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1. Synthesis and Antibacterial Activity of 3-(Substituted arylmethyl)-4-acylaminomethyloxazolidin-2-ones and Derivatization to Symmetrical Twin-Drug Type Molecules

Author

Yumiko Matsumura, Fumio Miake, Nobuhiro Kashige, Kunihiro Sumoto, Fumiko Fujisaki, Sachi Hiromatsu, and Aki Fukami

Subjects
Drug, Stereochemistry, media_common.quotation_subject, Organic Chemistry, medicine.disease_cause, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Staphylococcus aureus, medicine, Molecule, Antibacterial activity, Derivatization, Escherichia coli, media_common
Abstract

In connection with our studies on antibacterial active compounds in the class of new oxazolidinones against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) strains, some molecular modifications were attempted. In this study, molecular modifications of 4-aminomethyloxazolidin-2-ones (3a) to the corresponding 4-acylaminomethyloxazolidin-2-one derivatives (3c–d) and preparations of the represented twin-drug type molecules (10–14) were investigated. Some additional 4-dialkylaminomethyloxazolidin-2-ones (2) were also synthesized. The synthesized compounds were evaluated for antibacterial activity with Gram-positive (S. aureus) and Gram-negative (E. coli) strains.

Published
2013
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2. ChemInform Abstract: Synthesis and Antibacterial Activity of 3-(Substituted arylmethyl)-4-acylaminomethyloxazolidin-2-ones and Derivatization to Symmetrical Twin-Drug Type Molecules

Author

Aki Fukami, Yumiko Matsumura, Nobuhiro Kashige, Sachi Hiromatsu, Kunihiro Sumoto, Fumio Miake, and Fumiko Fujisaki

Subjects
Drug, Stereochemistry, media_common.quotation_subject, General Medicine, medicine.disease_cause, chemistry.chemical_compound, chemistry, Staphylococcus aureus, medicine, Molecule, Derivatization, Antibacterial activity, Escherichia coli, media_common
Abstract

In connection with our studies on antibacterial active compounds in the class of new oxazolidinones against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) strains, some molecular modifications were attempted. In this study, molecular modifications of 4-aminomethyloxazolidin-2-ones (3a) to the corresponding 4-acylaminomethyloxazolidin-2-one derivatives (3c–d) and preparations of the represented twin-drug type molecules (10–14) were investigated. Some additional 4-dialkylaminomethyloxazolidin-2-ones (2) were also synthesized. The synthesized compounds were evaluated for antibacterial activity with Gram-positive (S. aureus) and Gram-negative (E. coli) strains.

Published
2013
Full Text
View/download PDF

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