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24. Physicochemical evaluation to assess the quality of honey samples marketed in Oman.

Author

Said Al Hadhrami, Al Zahraa Mohammed, Abdullah Al Mazrooei, Fatema Rashid, Al Mamari, Sheikha Mohammed Ali, Juma AL Humaid, Sakina Habib, Khan, Shah Alam, and Akhtar, Md Jawaid

Subjects
FURFURAL, HONEY, STANDARDS, ACIDITY, SUGAR content of food
Abstract

The study aimes to investigate the physicochemical properties of seven honey samples to assess their quality as per GCC Standardization Organization (GSO) and international standard parameters. Seven honey samples, four marketed honey samples, and three locally produced Omani honey were collected and analysed for the pH, acidic content, % of insoluble matter, moisture content, proline, hydroxyl methyl furfural (HMF) and total reducing sugar contents. The results showed that pH of the tested honey samples are within the limit however acidity of the three samples did not comply with the prescribed limits. The moisture, proline, and hydroxy methyl furfural (HMF) contents of the honey samples tested are found to be within the acceptable range. However, the % of insoluble matter expressed for locally produced Sidr, Sumer, and Zah'r honey samples was below the maximum limit (0.5%) while marketed honey samples exceeded the limits of GSO (0.1%). The total reducing sugar concentration was below the limit in terms of four samples. Most of the tested honey samples meet the International/GSO standards for quality while a few failed to comply with acidity limits, the total reducing sugars content, and % of insoluble matter. [ABSTRACT FROM AUTHOR]

Published
2023
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25. In silico studies on olive oil polyphenolic natural products to identify neuroprotective lead compounds beneficial in the treatment of Alzheimer's disease

Author

Hachani, Khouloud, Othmani, Fahd, Essam, Mohamed, Akhtar, Md Jawaid, and KHAN, SHAH ALAM

Subjects
Alzheimer’s disease, Neuroprotection, Phenolic compounds, Antioxidant, AChE, BACE-1
Abstract

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders. Nearly 44 million people across the globe are living with it. In spite of tremendous progress in understanding the pathophysiology of AD, only a few drugs have been approved by FDA to date that too provides only symptomatic relief. We have contemplated historical and religious backgrounds in addition to the literature review and concluded that polyphenolic natural products from olive oil can be used for the treatment of AD. The current computational study was designed to investigate the potential of phenolic metabolites present in olive oil to identify lead molecule(s) that could help in fighting against AD. A total of 21 phenolic compounds from olive oil were selected, and their SMILES notations were generated using Chemsketch. Cheminformatics software such as, Molinspiration to predict the bioactivity scores and physicochemical properties, PASS to predict the acetylcholinesterase (AChE) inhibition, neuroprotective, antioxidants, and anti-inflammatory activities; OSIRIS for pharmacokinetic profile and toxicity and Autodock Vina for molecular docking were used for in silico studies. The results were compared with four clinically used AD drugs. All the tested compounds were predicted to possess anti-inflammatory activity (0.357-0.831 Pa score) and antioxidant activity (0.320-0.903 Pa values), but none of the compounds was found to be a butyrylcholinesterase inhibitor. Out of 21 initial polyphenolic compounds, we selected the best two bioactive compounds, luteolin and elenolic acid, based on their bioactivity and toxicity profile. Luteolin showed the most stable binding to both beta-secretase- 1 (BACE) and AChE enzymes followed by elenolic acid. It is concluded that luteolin and elenolic acid are the most potent polyphenolic compounds of the olive, which act at multiple targets in AD pathogenesis. These compounds hold promise for the development of anti-Alzheimer's therapy., Arabian Journal of Medicinal and Aromatic Plants, Vol 9, No 1 (2023)

Published
2023
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28. Role of sodium dependent SLC13 transporter inhibitors in various metabolic disorders.

Author

Akhtar, Md Jawaid, Khan, Shah Alam, Kumar, Bhupinder, Chawla, Pooja, Bhatia, Rohit, and Singh, Karanvir

Abstract

The sodium dependent SLC13 family transporters comprise of five genes SLC13A1, SLC13A2 (NaDC1), SLC13A3 (NaDC3), SLC13A4 and SLC13A5 (NaCT). Among them, NaDC1, NaDC3 and NaCT are sodium dependent transporters belonging to family of dicarboxylates (succinate, malate, α-ketoglutarate) and tricarboxylates (citrate). The mouse and the human NaCT structures have still not been crystallized, therefore structural information is taken from the related bacterial transporter of VcINDY. Citrate in the cytosol works as a precursor for the fatty acid synthesis, cholesterol, and low-density lipoproteins. The excess citrate from the matrix is translocated to the cytosol for fatty acid synthesis through these transporters and thus controls the energy balance by downregulating the glycolysis, tricarboxylic acid (TCA), and fatty acid breakdown. These transporters play an important role in regulating various metabolic diseases including cancer, diabetes, obesity, fatty liver diseases and CNS disorders. These di and tricarboxylate transporters are emerging as new targets for metabolic disorders such as obesity and diabetes. The mutation in the function of the NaCT causes several neurological diseases including neonatal epilepsy and impaired brain development whereas mutation of genes coding for citrate transport present in the liver may provide positive effect. Therefore, continued efforts from the earlier work on citrate transporters are required for the development of citrate inhibitors. This review discusses the structure, function, and regulation of the NaCT transporter. The review also highlights citrate role in diagnosing diseases such as cancer, diabetes, fatty liver, and diabetes. The therapeutic perspective of synthetic inhibitors against NaCT transporters is succinctly summarized. [ABSTRACT FROM AUTHOR]

Published
2023
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36. An Update on Recently Developed Analytical and Bio-analytical Methods for Some Anticancer Drugs

Author

Paul, Joyson, Singh, Karanvir, Pannu, Sumit, Pal, Rohit, Khan, Shah Alam, Kumar, Bhupinder, and Akhtar, Md Jawaid

Abstract

According to the WHO’s data for 2018, the global cancer burden was estimated to have risen to 18.1 million new cases and which alone accounted for 9.6 million deaths. Cancer is a group of diseases known as tumors that often spreads throughout the body, and may cause harm to multiple organs in the body. The global pharmaceutical spending is around 19% of the R&D cost annually to discover new and potent therapeutic agents. The major problems associated with currently available anticancer drugs are drug resistance and their side effects. They are the most widely explored groups of drugs either using instrumental or bioanalytical methods. In this review, we have compiled and reviewed the analytical and bio-analytical methods of some anticancer drugs developed by different authors. The review also briefly discusses the broad categories of cytotoxic drugs and targeted-based anticancer drugs. The analytical and bioanalytical methods of cytotoxic drugs such as alkylating agents, antimetabolites, hormones, and targetedbased drugs reported earlier and in recent research, articles are discussed in detail. These analytical methods are prerequisites for both the pharmaceutical industry and academics for their impurities profiling and qualitative as well as quantitative estimation. The accuracy, precision, LOD, and LOQ studies by UV-HPLC, LC-MS, and fluorometry HPLC are discussed. Some of the advanced methods developed, in the case of ifosfamide using Au/Pd@rGO@p(L-Cys) and the production of vincristine by endophytic fungi, are also included. This will further embolden the efforts of different researchers working in this field and ease the challenges they face through the analytical development of these drugs.

Published
2023
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41. Analytical Methodologies for Determination of Hydroxychloroquine and its Metabolites in Pharmaceutical, Biological and Environmental Samples

Author

Pannu, Sumit, Akhtar, Md. Jawaid, and Kumar, Bhupinder

Abstract

Background: Hydroxychloroquine (HCQ) was originally launched as an antimalarial drug, but now it is also used as a slow-acting anti-rheumatic drug. It contains equal proportions of (-)-(R)-hydroxychloroquine and (+)-(S)-hydroxychloroquine. Introduction: Hydroxychloroquine, a synthetic 4-aminoquinoline derivative, possesses antimalarial, anti-rheumatic activity and also exerts beneficial effects on lupus erythematous disease. Substantial levels of three metabolites of HCQ, which are desethylchloroquine (DCQ), bisdesethylhydroxychloroquine (BDCQ), and desethylhydroxychloroquine (DHCQ), have been determined by various analytical techniques from blood and plasma. Methods: Various analytical techniques have been reported for asynchronous and simultaneous estimation of HCQ and their metabolites in pharmaceuticals and biological samples like (serum, whole blood, and urine). The analytical techniques are Square-wave voltammetry employed with the cathodically pretreated boron-doped diamond electrode, fast UHPLC–fluorescent method, UV spectrophotometry, UHPLC-UV analysis, RP-HPLC, mass spectrometry, NMR, and CE. Results: We have complied various analytical methods to detect HCQ with its various metabolites simultaneously or alone in pharmaceutical dosage forms, biological and environmental samples. Conclusion: The authors believe that the above-mentioned studies compiled in this report will give a choice to readers to select the most appropriate and suitable method for the analysis of HCQ. Further, it is also believed that this study will help the researchers to develop a more sensitive, convenient, and rapid method for these based on literature reports.

Published
2022
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