGIYA, Hiroshi TAKAHASHI, Mitsunobu HONMA, Tomohiro KANAZAWA, Keiji TAKAHASHI, Hideki SASAKI, Shoji YASUI, Shiro IDA, Kiyo NISHIOKA, Tamotsu TAKISHIMA, Seiichi AONUMA, Kikuo ONUMA, Akira WATANABE, Masako SASAKI, Kotaro OIZUMI, Kiyoshi KONNO, Izumi HAYASHI, Tatsuya ABE, Shigeru TAMAKI, Masataka KATSU, Shinji OKUI, Mieko KAWAI, Fuyuhiko HIGASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Keimei MASHIMO, Tetsuro UKAI, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroichi TANIMOTO, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Yasushi UEDA, Jingoro SHIMADA, Kohya SHIBA, Takehisa YAMAJI, Hironobu IHARA, Tadashi MIYAHARA, Keiichi NAKAGAWA, Masaru KOYAMA, KOUJIN KIN, Fukuo IIJIMA, Ryuji AKIYOSHI, Hiroyuki KAWAHARA, Takashi YAMAMOTO, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kohta KOHNO, Seiji MITA, Yoshio KOBAYASHI, Ippei FUJIMORI, Akira ITO, Kunihiko SHINDO, Jun CHIBA, Shohei NAGAOKA, Kokichi FUKUSHIMA, Hideyuki HASEGAWA, Makio KURIHARA, Shigeki ODAGIRI, Hirotada IKEDA, Kohu MUROHASHI, Kaneo SUZUKI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Hajimu TAKEDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Yasuko YUASA, Isao NITTA, Kyoko WATANABE, Kaoru OYAMA, Ryusaku SHIMIZU, Kuninori SUZUKI, Fumio MIKI, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Muneto YOSHIOKA, Kojiro YASUNAGA, Yoshihiro UEDA, Hiroshi OKUBO, Rinzo SOEJIMA, Yoshihito NIKI, Osamu KURIHARA, Hideo SASAKI, Masao MIKITANI, Yoshihiko ARATANI, Eiji KANETO, Eiro TSUBURA, Toshihiro GOTO, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Nobuyuki HIROSE, Nobuaki SHIGEMATSU, Hitoshi NAGANO, Hiromi KIHARA, Masaro KAJI, Yoichiro ICHIKAWA, Fumio TANAKA, Syunji HAYASHI, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Keizo MATSUMOTO, Tomoyuki HARADA, Takeshi ISHIZAKI, Taketsune MATSUMOTO, Tsunetoshi KOTEDA, Shigeru KOHNO, Masaru NASU, Jun GOTO, Takashi ITOGA, Tsutomu YAMAZAKI, Kunio NOMURA, Shigetake MIYAZAKI, Junichi SUETSUNA, Kazumine KOBARI, Masao NAKATOMI, Yutoku KINJO, Yoshio AOKI, and Kenji MARUMO

Subjects
Adult, Male, medicine.medical_specialty, Clinical Trials as Topic, Respiratory tract infections, Cefotiam, business.industry, Ceftazidime, General Medicine, Cefotaxime, Middle Aged, Double blind, Clinical study, Double-Blind Method, medicine, Humans, Female, Intensive care medicine, business, Respiratory Tract Infections, medicine.drug, Aged
Published
1984

19. [A double-blind comparative study of aspoxicillin and piperacillin in the treatment of respiratory tract infections]

Author

Akira SAITO, Kiyofumi ISHIKAWA, Ichiro NAKAYAMA, Masumi TOMIZAWA, Morikuni ABE, Hidetoshi SHIBAKI, Takehisa CHIMOTO, Masahiro TANAKA, Choei ITO, Keisuke TAKEUCHI, Aiji KOJIMA, Kazuo SHIMOYAMA, Yoshinobu TAKASHIRO, Shinji OHNISHI, Masahide SHINOHARA, Akira UJIIE, Osamu YAJIMA, Fumio NAGAHAMA, Hisaji NISHIHARA, Yuichi SASAKI, Takehito NAKABAYASHI, Tetsuji KOROKU, Rensuke KURODA, Jutaro SHIMOMURA, Shin-ichi OSHIMA, Sokichi ONODERA, Nobuhiro SASAKI, Akira SUZUKI, Tohru NATSUIZAKA, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Tsuyoshi KIKUIRI, Tadashi MURAKAMI, Kazufumi TSUCHIHASHI, Kazuo TAKEBE, Katsuhiro OKAMOTO, Shuichiro TOSHIDA, Tadanao OHMI, Shuichi TAKAHASHI, Katsutoshi KARIYA, Tomio ONUMA, Shigeru OCHIAI, Yoshihiro KUMASAKA, Shigetoshi YANAGIYA, Osamu UEHARA, Yasukimi WATABIKI, Naoyoshi MASAKI, Toyoichi TAMURA, Naoki TAMAZAWA, Hajime INOOKA, Masao TAMURA, Takashi ITOH, Ken-ichi TAKEUCHI, Ryoji OGATA, Jun KOMURO, Hiroaki ITOH, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyoshi KONNO, Kotaro OHIZUMI, Akira WATANABE, Makoto KASHIWAGI, Hideo TOGASHI, Hidetaka SATO, Masato HAYASHI, Tsugushi ITOH, Izumi HAYASHI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Masataka KATSU, Masanori ADACHI, Keimei MASHIMO, Tetsuro UKAI, Chizuru ITOH, Atsushi SAITO, Tadashi MIYAHARA, Hiroichi TANIMOTO, Akio TACHIBANA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Keiichi NAKAGAWA, Masaru KOYAMA, Kohjin KIN, Masami UEDA, Fukuo IIJIMA, Ryuji AKIYOSHI, Yuzo FUNATSU, Fuyuhiko HIGASHI, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Ippei FUJIMORI, Yoshio KOBAYASHI, Yasushi NAKAMURA, Kazufuto FUKAYA, Kenzo TAKAGI, Ikuo YAMAKAWA, Michihiro HARA, Tatsuo SATAKE, Toshihiko TAKEUCHI, Masahito KATO, Saburo KITAURA, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Youichi ABE, Katsutaka TORIGAI, Kaoru OHYAMA, Kuninori SUZUKI, Nobuo OHYA, Mitsuru HAYASE, Nobuo MAEKAWA, Michiyasu NAKANISHI, Kohei AOKI, Tsuneo MATSUBARA, Nobuaki IKEDA, Takekuni IWATA, Nobuo INABA, Hiroyuki TSUJINO, Yuruko OKAMOTO, Keigo MAEHARA, Muneto YOSHIOKA, Yube IIDA, Hiroshi OKUBO, Yoshihiro UEDA, Fumio MIKI, Kenji TAKAMATSU, Osamu MIYAMOTO, Eiro TSUBURA, Toshihiro GOTO, Masakazu TAMURA, Rinzo SOEJIMA, Yoshito NIKI, Masatoshi WATANABE, Michio YAMAKIDO, Kanoko HAYASHI, Yoshiro SAWAE, Tomohiro KUSABA, Seizaburo KASHIWAGI, Akira UEDA, Kaoru OKADA, Michio ONO, Masahide TAKII, Takatoshi OTONARI, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Masao NAGASAWA, Keizo MATSUMOTO, Harumi SHISHIDO, Atsushi TAKAHASHI, Masakazu TAKASUGI, Shigeru TAMAKI, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Katsumasa TOKUNAGA, Yasutsugu FUKUDA, and Haruhiko TOKUOMI

Subjects
Piperacillin, medicine.medical_specialty, Clinical Trials as Topic, Respiratory tract infections, business.industry, Amoxicillin, Lung abscess, General Medicine, Pneumonia, medicine.disease, Double blind, Aspoxicillin, Chronic disease, Double-Blind Method, Internal medicine, Chronic Disease, medicine, Humans, Lung Abscess, business, Respiratory Tract Infections, medicine.drug
Published
1985

20. [Clinical studies on MT-141]

Author

Akihiko Kishimoto, Kanzo Suzuki, and Toshiyuki Yamamoto

Subjects
Male, Urinary Tract Infections, Drug Evaluation, Humans, Drug Resistance, Microbial, Female, General Medicine, Bacterial Infections, Pneumonia, Cephamycins, Respiratory Tract Infections, Aged
Published
1985

21. Studies of Ordered Monodisperse Latexes. IV. Mechanism of Ordering

Author

Shigeki Mitaku, Koji Okano, Akihiko Kishimoto, and Toshiya Ohtsuki

Subjects
Phase transition, Aqueous solution, Rigidity (electromagnetism), Condensed matter physics, Chemistry, Volume fraction, Dispersity, General Engineering, General Physics and Astronomy, Surface charge, Phase diagram, Iridescence
Abstract

The order-disorder phase transition of aqueous suspensions of charged polystyrene spheres was studied both experimentally and theoretically. Phase diagrams of four kinds of samples with different surface charge numbers were determined from the observation of disappearance of the characteristic iridescence in the ordered state. The ordered phase appeared in the large volume fraction and low salt concentration regions. The ordered region became larger according to the surface charge number increase. On the basis of Lindemann's law, phase diagrams were also obtained theoretically. The theory reproduced quantitatively the experimental phase diagrams of all the samples used. The applicability of the Debye-Hückel approximation was discussed and the evaluation of the static rigidity reported in a previous paper [Jpn. J. Appl. Phys.: 19 (1980) 439] was improved.

Published
1981
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